Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review

Autores
Martino, Diego Javier; Samame, Cecilia; Ibañez, Agustin Mariano; Strejilevich, Sergio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is well known that patients with bipolar disorder (BD) have cognitive impairments even during periods of euthymia. However, to date it remains unclear the moment when these deficits onset. Therefore, the aim of this study was to review the evidence focusing on the cognitive status of patients with BD in their premorbid stage and in their first episode. An extensive search was conducted through the online databases Pubmed/PsychInfo, covering the period between 1980 and 2014. A total of 23 studies were selected for the review (nine studies explored premorbid stage of people who lately develop BD and 14 examined first-episodes in bipolar patients). There is evidence that general intelligence is not impaired in the premorbid stage. Impairments in verbal memory, attention, and executive functions tend to be present during and after the first episode. Preliminary evidence suggests that these deficits in specific cognitive domains might precede the onset of illness.
Fil: Martino, Diego Javier. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Samame, Cecilia. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Australian Research Council. Centre of Excellence in Cognition and its Disorders; Australia
Fil: Strejilevich, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina
Materia
Cognition
Executive Functions
High-Risk
Memory
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37684
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic reviewMartino, Diego JavierSamame, CeciliaIbañez, Agustin MarianoStrejilevich, SergioCognitionExecutive FunctionsHigh-RiskMemoryhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3It is well known that patients with bipolar disorder (BD) have cognitive impairments even during periods of euthymia. However, to date it remains unclear the moment when these deficits onset. Therefore, the aim of this study was to review the evidence focusing on the cognitive status of patients with BD in their premorbid stage and in their first episode. An extensive search was conducted through the online databases Pubmed/PsychInfo, covering the period between 1980 and 2014. A total of 23 studies were selected for the review (nine studies explored premorbid stage of people who lately develop BD and 14 examined first-episodes in bipolar patients). There is evidence that general intelligence is not impaired in the premorbid stage. Impairments in verbal memory, attention, and executive functions tend to be present during and after the first episode. Preliminary evidence suggests that these deficits in specific cognitive domains might precede the onset of illness.Fil: Martino, Diego Javier. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Samame, Cecilia. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Australian Research Council. Centre of Excellence in Cognition and its Disorders; AustraliaFil: Strejilevich, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; ArgentinaElsevier Ireland2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37684Martino, Diego Javier; Samame, Cecilia; Ibañez, Agustin Mariano; Strejilevich, Sergio; Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review; Elsevier Ireland; Psychiatry Research; 226; 1; 3-2015; 23-300165-1781CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.psychres.2014.12.044info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165178115000049info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:36Zoai:ri.conicet.gov.ar:11336/37684instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:36.304CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
title Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
spellingShingle Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
Martino, Diego Javier
Cognition
Executive Functions
High-Risk
Memory
title_short Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
title_full Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
title_fullStr Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
title_full_unstemmed Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
title_sort Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review
dc.creator.none.fl_str_mv Martino, Diego Javier
Samame, Cecilia
Ibañez, Agustin Mariano
Strejilevich, Sergio
author Martino, Diego Javier
author_facet Martino, Diego Javier
Samame, Cecilia
Ibañez, Agustin Mariano
Strejilevich, Sergio
author_role author
author2 Samame, Cecilia
Ibañez, Agustin Mariano
Strejilevich, Sergio
author2_role author
author
author
dc.subject.none.fl_str_mv Cognition
Executive Functions
High-Risk
Memory
topic Cognition
Executive Functions
High-Risk
Memory
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It is well known that patients with bipolar disorder (BD) have cognitive impairments even during periods of euthymia. However, to date it remains unclear the moment when these deficits onset. Therefore, the aim of this study was to review the evidence focusing on the cognitive status of patients with BD in their premorbid stage and in their first episode. An extensive search was conducted through the online databases Pubmed/PsychInfo, covering the period between 1980 and 2014. A total of 23 studies were selected for the review (nine studies explored premorbid stage of people who lately develop BD and 14 examined first-episodes in bipolar patients). There is evidence that general intelligence is not impaired in the premorbid stage. Impairments in verbal memory, attention, and executive functions tend to be present during and after the first episode. Preliminary evidence suggests that these deficits in specific cognitive domains might precede the onset of illness.
Fil: Martino, Diego Javier. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Samame, Cecilia. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ibañez, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Australian Research Council. Centre of Excellence in Cognition and its Disorders; Australia
Fil: Strejilevich, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina
description It is well known that patients with bipolar disorder (BD) have cognitive impairments even during periods of euthymia. However, to date it remains unclear the moment when these deficits onset. Therefore, the aim of this study was to review the evidence focusing on the cognitive status of patients with BD in their premorbid stage and in their first episode. An extensive search was conducted through the online databases Pubmed/PsychInfo, covering the period between 1980 and 2014. A total of 23 studies were selected for the review (nine studies explored premorbid stage of people who lately develop BD and 14 examined first-episodes in bipolar patients). There is evidence that general intelligence is not impaired in the premorbid stage. Impairments in verbal memory, attention, and executive functions tend to be present during and after the first episode. Preliminary evidence suggests that these deficits in specific cognitive domains might precede the onset of illness.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37684
Martino, Diego Javier; Samame, Cecilia; Ibañez, Agustin Mariano; Strejilevich, Sergio; Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review; Elsevier Ireland; Psychiatry Research; 226; 1; 3-2015; 23-30
0165-1781
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37684
identifier_str_mv Martino, Diego Javier; Samame, Cecilia; Ibañez, Agustin Mariano; Strejilevich, Sergio; Neurocognitive functioning in the premorbid stage and in the first episode of bipolar disorder: A systematic review; Elsevier Ireland; Psychiatry Research; 226; 1; 3-2015; 23-30
0165-1781
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.psychres.2014.12.044
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165178115000049
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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