Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection

• Autores: Gonzalez Alemán, Gabriela; Vavougios, George D.; Tartaglia, Carmela; Uvais, Nalakath A.; Guekht, Alla; Hosseini, Akram A.; Lo Re, Vincenzina; Ferreccio, Catterina; D'Avossa, Giovanni; Zamponi, Hernan P.; Figueredo Aguiar, Mariana; Yecora, Agustin; Ul Haq Katshu, Mohammad Zia; Stavrou, Vasileios T.; Boutlas, Stylianos; Gourgoulianis, Konstantinos I.; Botero Rojas, Maria Camila; González Insua, Francisco; Perez Lloret, Santiago; Zinchuk, Mikhail; Gersamija, Anna; Popova, Sofya; Bryzgalova, Yulia; Sviatskaya, Ekaterina; Russelli, Giovanna; Avorio, Federica; Wang, Sophia; Edison, Paul; Niimi, Yoshiki; Sohrabi, Hamid R.; Mukaetova Ladinska, Elizabeta B.; Neidre, Daria; de Erausquin, Gabriel Alejandro
• Año de publicación: 2025
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: COVID-19; Cognitive dysfunction
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 controls from Argentina, Canada, Chile, Greece, India, Italy, Russia, and the UK. The meta-analysis found no differences by country of origin. The profile and severity of cognitive impairment varied by age, with mild attentional impairment observed in young and middle-aged adults, but memory, language, and executive function impairment in older adults. The risk of moderate to severe impairment doubled in older adults. Moderately severe or severe impairment was significantly associated with infection diagnoses (chi-square = 26.57, p ≤ 0.0001) and the severity of anosmia (chi-square = 31.81, p ≤ 0.0001). We found distinct age-related phenotypes of cognitive impairment in patients recovering from COVID-19. We identified the severity of acute illness and the presence of olfactory dysfunction as the primary predictors of dementia-like impairment in older adults.
Fil: Gonzalez Alemán, Gabriela. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Vavougios, George D.. University of Cyprus; Chipre. University of Thessaly; Grecia
Fil: Tartaglia, Carmela. University of Toronto; Canadá
Fil: Uvais, Nalakath A.. Iqraa International Hospital and Research Centre; India
Fil: Guekht, Alla. Moscow Research and Clinical Centre for Neuropsychiatry; Rusia. Pirogov Russian National Research Medical University; Rusia
Fil: Hosseini, Akram A.. Nottingham University Hospitals NHS Trust; Reino Unido. University of Nottingham; Estados Unidos
Fil: Lo Re, Vincenzina. University of Pittsburgh; Estados Unidos. IRCCS ISMETT; Italia
Fil: Ferreccio, Catterina. Pontificia Universidad Católica de Chile; Chile. Advanced Center for Chronic Diseases; Chile
Fil: D'Avossa, Giovanni. Bangor University; Reino Unido
Fil: Zamponi, Hernan P.. Gobierno de la Provincia de Jujuy. Ministerio de Salud; Argentina
Fil: Figueredo Aguiar, Mariana. Fundacion de Lucha contra los Trastornos Neurologicos y Psiquiatricos en Minorias; Argentina
Fil: Yecora, Agustin. Gobierno de la Provincia de Jujuy. Ministerio de Salud; Argentina. Fundacion de Lucha contra los Trastornos Neurologicos y Psiquiatricos en Minorias; Argentina
Fil: Ul Haq Katshu, Mohammad Zia. University of Nottingham; Estados Unidos
Fil: Stavrou, Vasileios T.. University of Cyprus; Chipre. University of Thessaly; Grecia
Fil: Boutlas, Stylianos. University of Cyprus; Chipre
Fil: Gourgoulianis, Konstantinos I.. University of Cyprus; Chipre
Fil: Botero Rojas, Maria Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: González Insua, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina
Fil: Perez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Pontificia Universidad Catolica Argentina "Santa Maria de los Buenos Aires". Vicerrectorado de Investigacion e Innovacion Academica. Laboratorio de Investigacion en Ciencias de Datos;
Fil: Zinchuk, Mikhail. Moscow Research and Clinical Centre for Neuropsychiatry; Rusia
Fil: Gersamija, Anna. Moscow Research and Clinical Centre for Neuropsychiatry; Rusia
Fil: Popova, Sofya. Moscow Research and Clinical Centre for Neuropsychiatry; Rusia
Fil: Bryzgalova, Yulia. Moscow Research and Clinical Centre for Neuropsychiatry; Rusia
Fil: Sviatskaya, Ekaterina. Moscow Research and Clinical Centre for Neuropsychiatry; Rusia
Fil: Russelli, Giovanna. IRCCS ISMETT; Italia. University of Pittsburgh; Estados Unidos
Fil: Avorio, Federica. IRCCS ISMETT; Italia. University of Pittsburgh; Estados Unidos
Fil: Wang, Sophia. Indiana University. School of Medicine; Estados Unidos. Indiana Alzheimer's Disease Research Center; Estados Unidos
Fil: Edison, Paul. Imperial College London; Reino Unido. Cardiff University; Reino Unido
Fil: Niimi, Yoshiki. University of Tokyo; Japón
Fil: Sohrabi, Hamid R.. Murdoch University; Australia
Fil: Mukaetova Ladinska, Elizabeta B.. University of Leicester; Reino Unido
Fil: Neidre, Daria. University of Texas; Estados Unidos
Fil: de Erausquin, Gabriel Alejandro. University of Texas; Estados Unidos