Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines

Autores
Bowen, John E.; Addetia, Amin; Dang, Ha V.; Stewart, Cameron; Brown, Jack T.; Sharkey, William K.; Sprouse, Kaitlin R.; Walls, Alexandra C.; Mazzitelli, Ignacio Gabriel; Logue, Jennifer K.; Franko, Nicholas M.; Czudnochowski, Nadine; Powell, Abigail E.; Dellota, Exequiel; Ahmed, Kumail; Ansari, Asefa Shariq; Cameroni, Elisabetta; Gori, Andrea; Bandera, Alessandra; Posavad, Christine M.; Dan, Jennifer M.; Zhang, Zeli; Weiskopf, Daniela; Sette, Alessandro; Crotty, Shane; Iqbal, Najeeha Talat; Corti, Davide; Geffner, Jorge Raúl; Snell, Gyorgy; Grifantini, Renata; Chu, Helen Y.; Veesler, David
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. Our data suggest that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary vaccine series, vaccine boosters may provide sufficient protection against Omicron-induced severe disease.
Fil: Bowen, John E.. University of Washington; Estados Unidos
Fil: Addetia, Amin. University of Washington; Estados Unidos
Fil: Dang, Ha V.. Vir Biotechnology, Inc.; Estados Unidos
Fil: Stewart, Cameron. University of Washington; Estados Unidos
Fil: Brown, Jack T.. University of Washington; Estados Unidos
Fil: Sharkey, William K.. University of Washington; Estados Unidos
Fil: Sprouse, Kaitlin R.. University of Washington; Estados Unidos
Fil: Walls, Alexandra C.. University of Washington; Estados Unidos
Fil: Mazzitelli, Ignacio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Logue, Jennifer K.. University of Washington; Estados Unidos
Fil: Franko, Nicholas M.. University of Washington; Estados Unidos
Fil: Czudnochowski, Nadine. Vir Biotechnology, Inc.; Estados Unidos
Fil: Powell, Abigail E.. Vir Biotechnology, Inc.; Estados Unidos
Fil: Dellota, Exequiel. Vir Biotechnology, Inc.; Estados Unidos
Fil: Ahmed, Kumail. The Aga Khan University; Pakistán
Fil: Ansari, Asefa Shariq. The Aga Khan University; Pakistán
Fil: Cameroni, Elisabetta. Vir Biotechnology, Inc.; Estados Unidos
Fil: Gori, Andrea. Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico; Italia. Università degli Studi di Milano; Italia
Fil: Bandera, Alessandra. Università degli Studi di Milano; Italia. Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico; Italia
Fil: Posavad, Christine M.. Fred Hutchinson Cancer Research Center; Estados Unidos
Fil: Dan, Jennifer M.. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados Unidos
Fil: Zhang, Zeli. La Jolla Institute for Allergy and Immunology; Estados Unidos
Fil: Weiskopf, Daniela. La Jolla Institute for Allergy and Immunology; Estados Unidos
Fil: Sette, Alessandro. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados Unidos
Fil: Crotty, Shane. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados Unidos
Fil: Iqbal, Najeeha Talat. The Aga Khan University; Pakistán
Fil: Corti, Davide. Vir Biotechnology, Inc.; Suiza
Fil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Snell, Gyorgy. Vir Biotechnology, Inc.; Estados Unidos
Fil: Grifantini, Renata. Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi"; Italia
Fil: Chu, Helen Y.. University of Washington; Estados Unidos
Fil: Veesler, David. University of Washington; Estados Unidos
Materia
SARS-CoV-2
Antibodies
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/230550

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccinesBowen, John E.Addetia, AminDang, Ha V.Stewart, CameronBrown, Jack T.Sharkey, William K.Sprouse, Kaitlin R.Walls, Alexandra C.Mazzitelli, Ignacio GabrielLogue, Jennifer K.Franko, Nicholas M.Czudnochowski, NadinePowell, Abigail E.Dellota, ExequielAhmed, KumailAnsari, Asefa ShariqCameroni, ElisabettaGori, AndreaBandera, AlessandraPosavad, Christine M.Dan, Jennifer M.Zhang, ZeliWeiskopf, DanielaSette, AlessandroCrotty, ShaneIqbal, Najeeha TalatCorti, DavideGeffner, Jorge RaúlSnell, GyorgyGrifantini, RenataChu, Helen Y.Veesler, DavidSARS-CoV-2AntibodiesCOVID-19https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. Our data suggest that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary vaccine series, vaccine boosters may provide sufficient protection against Omicron-induced severe disease.Fil: Bowen, John E.. University of Washington; Estados UnidosFil: Addetia, Amin. University of Washington; Estados UnidosFil: Dang, Ha V.. Vir Biotechnology, Inc.; Estados UnidosFil: Stewart, Cameron. University of Washington; Estados UnidosFil: Brown, Jack T.. University of Washington; Estados UnidosFil: Sharkey, William K.. University