Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice

Autores
Luque, Eugenia Mercedes; Carlini, Valeria Paola; Vincenti, Laura María; Puechagut, Patricia Beatriz; Stutz, Graciela; Santillan, Maria Emilia; Ruiz, Ruben Daniel; Martini, Ana Carolina; Fiol, Marta Haydee
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ghrelin (Ghr) has been associated with reproductive physiology and pre- and postnatal development. The objectives of the present study were to evaluate the effects of hexarelin (HEX; 100 or 200 µg kg-1 day-1), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice; (2) the physical, neurobiological and sexual development of offspring of female mice injected with HEX during the first, second or third week of pregnancy or throughout the entire pregnancy; and (3) adult memory acquisition in these offspring. We also evaluated the effects of chronic HEX administration on memory acquisition in adult mice. Treatment of non-pregnant female mice with HEX decreased ovulation rate. However, treatment of pregnant mice with HEX at any time during pregnancy tended to accelerate offspring maturation, regardless of bodyweight. This effect was only significant on neurobiological parameters following treatment during the first week. HEX treatment during the first week and/or throughout the entire pregnancy resulted in impaired memory acquisition in the offspring, with female mice being more susceptible to these effects. Similar results were observed for the effects of chronic HEX treatment on memory acquisition in adult mice. In conclusion, HEX seems to exert differential effects depending on when it is administered. Because HEX has started to be used therapeutically, its deleterious effects on ovulation and memory acquisition must be further evaluated.
Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Vincenti, Laura María. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Puechagut, Patricia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Stutz, Graciela. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Santillan, Maria Emilia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Materia
SPONTANEOUS OBJECT RECONIGTION TEST
GROWTH HORMONE SECRETAGOGUES
GHRELIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280565
Acceder
id CONICETDig_d68c013754a8004b75fad9d881937902
oai_identifier_str oai:ri.conicet.gov.ar:11336/280565
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of miceLuque, Eugenia MercedesCarlini, Valeria PaolaVincenti, Laura MaríaPuechagut, Patricia BeatrizStutz, GracielaSantillan, Maria EmiliaRuiz, Ruben DanielMartini, Ana CarolinaFiol, Marta HaydeeSPONTANEOUS OBJECT RECONIGTION TESTGROWTH HORMONE SECRETAGOGUESGHRELINhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Ghrelin (Ghr) has been associated with reproductive physiology and pre- and postnatal development. The objectives of the present study were to evaluate the effects of hexarelin (HEX; 100 or 200 µg kg-1 day-1), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice; (2) the physical, neurobiological and sexual development of offspring of female mice injected with HEX during the first, second or third week of pregnancy or throughout the entire pregnancy; and (3) adult memory acquisition in these offspring. We also evaluated the effects of chronic HEX administration on memory acquisition in adult mice. Treatment of non-pregnant female mice with HEX decreased ovulation rate. However, treatment of pregnant mice with HEX at any time during pregnancy tended to accelerate offspring maturation, regardless of bodyweight. This effect was only significant on neurobiological parameters following treatment during the first week. HEX treatment during the first week and/or throughout the entire pregnancy resulted in impaired memory acquisition in the offspring, with female mice being more susceptible to these effects. Similar results were observed for the effects of chronic HEX treatment on memory acquisition in adult mice. In conclusion, HEX seems to exert differential effects depending on when it is administered. Because HEX has started to be used therapeutically, its deleterious effects on ovulation and memory acquisition must be further evaluated.Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Vincenti, Laura María. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Puechagut, Patricia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Stutz, Graciela. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Santillan, Maria Emilia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Csiro Publishing2010-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280565Luque, Eugenia Mercedes; Carlini, Valeria Paola; Vincenti, Laura María; Puechagut, Patricia Beatriz; Stutz, Graciela; et al.; Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice; Csiro Publishing; Reproduction Fertility and Development; 22; 6; 4-2010; 926-9381031-3613CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://connectsci.au/rd/article-abstract/22/6/926/49001/Effects-of-hexarelin-a-ghrelin-analogue-oninfo:eu-repo/semantics/altIdentifier/doi/10.1071/RD09231info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-11T12:25:03Zoai:ri.conicet.gov.ar:11336/280565instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-11 12:25:04.201CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice
title Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice
spellingShingle Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice
Luque, Eugenia Mercedes
SPONTANEOUS OBJECT RECONIGTION TEST
GROWTH HORMONE SECRETAGOGUES
GHRELIN
title_short Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice
title_full Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice
title_fullStr Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice
