Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin

Autores
Puechagut, Patricia Beatriz; Martini, Ana Carolina; Stutz, Graciela; Santillán, M. E.; Luque, Eugenia Mercedes; Fiol, Marta Haydee; Ruiz, Ruben Daniel; Vincenti, Laura María
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hexarelin (HEXr), a synthetic ghrelin analogue, has been associated with modifications of reproductive physiology. In previous studies of adult mice, we detected that HEXr induced significantly reduced ovulation rate and significant correlation coefficients between sexual maturation and corporal weight in offspring. In this study, we investigated the effects of chronic HEXr administration on sperm concentration and functional activity, oestrous cyclicity and pregnancy index, in addition to the number of fetuses and its correlation with the number of corpora lutea. Adult Albino swiss mice were injected (sc) daily with HEXr: 100 mgkg 1 day 1 (HEXr D1) or 200 mgkg 1 day 1 (HEXr D2) for 53 days in males and 30 days in females.We detected a significantly decreased ratio in the number of fetuses per corpora lutea in females treated with HEXr D2 for 30 days before mating and during the first 6 days of pregnancy, in addition to a downward trend in the pregnancy index and percentage of females impregnated by each male treated with both doses of the analogue. Although we did not find any significant effect on additional parameters evaluated in both genders, we propose certain effects of HEXr on the implantation process and/or early development of embryos and over the in vivo reproductive capability of males.
Fil: Puechagut, Patricia Beatriz. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Stutz, Graciela. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Santillán, M. E.. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Vincenti, Laura María. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Materia
GHRELIN
GROWTH HORMONE SECRETAGOGUES
REPRODUCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/274630
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Reproductive performance and fertility in male and female adult mice chronically treated with hexarelinPuechagut, Patricia BeatrizMartini, Ana CarolinaStutz, GracielaSantillán, M. E.Luque, Eugenia MercedesFiol, Marta HaydeeRuiz, Ruben DanielVincenti, Laura MaríaGHRELINGROWTH HORMONE SECRETAGOGUESREPRODUCTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Hexarelin (HEXr), a synthetic ghrelin analogue, has been associated with modifications of reproductive physiology. In previous studies of adult mice, we detected that HEXr induced significantly reduced ovulation rate and significant correlation coefficients between sexual maturation and corporal weight in offspring. In this study, we investigated the effects of chronic HEXr administration on sperm concentration and functional activity, oestrous cyclicity and pregnancy index, in addition to the number of fetuses and its correlation with the number of corpora lutea. Adult Albino swiss mice were injected (sc) daily with HEXr: 100 mgkg 1 day 1 (HEXr D1) or 200 mgkg 1 day 1 (HEXr D2) for 53 days in males and 30 days in females.We detected a significantly decreased ratio in the number of fetuses per corpora lutea in females treated with HEXr D2 for 30 days before mating and during the first 6 days of pregnancy, in addition to a downward trend in the pregnancy index and percentage of females impregnated by each male treated with both doses of the analogue. Although we did not find any significant effect on additional parameters evaluated in both genders, we propose certain effects of HEXr on the implantation process and/or early development of embryos and over the in vivo reproductive capability of males.Fil: Puechagut, Patricia Beatriz. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Stutz, Graciela. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Santillán, M. E.. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Vincenti, Laura María. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Csiro Publishing2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/274630Puechagut, Patricia Beatriz; Martini, Ana Carolina; Stutz, Graciela; Santillán, M. E.; Luque, Eugenia Mercedes; et al.; Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin; Csiro Publishing; Reproduction Fertility and Development; 24; 3; 11-2011; 451-4601031-3613CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://connectsci.au/rd/article-abstract/24/3/451/49591/Reproductive-performance-and-fertility-in-male-and?redirectedFrom=fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1071/RD11009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:42:34Zoai:ri.conicet.gov.ar:11336/274630instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:42:34.897CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin
title Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin
spellingShingle Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin
Puechagut, Patricia Beatriz
GHRELIN
GROWTH HORMONE SECRETAGOGUES
REPRODUCTION
title_short Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin
title_full Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin
title_fullStr Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin
title_full_unstemmed Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin
title_sort Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin
dc.creator.none.fl_str_mv Puechagut, Patricia Beatriz
Martini, Ana Carolina
Stutz, Graciela
Santillán, M. E.
