Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels

Autores
Biglione, Catalina; Bergueiro, Julian; Wedepohl, Stefanie; Klemke, Bastian; Strumia, Miriam Cristina; Calderón, Marcelo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The combination of magnetic nanoparticles and thermoresponsive nanogels represents an appealing strategy for the development of theranostic probes. These hybrid nanocarriers present several advantages such as outstanding properties for guided therapy, magnetic resonance imaging, and triggered release of encapsulated cargoes. Most magnetic thermoresponsive nanogels are built with strategies that comprise a physical interaction of particles with the polymeric network or the covalent attachment of a single particle to the linear polymer. Herein, we report a facile synthetic approach for the synthesis of magnetic and thermoresponsive nanogels that allows the controlled incorporation of multiple superparamagnetic inorganic cores as covalent cross-linkers. An ultrasonication-assisted precipitation-polymerization afforded nanogels with sizes in the nanometric range and similar magnetization and light transduction properties compared to the discrete magnetic nanoparticles. The theranostic capability of these nanocarriers was further investigated both in vitro and in vivo. In vivo experiments demonstrated the capacity of these materials as nanocarriers for near-infrared (NIR) triggered chemotherapy and highlighted the relevance of the correct concentration/dose in this antitumoral modality to achieve a superior therapeutic efficacy.
Fil: Biglione, Catalina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina
Fil: Bergueiro, Julian. Freie Universität Berlin; Alemania
Fil: Wedepohl, Stefanie. Freie Universität Berlin; Alemania
Fil: Klemke, Bastian. No especifíca;
Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina
Fil: Calderón, Marcelo. Freie Universität Berlin; Alemania
Materia
THERANOSTIC
MAGNETIC NANOGELS
NANOMEDICINE
THERMORESPONSIVE NANOGELS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/145225
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/145225
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogelsBiglione, CatalinaBergueiro, JulianWedepohl, StefanieKlemke, BastianStrumia, Miriam CristinaCalderón, MarceloTHERANOSTICMAGNETIC NANOGELSNANOMEDICINETHERMORESPONSIVE NANOGELShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The combination of magnetic nanoparticles and thermoresponsive nanogels represents an appealing strategy for the development of theranostic probes. These hybrid nanocarriers present several advantages such as outstanding properties for guided therapy, magnetic resonance imaging, and triggered release of encapsulated cargoes. Most magnetic thermoresponsive nanogels are built with strategies that comprise a physical interaction of particles with the polymeric network or the covalent attachment of a single particle to the linear polymer. Herein, we report a facile synthetic approach for the synthesis of magnetic and thermoresponsive nanogels that allows the controlled incorporation of multiple superparamagnetic inorganic cores as covalent cross-linkers. An ultrasonication-assisted precipitation-polymerization afforded nanogels with sizes in the nanometric range and similar magnetization and light transduction properties compared to the discrete magnetic nanoparticles. The theranostic capability of these nanocarriers was further investigated both in vitro and in vivo. In vivo experiments demonstrated the capacity of these materials as nanocarriers for near-infrared (NIR) triggered chemotherapy and highlighted the relevance of the correct concentration/dose in this antitumoral modality to achieve a superior therapeutic efficacy.Fil: Biglione, Catalina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; ArgentinaFil: Bergueiro, Julian. Freie Universität Berlin; AlemaniaFil: Wedepohl, Stefanie. Freie Universität Berlin; AlemaniaFil: Klemke, Bastian. No especifíca;Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; ArgentinaFil: Calderón, Marcelo. Freie Universität Berlin; AlemaniaRoyal Society of Chemistry2020-07-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145225Biglione, Catalina; Bergueiro, Julian; Wedepohl, Stefanie; Klemke, Bastian; Strumia, Miriam Cristina; et al.; Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels; Royal Society of Chemistry; Nanoscale; 12; 42; 30-7-2020; 21635-216462040-3372CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/d0nr02953jinfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2020/NR/D0NR02953Jinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:03Zoai:ri.conicet.gov.ar:11336/145225instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:03.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels
title Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels
spellingShingle Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels
Biglione, Catalina
THERANOSTIC
MAGNETIC NANOGELS
NANOMEDICINE
THERMORESPONSIVE NANOGELS
