Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)

Autores
Maggio, Julian; Armando, Romina Gabriela; Balcone, Lara; Vilarullo, Roman Nicolas; Casco, María del Pilar; Mengual Gómez, Diego Luis; Gomez, Daniel Eduardo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Peptidyl-prolyl isomerase NIMA-interacting 1 (PIN1) plays a crucial regulatory role in cells, and it is the only enzyme capable of selectively binding to phosphorylated proline-directed serine/threonine (pSer/Thr-Pro) residues in target proteins and catalyzing their isomerization. The change in the conformational status of the protein, transitioning between cis and trans, affects its three-dimensional structure and, therefore, alters its function and stability. In this manner, PIN1 plays a role in the development of several human pathologies by regulating essential proteins. In cancer, the enzymatic activity of PIN1 induces conformational changes in essential proteins, promoting oncogenic processes and fostering aggressive tumor characteristics and resistance to chemotherapies. Moreover, the effects of PIN1 on viral infections are notable, as it interacts with viral proteins, enhancing their replication and infection mechanisms. In addition, PIN1 participates in autoimmune, cardiovascular, metabolic, neurodegenerative diseases and osteoporosis. These diverse functions render PIN1 as an attractive therapeutic target, leading to the development of PIN1 inhibitors. The critical role of PIN1 in human pathology is further underscored by its relevance to various diseases, rendering it a potential nexus for novel interventions in human pathologies.
Fil: Maggio, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Armando, Romina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Balcone, Lara. Universidad Nacional de Quilmes; Argentina
Fil: Vilarullo, Roman Nicolas. Universidad Nacional de Quilmes; Argentina
Fil: Casco, María del Pilar. Universidad Nacional de Quilmes; Argentina
Fil: Mengual Gómez, Diego Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Gomez, Daniel Eduardo. Universidad Nacional de Quilmes; Argentina
Materia
AUTOIMMUNE
CANCER
CARDIOVASCULAR
DISEASE
NEURODEGENERATIVE
OSTEOPOROSIS
PEPTIDYL-PROLYL ISOMERASE NIMA-INTERACTING 1
PIN1 INHIBITORS
VIRAL INFECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/231132
Acceder
id CONICETDig_f4925ca27a0727acc513ce8af268d562
oai_identifier_str oai:ri.conicet.gov.ar:11336/231132
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)Maggio, JulianArmando, Romina GabrielaBalcone, LaraVilarullo, Roman NicolasCasco, María del PilarMengual Gómez, Diego LuisGomez, Daniel EduardoAUTOIMMUNECANCERCARDIOVASCULARDISEASENEURODEGENERATIVEOSTEOPOROSISPEPTIDYL-PROLYL ISOMERASE NIMA-INTERACTING 1PIN1 INHIBITORSVIRAL INFECTIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Peptidyl-prolyl isomerase NIMA-interacting 1 (PIN1) plays a crucial regulatory role in cells, and it is the only enzyme capable of selectively binding to phosphorylated proline-directed serine/threonine (pSer/Thr-Pro) residues in target proteins and catalyzing their isomerization. The change in the conformational status of the protein, transitioning between cis and trans, affects its three-dimensional structure and, therefore, alters its function and stability. In this manner, PIN1 plays a role in the development of several human pathologies by regulating essential proteins. In cancer, the enzymatic activity of PIN1 induces conformational changes in essential proteins, promoting oncogenic processes and fostering aggressive tumor characteristics and resistance to chemotherapies. Moreover, the effects of PIN1 on viral infections are notable, as it interacts with viral proteins, enhancing their replication and infection mechanisms. In addition, PIN1 participates in autoimmune, cardiovascular, metabolic, neurodegenerative diseases and osteoporosis. These diverse functions render PIN1 as an attractive therapeutic target, leading to the development of PIN1 inhibitors. The critical role of PIN1 in human pathology is further underscored by its relevance to various diseases, rendering it a potential nexus for novel interventions in human pathologies.Fil: Maggio, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Armando, Romina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Balcone, Lara. Universidad Nacional de Quilmes; ArgentinaFil: Vilarullo, Roman Nicolas. Universidad Nacional de Quilmes; ArgentinaFil: Casco, María del Pilar. Universidad Nacional de Quilmes; ArgentinaFil: Mengual Gómez, Diego Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Gomez, Daniel Eduardo. Universidad Nacional de Quilmes; ArgentinaSpandidos Publications2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/231132Maggio, Julian; Armando, Romina Gabriela; Balcone, Lara; Vilarullo, Roman Nicolas; Casco, María del Pilar; et al.; Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review); Spandidos Publications; World Academy of Sciences Journal; 6; 1; 1-2024; 1-152632-29002632-2919CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/wasj.2023.220info:eu-repo/semantics/altIdentifier/doi/10.3892/wasj.2023.220info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:26Zoai:ri.conicet.gov.ar:11336/231132instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:26.554CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
title Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
spellingShingle Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
Maggio, Julian
AUTOIMMUNE
CANCER
CARDIOVASCULAR
DISEASE
NEURODEGENERATIVE
OSTEOPOROSIS
PEPTIDYL-PROLYL ISOMERASE NIMA-INTERACTING 1
PIN1 INHIBITORS
VIRAL INFECTION
