Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties

Autores
Nieto Peñalver, Carlos Gabriel; Savino, María Julieta; Bertini, Elisa Violeta; Sanchez, Leandro Arturo; Castellanos, Lucia Ines
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gluconic acid is produced in large quantities by the endophytic and diazotrophic bacterium Gluconacetobacter diazotrophicus Pal5. This organic acid derives from direct oxidation of glucose by a pyrroloquinoline-quinone-linked glucose dehydrogenase in this plant growth-promoting bacterium. In the present article, evidence is presented showing that gluconic acid is also responsible for the antimicrobial activity of G. diazotrophicus Pal5. The broad antagonistic spectrum includes Gram-positive and -negative bacteria. Eukaryotic microorganisms are more resistant to growth inhibition by this acid. Inhibition by gluconic acid can be modified through the presence of other organic acids. In contrast to other microorganisms, the Quorum Sensing system of G. diazotrophicus Pal5, a regulatory mechanism that plays a key role in several microbe–microbe interactions, is not related to gluconic acid production and the concomitant antagonistic activity.
Fil: Nieto Peñalver, Carlos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; Argentina
Fil: Savino, María Julieta. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología "luis Verna". Cátedra de Microbiología Gral.; Argentina
Fil: Bertini, Elisa Violeta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; Argentina
Fil: Sanchez, Leandro Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; Argentina
Fil: Castellanos, Lucia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; Argentina
Materia
Organic Acid
Glucose
Inhibition
Antimicrobial
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/28003
Acceder
id CONICETDig_f4957c055341b6aae017cdae1f1ca146
oai_identifier_str oai:ri.conicet.gov.ar:11336/28003
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial propertiesNieto Peñalver, Carlos GabrielSavino, María JulietaBertini, Elisa VioletaSanchez, Leandro ArturoCastellanos, Lucia InesOrganic AcidGlucoseInhibitionAntimicrobialhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Gluconic acid is produced in large quantities by the endophytic and diazotrophic bacterium Gluconacetobacter diazotrophicus Pal5. This organic acid derives from direct oxidation of glucose by a pyrroloquinoline-quinone-linked glucose dehydrogenase in this plant growth-promoting bacterium. In the present article, evidence is presented showing that gluconic acid is also responsible for the antimicrobial activity of G. diazotrophicus Pal5. The broad antagonistic spectrum includes Gram-positive and -negative bacteria. Eukaryotic microorganisms are more resistant to growth inhibition by this acid. Inhibition by gluconic acid can be modified through the presence of other organic acids. In contrast to other microorganisms, the Quorum Sensing system of G. diazotrophicus Pal5, a regulatory mechanism that plays a key role in several microbe–microbe interactions, is not related to gluconic acid production and the concomitant antagonistic activity.Fil: Nieto Peñalver, Carlos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; ArgentinaFil: Savino, María Julieta. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología "luis Verna". Cátedra de Microbiología Gral.; ArgentinaFil: Bertini, Elisa Violeta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; ArgentinaFil: Sanchez, Leandro Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; ArgentinaFil: Castellanos, Lucia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; ArgentinaElsevier Science2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28003Nieto Peñalver, Carlos Gabriel; Savino, María Julieta; Bertini, Elisa Violeta; Sanchez, Leandro Arturo; Castellanos, Lucia Ines; Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties; Elsevier Science; Research In Microbiology; 165; 7; 9-2014; 549-5580923-2508CONICET DigitalCONICETenginfo:eu-repo/semantics/reference/doi/http://dx.doi.org/10.1016/j.resmic.2014.06.003info:eu-repo/semantics/reference/url/http://www.sciencedirect.com/science/article/pii/S0923250814001028info:eu-repo/semantics/altIdentifier/doi/10.1016/j.resmic.2014.06.003info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0923250814001028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:33Zoai:ri.conicet.gov.ar:11336/28003instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:33.521CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties
title Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties
spellingShingle Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties
Nieto Peñalver, Carlos Gabriel
