A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface

Autores
Zhao, Fangqi; Tallarek, Ann Christin; Wang, Yiru; Xie, Yiran; Diemert, Anke; Lu Culligan, Alice; Vijayakumar, Pavithra; Kittmann, Enrico; Urbschat, Christopher; Bayo Fina, Juan Miguel; Arck, Petra Clara; Farhadian, Shelli F.; Dveksler, Gabriela S.; Garcia, Mariana; Blois, Sandra M.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a risk of infection and disease in pregnant women and neonates. Successful pregnancy requires a fine-tuned regulation of the maternal immune system to accommodate the growing fetus and to protect the mother from infection. Galectins, a family of β-galactoside–binding proteins, modulate immune and inflammatory processes and have been recognized as critical factors in reproductive orchestration, including maternal immune adaptation in pregnancy. Pregnancy-specific glycoprotein 1 (PSG1) is a recently identified gal-1 ligand at the maternal–fetal interface, which may facilitate a successful pregnancy. Several studies suggest that galectins are involved in the immune response in SARS-CoV-2–infected patients. However, the galectins and PSG1 signature upon SARS-CoV-2 infection and vaccination during pregnancy remain unclear. In the present study, we examined the maternal circulating levels of galectins (gal-1, gal-3, gal-7, and gal-9) and PSG1 in pregnant women infected with SARS-CoV-2 before vaccination or uninfected women who were vaccinated against SARS-CoV-2 and correlated their expression with different pregnancy parameters. SARS-CoV-2 infection or vaccination during pregnancy provoked an increase in maternal gal-1 circulating levels. On the other hand, levels of PSG1 were only augmented upon SARS-CoV-2 infection. A healthy pregnancy is associated with a positive correlation between gal-1 concentrations and gal-3 or gal-9; however, no correlation was observed between these lectins during SARS-CoV-2 infection. Transcriptome analysis of the placenta showed that gal-1, gal-3, and several PSG and glycoenzymes responsible for the synthesis of gal-1-binding glycotopes (such as linkage-specific N-acetyl-glucosaminyltransferases (MGATs)) are upregulated in pregnant women infected with SARS-CoV-2. Collectively, our findings identify a dynamically regulated “galectin-specific signature” that accompanies the SARS-CoV-2 infection and vaccination in pregnancy, and they highlight a potentially significant role for gal-1 as a key pregnancy protective alarmin during virus infection.
Fil: Zhao, Fangqi. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Tallarek, Ann Christin. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Wang, Yiru. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Xie, Yiran. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Diemert, Anke. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Lu Culligan, Alice. University of Yale. School of Medicine; Estados Unidos
Fil: Vijayakumar, Pavithra. University Of Yale. School Of Medicine. Departament Of Obstretics And Gynecology; Estados Unidos
Fil: Kittmann, Enrico. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Urbschat, Christopher. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Bayo Fina, Juan Miguel. Universidad Austral; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Arck, Petra Clara. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Farhadian, Shelli F.. University of Yale. School of Medicine; Estados Unidos
Fil: Dveksler, Gabriela S.. Uniformed Services University of the Health Sciences; Estados Unidos
Fil: Garcia, Mariana. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Blois, Sandra M.. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Materia
SARS-CoV-2
Galectin-1
Placent
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256915
Acceder
id CONICETDig_5601fd57cb47926a8362c63299cf6d3a
oai_identifier_str oai:ri.conicet.gov.ar:11336/256915
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interfaceZhao, FangqiTallarek, Ann ChristinWang, YiruXie, YiranDiemert, AnkeLu Culligan, AliceVijayakumar, PavithraKittmann, EnricoUrbschat, ChristopherBayo Fina, Juan MiguelArck, Petra ClaraFarhadian, Shelli F.Dveksler, Gabriela S.Garcia, MarianaBlois, Sandra M.SARS-CoV-2Galectin-1Placenthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a risk of infection and disease in pregnant women and neonates. Successful pregnancy requires a fine-tuned regulation of the maternal immune system to accommodate the growing fetus and to protect the mother from infection. Galectins, a family of β-galactoside–binding proteins, modulate immune and inflammatory processes and have been recognized as critical factors in reproductive orchestration, including maternal immune adaptation in pregnancy. Pregnancy-specific