title_short Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
title_full Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
title_fullStr Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
title_full_unstemmed Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
title_sort Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review)
dc.creator.none.fl_str_mv Maggio, Julian
Armando, Romina Gabriela
Balcone, Lara
Vilarullo, Roman Nicolas
Casco, María del Pilar
Mengual Gómez, Diego Luis
Gomez, Daniel Eduardo
author Maggio, Julian
author_facet Maggio, Julian
Armando, Romina Gabriela
Balcone, Lara
Vilarullo, Roman Nicolas
Casco, María del Pilar
Mengual Gómez, Diego Luis
Gomez, Daniel Eduardo
author_role author
author2 Armando, Romina Gabriela
Balcone, Lara
Vilarullo, Roman Nicolas
Casco, María del Pilar
Mengual Gómez, Diego Luis
Gomez, Daniel Eduardo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AUTOIMMUNE
CANCER
CARDIOVASCULAR
DISEASE
NEURODEGENERATIVE
OSTEOPOROSIS
PEPTIDYL-PROLYL ISOMERASE NIMA-INTERACTING 1
PIN1 INHIBITORS
VIRAL INFECTION
topic AUTOIMMUNE
CANCER
CARDIOVASCULAR
DISEASE
NEURODEGENERATIVE
OSTEOPOROSIS
PEPTIDYL-PROLYL ISOMERASE NIMA-INTERACTING 1
PIN1 INHIBITORS
VIRAL INFECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Peptidyl-prolyl isomerase NIMA-interacting 1 (PIN1) plays a crucial regulatory role in cells, and it is the only enzyme capable of selectively binding to phosphorylated proline-directed serine/threonine (pSer/Thr-Pro) residues in target proteins and catalyzing their isomerization. The change in the conformational status of the protein, transitioning between cis and trans, affects its three-dimensional structure and, therefore, alters its function and stability. In this manner, PIN1 plays a role in the development of several human pathologies by regulating essential proteins. In cancer, the enzymatic activity of PIN1 induces conformational changes in essential proteins, promoting oncogenic processes and fostering aggressive tumor characteristics and resistance to chemotherapies. Moreover, the effects of PIN1 on viral infections are notable, as it interacts with viral proteins, enhancing their replication and infection mechanisms. In addition, PIN1 participates in autoimmune, cardiovascular, metabolic, neurodegenerative diseases and osteoporosis. These diverse functions render PIN1 as an attractive therapeutic target, leading to the development of PIN1 inhibitors. The critical role of PIN1 in human pathology is further underscored by its relevance to various diseases, rendering it a potential nexus for novel interventions in human pathologies.
Fil: Maggio, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Armando, Romina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Balcone, Lara. Universidad Nacional de Quilmes; Argentina
Fil: Vilarullo, Roman Nicolas. Universidad Nacional de Quilmes; Argentina
Fil: Casco, María del Pilar. Universidad Nacional de Quilmes; Argentina
Fil: Mengual Gómez, Diego Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; Argentina
Fil: Gomez, Daniel Eduardo. Universidad Nacional de Quilmes; Argentina
description Peptidyl-prolyl isomerase NIMA-interacting 1 (PIN1) plays a crucial regulatory role in cells, and it is the only enzyme capable of selectively binding to phosphorylated proline-directed serine/threonine (pSer/Thr-Pro) residues in target proteins and catalyzing their isomerization. The change in the conformational status of the protein, transitioning between cis and trans, affects its three-dimensional structure and, therefore, alters its function and stability. In this manner, PIN1 plays a role in the development of several human pathologies by regulating essential proteins. In cancer, the enzymatic activity of PIN1 induces conformational changes in essential proteins, promoting oncogenic processes and fostering aggressive tumor characteristics and resistance to chemotherapies. Moreover, the effects of PIN1 on viral infections are notable, as it interacts with viral proteins, enhancing their replication and infection mechanisms. In addition, PIN1 participates in autoimmune, cardiovascular, metabolic, neurodegenerative diseases and osteoporosis. These diverse functions render PIN1 as an attractive therapeutic target, leading to the development of PIN1 inhibitors. The critical role of PIN1 in human pathology is further underscored by its relevance to various diseases, rendering it a potential nexus for novel interventions in human pathologies.
publishDate 2024
dc.date.none.fl_str_mv 2024-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/231132
Maggio, Julian; Armando, Romina Gabriela; Balcone, Lara; Vilarullo, Roman Nicolas; Casco, María del Pilar; et al.; Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review); Spandidos Publications; World Academy of Sciences Journal; 6; 1; 1-2024; 1-15
2632-2900
2632-2919
CONICET Digital
CONICET
url http://hdl.handle.net/11336/231132
identifier_str_mv Maggio, Julian; Armando, Romina Gabriela; Balcone, Lara; Vilarullo, Roman Nicolas; Casco, María del Pilar; et al.; Role of PIN1 in human pathology: Cellular regulation, pathogenesis and therapeutic implications (Review); Spandidos Publications; World Academy of Sciences Journal; 6; 1; 1-2024; 1-15
2632-2900
2632-2919
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/wasj.2023.220
info:eu-repo/semantics/altIdentifier/doi/10.3892/wasj.2023.220
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Spandidos Publications
publisher.none.fl_str_mv Spandidos Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613027728457728
score 13.070432

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