Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis

Autores
Balan, Dario Javier; Bardach, Ariel Esteban; Palermo, Carolina; Alconada, Tomás; Sandoval, Macarena; Nieto Guevara, Javier; Gomez, Jorge; Ciapponi, Agustín
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This systematic review describes herpes zoster (HZ) economic burden in terms of healthcare resource use and cost outcomes in the Latin America and Caribbean (LAC) region. We searched online databases from 1 January 2000 to 20 February 2020 to identify eligible publications. We identified 23 publications that reported direct costs, indirect costs, and resources associated with HZ and its complications. The primary direct medical resources reported in the different studies were visits to doctors, transportation, days in the hospital, nursing, medication schedules, and physical therapy. Direct total costs per patient ranged from $99.99 to $4177.91. The highest cost was found in Brazil. Direct costs are, in average, 81.39% higher than indirect costs. The cost per patient that includes postherpetic neuralgia treatment is 115% higher on average for the directs and 73% for the indirect costs. Brazil reported a higher total cost per patient than Argentina and Mexico, while for indirect costs per patient, Brazil and Argentina had higher costs than Mexico, respectively. A meta-analysis on the number of days due to HZ hospitalization, performed on non-immunosuppressed patients over 65 years of age from three studies, resulted in a cumulative measure of 4.5 days of hospitalization. In the LAC region, the economic burden of HZ and associated complications is high, particularly among high-risk populations and older age groups. Preventative strategies such as vaccination could help avoid or reduce the HZ-associated disease economic burden in the LAC region.
Fil: Balan, Dario Javier. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bardach, Ariel Esteban. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Sandoval, Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Nieto Guevara, Javier. No especifíca;
Fil: Gomez, Jorge. No especifíca;
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Materia
AND THE CARIBBEAN
DIRECT COST
HEALTH ECONOMICS
HERPES ZOSTER
INDIRECT COST
LATIN AMERICA
POSTHERPETIC NEURALGIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/222118
Acceder
id CONICETDig_fa40e547b8522feb397fd1ba36d43dcf
oai_identifier_str oai:ri.conicet.gov.ar:11336/222118
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Economic burden of herpes zoster in Latin America: A systematic review and meta-analysisBalan, Dario JavierBardach, Ariel EstebanPalermo, CarolinaAlconada, TomásSandoval, MacarenaNieto Guevara, JavierGomez, JorgeCiapponi, AgustínAND THE CARIBBEANDIRECT COSTHEALTH ECONOMICSHERPES ZOSTERINDIRECT COSTLATIN AMERICAPOSTHERPETIC NEURALGIAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3This systematic review describes herpes zoster (HZ) economic burden in terms of healthcare resource use and cost outcomes in the Latin America and Caribbean (LAC) region. We searched online databases from 1 January 2000 to 20 February 2020 to identify eligible publications. We identified 23 publications that reported direct costs, indirect costs, and resources associated with HZ and its complications. The primary direct medical resources reported in the different studies were visits to doctors, transportation, days in the hospital, nursing, medication schedules, and physical therapy. Direct total costs per patient ranged from $99.99 to $4177.91. The highest cost was found in Brazil. Direct costs are, in average, 81.39% higher than indirect costs. The cost per patient that includes postherpetic neuralgia treatment is 115% higher on average for the directs and 73% for the indirect costs. Brazil reported a higher total cost per patient than Argentina and Mexico, while for indirect costs per patient, Brazil and Argentina had higher costs than Mexico, respectively. A meta-analysis on the number of days due to HZ hospitalization, performed on non-immunosuppressed patients over 65 years of age from three studies, resulted in a cumulative measure of 4.5 days of hospitalization. In the LAC region, the economic burden of HZ and associated complications is high, particularly among high-risk populations and older age groups. Preventative strategies such as vaccination could help avoid or reduce the HZ-associated disease economic burden in the LAC region.Fil: Balan, Dario Javier. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Bardach, Ariel Esteban. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Sandoval, Macarena. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Nieto Guevara, Javier. No especifíca;Fil: Gomez, Jorge. No especifíca;Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaTaylor & Francis2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/222118Balan, Dario Javier; Bardach, Ariel Esteban; Palermo, Carolina; Alconada, Tomás; Sandoval, Macarena; et al.; Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis; Taylor & Francis; Human Vaccines and Immunotherapeutics; 18; 7; 12-2022; 1-142164-55152164-554XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/21645515.2022.2131167info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:46:29Zoai:ri.conicet.gov.ar:11336/222118instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:46:29.506CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis
title Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis
spellingShingle Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis
Balan, Dario Javier
AND THE CARIBBEAN