glycoprotein 1 (PSG1) is a recently identified gal-1 ligand at the maternal–fetal interface, which may facilitate a successful pregnancy. Several studies suggest that galectins are involved in the immune response in SARS-CoV-2–infected patients. However, the galectins and PSG1 signature upon SARS-CoV-2 infection and vaccination during pregnancy remain unclear. In the present study, we examined the maternal circulating levels of galectins (gal-1, gal-3, gal-7, and gal-9) and PSG1 in pregnant women infected with SARS-CoV-2 before vaccination or uninfected women who were vaccinated against SARS-CoV-2 and correlated their expression with different pregnancy parameters. SARS-CoV-2 infection or vaccination during pregnancy provoked an increase in maternal gal-1 circulating levels. On the other hand, levels of PSG1 were only augmented upon SARS-CoV-2 infection. A healthy pregnancy is associated with a positive correlation between gal-1 concentrations and gal-3 or gal-9; however, no correlation was observed between these lectins during SARS-CoV-2 infection. Transcriptome analysis of the placenta showed that gal-1, gal-3, and several PSG and glycoenzymes responsible for the synthesis of gal-1-binding glycotopes (such as linkage-specific N-acetyl-glucosaminyltransferases (MGATs)) are upregulated in pregnant women infected with SARS-CoV-2. Collectively, our findings identify a dynamically regulated “galectin-specific signature” that accompanies the SARS-CoV-2 infection and vaccination in pregnancy, and they highlight a potentially significant role for gal-1 as a key pregnancy protective alarmin during virus infection.Fil: Zhao, Fangqi. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Tallarek, Ann Christin. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Wang, Yiru. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Xie, Yiran. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Diemert, Anke. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Lu Culligan, Alice. University of Yale. School of Medicine; Estados UnidosFil: Vijayakumar, Pavithra. University Of Yale. School Of Medicine. Departament Of Obstretics And Gynecology; Estados UnidosFil: Kittmann, Enrico. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Urbschat, Christopher. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Bayo Fina, Juan Miguel. Universidad Austral; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Arck, Petra Clara. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Farhadian, Shelli F.. University of Yale. School of Medicine; Estados UnidosFil: Dveksler, Gabriela S.. Uniformed Services University of the Health Sciences; Estados UnidosFil: Garcia, Mariana. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFil: Blois, Sandra M.. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; AlemaniaFrontiers Media2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256915Zhao, Fangqi; Tallarek, Ann Christin; Wang, Yiru; Xie, Yiran; Diemert, Anke; et al.; A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface; Frontiers Media; Frontiers in Immunology; 14; 7-2023; 1-131664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2023.1196395info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:18Zoai:ri.conicet.gov.ar:11336/256915instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:18.387CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
title A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
spellingShingle A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
Zhao, Fangqi
SARS-CoV-2
Galectin-1
Placent
title_short A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
title_full A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
title_fullStr A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
title_full_unstemmed A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
title_sort A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface
dc.creator.none.fl_str_mv Zhao, Fangqi
Tallarek, Ann Christin
Wang, Yiru
Xie, Yiran
Diemert, Anke
Lu Culligan, Alice
Vijayakumar, Pavithra
Kittmann, Enrico
Urbschat, Christopher
Bayo Fina, Juan Miguel
Arck, Petra Clara
Farhadian, Shelli F.
Dveksler, Gabriela S.
Garcia, Mariana
Blois, Sandra M.
author Zhao, Fangqi
author_facet Zhao, Fangqi
Tallarek, Ann Christin
Wang, Yiru
Xie, Yiran
Diemert, Anke
Lu Culligan, Alice
Vijayakumar, Pavithra
Kittmann, Enrico
Urbschat, Christopher
Bayo Fina, Juan Miguel
Arck, Petra Clara
Farhadian, Shelli F.
Dveksler, Gabriela S.
Garcia, Mariana
Blois, Sandra M.
author_role author
author2 Tallarek, Ann Christin
Wang, Yiru
Xie, Yiran
Diemert, Anke
Lu Culligan, Alice
Vijayakumar, Pavithra
Kittmann, Enrico
Urbschat, Christopher
Bayo Fina, Juan Miguel
Arck, Petra Clara
Farhadian, Shelli F.
Dveksler, Gabriela S.