Organic Acid
Glucose
Inhibition
Antimicrobial
title_short Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties
title_full Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties
title_fullStr Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties
title_full_unstemmed Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties
title_sort Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties
dc.creator.none.fl_str_mv Nieto Peñalver, Carlos Gabriel
Savino, María Julieta
Bertini, Elisa Violeta
Sanchez, Leandro Arturo
Castellanos, Lucia Ines
author Nieto Peñalver, Carlos Gabriel
author_facet Nieto Peñalver, Carlos Gabriel
Savino, María Julieta
Bertini, Elisa Violeta
Sanchez, Leandro Arturo
Castellanos, Lucia Ines
author_role author
author2 Savino, María Julieta
Bertini, Elisa Violeta
Sanchez, Leandro Arturo
Castellanos, Lucia Ines
author2_role author
author
author
author
dc.subject.none.fl_str_mv Organic Acid
Glucose
Inhibition
Antimicrobial
topic Organic Acid
Glucose
Inhibition
Antimicrobial
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Gluconic acid is produced in large quantities by the endophytic and diazotrophic bacterium Gluconacetobacter diazotrophicus Pal5. This organic acid derives from direct oxidation of glucose by a pyrroloquinoline-quinone-linked glucose dehydrogenase in this plant growth-promoting bacterium. In the present article, evidence is presented showing that gluconic acid is also responsible for the antimicrobial activity of G. diazotrophicus Pal5. The broad antagonistic spectrum includes Gram-positive and -negative bacteria. Eukaryotic microorganisms are more resistant to growth inhibition by this acid. Inhibition by gluconic acid can be modified through the presence of other organic acids. In contrast to other microorganisms, the Quorum Sensing system of G. diazotrophicus Pal5, a regulatory mechanism that plays a key role in several microbe–microbe interactions, is not related to gluconic acid production and the concomitant antagonistic activity.
Fil: Nieto Peñalver, Carlos Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; Argentina
Fil: Savino, María Julieta. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Microbiología "luis Verna". Cátedra de Microbiología Gral.; Argentina
Fil: Bertini, Elisa Violeta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; Argentina
Fil: Sanchez, Leandro Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; Argentina
Fil: Castellanos, Lucia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Planta Piloto de Procesos Industriales Microbiologicos; Argentina
description Gluconic acid is produced in large quantities by the endophytic and diazotrophic bacterium Gluconacetobacter diazotrophicus Pal5. This organic acid derives from direct oxidation of glucose by a pyrroloquinoline-quinone-linked glucose dehydrogenase in this plant growth-promoting bacterium. In the present article, evidence is presented showing that gluconic acid is also responsible for the antimicrobial activity of G. diazotrophicus Pal5. The broad antagonistic spectrum includes Gram-positive and -negative bacteria. Eukaryotic microorganisms are more resistant to growth inhibition by this acid. Inhibition by gluconic acid can be modified through the presence of other organic acids. In contrast to other microorganisms, the Quorum Sensing system of G. diazotrophicus Pal5, a regulatory mechanism that plays a key role in several microbe–microbe interactions, is not related to gluconic acid production and the concomitant antagonistic activity.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/28003
Nieto Peñalver, Carlos Gabriel; Savino, María Julieta; Bertini, Elisa Violeta; Sanchez, Leandro Arturo; Castellanos, Lucia Ines; Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties; Elsevier Science; Research In Microbiology; 165; 7; 9-2014; 549-558
0923-2508
CONICET Digital
CONICET
url http://hdl.handle.net/11336/28003
identifier_str_mv Nieto Peñalver, Carlos Gabriel; Savino, María Julieta; Bertini, Elisa Violeta; Sanchez, Leandro Arturo; Castellanos, Lucia Ines; Gluconic acid produced by Gluconacetobacter diazotrophicus Pal5 possesses antimicrobial properties; Elsevier Science; Research In Microbiology; 165; 7; 9-2014; 549-558
0923-2508
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/reference/doi/http://dx.doi.org/10.1016/j.resmic.2014.06.003
info:eu-repo/semantics/reference/url/http://www.sciencedirect.com/science/article/pii/S0923250814001028
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.resmic.2014.06.003
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0923250814001028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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