Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity

Autores
Galletti, Jeremías Gastón; de Paiva, Cintia S.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The ocular surface is the part of the visual system directly exposed to the environment, and it comprises the cornea, the first refractive tissue layer and its surrounding structures. The ocular surface has evolved to keep the cornea smooth and wet, a prerequisite for proper sight, and also protected. To this aim, the ocular surface is a bona fide mucosal niche with an immune system capable of fighting against dangerous pathogens. However, due to the potential harmful effects of uncontrolled inflammation, the ocular surface has several mechanisms to keep the immune response in check. Specifically, the ocular surface is maintained inflammation-free and functional by a particular form of peripheral tolerance known as mucosal tolerance, markedly different from the immune privilege of intraocular structures. Remarkably, conjunctival tolerance is akin to the oral and respiratory tolerance mechanisms found in the gut and airways, respectively. And also similarly, this form of immunoregulation in the eye is affected by ageing just as it is in the digestive and respiratory tracts. With ageing comes an increased prevalence of immune-based ocular surface disorders, which could be related to an age-related impairment of conjunctival tolerance. The purpose of this review was to summarize the present knowledge of ocular mucosal tolerance and how it is affected by the ageing process in the light of the current literature on mucosal immunoregulation of the gut and airways.
Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: de Paiva, Cintia S.. Baylor College of Medicine; Estados Unidos
Materia
AGEING
CONJUNCTIVAL TOLERANCE
DRY EYE
GOBLET CELLS
MUCOSAL TOLERANCE
NASAL TOLERANCE
ORAL TOLERANCE
T CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/153195
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/153195
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunityGalletti, Jeremías Gastónde Paiva, Cintia S.AGEINGCONJUNCTIVAL TOLERANCEDRY EYEGOBLET CELLSMUCOSAL TOLERANCENASAL TOLERANCEORAL TOLERANCET CELLShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The ocular surface is the part of the visual system directly exposed to the environment, and it comprises the cornea, the first refractive tissue layer and its surrounding structures. The ocular surface has evolved to keep the cornea smooth and wet, a prerequisite for proper sight, and also protected. To this aim, the ocular surface is a bona fide mucosal niche with an immune system capable of fighting against dangerous pathogens. However, due to the potential harmful effects of uncontrolled inflammation, the ocular surface has several mechanisms to keep the immune response in check. Specifically, the ocular surface is maintained inflammation-free and functional by a particular form of peripheral tolerance known as mucosal tolerance, markedly different from the immune privilege of intraocular structures. Remarkably, conjunctival tolerance is akin to the oral and respiratory tolerance mechanisms found in the gut and airways, respectively. And also similarly, this form of immunoregulation in the eye is affected by ageing just as it is in the digestive and respiratory tracts. With ageing comes an increased prevalence of immune-based ocular surface disorders, which could be related to an age-related impairment of conjunctival tolerance. The purpose of this review was to summarize the present knowledge of ocular mucosal tolerance and how it is affected by the ageing process in the light of the current literature on mucosal immunoregulation of the gut and airways.Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: de Paiva, Cintia S.. Baylor College of Medicine; Estados UnidosWiley Blackwell Publishing, Inc2021-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/153195Galletti, Jeremías Gastón; de Paiva, Cintia S.; Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity; Wiley Blackwell Publishing, Inc; Immunology; 164; 1; 4-2021; 43-560019-2805CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/imm.13338info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/imm.13338info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:27Zoai:ri.conicet.gov.ar:11336/153195instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:27.801CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
title Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
spellingShingle Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
Galletti, Jeremías Gastón
AGEING
CONJUNCTIVAL TOLERANCE
DRY EYE
GOBLET CELLS
MUCOSAL TOLERANCE
NASAL TOLERANCE
ORAL TOLERANCE
T CELLS
title_short Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
title_full Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
title_fullStr Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
title_full_unstemmed Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
title_sort Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity
dc.creator.none.fl_str_mv Galletti, Jeremías Gastón
de Paiva, Cintia S.