Garcia, Mariana
Blois, Sandra M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2
Galectin-1
Placent
topic SARS-CoV-2
Galectin-1
Placent
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a risk of infection and disease in pregnant women and neonates. Successful pregnancy requires a fine-tuned regulation of the maternal immune system to accommodate the growing fetus and to protect the mother from infection. Galectins, a family of β-galactoside–binding proteins, modulate immune and inflammatory processes and have been recognized as critical factors in reproductive orchestration, including maternal immune adaptation in pregnancy. Pregnancy-specific glycoprotein 1 (PSG1) is a recently identified gal-1 ligand at the maternal–fetal interface, which may facilitate a successful pregnancy. Several studies suggest that galectins are involved in the immune response in SARS-CoV-2–infected patients. However, the galectins and PSG1 signature upon SARS-CoV-2 infection and vaccination during pregnancy remain unclear. In the present study, we examined the maternal circulating levels of galectins (gal-1, gal-3, gal-7, and gal-9) and PSG1 in pregnant women infected with SARS-CoV-2 before vaccination or uninfected women who were vaccinated against SARS-CoV-2 and correlated their expression with different pregnancy parameters. SARS-CoV-2 infection or vaccination during pregnancy provoked an increase in maternal gal-1 circulating levels. On the other hand, levels of PSG1 were only augmented upon SARS-CoV-2 infection. A healthy pregnancy is associated with a positive correlation between gal-1 concentrations and gal-3 or gal-9; however, no correlation was observed between these lectins during SARS-CoV-2 infection. Transcriptome analysis of the placenta showed that gal-1, gal-3, and several PSG and glycoenzymes responsible for the synthesis of gal-1-binding glycotopes (such as linkage-specific N-acetyl-glucosaminyltransferases (MGATs)) are upregulated in pregnant women infected with SARS-CoV-2. Collectively, our findings identify a dynamically regulated “galectin-specific signature” that accompanies the SARS-CoV-2 infection and vaccination in pregnancy, and they highlight a potentially significant role for gal-1 as a key pregnancy protective alarmin during virus infection.
Fil: Zhao, Fangqi. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Tallarek, Ann Christin. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Wang, Yiru. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Xie, Yiran. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Diemert, Anke. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Lu Culligan, Alice. University of Yale. School of Medicine; Estados Unidos
Fil: Vijayakumar, Pavithra. University Of Yale. School Of Medicine. Departament Of Obstretics And Gynecology; Estados Unidos
Fil: Kittmann, Enrico. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Urbschat, Christopher. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Bayo Fina, Juan Miguel. Universidad Austral; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina
Fil: Arck, Petra Clara. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Farhadian, Shelli F.. University of Yale. School of Medicine; Estados Unidos
Fil: Dveksler, Gabriela S.. Uniformed Services University of the Health Sciences; Estados Unidos
Fil: Garcia, Mariana. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
Fil: Blois, Sandra M.. University Medical Center Hamburg-Eppendorf. Department of Obstetrics and Fetal Medicine; Alemania
description The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a risk of infection and disease in pregnant women and neonates. Successful pregnancy requires a fine-tuned regulation of the maternal immune system to accommodate the growing fetus and to protect the mother from infection. Galectins, a family of β-galactoside–binding proteins, modulate immune and inflammatory processes and have been recognized as critical factors in reproductive orchestration, including maternal immune adaptation in pregnancy. Pregnancy-specific glycoprotein 1 (PSG1) is a recently identified gal-1 ligand at the maternal–fetal interface, which may facilitate a successful pregnancy. Several studies suggest that galectins are involved in the immune response in SARS-CoV-2–infected patients. However, the galectins and PSG1 signature upon SARS-CoV-2 infection and vaccination during pregnancy remain unclear. In the present study, we examined the maternal circulating levels of galectins (gal-1, gal-3, gal-7, and gal-9) and PSG1 in pregnant women infected with SARS-CoV-2 before vaccination or uninfected women who were vaccinated against SARS-CoV-2 and correlated their expression with different pregnancy parameters. SARS-CoV-2 infection or vaccination during pregnancy provoked an increase in maternal gal-1 circulating levels. On the other hand, levels of PSG1 were only augmented upon SARS-CoV-2 infection. A healthy pregnancy is associated with a positive correlation between gal-1 concentrations and gal-3 or gal-9; however, no correlation was observed between these lectins during SARS-CoV-2 infection. Transcriptome analysis of the placenta showed that gal-1, gal-3, and several PSG and glycoenzymes responsible for the synthesis of gal-1-binding glycotopes (such as linkage-specific N-acetyl-glucosaminyltransferases (MGATs)) are upregulated in pregnant women infected with SARS-CoV-2. Collectively, our findings identify a dynamically regulated “galectin-specific signature” that accompanies the SARS-CoV-2 infection and vaccination in pregnancy, and they highlight a potentially significant role for gal-1 as a key pregnancy protective alarmin during virus infection.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256915
Zhao, Fangqi; Tallarek, Ann Christin; Wang, Yiru; Xie, Yiran; Diemert, Anke; et al.; A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface; Frontiers Media; Frontiers in Immunology; 14; 7-2023; 1-13
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256915
identifier_str_mv Zhao, Fangqi; Tallarek, Ann Christin; Wang, Yiru; Xie, Yiran; Diemert, Anke; et al.; A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal–fetal interface; Frontiers Media; Frontiers in Immunology; 14; 7-2023; 1-13
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2023.1196395
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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