Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression

Autores
Cao, Gabriel Fernando; Gómez Llambí de Oromí, Hernán Jorge; Muller, Angelica del Carmen; Ottaviano, Graciela Mabel
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Beyond their lipid-lowering action, rosuvastatin possesses pleiotropic effects including anti-inflammatory, pro-angiogenic, antioxidant effects and protective actions against endothelial dysfunction [1,2]. The spontaneously hypertensive rats (SHR) have been extensively studied as a model of essential hypertension. Analogous to that seen in humans, prolonged periods of hypertension produce left ventricular (LV) remodeling, hypertrophy and oxidative stress. Thioredoxin (Trx) and peroxiredoxin (Prx) are a ubiquitous family of cysteine-dependent antioxidant proteins, present in mammalian cells including the heart. Several reports exist in the literature indicating that these proteins are induced by oxidative stress [3]. We investigated the possible effect of long-term monotherapy with rosuvastatin in myocardial expression of redoxins and vascular endothelial growth factor (VEGF), and their relations with LV remodeling in adult SHR. Eight-week-old male SHR and Wistar-Kyoto (WKY) rats, were divided into three groups: SHR (n = 20), SHR-R (n = 20; rosuvastatin 10 mg/kg/day) and WKY (n = 20).
Fil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Gómez Llambí de Oromí, Hernán Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Ottaviano, Graciela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
Antioxidant Effect
Heart
Rosuvastatin
Spontaneously Hypertensive Rat
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30180
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expressionCao, Gabriel FernandoGómez Llambí de Oromí, Hernán JorgeMuller, Angelica del CarmenOttaviano, Graciela MabelAntioxidant EffectHeartRosuvastatinSpontaneously Hypertensive Rathttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Beyond their lipid-lowering action, rosuvastatin possesses pleiotropic effects including anti-inflammatory, pro-angiogenic, antioxidant effects and protective actions against endothelial dysfunction [1,2]. The spontaneously hypertensive rats (SHR) have been extensively studied as a model of essential hypertension. Analogous to that seen in humans, prolonged periods of hypertension produce left ventricular (LV) remodeling, hypertrophy and oxidative stress. Thioredoxin (Trx) and peroxiredoxin (Prx) are a ubiquitous family of cysteine-dependent antioxidant proteins, present in mammalian cells including the heart. Several reports exist in the literature indicating that these proteins are induced by oxidative stress [3]. We investigated the possible effect of long-term monotherapy with rosuvastatin in myocardial expression of redoxins and vascular endothelial growth factor (VEGF), and their relations with LV remodeling in adult SHR. Eight-week-old male SHR and Wistar-Kyoto (WKY) rats, were divided into three groups: SHR (n = 20), SHR-R (n = 20; rosuvastatin 10 mg/kg/day) and WKY (n = 20).Fil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Gómez Llambí de Oromí, Hernán Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Ottaviano, Graciela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaElsevier Ireland2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30180Cao, Gabriel Fernando; Gómez Llambí de Oromí, Hernán Jorge; Muller, Angelica del Carmen; Ottaviano, Graciela Mabel; Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression; Elsevier Ireland; International Journal of Cardiology; 174; 1; 3-2014; 153-1550167-5273CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0167527314006020info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijcard.2014.03.166info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:03:13Zoai:ri.conicet.gov.ar:11336/30180instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:03:13.807CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
title Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
spellingShingle Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
Cao, Gabriel Fernando
Antioxidant Effect
Heart
Rosuvastatin
Spontaneously Hypertensive Rat
title_short Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
title_full Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
title_fullStr Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
title_full_unstemmed Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
title_sort Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression
dc.creator.none.fl_str_mv Cao, Gabriel Fernando
Gómez Llambí de Oromí, Hernán Jorge
Muller, Angelica del Carmen
Ottaviano, Graciela Mabel
author Cao, Gabriel Fernando
author_facet Cao, Gabriel Fernando
Gómez Llambí de Oromí, Hernán Jorge
Muller, Angelica del Carmen
Ottaviano, Graciela Mabel
author_role author
author2 Gómez Llambí de Oromí, Hernán Jorge
Muller, Angelica del Carmen
Ottaviano, Graciela Mabel
author2_role author
author
author
dc.subject.none.fl_str_mv Antioxidant Effect
Heart
Rosuvastatin
Spontaneously Hypertensive Rat
topic Antioxidant Effect
Heart
Rosuvastatin
Spontaneously Hypertensive Rat
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Beyond their lipid-lowering action, rosuvastatin possesses pleiotropic effects including anti-inflammatory, pro-angiogenic, antioxidant effects and protective actions against endothelial dysfunction [1,2]. The spontaneously hypertensive rats (SHR) have been extensively studied as a model of essential hypertension. Analogous to that seen in humans, prolonged periods of hypertension produce left ventricular (LV) remodeling, hypertrophy and oxidative stress. Thioredoxin (Trx) and peroxiredoxin (Prx) are a ubiquitous family of cysteine-dependent antioxidant proteins, present in mammalian cells including the heart. Several reports exist in the literature indicating that these proteins are induced by oxidative stress [3]. We investigated the possible effect of long-term monotherapy with rosuvastatin in myocardial expression of redoxins and vascular endothelial growth factor (VEGF), and their relations with LV remodeling in adult SHR. Eight-week-old male SHR and Wistar-Kyoto (WKY) rats, were divided into three groups: SHR (n = 20), SHR-R (n = 20; rosuvastatin 10 mg/kg/day) and WKY (n = 20).
Fil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Gómez Llambí de Oromí, Hernán Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Ottaviano, Graciela Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description Beyond their lipid-lowering action, rosuvastatin possesses pleiotropic effects including anti-inflammatory, pro-angiogenic, antioxidant effects and protective actions against endothelial dysfunction [1,2]. The spontaneously hypertensive rats (SHR) have been extensively studied as a model of essential hypertension. Analogous to that seen in humans, prolonged periods of hypertension produce left ventricular (LV) remodeling, hypertrophy and oxidative stress. Thioredoxin (Trx) and peroxiredoxin (Prx) are a ubiquitous family of cysteine-dependent antioxidant proteins, present in mammalian cells including the heart. Several reports exist in the literature indicating that these proteins are induced by oxidative stress [3]. We investigated the possible effect of long-term monotherapy with rosuvastatin in myocardial expression of redoxins and vascular endothelial growth factor (VEGF), and their relations with LV remodeling in adult SHR. Eight-week-old male SHR and Wistar-Kyoto (WKY) rats, were divided into three groups: SHR (n = 20), SHR-R (n = 20; rosuvastatin 10 mg/kg/day) and WKY (n = 20).
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30180
Cao, Gabriel Fernando; Gómez Llambí de Oromí, Hernán Jorge; Muller, Angelica del Carmen; Ottaviano, Graciela Mabel; Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression; Elsevier Ireland; International Journal of Cardiology; 174; 1; 3-2014; 153-155
0167-5273
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30180
identifier_str_mv Cao, Gabriel Fernando; Gómez Llambí de Oromí, Hernán Jorge; Muller, Angelica del Carmen; Ottaviano, Graciela Mabel; Rosuvastatin increases myocardial microvessels in SHR rats. Role of thioredoxin-1 and peroxiredoxin-2 expression; Elsevier Ireland; International Journal of Cardiology; 174; 1; 3-2014; 153-155
0167-5273
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0167527314006020
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijcard.2014.03.166
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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