Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications

Autores
Debandi, María Valeria; Bernal, Celina Raquel; Francois, Nora
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the present work, chitosan/glycerol blends were used to prepare biodegradable films with potential applicationin dermal treatment. While the presence of glycerol gives the hydrating effect, the chitosan characteristics contribute to dermal regeneration. Swelling degree measurements, water vapor permeability determinations, mechanical tests, scanning electronic microscopy and Fourier transform infrared spectroscopy analysis; biodegradability studies, thermogravimetric and differential scanning calorimetry analysis were used to analyze the influence of the incorporation of significant amounts of glycerol in film properties. The obtained results suggested that the glycerol addition provide the films with the required properties for the intended application related to dermal treatment. Increasing the glycerol concentration, a cluster effect produced by the glycerol molecules surrounding the macromolecular chains led to a decrease in the swelling degree and an increase in the WVP along with improvements in mechanical properties.
Fil: Debandi, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
Fil: Bernal, Celina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
Fil: Francois, Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
Materia
CHITOSAN
GLYCEROL
BIODEGRADABLE POLYMERS
FILMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123037
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical ApplicationsDebandi, María ValeriaBernal, Celina RaquelFrancois, NoraCHITOSANGLYCEROLBIODEGRADABLE POLYMERSFILMShttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2In the present work, chitosan/glycerol blends were used to prepare biodegradable films with potential applicationin dermal treatment. While the presence of glycerol gives the hydrating effect, the chitosan characteristics contribute to dermal regeneration. Swelling degree measurements, water vapor permeability determinations, mechanical tests, scanning electronic microscopy and Fourier transform infrared spectroscopy analysis; biodegradability studies, thermogravimetric and differential scanning calorimetry analysis were used to analyze the influence of the incorporation of significant amounts of glycerol in film properties. The obtained results suggested that the glycerol addition provide the films with the required properties for the intended application related to dermal treatment. Increasing the glycerol concentration, a cluster effect produced by the glycerol molecules surrounding the macromolecular chains led to a decrease in the swelling degree and an increase in the WVP along with improvements in mechanical properties.Fil: Debandi, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; ArgentinaFil: Bernal, Celina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; ArgentinaFil: Francois, Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; ArgentinaOmics International2016-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123037Debandi, María Valeria; Bernal, Celina Raquel; Francois, Nora; Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications; Omics International; Journal of Tissue Science and Engineering; 7; 12-2016; 1-92157-7552CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/development-of-biodegradable-films-based-on-chitosanglycerol-blendssuitable-for-biomedical-applications-2157-7552-1000187.php?aid=83339info:eu-repo/semantics/altIdentifier/doi/ 10.4172/2157-7552.1000187info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:04Zoai:ri.conicet.gov.ar:11336/123037instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:04.803CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications
title Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications
spellingShingle Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications
Debandi, María Valeria
CHITOSAN
GLYCEROL
BIODEGRADABLE POLYMERS
FILMS
title_short Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications
title_full Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications
title_fullStr Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications
title_full_unstemmed Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications
title_sort Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications
dc.creator.none.fl_str_mv Debandi, María Valeria
Bernal, Celina Raquel
Francois, Nora
author Debandi, María Valeria
author_facet Debandi, María Valeria
Bernal, Celina Raquel
Francois, Nora
author_role author
author2 Bernal, Celina Raquel
Francois, Nora
author2_role author
author
dc.subject.none.fl_str_mv CHITOSAN
GLYCEROL
BIODEGRADABLE POLYMERS
FILMS
topic CHITOSAN
GLYCEROL
BIODEGRADABLE POLYMERS
FILMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In the present work, chitosan/glycerol blends were used to prepare biodegradable films with potential applicationin dermal treatment. While the presence of glycerol gives the hydrating effect, the chitosan characteristics contribute to dermal regeneration. Swelling degree measurements, water vapor permeability determinations, mechanical tests, scanning electronic microscopy and Fourier transform infrared spectroscopy analysis; biodegradability studies, thermogravimetric and differential scanning calorimetry analysis were used to analyze the influence of the incorporation of significant amounts of glycerol in film properties. The obtained results suggested that the glycerol addition provide the films with the required properties for the intended application related to dermal treatment. Increasing the glycerol concentration, a cluster effect produced by the glycerol molecules surrounding the macromolecular chains led to a decrease in the swelling degree and an increase in the WVP along with improvements in mechanical properties.
Fil: Debandi, María Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
Fil: Bernal, Celina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
Fil: Francois, Nora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnología en Polímeros y Nanotecnología. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina
description In the present work, chitosan/glycerol blends were used to prepare biodegradable films with potential applicationin dermal treatment. While the presence of glycerol gives the hydrating effect, the chitosan characteristics contribute to dermal regeneration. Swelling degree measurements, water vapor permeability determinations, mechanical tests, scanning electronic microscopy and Fourier transform infrared spectroscopy analysis; biodegradability studies, thermogravimetric and differential scanning calorimetry analysis were used to analyze the influence of the incorporation of significant amounts of glycerol in film properties. The obtained results suggested that the glycerol addition provide the films with the required properties for the intended application related to dermal treatment. Increasing the glycerol concentration, a cluster effect produced by the glycerol molecules surrounding the macromolecular chains led to a decrease in the swelling degree and an increase in the WVP along with improvements in mechanical properties.
publishDate 2016
dc.date.none.fl_str_mv 2016-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123037
Debandi, María Valeria; Bernal, Celina Raquel; Francois, Nora; Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications; Omics International; Journal of Tissue Science and Engineering; 7; 12-2016; 1-9
2157-7552
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123037
identifier_str_mv Debandi, María Valeria; Bernal, Celina Raquel; Francois, Nora; Development of Biodegradable Films Based on Chitosan/Glycerol Blends Suitable for Biomedical Applications; Omics International; Journal of Tissue Science and Engineering; 7; 12-2016; 1-9
2157-7552
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/development-of-biodegradable-films-based-on-chitosanglycerol-blendssuitable-for-biomedical-applications-2157-7552-1000187.php?aid=83339
info:eu-repo/semantics/altIdentifier/doi/ 10.4172/2157-7552.1000187
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Omics International
publisher.none.fl_str_mv Omics International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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