Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion

Autores
Olea, Fernanda Daniela; De Lorenzi, Andrea; Cortés, Claudia; Cabeza Meckert, Patricia; Cendoya, Oscar; Barra, Juan G.; Bercovich, Andrés; González, Eliseo; Laguens, Rubén; Crottogini, Alberto José
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effects of growth hormone (GH) on infarct size and left ventricular (LV) function in experimental acute myocardial infarction (AMI) have been controversial. Moreover, little, if any, information exists regarding long-term evaluation of therapeutic doses of GH in large mammalian models of AMI. We therefore aimed to assess the effect of therapeutic doses of GH over 3.5 months on infarct size and heart function in sheep with AMI. After coronary artery ligation, sheep received subcutaneous human GH 8 IU/d (n = 8) or vehicle (n = 8) over 100 days. Infarct area was similar in GH (16.9% 6 3% of LV area) and placebo (16.5% 6 3.7%, P = not significant) sheep. At 3 days of treatment onset, but not at later times, GH sheep had higher LV shortening fraction (30.7% 6 3.5% vs. 24.8% 6 6.1%, P , 0.04), systolic anterior wall thickness (10.1 6 0.8 vs. 8.6 6 1.2 mm, P , 0.02), and cardiac index (3.8 6 0.6 vs. 2.8 6 0.7 L min21 m22 , P , 0.01). This evolution of function parameters paralleled that of serum insulin-like growth factor 1 levels, which differed significantly only during the first week, suggesting a direct effect of GH on LV contractility. These results may suggest the usefulness of therapeutic doses of GH at the early phases of AMI but do not support maintaining the treatment for longer time.
Fil: Olea, Fernanda Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: De Lorenzi, Andrea. Universidad Favaloro; Argentina
Fil: Cortés, Claudia. Universidad Favaloro; Argentina
Fil: Cabeza Meckert, Patricia. Universidad Favaloro; Argentina
Fil: Cendoya, Oscar. Universidad Favaloro; Argentina
Fil: Barra, Juan G.. Universidad Favaloro; Argentina
Fil: Bercovich, Andrés. Biosidus S. A.; Argentina
Fil: González, Eliseo. Biosidus S. A.; Argentina
Fil: Laguens, Rubén. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Crottogini, Alberto José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Materia
GROWTH HORMONE
ACUTE MYOCARDIAL INFARCTION
INFARCT SIZE
SHEEP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/104270
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/104270
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusionOlea, Fernanda DanielaDe Lorenzi, AndreaCortés, ClaudiaCabeza Meckert, PatriciaCendoya, OscarBarra, Juan G.Bercovich, AndrésGonzález, EliseoLaguens, RubénCrottogini, Alberto JoséGROWTH HORMONEACUTE MYOCARDIAL INFARCTIONINFARCT SIZESHEEPhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The effects of growth hormone (GH) on infarct size and left ventricular (LV) function in experimental acute myocardial infarction (AMI) have been controversial. Moreover, little, if any, information exists regarding long-term evaluation of therapeutic doses of GH in large mammalian models of AMI. We therefore aimed to assess the effect of therapeutic doses of GH over 3.5 months on infarct size and heart function in sheep with AMI. After coronary artery ligation, sheep received subcutaneous human GH 8 IU/d (n = 8) or vehicle (n = 8) over 100 days. Infarct area was similar in GH (16.9% 6 3% of LV area) and placebo (16.5% 6 3.7%, P = not significant) sheep. At 3 days of treatment onset, but not at later times, GH sheep had higher LV shortening fraction (30.7% 6 3.5% vs. 24.8% 6 6.1%, P , 0.04), systolic anterior wall thickness (10.1 6 0.8 vs. 8.6 6 1.2 mm, P , 0.02), and cardiac index (3.8 6 0.6 vs. 2.8 6 0.7 L min21 m22 , P , 0.01). This evolution of function parameters paralleled that of serum insulin-like growth factor 1 levels, which differed significantly only during the first week, suggesting a direct effect of GH on LV contractility. These results may suggest the usefulness of therapeutic doses of GH at the early phases of AMI but do not support maintaining the treatment for longer time.Fil: Olea, Fernanda Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: De Lorenzi, Andrea. Universidad Favaloro; ArgentinaFil: Cortés, Claudia. Universidad Favaloro; ArgentinaFil: Cabeza Meckert, Patricia. Universidad Favaloro; ArgentinaFil: Cendoya, Oscar. Universidad Favaloro; ArgentinaFil: Barra, Juan G.. Universidad Favaloro; ArgentinaFil: Bercovich, Andrés. Biosidus S. A.; ArgentinaFil: González, Eliseo. Biosidus S. A.; ArgentinaFil: Laguens, Rubén. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Crottogini, Alberto José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaLippincott Williams2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/104270Olea, Fernanda Daniela; De Lorenzi, Andrea; Cortés, Claudia; Cabeza Meckert, Patricia; Cendoya, Oscar; et al.; Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion; Lippincott Williams; Journal Of Cardiovascular Pharmacology; 55; 3; 3-2010; 255-2610160-2446CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/20051878/info:eu-repo/semantics/altIdentifier/doi/10.1097/FJC.0b013e3181cf9190info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/cardiovascularpharm/Abstract/2010/03000/Long_Term_Effects_of_Growth_Hormone_on_Infarct.6.aspxinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:30Zoai:ri.conicet.gov.ar:11336/104270instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:31.226CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
title Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
spellingShingle Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
Olea, Fernanda Daniela
GROWTH HORMONE
ACUTE MYOCARDIAL INFARCTION
INFARCT SIZE
SHEEP
title_short Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
title_full Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
title_fullStr Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
title_full_unstemmed Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
title_sort Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion
dc.creator.none.fl_str_mv Olea, Fernanda Daniela
De Lorenzi, Andrea
Cortés, Claudia
Cabeza Meckert, Patricia
Cendoya, Oscar
Barra, Juan G.