of Washington; Estados UnidosFil: Sprouse, Kaitlin R.. University of Washington; Estados UnidosFil: Walls, Alexandra C.. University of Washington; Estados UnidosFil: Mazzitelli, Ignacio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Logue, Jennifer K.. University of Washington; Estados UnidosFil: Franko, Nicholas M.. University of Washington; Estados UnidosFil: Czudnochowski, Nadine. Vir Biotechnology, Inc.; Estados UnidosFil: Powell, Abigail E.. Vir Biotechnology, Inc.; Estados UnidosFil: Dellota, Exequiel. Vir Biotechnology, Inc.; Estados UnidosFil: Ahmed, Kumail. The Aga Khan University; PakistánFil: Ansari, Asefa Shariq. The Aga Khan University; PakistánFil: Cameroni, Elisabetta. Vir Biotechnology, Inc.; Estados UnidosFil: Gori, Andrea. Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico; Italia. Università degli Studi di Milano; ItaliaFil: Bandera, Alessandra. Università degli Studi di Milano; Italia. Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico; ItaliaFil: Posavad, Christine M.. Fred Hutchinson Cancer Research Center; Estados UnidosFil: Dan, Jennifer M.. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados UnidosFil: Zhang, Zeli. La Jolla Institute for Allergy and Immunology; Estados UnidosFil: Weiskopf, Daniela. La Jolla Institute for Allergy and Immunology; Estados UnidosFil: Sette, Alessandro. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados UnidosFil: Crotty, Shane. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados UnidosFil: Iqbal, Najeeha Talat. The Aga Khan University; PakistánFil: Corti, Davide. Vir Biotechnology, Inc.; SuizaFil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Snell, Gyorgy. Vir Biotechnology, Inc.; Estados UnidosFil: Grifantini, Renata. Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi"; ItaliaFil: Chu, Helen Y.. University of Washington; Estados UnidosFil: Veesler, David. University of Washington; Estados UnidosAmerican Association for the Advancement of Science2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/230550Bowen, John E.; Addetia, Amin; Dang, Ha V.; Stewart, Cameron; Brown, Jack T.; et al.; Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines; American Association for the Advancement of Science; Science; 377; 6608; 8-2022; 890-8940036-80751095-9203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.abq0203info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/science.abq0203info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:52Zoai:ri.conicet.gov.ar:11336/230550instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:53.855CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
title Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
spellingShingle Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
Bowen, John E.
SARS-CoV-2
Antibodies
COVID-19
title_short Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
title_full Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
title_fullStr Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
title_full_unstemmed Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
title_sort Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines
dc.creator.none.fl_str_mv Bowen, John E.
Addetia, Amin
Dang, Ha V.
Stewart, Cameron
Brown, Jack T.
Sharkey, William K.
Sprouse, Kaitlin R.
Walls, Alexandra C.
Mazzitelli, Ignacio Gabriel
Logue, Jennifer K.
Franko, Nicholas M.
Czudnochowski, Nadine
Powell, Abigail E.
Dellota, Exequiel
Ahmed, Kumail
Ansari, Asefa Shariq
Cameroni, Elisabetta
Gori, Andrea
Bandera, Alessandra
Posavad, Christine M.
Dan, Jennifer M.
Zhang, Zeli
Weiskopf, Daniela
Sette, Alessandro
Crotty, Shane
Iqbal, Najeeha Talat
Corti, Davide
Geffner, Jorge Raúl
Snell, Gyorgy
Grifantini, Renata
Chu, Helen Y.
Veesler, David
author Bowen, John E.
author_facet Bowen, John E.
Addetia, Amin
Dang, Ha V.
Stewart, Cameron
Brown, Jack T.
Sharkey, William K.
Sprouse, Kaitlin R.
Walls, Alexandra C.
Mazzitelli, Ignacio Gabriel
Logue, Jennifer K.
Franko, Nicholas M.
Czudnochowski, Nadine
Powell, Abigail E.
Dellota, Exequiel
Ahmed, Kumail
Ansari, Asefa Shariq
Cameroni, Elisabetta
Gori, Andrea
Bandera, Alessandra
Posavad, Christine M.
Dan, Jennifer M.
Zhang, Zeli
Weiskopf, Daniela
Sette, Alessandro
Crotty, Shane
Iqbal, Najeeha Talat
Corti, Davide
Geffner, Jorge Raúl
Snell, Gyorgy
Grifantini, Renata
Chu, Helen Y.
Veesler, David
author_role author
author2 Addetia, Amin
Dang, Ha V.
Stewart, Cameron
Brown, Jack T.
Sharkey, William K.
Sprouse, Kaitlin R.
Walls, Alexandra C.
