Microbial synthesis of 2,6-diaminopurine nucleosides

Autores
Médici, Rosario; Lewkowicz, Elizabeth Sandra; Iribarren, Adolfo Marcelo
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
2,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases. The synthesis of 2,6-diaminopurine riboside, -2 -deoxyriboside, -2 ,3 -dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as biocatalysts. The preparation of 2,6-diaminopurine-2 ,3 -dideoxyriboside catalysed by whole cells is here reported for the first time.
Fil: Médici, Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Lewkowicz, Elizabeth Sandra. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Materia
2,6-Diaminopurine nucleoside
Whole cells
Microbial transglycosylation
Nucleoside analogues
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/245392
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/245392
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Microbial synthesis of 2,6-diaminopurine nucleosidesMédici, RosarioLewkowicz, Elizabeth SandraIribarren, Adolfo Marcelo2,6-Diaminopurine nucleosideWhole cellsMicrobial transglycosylationNucleoside analogueshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/12,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases. The synthesis of 2,6-diaminopurine riboside, -2 -deoxyriboside, -2 ,3 -dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as biocatalysts. The preparation of 2,6-diaminopurine-2 ,3 -dideoxyriboside catalysed by whole cells is here reported for the first time.Fil: Médici, Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Lewkowicz, Elizabeth Sandra. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaElsevier Science2006-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/245392Médici, Rosario; Lewkowicz, Elizabeth Sandra; Iribarren, Adolfo Marcelo; Microbial synthesis of 2,6-diaminopurine nucleosides; Elsevier Science; Journal of Molecular Catalysis B: Enzymatic; 39; 1-4; 5-2006; 40-441381-1177CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1381117706000464info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molcatb.2006.01.024info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:17Zoai:ri.conicet.gov.ar:11336/245392instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:17.586CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Microbial synthesis of 2,6-diaminopurine nucleosides
title Microbial synthesis of 2,6-diaminopurine nucleosides
spellingShingle Microbial synthesis of 2,6-diaminopurine nucleosides
Médici, Rosario
2,6-Diaminopurine nucleoside
Whole cells
Microbial transglycosylation
Nucleoside analogues
title_short Microbial synthesis of 2,6-diaminopurine nucleosides
title_full Microbial synthesis of 2,6-diaminopurine nucleosides
title_fullStr Microbial synthesis of 2,6-diaminopurine nucleosides
title_full_unstemmed Microbial synthesis of 2,6-diaminopurine nucleosides
title_sort Microbial synthesis of 2,6-diaminopurine nucleosides
dc.creator.none.fl_str_mv Médici, Rosario
Lewkowicz, Elizabeth Sandra
Iribarren, Adolfo Marcelo
author Médici, Rosario
author_facet Médici, Rosario
Lewkowicz, Elizabeth Sandra
Iribarren, Adolfo Marcelo
author_role author
author2 Lewkowicz, Elizabeth Sandra
Iribarren, Adolfo Marcelo
author2_role author
author
dc.subject.none.fl_str_mv 2,6-Diaminopurine nucleoside
Whole cells
Microbial transglycosylation
Nucleoside analogues
topic 2,6-Diaminopurine nucleoside
Whole cells
Microbial transglycosylation
Nucleoside analogues
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv 2,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases. The synthesis of 2,6-diaminopurine riboside, -2 -deoxyriboside, -2 ,3 -dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as biocatalysts. The preparation of 2,6-diaminopurine-2 ,3 -dideoxyriboside catalysed by whole cells is here reported for the first time.
Fil: Médici, Rosario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Lewkowicz, Elizabeth Sandra. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Iribarren, Adolfo Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
description 2,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases. The synthesis of 2,6-diaminopurine riboside, -2 -deoxyriboside, -2 ,3 -dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as biocatalysts. The preparation of 2,6-diaminopurine-2 ,3 -dideoxyriboside catalysed by whole cells is here reported for the first time.
publishDate 2006
dc.date.none.fl_str_mv 2006-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/245392
Médici, Rosario; Lewkowicz, Elizabeth Sandra; Iribarren, Adolfo Marcelo; Microbial synthesis of 2,6-diaminopurine nucleosides; Elsevier Science; Journal of Molecular Catalysis B: Enzymatic; 39; 1-4; 5-2006; 40-44
1381-1177
CONICET Digital
CONICET
url http://hdl.handle.net/11336/245392
identifier_str_mv Médici, Rosario; Lewkowicz, Elizabeth Sandra; Iribarren, Adolfo Marcelo; Microbial synthesis of 2,6-diaminopurine nucleosides; Elsevier Science; Journal of Molecular Catalysis B: Enzymatic; 39; 1-4; 5-2006; 40-44
1381-1177
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1381117706000464
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molcatb.2006.01.024
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269454013038592
score 13.13397

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