Bercovich, Andrés
González, Eliseo
Laguens, Rubén
Crottogini, Alberto José
author Olea, Fernanda Daniela
author_facet Olea, Fernanda Daniela
De Lorenzi, Andrea
Cortés, Claudia
Cabeza Meckert, Patricia
Cendoya, Oscar
Barra, Juan G.
Bercovich, Andrés
González, Eliseo
Laguens, Rubén
Crottogini, Alberto José
author_role author
author2 De Lorenzi, Andrea
Cortés, Claudia
Cabeza Meckert, Patricia
Cendoya, Oscar
Barra, Juan G.
Bercovich, Andrés
González, Eliseo
Laguens, Rubén
Crottogini, Alberto José
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GROWTH HORMONE
ACUTE MYOCARDIAL INFARCTION
INFARCT SIZE
SHEEP
topic GROWTH HORMONE
ACUTE MYOCARDIAL INFARCTION
INFARCT SIZE
SHEEP
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The effects of growth hormone (GH) on infarct size and left ventricular (LV) function in experimental acute myocardial infarction (AMI) have been controversial. Moreover, little, if any, information exists regarding long-term evaluation of therapeutic doses of GH in large mammalian models of AMI. We therefore aimed to assess the effect of therapeutic doses of GH over 3.5 months on infarct size and heart function in sheep with AMI. After coronary artery ligation, sheep received subcutaneous human GH 8 IU/d (n = 8) or vehicle (n = 8) over 100 days. Infarct area was similar in GH (16.9% 6 3% of LV area) and placebo (16.5% 6 3.7%, P = not significant) sheep. At 3 days of treatment onset, but not at later times, GH sheep had higher LV shortening fraction (30.7% 6 3.5% vs. 24.8% 6 6.1%, P , 0.04), systolic anterior wall thickness (10.1 6 0.8 vs. 8.6 6 1.2 mm, P , 0.02), and cardiac index (3.8 6 0.6 vs. 2.8 6 0.7 L min21 m22 , P , 0.01). This evolution of function parameters paralleled that of serum insulin-like growth factor 1 levels, which differed significantly only during the first week, suggesting a direct effect of GH on LV contractility. These results may suggest the usefulness of therapeutic doses of GH at the early phases of AMI but do not support maintaining the treatment for longer time.
Fil: Olea, Fernanda Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: De Lorenzi, Andrea. Universidad Favaloro; Argentina
Fil: Cortés, Claudia. Universidad Favaloro; Argentina
Fil: Cabeza Meckert, Patricia. Universidad Favaloro; Argentina
Fil: Cendoya, Oscar. Universidad Favaloro; Argentina
Fil: Barra, Juan G.. Universidad Favaloro; Argentina
Fil: Bercovich, Andrés. Biosidus S. A.; Argentina
Fil: González, Eliseo. Biosidus S. A.; Argentina
Fil: Laguens, Rubén. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Crottogini, Alberto José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
description The effects of growth hormone (GH) on infarct size and left ventricular (LV) function in experimental acute myocardial infarction (AMI) have been controversial. Moreover, little, if any, information exists regarding long-term evaluation of therapeutic doses of GH in large mammalian models of AMI. We therefore aimed to assess the effect of therapeutic doses of GH over 3.5 months on infarct size and heart function in sheep with AMI. After coronary artery ligation, sheep received subcutaneous human GH 8 IU/d (n = 8) or vehicle (n = 8) over 100 days. Infarct area was similar in GH (16.9% 6 3% of LV area) and placebo (16.5% 6 3.7%, P = not significant) sheep. At 3 days of treatment onset, but not at later times, GH sheep had higher LV shortening fraction (30.7% 6 3.5% vs. 24.8% 6 6.1%, P , 0.04), systolic anterior wall thickness (10.1 6 0.8 vs. 8.6 6 1.2 mm, P , 0.02), and cardiac index (3.8 6 0.6 vs. 2.8 6 0.7 L min21 m22 , P , 0.01). This evolution of function parameters paralleled that of serum insulin-like growth factor 1 levels, which differed significantly only during the first week, suggesting a direct effect of GH on LV contractility. These results may suggest the usefulness of therapeutic doses of GH at the early phases of AMI but do not support maintaining the treatment for longer time.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/104270
Olea, Fernanda Daniela; De Lorenzi, Andrea; Cortés, Claudia; Cabeza Meckert, Patricia; Cendoya, Oscar; et al.; Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion; Lippincott Williams; Journal Of Cardiovascular Pharmacology; 55; 3; 3-2010; 255-261
0160-2446
CONICET Digital
CONICET
url http://hdl.handle.net/11336/104270
identifier_str_mv Olea, Fernanda Daniela; De Lorenzi, Andrea; Cortés, Claudia; Cabeza Meckert, Patricia; Cendoya, Oscar; et al.; Long-term effects of growth hormone on infarct size and left ventricular function in sheep with coronary artery occlusion; Lippincott Williams; Journal Of Cardiovascular Pharmacology; 55; 3; 3-2010; 255-261
0160-2446
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/20051878/
info:eu-repo/semantics/altIdentifier/doi/10.1097/FJC.0b013e3181cf9190
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/cardiovascularpharm/Abstract/2010/03000/Long_Term_Effects_of_Growth_Hormone_on_Infarct.6.aspx
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269914566492160
score 13.13397

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