Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications

Autores
Cuggino, Julio César; Alvarez Igarzabal, Cecilia Ines; Strumia, Miriam Cristina; Welker, Pia; Licha, Kai; Steinhilber, Dirk; Mutihac, Radu Cristian; Calderón, Marcelo
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.
Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Welker, Pia. mivenion GmbH; Alemania
Fil: Licha, Kai. mivenion GmbH; Alemania
Fil: Steinhilber, Dirk. Freie Universität Berlin; Alemania
Fil: Mutihac, Radu Cristian. Freie Universität Berlin; Alemania
Fil: Calderón, Marcelo. Freie Universität Berlin; Argentina
Materia
Thermoresponsive Nanogels
Nanogels
Hyperbranched Polyglycerol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12935
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/12935
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applicationsCuggino, Julio CésarAlvarez Igarzabal, Cecilia InesStrumia, Miriam CristinaWelker, PiaLicha, KaiSteinhilber, DirkMutihac, Radu CristianCalderón, MarceloThermoresponsive NanogelsNanogelsHyperbranched Polyglycerolhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Welker, Pia. mivenion GmbH; AlemaniaFil: Licha, Kai. mivenion GmbH; AlemaniaFil: Steinhilber, Dirk. Freie Universität Berlin; AlemaniaFil: Mutihac, Radu Cristian. Freie Universität Berlin; AlemaniaFil: Calderón, Marcelo. Freie Universität Berlin; ArgentinaRoyal Society Of Chemistry2011-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12935Cuggino, Julio César; Alvarez Igarzabal, Cecilia Ines; Strumia, Miriam Cristina; Welker, Pia; Licha, Kai; et al.; Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications; Royal Society Of Chemistry; Soft Matter; 7; 23; 10-2011; 11259-112661744-683Xenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/C1SM06357Jinfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2011/SM/c1sm06357j#!divAbstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:01Zoai:ri.conicet.gov.ar:11336/12935instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:01.812CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications
title Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications
spellingShingle Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications
Cuggino, Julio César
Thermoresponsive Nanogels
Nanogels
Hyperbranched Polyglycerol
title_short Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications
title_full Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications
title_fullStr Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications
title_full_unstemmed Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications
title_sort Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications
dc.creator.none.fl_str_mv Cuggino, Julio César
Alvarez Igarzabal, Cecilia Ines
Strumia, Miriam Cristina
Welker, Pia
Licha, Kai
Steinhilber, Dirk
Mutihac, Radu Cristian
Calderón, Marcelo
author Cuggino, Julio César
author_facet Cuggino, Julio César
Alvarez Igarzabal, Cecilia Ines
Strumia, Miriam Cristina
Welker, Pia
Licha, Kai
Steinhilber, Dirk
Mutihac, Radu Cristian
Calderón, Marcelo
author_role author
author2 Alvarez Igarzabal, Cecilia Ines
Strumia, Miriam Cristina
Welker, Pia
Licha, Kai
Steinhilber, Dirk
Mutihac, Radu Cristian
Calderón, Marcelo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Thermoresponsive Nanogels
Nanogels
Hyperbranched Polyglycerol
topic Thermoresponsive Nanogels
Nanogels
Hyperbranched Polyglycerol
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.
Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Welker, Pia. mivenion GmbH; Alemania
Fil: Licha, Kai. mivenion GmbH; Alemania
Fil: Steinhilber, Dirk. Freie Universität Berlin; Alemania
Fil: Mutihac, Radu Cristian. Freie Universität Berlin; Alemania
Fil: Calderón, Marcelo. Freie Universität Berlin; Argentina
description In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.
publishDate 2011
dc.date.none.fl_str_mv 2011-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12935
Cuggino, Julio César; Alvarez Igarzabal, Cecilia Ines; Strumia, Miriam Cristina; Welker, Pia; Licha, Kai; et al.; Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications; Royal Society Of Chemistry; Soft Matter; 7; 23; 10-2011; 11259-11266
1744-683X
url http://hdl.handle.net/11336/12935
identifier_str_mv Cuggino, Julio César; Alvarez Igarzabal, Cecilia Ines; Strumia, Miriam Cristina; Welker, Pia; Licha, Kai; et al.; Thermosensitive nanogels based in dendritic polyglycerol and NIPAm for biomedical applications; Royal Society Of Chemistry; Soft Matter; 7; 23; 10-2011; 11259-11266
1744-683X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/C1SM06357J
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2011/SM/c1sm06357j#!divAbstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society Of Chemistry
publisher.none.fl_str_mv Royal Society Of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270103294443520
score 13.13397

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