title_full_unstemmed Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice
title_sort Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice
dc.creator.none.fl_str_mv Luque, Eugenia Mercedes
Carlini, Valeria Paola
Vincenti, Laura María
Puechagut, Patricia Beatriz
Stutz, Graciela
Santillan, Maria Emilia
Ruiz, Ruben Daniel
Martini, Ana Carolina
Fiol, Marta Haydee
author Luque, Eugenia Mercedes
author_facet Luque, Eugenia Mercedes
Carlini, Valeria Paola
Vincenti, Laura María
Puechagut, Patricia Beatriz
Stutz, Graciela
Santillan, Maria Emilia
Ruiz, Ruben Daniel
Martini, Ana Carolina
Fiol, Marta Haydee
author_role author
author2 Carlini, Valeria Paola
Vincenti, Laura María
Puechagut, Patricia Beatriz
Stutz, Graciela
Santillan, Maria Emilia
Ruiz, Ruben Daniel
Martini, Ana Carolina
Fiol, Marta Haydee
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SPONTANEOUS OBJECT RECONIGTION TEST
GROWTH HORMONE SECRETAGOGUES
GHRELIN
topic SPONTANEOUS OBJECT RECONIGTION TEST
GROWTH HORMONE SECRETAGOGUES
GHRELIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Ghrelin (Ghr) has been associated with reproductive physiology and pre- and postnatal development. The objectives of the present study were to evaluate the effects of hexarelin (HEX; 100 or 200 µg kg-1 day-1), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice; (2) the physical, neurobiological and sexual development of offspring of female mice injected with HEX during the first, second or third week of pregnancy or throughout the entire pregnancy; and (3) adult memory acquisition in these offspring. We also evaluated the effects of chronic HEX administration on memory acquisition in adult mice. Treatment of non-pregnant female mice with HEX decreased ovulation rate. However, treatment of pregnant mice with HEX at any time during pregnancy tended to accelerate offspring maturation, regardless of bodyweight. This effect was only significant on neurobiological parameters following treatment during the first week. HEX treatment during the first week and/or throughout the entire pregnancy resulted in impaired memory acquisition in the offspring, with female mice being more susceptible to these effects. Similar results were observed for the effects of chronic HEX treatment on memory acquisition in adult mice. In conclusion, HEX seems to exert differential effects depending on when it is administered. Because HEX has started to be used therapeutically, its deleterious effects on ovulation and memory acquisition must be further evaluated.
Fil: Luque, Eugenia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Vincenti, Laura María. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Puechagut, Patricia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Stutz, Graciela. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Santillan, Maria Emilia. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
Fil: Fiol, Marta Haydee. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;
description Ghrelin (Ghr) has been associated with reproductive physiology and pre- and postnatal development. The objectives of the present study were to evaluate the effects of hexarelin (HEX; 100 or 200 µg kg-1 day-1), a therapeutic Ghr analogue, on: (1) embryo development 60 h post ovulation, induced pharmacologically, in pregnant mice; (2) the physical, neurobiological and sexual development of offspring of female mice injected with HEX during the first, second or third week of pregnancy or throughout the entire pregnancy; and (3) adult memory acquisition in these offspring. We also evaluated the effects of chronic HEX administration on memory acquisition in adult mice. Treatment of non-pregnant female mice with HEX decreased ovulation rate. However, treatment of pregnant mice with HEX at any time during pregnancy tended to accelerate offspring maturation, regardless of bodyweight. This effect was only significant on neurobiological parameters following treatment during the first week. HEX treatment during the first week and/or throughout the entire pregnancy resulted in impaired memory acquisition in the offspring, with female mice being more susceptible to these effects. Similar results were observed for the effects of chronic HEX treatment on memory acquisition in adult mice. In conclusion, HEX seems to exert differential effects depending on when it is administered. Because HEX has started to be used therapeutically, its deleterious effects on ovulation and memory acquisition must be further evaluated.
publishDate 2010
dc.date.none.fl_str_mv 2010-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280565
Luque, Eugenia Mercedes; Carlini, Valeria Paola; Vincenti, Laura María; Puechagut, Patricia Beatriz; Stutz, Graciela; et al.; Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice; Csiro Publishing; Reproduction Fertility and Development; 22; 6; 4-2010; 926-938
1031-3613
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280565
identifier_str_mv Luque, Eugenia Mercedes; Carlini, Valeria Paola; Vincenti, Laura María; Puechagut, Patricia Beatriz; Stutz, Graciela; et al.; Effects of hexarelin (a ghrelin analogue) on fertilisation and the pre- and postnatal development of mice; Csiro Publishing; Reproduction Fertility and Development; 22; 6; 4-2010; 926-938
1031-3613
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://connectsci.au/rd/article-abstract/22/6/926/49001/Effects-of-hexarelin-a-ghrelin-analogue-on
info:eu-repo/semantics/altIdentifier/doi/10.1071/RD09231
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
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application/pdf
dc.publisher.none.fl_str_mv Csiro Publishing
publisher.none.fl_str_mv Csiro Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.930639

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