Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis

Autores
Crivelli, Lucía; Palmer, Katie; Calandri, Ismael; Guekht, Alla; Beghi, Ettore; Carroll, William; Frontera, Jennifer; García Azorín, David; Westenberg, Erica; Winkler, Andrea Sylvia; Mangialasche, Francesca; Allegri, Ricardo Francisco; Kivipelto, Miia
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: We conducted a systematic review and meta-analysis of the cognitive effects of coronavirus disease 2019 (COVID-19) in adults with no prior history of cognitive impairment. Methods: Searches in Medline/Web of Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A meta-analysis of the Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID-19 and healthy controls was performed. Results: Oof 6202 articles, 27 studies with 2049 individuals were included (mean age = 56.05 years, evaluation time ranged from the acute phase to 7 months post-infection). Impairment in executive functions, attention, and memory were found in post-COVID-19 patients. The meta-analysis was performed with a subgroup of 290 individuals and showed a difference in MoCA score between post-COVID-19 patients versus controls (mean difference = −0.94, 95% confidence interval [CI] −1.59, −0.29; P =.0049). Discussion: Patients recovered from COVID-19 have lower general cognition compared to healthy controls up to 7 months post-infection.
Fil: Crivelli, Lucía. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
Fil: Palmer, Katie. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Calandri, Ismael. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Guekht, Alla. Pirogov Russian National Research University; Rusia
Fil: Beghi, Ettore. Instituto di Ricerche Farmacologiche Mario Negri; Italia
Fil: Carroll, William. University of Western Australia; Australia
Fil: Frontera, Jennifer. No especifíca;
Fil: García Azorín, David. Hospital Clínico Universitario de Valladolid; España
Fil: Westenberg, Erica. Universitat Technical Zu Munich; Alemania
Fil: Winkler, Andrea Sylvia. Universitat Technical Zu Munich; Alemania
Fil: Mangialasche, Francesca. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Allegri, Ricardo Francisco. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
Fil: Kivipelto, Miia. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Materia
ATTENTION
COGNITION
COGNITIVE DYSFUNCTION
COVID-19
EXECUTIVE FUNCTIONS
NEUROPSYCHOLOGICAL TEST
SARS-COV-2 CORONAVIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216394
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/216394
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Changes in cognitive functioning after COVID-19: A systematic review and meta-analysisCrivelli, LucíaPalmer, KatieCalandri, IsmaelGuekht, AllaBeghi, EttoreCarroll, WilliamFrontera, JenniferGarcía Azorín, DavidWestenberg, EricaWinkler, Andrea SylviaMangialasche, FrancescaAllegri, Ricardo FranciscoKivipelto, MiiaATTENTIONCOGNITIONCOGNITIVE DYSFUNCTIONCOVID-19EXECUTIVE FUNCTIONSNEUROPSYCHOLOGICAL TESTSARS-COV-2 CORONAVIRUShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: We conducted a systematic review and meta-analysis of the cognitive effects of coronavirus disease 2019 (COVID-19) in adults with no prior history of cognitive impairment. Methods: Searches in Medline/Web of Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A meta-analysis of the Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID-19 and healthy controls was performed. Results: Oof 6202 articles, 27 studies with 2049 individuals were included (mean age = 56.05 years, evaluation time ranged from the acute phase to 7 months post-infection). Impairment in executive functions, attention, and memory were found in post-COVID-19 patients. The meta-analysis was performed with a subgroup of 290 individuals and showed a difference in MoCA score between post-COVID-19 patients versus controls (mean difference = −0.94, 95% confidence interval [CI] −1.59, −0.29; P =.0049). Discussion: Patients recovered from COVID-19 have lower general cognition compared to healthy controls up to 7 months post-infection.Fil: Crivelli, Lucía. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; ArgentinaFil: Palmer, Katie. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Calandri, Ismael. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Guekht, Alla. Pirogov Russian National Research University; RusiaFil: Beghi, Ettore. Instituto di Ricerche Farmacologiche Mario Negri; ItaliaFil: Carroll, William. University of Western Australia; AustraliaFil: Frontera, Jennifer. No especifíca;Fil: García Azorín, David. Hospital Clínico Universitario de Valladolid; EspañaFil: Westenberg, Erica. Universitat Technical Zu Munich; AlemaniaFil: Winkler, Andrea Sylvia. Universitat Technical Zu Munich; AlemaniaFil: Mangialasche, Francesca. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Allegri, Ricardo Francisco. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; ArgentinaFil: Kivipelto, Miia. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaElsevier Science Inc.2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216394Crivelli, Lucía; Palmer, Katie; Calandri, Ismael; Guekht, Alla; Beghi, Ettore; et al.; Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis; Elsevier Science Inc.; Alzheimers & Dementia; 18; 5; 5-2022; 1047-10661552-5260CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12644info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.12644info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:02Zoai:ri.conicet.gov.ar:11336/216394instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:03.152CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
title Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
spellingShingle Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
Crivelli, Lucía
ATTENTION
COGNITION
COGNITIVE DYSFUNCTION
COVID-19
EXECUTIVE FUNCTIONS
NEUROPSYCHOLOGICAL TEST
SARS-COV-2 CORONAVIRUS
title_short Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
title_full Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
title_fullStr Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
title_full_unstemmed Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
title_sort Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Crivelli, Lucía
Palmer, Katie
Calandri, Ismael
Guekht, Alla
Beghi, Ettore
Carroll, William
Frontera, Jennifer
García Azorín, David
Westenberg, Erica
Winkler, Andrea Sylvia
Mangialasche, Francesca
Allegri, Ricardo Francisco
Kivipelto, Miia
author Crivelli, Lucía
author_facet Crivelli, Lucía
Palmer, Katie
Calandri, Ismael
Guekht, Alla
Beghi, Ettore
Carroll, William
Frontera, Jennifer
García Azorín, David
Westenberg, Erica
Winkler, Andrea Sylvia
Mangialasche, Francesca
Allegri, Ricardo Francisco
Kivipelto, Miia
author_role author
author2 Palmer, Katie
Calandri, Ismael
Guekht, Alla
Beghi, Ettore
Carroll, William
Frontera, Jennifer
García Azorín, David
Westenberg, Erica
Winkler, Andrea Sylvia
Mangialasche, Francesca
Allegri, Ricardo Francisco
Kivipelto, Miia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ATTENTION
COGNITION
COGNITIVE DYSFUNCTION
COVID-19
EXECUTIVE FUNCTIONS
NEUROPSYCHOLOGICAL TEST
SARS-COV-2 CORONAVIRUS
topic ATTENTION
COGNITION
COGNITIVE DYSFUNCTION
COVID-19
EXECUTIVE FUNCTIONS
NEUROPSYCHOLOGICAL TEST
SARS-COV-2 CORONAVIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: We conducted a systematic review and meta-analysis of the cognitive effects of coronavirus disease 2019 (COVID-19) in adults with no prior history of cognitive impairment. Methods: Searches in Medline/Web of Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A meta-analysis of the Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID-19 and healthy controls was performed. Results: Oof 6202 articles, 27 studies with 2049 individuals were included (mean age = 56.05 years, evaluation time ranged from the acute phase to 7 months post-infection). Impairment in executive functions, attention, and memory were found in post-COVID-19 patients. The meta-analysis was performed with a subgroup of 290 individuals and showed a difference in MoCA score between post-COVID-19 patients versus controls (mean difference = −0.94, 95% confidence interval [CI] −1.59, −0.29; P =.0049). Discussion: Patients recovered from COVID-19 have lower general cognition compared to healthy controls up to 7 months post-infection.
Fil: Crivelli, Lucía. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
Fil: Palmer, Katie. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Calandri, Ismael. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Guekht, Alla. Pirogov Russian National Research University; Rusia
Fil: Beghi, Ettore. Instituto di Ricerche Farmacologiche Mario Negri; Italia
Fil: Carroll, William. University of Western Australia; Australia
Fil: Frontera, Jennifer. No especifíca;
Fil: García Azorín, David. Hospital Clínico Universitario de Valladolid; España
Fil: Westenberg, Erica. Universitat Technical Zu Munich; Alemania
Fil: Winkler, Andrea Sylvia. Universitat Technical Zu Munich; Alemania
Fil: Mangialasche, Francesca. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Allegri, Ricardo Francisco. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto de Neurociencias - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Neurociencias; Argentina
Fil: Kivipelto, Miia. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
description Introduction: We conducted a systematic review and meta-analysis of the cognitive effects of coronavirus disease 2019 (COVID-19) in adults with no prior history of cognitive impairment. Methods: Searches in Medline/Web of Science/Embase from January 1, 2020, to December 13, 2021, were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A meta-analysis of the Montreal Cognitive Assessment (MoCA) total score comparing recovered COVID-19 and healthy controls was performed. Results: Oof 6202 articles, 27 studies with 2049 individuals were included (mean age = 56.05 years, evaluation time ranged from the acute phase to 7 months post-infection). Impairment in executive functions, attention, and memory were found in post-COVID-19 patients. The meta-analysis was performed with a subgroup of 290 individuals and showed a difference in MoCA score between post-COVID-19 patients versus controls (mean difference = −0.94, 95% confidence interval [CI] −1.59, −0.29; P =.0049). Discussion: Patients recovered from COVID-19 have lower general cognition compared to healthy controls up to 7 months post-infection.
publishDate 2022
dc.date.none.fl_str_mv 2022-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216394
Crivelli, Lucía; Palmer, Katie; Calandri, Ismael; Guekht, Alla; Beghi, Ettore; et al.; Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis; Elsevier Science Inc.; Alzheimers & Dementia; 18; 5; 5-2022; 1047-1066
1552-5260
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216394
identifier_str_mv Crivelli, Lucía; Palmer, Katie; Calandri, Ismael; Guekht, Alla; Beghi, Ettore; et al.; Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis; Elsevier Science Inc.; Alzheimers & Dementia; 18; 5; 5-2022; 1047-1066
1552-5260
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12644
info:eu-repo/semantics/altIdentifier/doi/10.1002/alz.12644
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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