Precision of genetic oscillators and clocks

Autores
Morelli, Luis Guillermo; Jülicher, Frank
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We develop a stochastic description of feedback oscillators in which functional molecules are produced by an assembly line consisting of many identical steps. The initiation rate of this assembly is regulated by its products via a negative feedback. This model is motivated by genetic oscillators such as circadian clocks. We show that precise oscillations of high quality are possible even when the number of product molecules is low and the fluctuations of amplitude are large. We discuss parameter values which can account for high quality oscillations as observed in single cells. Furthermore, we discuss effects of stochastic amplification steps on precision to account for translational bursting. © 2007 The American Physical Society.
Fil: Morelli, Luis Guillermo. Max Planck Institute For The Physics Of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Jülicher, Frank. Max Planck Institute For The Physics Of Complex Systems; Alemania
Materia
Noise in Gene Expression
Genetic Oscillators
Stochastic Feedback
Negative Feedback
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67515
Acceder
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spelling Precision of genetic oscillators and clocksMorelli, Luis GuillermoJülicher, FrankNoise in Gene ExpressionGenetic OscillatorsStochastic FeedbackNegative Feedbackhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We develop a stochastic description of feedback oscillators in which functional molecules are produced by an assembly line consisting of many identical steps. The initiation rate of this assembly is regulated by its products via a negative feedback. This model is motivated by genetic oscillators such as circadian clocks. We show that precise oscillations of high quality are possible even when the number of product molecules is low and the fluctuations of amplitude are large. We discuss parameter values which can account for high quality oscillations as observed in single cells. Furthermore, we discuss effects of stochastic amplification steps on precision to account for translational bursting. © 2007 The American Physical Society.Fil: Morelli, Luis Guillermo. Max Planck Institute For The Physics Of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Jülicher, Frank. Max Planck Institute For The Physics Of Complex Systems; AlemaniaAmerican Physical Society2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67515Morelli, Luis Guillermo; Jülicher, Frank; Precision of genetic oscillators and clocks; American Physical Society; Physical Review Letters; 98; 22; 12-2007; 1-40031-9007CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevLett.98.228101info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:43:15Zoai:ri.conicet.gov.ar:11336/67515instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:43:16.092CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Precision of genetic oscillators and clocks
title Precision of genetic oscillators and clocks
spellingShingle Precision of genetic oscillators and clocks
Morelli, Luis Guillermo
Noise in Gene Expression
Genetic Oscillators
Stochastic Feedback
Negative Feedback
title_short Precision of genetic oscillators and clocks
title_full Precision of genetic oscillators and clocks
title_fullStr Precision of genetic oscillators and clocks
title_full_unstemmed Precision of genetic oscillators and clocks
title_sort Precision of genetic oscillators and clocks
dc.creator.none.fl_str_mv Morelli, Luis Guillermo
Jülicher, Frank
author Morelli, Luis Guillermo
author_facet Morelli, Luis Guillermo
Jülicher, Frank
author_role author
author2 Jülicher, Frank
author2_role author
dc.subject.none.fl_str_mv Noise in Gene Expression
Genetic Oscillators
Stochastic Feedback
Negative Feedback
topic Noise in Gene Expression
Genetic Oscillators
Stochastic Feedback
Negative Feedback
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We develop a stochastic description of feedback oscillators in which functional molecules are produced by an assembly line consisting of many identical steps. The initiation rate of this assembly is regulated by its products via a negative feedback. This model is motivated by genetic oscillators such as circadian clocks. We show that precise oscillations of high quality are possible even when the number of product molecules is low and the fluctuations of amplitude are large. We discuss parameter values which can account for high quality oscillations as observed in single cells. Furthermore, we discuss effects of stochastic amplification steps on precision to account for translational bursting. © 2007 The American Physical Society.
Fil: Morelli, Luis Guillermo. Max Planck Institute For The Physics Of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Jülicher, Frank. Max Planck Institute For The Physics Of Complex Systems; Alemania
description We develop a stochastic description of feedback oscillators in which functional molecules are produced by an assembly line consisting of many identical steps. The initiation rate of this assembly is regulated by its products via a negative feedback. This model is motivated by genetic oscillators such as circadian clocks. We show that precise oscillations of high quality are possible even when the number of product molecules is low and the fluctuations of amplitude are large. We discuss parameter values which can account for high quality oscillations as observed in single cells. Furthermore, we discuss effects of stochastic amplification steps on precision to account for translational bursting. © 2007 The American Physical Society.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67515
Morelli, Luis Guillermo; Jülicher, Frank; Precision of genetic oscillators and clocks; American Physical Society; Physical Review Letters; 98; 22; 12-2007; 1-4
0031-9007
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67515
identifier_str_mv Morelli, Luis Guillermo; Jülicher, Frank; Precision of genetic oscillators and clocks; American Physical Society; Physical Review Letters; 98; 22; 12-2007; 1-4
0031-9007
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevLett.98.228101
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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