Precision of genetic oscillators and clocks
- Autores
- Morelli, Luis Guillermo; Jülicher, Frank
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We develop a stochastic description of feedback oscillators in which functional molecules are produced by an assembly line consisting of many identical steps. The initiation rate of this assembly is regulated by its products via a negative feedback. This model is motivated by genetic oscillators such as circadian clocks. We show that precise oscillations of high quality are possible even when the number of product molecules is low and the fluctuations of amplitude are large. We discuss parameter values which can account for high quality oscillations as observed in single cells. Furthermore, we discuss effects of stochastic amplification steps on precision to account for translational bursting. © 2007 The American Physical Society.
Fil: Morelli, Luis Guillermo. Max Planck Institute For The Physics Of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Jülicher, Frank. Max Planck Institute For The Physics Of Complex Systems; Alemania - Materia
-
Noise in Gene Expression
Genetic Oscillators
Stochastic Feedback
Negative Feedback - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/67515
Ver los metadatos del registro completo
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Precision of genetic oscillators and clocksMorelli, Luis GuillermoJülicher, FrankNoise in Gene ExpressionGenetic OscillatorsStochastic FeedbackNegative Feedbackhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We develop a stochastic description of feedback oscillators in which functional molecules are produced by an assembly line consisting of many identical steps. The initiation rate of this assembly is regulated by its products via a negative feedback. This model is motivated by genetic oscillators such as circadian clocks. We show that precise oscillations of high quality are possible even when the number of product molecules is low and the fluctuations of amplitude are large. We discuss parameter values which can account for high quality oscillations as observed in single cells. Furthermore, we discuss effects of stochastic amplification steps on precision to account for translational bursting. © 2007 The American Physical Society.Fil: Morelli, Luis Guillermo. Max Planck Institute For The Physics Of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Jülicher, Frank. Max Planck Institute For The Physics Of Complex Systems; AlemaniaAmerican Physical Society2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67515Morelli, Luis Guillermo; Jülicher, Frank; Precision of genetic oscillators and clocks; American Physical Society; Physical Review Letters; 98; 22; 12-2007; 1-40031-9007CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevLett.98.228101info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:50Zoai:ri.conicet.gov.ar:11336/67515instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:51.247CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Precision of genetic oscillators and clocks |
title |
Precision of genetic oscillators and clocks |
spellingShingle |
Precision of genetic oscillators and clocks Morelli, Luis Guillermo Noise in Gene Expression Genetic Oscillators Stochastic Feedback Negative Feedback |
title_short |
Precision of genetic oscillators and clocks |
title_full |
Precision of genetic oscillators and clocks |
title_fullStr |
Precision of genetic oscillators and clocks |
title_full_unstemmed |
Precision of genetic oscillators and clocks |
title_sort |
Precision of genetic oscillators and clocks |
dc.creator.none.fl_str_mv |
Morelli, Luis Guillermo Jülicher, Frank |
author |
Morelli, Luis Guillermo |
author_facet |
Morelli, Luis Guillermo Jülicher, Frank |
author_role |
author |
author2 |
Jülicher, Frank |
author2_role |
author |
dc.subject.none.fl_str_mv |
Noise in Gene Expression Genetic Oscillators Stochastic Feedback Negative Feedback |
topic |
Noise in Gene Expression Genetic Oscillators Stochastic Feedback Negative Feedback |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We develop a stochastic description of feedback oscillators in which functional molecules are produced by an assembly line consisting of many identical steps. The initiation rate of this assembly is regulated by its products via a negative feedback. This model is motivated by genetic oscillators such as circadian clocks. We show that precise oscillations of high quality are possible even when the number of product molecules is low and the fluctuations of amplitude are large. We discuss parameter values which can account for high quality oscillations as observed in single cells. Furthermore, we discuss effects of stochastic amplification steps on precision to account for translational bursting. © 2007 The American Physical Society. Fil: Morelli, Luis Guillermo. Max Planck Institute For The Physics Of Complex Systems; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Jülicher, Frank. Max Planck Institute For The Physics Of Complex Systems; Alemania |
description |
We develop a stochastic description of feedback oscillators in which functional molecules are produced by an assembly line consisting of many identical steps. The initiation rate of this assembly is regulated by its products via a negative feedback. This model is motivated by genetic oscillators such as circadian clocks. We show that precise oscillations of high quality are possible even when the number of product molecules is low and the fluctuations of amplitude are large. We discuss parameter values which can account for high quality oscillations as observed in single cells. Furthermore, we discuss effects of stochastic amplification steps on precision to account for translational bursting. © 2007 The American Physical Society. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/67515 Morelli, Luis Guillermo; Jülicher, Frank; Precision of genetic oscillators and clocks; American Physical Society; Physical Review Letters; 98; 22; 12-2007; 1-4 0031-9007 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/67515 |
identifier_str_mv |
Morelli, Luis Guillermo; Jülicher, Frank; Precision of genetic oscillators and clocks; American Physical Society; Physical Review Letters; 98; 22; 12-2007; 1-4 0031-9007 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevLett.98.228101 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Physical Society |
publisher.none.fl_str_mv |
American Physical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614486824058880 |
score |
13.070432 |