DIRECT COST
HEALTH ECONOMICS
HERPES ZOSTER
INDIRECT COST
LATIN AMERICA
POSTHERPETIC NEURALGIA
title_short Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis
title_full Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis
title_fullStr Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis
title_full_unstemmed Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis
title_sort Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Balan, Dario Javier
Bardach, Ariel Esteban
Palermo, Carolina
Alconada, Tomás
Sandoval, Macarena
Nieto Guevara, Javier
Gomez, Jorge
Ciapponi, Agustín
author Balan, Dario Javier
author_facet Balan, Dario Javier
Bardach, Ariel Esteban
Palermo, Carolina
Alconada, Tomás
Sandoval, Macarena
Nieto Guevara, Javier
Gomez, Jorge
Ciapponi, Agustín
author_role author
author2 Bardach, Ariel Esteban
Palermo, Carolina
Alconada, Tomás
Sandoval, Macarena
Nieto Guevara, Javier
Gomez, Jorge
Ciapponi, Agustín
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AND THE CARIBBEAN
DIRECT COST
HEALTH ECONOMICS
HERPES ZOSTER
INDIRECT COST
LATIN AMERICA
POSTHERPETIC NEURALGIA
topic AND THE CARIBBEAN
DIRECT COST
HEALTH ECONOMICS
HERPES ZOSTER
INDIRECT COST
LATIN AMERICA
POSTHERPETIC NEURALGIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This systematic review describes herpes zoster (HZ) economic burden in terms of healthcare resource use and cost outcomes in the Latin America and Caribbean (LAC) region. We searched online databases from 1 January 2000 to 20 February 2020 to identify eligible publications. We identified 23 publications that reported direct costs, indirect costs, and resources associated with HZ and its complications. The primary direct medical resources reported in the different studies were visits to doctors, transportation, days in the hospital, nursing, medication schedules, and physical therapy. Direct total costs per patient ranged from $99.99 to $4177.91. The highest cost was found in Brazil. Direct costs are, in average, 81.39% higher than indirect costs. The cost per patient that includes postherpetic neuralgia treatment is 115% higher on average for the directs and 73% for the indirect costs. Brazil reported a higher total cost per patient than Argentina and Mexico, while for indirect costs per patient, Brazil and Argentina had higher costs than Mexico, respectively. A meta-analysis on the number of days due to HZ hospitalization, performed on non-immunosuppressed patients over 65 years of age from three studies, resulted in a cumulative measure of 4.5 days of hospitalization. In the LAC region, the economic burden of HZ and associated complications is high, particularly among high-risk populations and older age groups. Preventative strategies such as vaccination could help avoid or reduce the HZ-associated disease economic burden in the LAC region.
Fil: Balan, Dario Javier. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bardach, Ariel Esteban. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Sandoval, Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Nieto Guevara, Javier. No especifíca;
Fil: Gomez, Jorge. No especifíca;
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
description This systematic review describes herpes zoster (HZ) economic burden in terms of healthcare resource use and cost outcomes in the Latin America and Caribbean (LAC) region. We searched online databases from 1 January 2000 to 20 February 2020 to identify eligible publications. We identified 23 publications that reported direct costs, indirect costs, and resources associated with HZ and its complications. The primary direct medical resources reported in the different studies were visits to doctors, transportation, days in the hospital, nursing, medication schedules, and physical therapy. Direct total costs per patient ranged from $99.99 to $4177.91. The highest cost was found in Brazil. Direct costs are, in average, 81.39% higher than indirect costs. The cost per patient that includes postherpetic neuralgia treatment is 115% higher on average for the directs and 73% for the indirect costs. Brazil reported a higher total cost per patient than Argentina and Mexico, while for indirect costs per patient, Brazil and Argentina had higher costs than Mexico, respectively. A meta-analysis on the number of days due to HZ hospitalization, performed on non-immunosuppressed patients over 65 years of age from three studies, resulted in a cumulative measure of 4.5 days of hospitalization. In the LAC region, the economic burden of HZ and associated complications is high, particularly among high-risk populations and older age groups. Preventative strategies such as vaccination could help avoid or reduce the HZ-associated disease economic burden in the LAC region.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/222118
Balan, Dario Javier; Bardach, Ariel Esteban; Palermo, Carolina; Alconada, Tomás; Sandoval, Macarena; et al.; Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis; Taylor & Francis; Human Vaccines and Immunotherapeutics; 18; 7; 12-2022; 1-14
2164-5515
2164-554X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/222118
identifier_str_mv Balan, Dario Javier; Bardach, Ariel Esteban; Palermo, Carolina; Alconada, Tomás; Sandoval, Macarena; et al.; Economic burden of herpes zoster in Latin America: A systematic review and meta-analysis; Taylor & Francis; Human Vaccines and Immunotherapeutics; 18; 7; 12-2022; 1-14
2164-5515
2164-554X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/21645515.2022.2131167
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.000565

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