Mazzitelli, Ignacio Gabriel
Logue, Jennifer K.
Franko, Nicholas M.
Czudnochowski, Nadine
Powell, Abigail E.
Dellota, Exequiel
Ahmed, Kumail
Ansari, Asefa Shariq
Cameroni, Elisabetta
Gori, Andrea
Bandera, Alessandra
Posavad, Christine M.
Dan, Jennifer M.
Zhang, Zeli
Weiskopf, Daniela
Sette, Alessandro
Crotty, Shane
Iqbal, Najeeha Talat
Corti, Davide
Geffner, Jorge Raúl
Snell, Gyorgy
Grifantini, Renata
Chu, Helen Y.
Veesler, David
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2
Antibodies
COVID-19
topic SARS-CoV-2
Antibodies
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. Our data suggest that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary vaccine series, vaccine boosters may provide sufficient protection against Omicron-induced severe disease.
Fil: Bowen, John E.. University of Washington; Estados Unidos
Fil: Addetia, Amin. University of Washington; Estados Unidos
Fil: Dang, Ha V.. Vir Biotechnology, Inc.; Estados Unidos
Fil: Stewart, Cameron. University of Washington; Estados Unidos
Fil: Brown, Jack T.. University of Washington; Estados Unidos
Fil: Sharkey, William K.. University of Washington; Estados Unidos
Fil: Sprouse, Kaitlin R.. University of Washington; Estados Unidos
Fil: Walls, Alexandra C.. University of Washington; Estados Unidos
Fil: Mazzitelli, Ignacio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Logue, Jennifer K.. University of Washington; Estados Unidos
Fil: Franko, Nicholas M.. University of Washington; Estados Unidos
Fil: Czudnochowski, Nadine. Vir Biotechnology, Inc.; Estados Unidos
Fil: Powell, Abigail E.. Vir Biotechnology, Inc.; Estados Unidos
Fil: Dellota, Exequiel. Vir Biotechnology, Inc.; Estados Unidos
Fil: Ahmed, Kumail. The Aga Khan University; Pakistán
Fil: Ansari, Asefa Shariq. The Aga Khan University; Pakistán
Fil: Cameroni, Elisabetta. Vir Biotechnology, Inc.; Estados Unidos
Fil: Gori, Andrea. Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico; Italia. Università degli Studi di Milano; Italia
Fil: Bandera, Alessandra. Università degli Studi di Milano; Italia. Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico; Italia
Fil: Posavad, Christine M.. Fred Hutchinson Cancer Research Center; Estados Unidos
Fil: Dan, Jennifer M.. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados Unidos
Fil: Zhang, Zeli. La Jolla Institute for Allergy and Immunology; Estados Unidos
Fil: Weiskopf, Daniela. La Jolla Institute for Allergy and Immunology; Estados Unidos
Fil: Sette, Alessandro. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados Unidos
Fil: Crotty, Shane. La Jolla Institute for Allergy and Immunology; Estados Unidos. University of California; Estados Unidos
Fil: Iqbal, Najeeha Talat. The Aga Khan University; Pakistán
Fil: Corti, Davide. Vir Biotechnology, Inc.; Suiza
Fil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Snell, Gyorgy. Vir Biotechnology, Inc.; Estados Unidos
Fil: Grifantini, Renata. Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi"; Italia
Fil: Chu, Helen Y.. University of Washington; Estados Unidos
Fil: Veesler, David. University of Washington; Estados Unidos
description The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern comprises several sublineages, with BA.2 and BA.2.12.1 having replaced the previously dominant BA.1 and with BA.4 and BA.5 increasing in prevalence worldwide. We show that the large number of Omicron sublineage spike mutations leads to enhanced angiotensin-converting enzyme 2 (ACE2) binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus. Administration of a homologous or heterologous booster based on the Wuhan-Hu-1 spike sequence markedly increased neutralizing antibody titers and breadth against BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 across all vaccines evaluated. Our data suggest that although Omicron sublineages evade polyclonal neutralizing antibody responses elicited by primary vaccine series, vaccine boosters may provide sufficient protection against Omicron-induced severe disease.
publishDate 2022
dc.date.none.fl_str_mv 2022-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/230550
Bowen, John E.; Addetia, Amin; Dang, Ha V.; Stewart, Cameron; Brown, Jack T.; et al.; Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines; American Association for the Advancement of Science; Science; 377; 6608; 8-2022; 890-894
0036-8075
1095-9203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/230550
identifier_str_mv Bowen, John E.; Addetia, Amin; Dang, Ha V.; Stewart, Cameron; Brown, Jack T.; et al.; Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines; American Association for the Advancement of Science; Science; 377; 6608; 8-2022; 890-894
0036-8075
1095-9203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1126/science.abq0203
info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/science.abq0203
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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