Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador
- Autores
- Zhingre, Alicia; Bedoya Pilozo, César; Gutierrez Pallo, Diana; Badano, Ines; Herrera Yela, Andrés; Salazar, Zoila; Alarcón, Damaris; Arguello Bravo, Natali; Espinoza, Maylen; Ponce, Patricio; Soto, Yudira; Carrazco Montalvo, Andrés Ricardo
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Human Papillomavirus (HPV) infection is associated with intraepithelial neoplasia and cervical cancer (CC). Ecuador has a high prevalence of cervical cancer, with more than 1600 new cases diagnosed annually. This study aimed to analyze oncogenes E6 and E7 of HPV16 in samples collected from women with cancerous and precancerous cervical lesions from the Ecuadorian coast. Twenty-nine women, including six with ASCUS, three with LSIL, thirteen with HSIL, and seven with Cacu, were analyzed. The most common SNPs were E6 350G or L83V (82.6%) and E6 145T/286A/289G/335T/350G or Q14H/F78Y/L83V (17.4%). Both variants are reported to be associated with an increased risk of cervical cancer in worldwide studies. In contrast, all E7 genes have conserved amino-acid positions. Phylogenetic trees showed the circulation of the D (26.1%) and A (73.9) lineages. The frequency of D was higher than that reported in other comparable studies in Ecuador and Latin America, and may be related to the ethnic composition of the studied populations. This study contributes to the characterization of the potential risk factors for cervical carcinogenesis associated with Ecuadorian women infected with HPV16.
Fil: Zhingre, Alicia. Universidad Católica de Cuenca; Ecuador
Fil: Bedoya Pilozo, César. Hospital Luis Vernaza; Ecuador
Fil: Gutierrez Pallo, Diana. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador
Fil: Badano, Ines. Universidad Nacional de Misiones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herrera Yela, Andrés. Pontificia Universidad Católica del Ecuador; Ecuador
Fil: Salazar, Zoila. Universidad Católica de Cuenca; Ecuador
Fil: Alarcón, Damaris. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador
Fil: Arguello Bravo, Natali. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador
Fil: Espinoza, Maylen. No especifíca;
Fil: Ponce, Patricio. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador
Fil: Soto, Yudira. Instituto de Medicina Tropical “Pedro Kouri”; Cuba
Fil: Carrazco Montalvo, Andrés Ricardo. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador. Universidad Autónoma de Madrid; España - Materia
-
cervical cancer
genetics
Human papillomavirus
Lineage - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/235433
Ver los metadatos del registro completo
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Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from EcuadorZhingre, AliciaBedoya Pilozo, CésarGutierrez Pallo, DianaBadano, InesHerrera Yela, AndrésSalazar, ZoilaAlarcón, DamarisArguello Bravo, NataliEspinoza, MaylenPonce, PatricioSoto, YudiraCarrazco Montalvo, Andrés Ricardocervical cancergeneticsHuman papillomavirusLineagehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Human Papillomavirus (HPV) infection is associated with intraepithelial neoplasia and cervical cancer (CC). Ecuador has a high prevalence of cervical cancer, with more than 1600 new cases diagnosed annually. This study aimed to analyze oncogenes E6 and E7 of HPV16 in samples collected from women with cancerous and precancerous cervical lesions from the Ecuadorian coast. Twenty-nine women, including six with ASCUS, three with LSIL, thirteen with HSIL, and seven with Cacu, were analyzed. The most common SNPs were E6 350G or L83V (82.6%) and E6 145T/286A/289G/335T/350G or Q14H/F78Y/L83V (17.4%). Both variants are reported to be associated with an increased risk of cervical cancer in worldwide studies. In contrast, all E7 genes have conserved amino-acid positions. Phylogenetic trees showed the circulation of the D (26.1%) and A (73.9) lineages. The frequency of D was higher than that reported in other comparable studies in Ecuador and Latin America, and may be related to the ethnic composition of the studied populations. This study contributes to the characterization of the potential risk factors for cervical carcinogenesis associated with Ecuadorian women infected with HPV16.Fil: Zhingre, Alicia. Universidad Católica de Cuenca; EcuadorFil: Bedoya Pilozo, César. Hospital Luis Vernaza; EcuadorFil: Gutierrez Pallo, Diana. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; EcuadorFil: Badano, Ines. Universidad Nacional de Misiones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Herrera Yela, Andrés. Pontificia Universidad Católica del Ecuador; EcuadorFil: Salazar, Zoila. Universidad Católica de Cuenca; EcuadorFil: Alarcón, Damaris. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; EcuadorFil: Arguello Bravo, Natali. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; EcuadorFil: Espinoza, Maylen. No especifíca;Fil: Ponce, Patricio. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; EcuadorFil: Soto, Yudira. Instituto de Medicina Tropical “Pedro Kouri”; CubaFil: Carrazco Montalvo, Andrés Ricardo. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador. Universidad Autónoma de Madrid; EspañaMDPI2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/235433Zhingre, Alicia; Bedoya Pilozo, César; Gutierrez Pallo, Diana; Badano, Ines; Herrera Yela, Andrés; et al.; Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador; MDPI; Viruses; 15; 6; 6-2023; 1-91999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/v15061393info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:53:51Zoai:ri.conicet.gov.ar:11336/235433instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:53:52.301CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title |
Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
spellingShingle |
Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador Zhingre, Alicia cervical cancer genetics Human papillomavirus Lineage |
title_short |
Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_full |
Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_fullStr |
Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_full_unstemmed |
Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
title_sort |
Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador |
dc.creator.none.fl_str_mv |
Zhingre, Alicia Bedoya Pilozo, César Gutierrez Pallo, Diana Badano, Ines Herrera Yela, Andrés Salazar, Zoila Alarcón, Damaris Arguello Bravo, Natali Espinoza, Maylen Ponce, Patricio Soto, Yudira Carrazco Montalvo, Andrés Ricardo |
author |
Zhingre, Alicia |
author_facet |
Zhingre, Alicia Bedoya Pilozo, César Gutierrez Pallo, Diana Badano, Ines Herrera Yela, Andrés Salazar, Zoila Alarcón, Damaris Arguello Bravo, Natali Espinoza, Maylen Ponce, Patricio Soto, Yudira Carrazco Montalvo, Andrés Ricardo |
author_role |
author |
author2 |
Bedoya Pilozo, César Gutierrez Pallo, Diana Badano, Ines Herrera Yela, Andrés Salazar, Zoila Alarcón, Damaris Arguello Bravo, Natali Espinoza, Maylen Ponce, Patricio Soto, Yudira Carrazco Montalvo, Andrés Ricardo |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
cervical cancer genetics Human papillomavirus Lineage |
topic |
cervical cancer genetics Human papillomavirus Lineage |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Human Papillomavirus (HPV) infection is associated with intraepithelial neoplasia and cervical cancer (CC). Ecuador has a high prevalence of cervical cancer, with more than 1600 new cases diagnosed annually. This study aimed to analyze oncogenes E6 and E7 of HPV16 in samples collected from women with cancerous and precancerous cervical lesions from the Ecuadorian coast. Twenty-nine women, including six with ASCUS, three with LSIL, thirteen with HSIL, and seven with Cacu, were analyzed. The most common SNPs were E6 350G or L83V (82.6%) and E6 145T/286A/289G/335T/350G or Q14H/F78Y/L83V (17.4%). Both variants are reported to be associated with an increased risk of cervical cancer in worldwide studies. In contrast, all E7 genes have conserved amino-acid positions. Phylogenetic trees showed the circulation of the D (26.1%) and A (73.9) lineages. The frequency of D was higher than that reported in other comparable studies in Ecuador and Latin America, and may be related to the ethnic composition of the studied populations. This study contributes to the characterization of the potential risk factors for cervical carcinogenesis associated with Ecuadorian women infected with HPV16. Fil: Zhingre, Alicia. Universidad Católica de Cuenca; Ecuador Fil: Bedoya Pilozo, César. Hospital Luis Vernaza; Ecuador Fil: Gutierrez Pallo, Diana. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador Fil: Badano, Ines. Universidad Nacional de Misiones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Herrera Yela, Andrés. Pontificia Universidad Católica del Ecuador; Ecuador Fil: Salazar, Zoila. Universidad Católica de Cuenca; Ecuador Fil: Alarcón, Damaris. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador Fil: Arguello Bravo, Natali. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador Fil: Espinoza, Maylen. No especifíca; Fil: Ponce, Patricio. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador Fil: Soto, Yudira. Instituto de Medicina Tropical “Pedro Kouri”; Cuba Fil: Carrazco Montalvo, Andrés Ricardo. Instituto Nacional de Investigación en Salud Pública “Leopoldo Izquieta Pérez”; Ecuador. Universidad Autónoma de Madrid; España |
description |
Human Papillomavirus (HPV) infection is associated with intraepithelial neoplasia and cervical cancer (CC). Ecuador has a high prevalence of cervical cancer, with more than 1600 new cases diagnosed annually. This study aimed to analyze oncogenes E6 and E7 of HPV16 in samples collected from women with cancerous and precancerous cervical lesions from the Ecuadorian coast. Twenty-nine women, including six with ASCUS, three with LSIL, thirteen with HSIL, and seven with Cacu, were analyzed. The most common SNPs were E6 350G or L83V (82.6%) and E6 145T/286A/289G/335T/350G or Q14H/F78Y/L83V (17.4%). Both variants are reported to be associated with an increased risk of cervical cancer in worldwide studies. In contrast, all E7 genes have conserved amino-acid positions. Phylogenetic trees showed the circulation of the D (26.1%) and A (73.9) lineages. The frequency of D was higher than that reported in other comparable studies in Ecuador and Latin America, and may be related to the ethnic composition of the studied populations. This study contributes to the characterization of the potential risk factors for cervical carcinogenesis associated with Ecuadorian women infected with HPV16. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/235433 Zhingre, Alicia; Bedoya Pilozo, César; Gutierrez Pallo, Diana; Badano, Ines; Herrera Yela, Andrés; et al.; Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador; MDPI; Viruses; 15; 6; 6-2023; 1-9 1999-4915 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/235433 |
identifier_str_mv |
Zhingre, Alicia; Bedoya Pilozo, César; Gutierrez Pallo, Diana; Badano, Ines; Herrera Yela, Andrés; et al.; Genetic Variability in the E6/E7 Region of Human Papillomavirus 16 in Women from Ecuador; MDPI; Viruses; 15; 6; 6-2023; 1-9 1999-4915 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3390/v15061393 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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