Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research

Autores
Sookoian, Silvia Cristina; Fernandez Gianotti, Tomas; Burgueño, Adriana Laura; Pirola, Carlos Jose
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study, we review the current knowledge and recent insights on the role of epigenetic factors in the development of human insulin resistance (IR)- and metabolic syndrome (MS)-related phenotypes, and attempt to lay a framework to consider IR as a potentially reversible incapacity to control metabolic homeostasis that is strongly influenced by the interplay between external and internal cues. We summarize the evidence on how tissue-specific epigenetic markers participate either by activating or repressing the gene expression programs to modulate IR- and MS-associated traits. Some additional data are provided about how the exploration of DNA methylation markers in peripheral blood mononuclear cells potentially offers appealing information about the impact of epigenetics in the pathogenesis of IR. Clues about the relation between IR and impaired intrauterine growth explained by fetal metabolic programming and epigenetic modifications are shown, including novel findings about the impact of histone modifications. For instance, we observed that specific epigenetic factors in genes associated with mitochondrial biogenesis may be associated with birth weight. Furthermore, some prospective ideas about the functional consequences of genetic variation modulated by allele-specific epigenetic markers and its impact on MS susceptibility are also illustrated. Finally, we summarize the current knowledge of epigenetics as the biological rationale for potential therapeutic intervention in IR and MS.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Fernandez Gianotti, Tomas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Materia
Allele-Specific Epigenetic Marks
Dna Methylation
Epigenetic
Fatty Liver
Fetal Metabolic Programming
Histone Deacetylases
Histone Modifications
Insulin Resistance
Intrauterine Growth
Large for Gestational Age
Metabolic Syndrome
Mtdna Copy Number
Pgc1a
Ppargc1a
Small for Gestational Age
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15006
Acceder
id CONICETDig_f6bce6c27a1af92825e52ad4286c4c17
oai_identifier_str oai:ri.conicet.gov.ar:11336/15006
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Insulin resistance and epigenetic regulation: insights from human studies and prospects for future researchSookoian, Silvia CristinaFernandez Gianotti, TomasBurgueño, Adriana LauraPirola, Carlos JoseAllele-Specific Epigenetic MarksDna MethylationEpigeneticFatty LiverFetal Metabolic ProgrammingHistone DeacetylasesHistone ModificationsInsulin ResistanceIntrauterine GrowthLarge for Gestational AgeMetabolic SyndromeMtdna Copy NumberPgc1aPpargc1aSmall for Gestational Agehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In this study, we review the current knowledge and recent insights on the role of epigenetic factors in the development of human insulin resistance (IR)- and metabolic syndrome (MS)-related phenotypes, and attempt to lay a framework to consider IR as a potentially reversible incapacity to control metabolic homeostasis that is strongly influenced by the interplay between external and internal cues. We summarize the evidence on how tissue-specific epigenetic markers participate either by activating or repressing the gene expression programs to modulate IR- and MS-associated traits. Some additional data are provided about how the exploration of DNA methylation markers in peripheral blood mononuclear cells potentially offers appealing information about the impact of epigenetics in the pathogenesis of IR. Clues about the relation between IR and impaired intrauterine growth explained by fetal metabolic programming and epigenetic modifications are shown, including novel findings about the impact of histone modifications. For instance, we observed that specific epigenetic factors in genes associated with mitochondrial biogenesis may be associated with birth weight. Furthermore, some prospective ideas about the functional consequences of genetic variation modulated by allele-specific epigenetic markers and its impact on MS susceptibility are also illustrated. Finally, we summarize the current knowledge of epigenetics as the biological rationale for potential therapeutic intervention in IR and MS.Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Fernandez Gianotti, Tomas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaFil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pirola, Carlos Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; ArgentinaDe Gruyter2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15006Sookoian, Silvia Cristina; Fernandez Gianotti, Tomas; Burgueño, Adriana Laura; Pirola, Carlos Jose; Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research; De Gruyter; Biomolecular Concepts; 2; 6; 12-2011; 445-5471868-50211868-503Xenginfo:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/bmc.2011.2.issue-6/bmc.2011.043/bmc.2011.043.xmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/BMC.2011.043info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:20Zoai:ri.conicet.gov.ar:11336/15006instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:21.073CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
title Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
spellingShingle Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
Sookoian, Silvia Cristina
Allele-Specific Epigenetic Marks
Dna Methylation
Epigenetic
Fatty Liver
Fetal Metabolic Programming
Histone Deacetylases
Histone Modifications
Insulin Resistance
