DNA methylation and hepatic insulin resistance and steatosis

Autores
Sookoian, Silvia Cristina; Pirola, Carlos José
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose of review: In this review, we show novel evidence about the role of the liver in the development of insulin resistance and suggest that abnormal hepatic triglyceride accumulation is not an innocent bystander comorbidity but adversely affects the peripheral insulin sensitivity. Recent findings: The core of this review is built up around the concept that liver DNA methylation of the peroxisome proliferative activated receptor gamma coactivator one alpha gene promoter modulates the status of peripheral insulin resistance and is strongly associated with plasma fasting insulin levels. We discuss about other mechanisms associated with peroxisome proliferative activated receptor gamma coactivator one alpha regulation, such as an acetylation and deacetylation switch and how these events impact on the liver metabolic function. We suggest a mitochondrial-centric approach to understand the connection between nonalcoholic fatty liver disease and insulin resistance. We finally show new data about how the liver epigenome is modulated by nutritional cues and introduce the role of epigenetics in liver metabolic programming. Summary: The implications of these findings for clinical practice are promising, as the inherent plasticity of epigenetic modifications, produced either physiologically or pathologically, suggests that early therapeutic intervention in patients with fatty liver can potentially revert the systemic phenotype associated with insulin resistance. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
Acetylation
Deacetylation
Dna Methylation
Epigenetics
Fatty Liver
Histones
Mitochondria
Nonalcoholic Steatohepatitis
Pgc1a
Ppargc1a
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67419
Acceder
id CONICETDig_3c9f5dcea21077e575147e474cc467f6
oai_identifier_str oai:ri.conicet.gov.ar:11336/67419
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling DNA methylation and hepatic insulin resistance and steatosisSookoian, Silvia CristinaPirola, Carlos JoséAcetylationDeacetylationDna MethylationEpigeneticsFatty LiverHistonesMitochondriaNonalcoholic SteatohepatitisPgc1aPpargc1ahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose of review: In this review, we show novel evidence about the role of the liver in the development of insulin resistance and suggest that abnormal hepatic triglyceride accumulation is not an innocent bystander comorbidity but adversely affects the peripheral insulin sensitivity. Recent findings: The core of this review is built up around the concept that liver DNA methylation of the peroxisome proliferative activated receptor gamma coactivator one alpha gene promoter modulates the status of peripheral insulin resistance and is strongly associated with plasma fasting insulin levels. We discuss about other mechanisms associated with peroxisome proliferative activated receptor gamma coactivator one alpha regulation, such as an acetylation and deacetylation switch and how these events impact on the liver metabolic function. We suggest a mitochondrial-centric approach to understand the connection between nonalcoholic fatty liver disease and insulin resistance. We finally show new data about how the liver epigenome is modulated by nutritional cues and introduce the role of epigenetics in liver metabolic programming. Summary: The implications of these findings for clinical practice are promising, as the inherent plasticity of epigenetic modifications, produced either physiologically or pathologically, suggests that early therapeutic intervention in patients with fatty liver can potentially revert the systemic phenotype associated with insulin resistance. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaLippincott Williams2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67419Sookoian, Silvia Cristina; Pirola, Carlos José; DNA methylation and hepatic insulin resistance and steatosis; Lippincott Williams; Current Opinion In Clinical Nutrition And Metabolic Care; 15; 4; 7-2012; 350-3561363-1950CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/MCO.0b013e3283546f9finfo:eu-repo/semantics/altIdentifier/url/https://ovidsp.tx.ovid.com/sp-3.32.0a/ovidweb.cgi?QS2=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:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/co-clinicalnutrition/pages/articleviewer.aspx?year=2012&issue=07000&article=00006&type=abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:17Zoai:ri.conicet.gov.ar:11336/67419instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:18.245CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv DNA methylation and hepatic insulin resistance and steatosis
title DNA methylation and hepatic insulin resistance and steatosis
spellingShingle DNA methylation and hepatic insulin resistance and steatosis
Sookoian, Silvia Cristina
Acetylation
Deacetylation
Dna Methylation
Epigenetics
Fatty Liver
Histones
Mitochondria