author Galletti, Jeremías Gastón
author_facet Galletti, Jeremías Gastón
de Paiva, Cintia S.
author_role author
author2 de Paiva, Cintia S.
author2_role author
dc.subject.none.fl_str_mv AGEING
CONJUNCTIVAL TOLERANCE
DRY EYE
GOBLET CELLS
MUCOSAL TOLERANCE
NASAL TOLERANCE
ORAL TOLERANCE
T CELLS
topic AGEING
CONJUNCTIVAL TOLERANCE
DRY EYE
GOBLET CELLS
MUCOSAL TOLERANCE
NASAL TOLERANCE
ORAL TOLERANCE
T CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The ocular surface is the part of the visual system directly exposed to the environment, and it comprises the cornea, the first refractive tissue layer and its surrounding structures. The ocular surface has evolved to keep the cornea smooth and wet, a prerequisite for proper sight, and also protected. To this aim, the ocular surface is a bona fide mucosal niche with an immune system capable of fighting against dangerous pathogens. However, due to the potential harmful effects of uncontrolled inflammation, the ocular surface has several mechanisms to keep the immune response in check. Specifically, the ocular surface is maintained inflammation-free and functional by a particular form of peripheral tolerance known as mucosal tolerance, markedly different from the immune privilege of intraocular structures. Remarkably, conjunctival tolerance is akin to the oral and respiratory tolerance mechanisms found in the gut and airways, respectively. And also similarly, this form of immunoregulation in the eye is affected by ageing just as it is in the digestive and respiratory tracts. With ageing comes an increased prevalence of immune-based ocular surface disorders, which could be related to an age-related impairment of conjunctival tolerance. The purpose of this review was to summarize the present knowledge of ocular mucosal tolerance and how it is affected by the ageing process in the light of the current literature on mucosal immunoregulation of the gut and airways.
Fil: Galletti, Jeremías Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: de Paiva, Cintia S.. Baylor College of Medicine; Estados Unidos
description The ocular surface is the part of the visual system directly exposed to the environment, and it comprises the cornea, the first refractive tissue layer and its surrounding structures. The ocular surface has evolved to keep the cornea smooth and wet, a prerequisite for proper sight, and also protected. To this aim, the ocular surface is a bona fide mucosal niche with an immune system capable of fighting against dangerous pathogens. However, due to the potential harmful effects of uncontrolled inflammation, the ocular surface has several mechanisms to keep the immune response in check. Specifically, the ocular surface is maintained inflammation-free and functional by a particular form of peripheral tolerance known as mucosal tolerance, markedly different from the immune privilege of intraocular structures. Remarkably, conjunctival tolerance is akin to the oral and respiratory tolerance mechanisms found in the gut and airways, respectively. And also similarly, this form of immunoregulation in the eye is affected by ageing just as it is in the digestive and respiratory tracts. With ageing comes an increased prevalence of immune-based ocular surface disorders, which could be related to an age-related impairment of conjunctival tolerance. The purpose of this review was to summarize the present knowledge of ocular mucosal tolerance and how it is affected by the ageing process in the light of the current literature on mucosal immunoregulation of the gut and airways.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/153195
Galletti, Jeremías Gastón; de Paiva, Cintia S.; Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity; Wiley Blackwell Publishing, Inc; Immunology; 164; 1; 4-2021; 43-56
0019-2805
CONICET Digital
CONICET
url http://hdl.handle.net/11336/153195
identifier_str_mv Galletti, Jeremías Gastón; de Paiva, Cintia S.; Age-related changes in ocular mucosal tolerance: Lessons learned from gut and respiratory tract immunity; Wiley Blackwell Publishing, Inc; Immunology; 164; 1; 4-2021; 43-56
0019-2805
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/imm.13338
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/imm.13338
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270158979072000
score 13.13397

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