Luque, Eugenia Mercedes
Fiol, Marta Haydee
Ruiz, Ruben Daniel
Vincenti, Laura María
author Puechagut, Patricia Beatriz
author_facet Puechagut, Patricia Beatriz
Martini, Ana Carolina
Stutz, Graciela
Santillán, M. E.
Luque, Eugenia Mercedes
Fiol, Marta Haydee
Ruiz, Ruben Daniel
Vincenti, Laura María
author_role author
author2 Martini, Ana Carolina
Stutz, Graciela
Santillán, M. E.
Luque, Eugenia Mercedes
Fiol, Marta Haydee
Ruiz, Ruben Daniel
Vincenti, Laura María
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GHRELIN
GROWTH HORMONE SECRETAGOGUES
REPRODUCTION
topic GHRELIN
GROWTH HORMONE SECRETAGOGUES
REPRODUCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hexarelin (HEXr), a synthetic ghrelin analogue, has been associated with modifications of reproductive physiology. In previous studies of adult mice, we detected that HEXr induced significantly reduced ovulation rate and significant correlation coefficients between sexual maturation and corporal weight in offspring. In this study, we investigated the effects of chronic HEXr administration on sperm concentration and functional activity, oestrous cyclicity and pregnancy index, in addition to the number of fetuses and its correlation with the number of corpora lutea. Adult Albino swiss mice were injected (sc) daily with HEXr: 100 mgkg 1 day 1 (HEXr D1) or 200 mgkg 1 day 1 (HEXr D2) for 53 days in males and 30 days in females.We detected a significantly decreased ratio in the number of fetuses per corpora lutea in females treated with HEXr D2 for 30 days before mating and during the first 6 days of pregnancy, in addition to a downward trend in the pregnancy index and percentage of females impregnated by each male treated with both doses of the analogue. Although we did not find any significant effect on additional parameters evaluated in both genders, we propose certain effects of HEXr on the implantation process and/or early development of embryos and over the in vivo reproductive capability of males.
Fil: Puechagut, Patricia Beatriz. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Stutz, Graciela. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Santillán, M. E.. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Vincenti, Laura María. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
description Hexarelin (HEXr), a synthetic ghrelin analogue, has been associated with modifications of reproductive physiology. In previous studies of adult mice, we detected that HEXr induced significantly reduced ovulation rate and significant correlation coefficients between sexual maturation and corporal weight in offspring. In this study, we investigated the effects of chronic HEXr administration on sperm concentration and functional activity, oestrous cyclicity and pregnancy index, in addition to the number of fetuses and its correlation with the number of corpora lutea. Adult Albino swiss mice were injected (sc) daily with HEXr: 100 mgkg 1 day 1 (HEXr D1) or 200 mgkg 1 day 1 (HEXr D2) for 53 days in males and 30 days in females.We detected a significantly decreased ratio in the number of fetuses per corpora lutea in females treated with HEXr D2 for 30 days before mating and during the first 6 days of pregnancy, in addition to a downward trend in the pregnancy index and percentage of females impregnated by each male treated with both doses of the analogue. Although we did not find any significant effect on additional parameters evaluated in both genders, we propose certain effects of HEXr on the implantation process and/or early development of embryos and over the in vivo reproductive capability of males.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/274630
Puechagut, Patricia Beatriz; Martini, Ana Carolina; Stutz, Graciela; Santillán, M. E.; Luque, Eugenia Mercedes; et al.; Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin; Csiro Publishing; Reproduction Fertility and Development; 24; 3; 11-2011; 451-460
1031-3613
CONICET Digital
CONICET
url http://hdl.handle.net/11336/274630
identifier_str_mv Puechagut, Patricia Beatriz; Martini, Ana Carolina; Stutz, Graciela; Santillán, M. E.; Luque, Eugenia Mercedes; et al.; Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin; Csiro Publishing; Reproduction Fertility and Development; 24; 3; 11-2011; 451-460
1031-3613
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1071/RD11009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Csiro Publishing
publisher.none.fl_str_mv Csiro Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.082534

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