Intrauterine Growth
Large for Gestational Age
Metabolic Syndrome
Mtdna Copy Number
Pgc1a
Ppargc1a
Small for Gestational Age
title_short Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
title_full Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
title_fullStr Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
title_full_unstemmed Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
title_sort Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research
dc.creator.none.fl_str_mv Sookoian, Silvia Cristina
Fernandez Gianotti, Tomas
Burgueño, Adriana Laura
Pirola, Carlos Jose
author Sookoian, Silvia Cristina
author_facet Sookoian, Silvia Cristina
Fernandez Gianotti, Tomas
Burgueño, Adriana Laura
Pirola, Carlos Jose
author_role author
author2 Fernandez Gianotti, Tomas
Burgueño, Adriana Laura
Pirola, Carlos Jose
author2_role author
author
author
dc.subject.none.fl_str_mv Allele-Specific Epigenetic Marks
Dna Methylation
Epigenetic
Fatty Liver
Fetal Metabolic Programming
Histone Deacetylases
Histone Modifications
Insulin Resistance
Intrauterine Growth
Large for Gestational Age
Metabolic Syndrome
Mtdna Copy Number
Pgc1a
Ppargc1a
Small for Gestational Age
topic Allele-Specific Epigenetic Marks
Dna Methylation
Epigenetic
Fatty Liver
Fetal Metabolic Programming
Histone Deacetylases
Histone Modifications
Insulin Resistance
Intrauterine Growth
Large for Gestational Age
Metabolic Syndrome
Mtdna Copy Number
Pgc1a
Ppargc1a
Small for Gestational Age
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In this study, we review the current knowledge and recent insights on the role of epigenetic factors in the development of human insulin resistance (IR)- and metabolic syndrome (MS)-related phenotypes, and attempt to lay a framework to consider IR as a potentially reversible incapacity to control metabolic homeostasis that is strongly influenced by the interplay between external and internal cues. We summarize the evidence on how tissue-specific epigenetic markers participate either by activating or repressing the gene expression programs to modulate IR- and MS-associated traits. Some additional data are provided about how the exploration of DNA methylation markers in peripheral blood mononuclear cells potentially offers appealing information about the impact of epigenetics in the pathogenesis of IR. Clues about the relation between IR and impaired intrauterine growth explained by fetal metabolic programming and epigenetic modifications are shown, including novel findings about the impact of histone modifications. For instance, we observed that specific epigenetic factors in genes associated with mitochondrial biogenesis may be associated with birth weight. Furthermore, some prospective ideas about the functional consequences of genetic variation modulated by allele-specific epigenetic markers and its impact on MS susceptibility are also illustrated. Finally, we summarize the current knowledge of epigenetics as the biological rationale for potential therapeutic intervention in IR and MS.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Fernandez Gianotti, Tomas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos Jose. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Medicas; Argentina
description In this study, we review the current knowledge and recent insights on the role of epigenetic factors in the development of human insulin resistance (IR)- and metabolic syndrome (MS)-related phenotypes, and attempt to lay a framework to consider IR as a potentially reversible incapacity to control metabolic homeostasis that is strongly influenced by the interplay between external and internal cues. We summarize the evidence on how tissue-specific epigenetic markers participate either by activating or repressing the gene expression programs to modulate IR- and MS-associated traits. Some additional data are provided about how the exploration of DNA methylation markers in peripheral blood mononuclear cells potentially offers appealing information about the impact of epigenetics in the pathogenesis of IR. Clues about the relation between IR and impaired intrauterine growth explained by fetal metabolic programming and epigenetic modifications are shown, including novel findings about the impact of histone modifications. For instance, we observed that specific epigenetic factors in genes associated with mitochondrial biogenesis may be associated with birth weight. Furthermore, some prospective ideas about the functional consequences of genetic variation modulated by allele-specific epigenetic markers and its impact on MS susceptibility are also illustrated. Finally, we summarize the current knowledge of epigenetics as the biological rationale for potential therapeutic intervention in IR and MS.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15006
Sookoian, Silvia Cristina; Fernandez Gianotti, Tomas; Burgueño, Adriana Laura; Pirola, Carlos Jose; Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research; De Gruyter; Biomolecular Concepts; 2; 6; 12-2011; 445-547
1868-5021
1868-503X
url http://hdl.handle.net/11336/15006
identifier_str_mv Sookoian, Silvia Cristina; Fernandez Gianotti, Tomas; Burgueño, Adriana Laura; Pirola, Carlos Jose; Insulin resistance and epigenetic regulation: insights from human studies and prospects for future research; De Gruyter; Biomolecular Concepts; 2; 6; 12-2011; 445-547
1868-5021
1868-503X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/bmc.2011.2.issue-6/bmc.2011.043/bmc.2011.043.xml
info:eu-repo/semantics/altIdentifier/doi/10.1515/BMC.2011.043
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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