Nonalcoholic Steatohepatitis
Pgc1a
Ppargc1a
title_short DNA methylation and hepatic insulin resistance and steatosis
title_full DNA methylation and hepatic insulin resistance and steatosis
title_fullStr DNA methylation and hepatic insulin resistance and steatosis
title_full_unstemmed DNA methylation and hepatic insulin resistance and steatosis
title_sort DNA methylation and hepatic insulin resistance and steatosis
dc.creator.none.fl_str_mv Sookoian, Silvia Cristina
Pirola, Carlos José
author Sookoian, Silvia Cristina
author_facet Sookoian, Silvia Cristina
Pirola, Carlos José
author_role author
author2 Pirola, Carlos José
author2_role author
dc.subject.none.fl_str_mv Acetylation
Deacetylation
Dna Methylation
Epigenetics
Fatty Liver
Histones
Mitochondria
Nonalcoholic Steatohepatitis
Pgc1a
Ppargc1a
topic Acetylation
Deacetylation
Dna Methylation
Epigenetics
Fatty Liver
Histones
Mitochondria
Nonalcoholic Steatohepatitis
Pgc1a
Ppargc1a
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose of review: In this review, we show novel evidence about the role of the liver in the development of insulin resistance and suggest that abnormal hepatic triglyceride accumulation is not an innocent bystander comorbidity but adversely affects the peripheral insulin sensitivity. Recent findings: The core of this review is built up around the concept that liver DNA methylation of the peroxisome proliferative activated receptor gamma coactivator one alpha gene promoter modulates the status of peripheral insulin resistance and is strongly associated with plasma fasting insulin levels. We discuss about other mechanisms associated with peroxisome proliferative activated receptor gamma coactivator one alpha regulation, such as an acetylation and deacetylation switch and how these events impact on the liver metabolic function. We suggest a mitochondrial-centric approach to understand the connection between nonalcoholic fatty liver disease and insulin resistance. We finally show new data about how the liver epigenome is modulated by nutritional cues and introduce the role of epigenetics in liver metabolic programming. Summary: The implications of these findings for clinical practice are promising, as the inherent plasticity of epigenetic modifications, produced either physiologically or pathologically, suggests that early therapeutic intervention in patients with fatty liver can potentially revert the systemic phenotype associated with insulin resistance. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Purpose of review: In this review, we show novel evidence about the role of the liver in the development of insulin resistance and suggest that abnormal hepatic triglyceride accumulation is not an innocent bystander comorbidity but adversely affects the peripheral insulin sensitivity. Recent findings: The core of this review is built up around the concept that liver DNA methylation of the peroxisome proliferative activated receptor gamma coactivator one alpha gene promoter modulates the status of peripheral insulin resistance and is strongly associated with plasma fasting insulin levels. We discuss about other mechanisms associated with peroxisome proliferative activated receptor gamma coactivator one alpha regulation, such as an acetylation and deacetylation switch and how these events impact on the liver metabolic function. We suggest a mitochondrial-centric approach to understand the connection between nonalcoholic fatty liver disease and insulin resistance. We finally show new data about how the liver epigenome is modulated by nutritional cues and introduce the role of epigenetics in liver metabolic programming. Summary: The implications of these findings for clinical practice are promising, as the inherent plasticity of epigenetic modifications, produced either physiologically or pathologically, suggests that early therapeutic intervention in patients with fatty liver can potentially revert the systemic phenotype associated with insulin resistance. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67419
Sookoian, Silvia Cristina; Pirola, Carlos José; DNA methylation and hepatic insulin resistance and steatosis; Lippincott Williams; Current Opinion In Clinical Nutrition And Metabolic Care; 15; 4; 7-2012; 350-356
1363-1950
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67419
identifier_str_mv Sookoian, Silvia Cristina; Pirola, Carlos José; DNA methylation and hepatic insulin resistance and steatosis; Lippincott Williams; Current Opinion In Clinical Nutrition And Metabolic Care; 15; 4; 7-2012; 350-356
1363-1950
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/MCO.0b013e3283546f9f
info:eu-repo/semantics/altIdentifier/url/https://ovidsp.tx.ovid.com/sp-3.32.0a/ovidweb.cgi?QS2=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
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/co-clinicalnutrition/pages/articleviewer.aspx?year=2012&issue=07000&article=00006&type=abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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