title_short Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels
title_full Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels
title_fullStr Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels
title_full_unstemmed Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels
title_sort Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels
dc.creator.none.fl_str_mv Biglione, Catalina
Bergueiro, Julian
Wedepohl, Stefanie
Klemke, Bastian
Strumia, Miriam Cristina
Calderón, Marcelo
author Biglione, Catalina
author_facet Biglione, Catalina
Bergueiro, Julian
Wedepohl, Stefanie
Klemke, Bastian
Strumia, Miriam Cristina
Calderón, Marcelo
author_role author
author2 Bergueiro, Julian
Wedepohl, Stefanie
Klemke, Bastian
Strumia, Miriam Cristina
Calderón, Marcelo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv THERANOSTIC
MAGNETIC NANOGELS
NANOMEDICINE
THERMORESPONSIVE NANOGELS
topic THERANOSTIC
MAGNETIC NANOGELS
NANOMEDICINE
THERMORESPONSIVE NANOGELS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The combination of magnetic nanoparticles and thermoresponsive nanogels represents an appealing strategy for the development of theranostic probes. These hybrid nanocarriers present several advantages such as outstanding properties for guided therapy, magnetic resonance imaging, and triggered release of encapsulated cargoes. Most magnetic thermoresponsive nanogels are built with strategies that comprise a physical interaction of particles with the polymeric network or the covalent attachment of a single particle to the linear polymer. Herein, we report a facile synthetic approach for the synthesis of magnetic and thermoresponsive nanogels that allows the controlled incorporation of multiple superparamagnetic inorganic cores as covalent cross-linkers. An ultrasonication-assisted precipitation-polymerization afforded nanogels with sizes in the nanometric range and similar magnetization and light transduction properties compared to the discrete magnetic nanoparticles. The theranostic capability of these nanocarriers was further investigated both in vitro and in vivo. In vivo experiments demonstrated the capacity of these materials as nanocarriers for near-infrared (NIR) triggered chemotherapy and highlighted the relevance of the correct concentration/dose in this antitumoral modality to achieve a superior therapeutic efficacy.
Fil: Biglione, Catalina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina
Fil: Bergueiro, Julian. Freie Universität Berlin; Alemania
Fil: Wedepohl, Stefanie. Freie Universität Berlin; Alemania
Fil: Klemke, Bastian. No especifíca;
Fil: Strumia, Miriam Cristina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina
Fil: Calderón, Marcelo. Freie Universität Berlin; Alemania
description The combination of magnetic nanoparticles and thermoresponsive nanogels represents an appealing strategy for the development of theranostic probes. These hybrid nanocarriers present several advantages such as outstanding properties for guided therapy, magnetic resonance imaging, and triggered release of encapsulated cargoes. Most magnetic thermoresponsive nanogels are built with strategies that comprise a physical interaction of particles with the polymeric network or the covalent attachment of a single particle to the linear polymer. Herein, we report a facile synthetic approach for the synthesis of magnetic and thermoresponsive nanogels that allows the controlled incorporation of multiple superparamagnetic inorganic cores as covalent cross-linkers. An ultrasonication-assisted precipitation-polymerization afforded nanogels with sizes in the nanometric range and similar magnetization and light transduction properties compared to the discrete magnetic nanoparticles. The theranostic capability of these nanocarriers was further investigated both in vitro and in vivo. In vivo experiments demonstrated the capacity of these materials as nanocarriers for near-infrared (NIR) triggered chemotherapy and highlighted the relevance of the correct concentration/dose in this antitumoral modality to achieve a superior therapeutic efficacy.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145225
Biglione, Catalina; Bergueiro, Julian; Wedepohl, Stefanie; Klemke, Bastian; Strumia, Miriam Cristina; et al.; Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels; Royal Society of Chemistry; Nanoscale; 12; 42; 30-7-2020; 21635-21646
2040-3372
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145225
identifier_str_mv Biglione, Catalina; Bergueiro, Julian; Wedepohl, Stefanie; Klemke, Bastian; Strumia, Miriam Cristina; et al.; Revealing the NIR-triggered chemotherapy therapeutic window of magnetic and thermoresponsive nanogels; Royal Society of Chemistry; Nanoscale; 12; 42; 30-7-2020; 21635-21646
2040-3372
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/d0nr02953j
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2020/NR/D0NR02953J
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268770810200064
score 13.13397

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