Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer

Autores
Labovsky, Vivian; Martinez, Leandro Marcelo; Davies, Kevin Mauro; de Luján Calcagno, María; García Rivello, Hernán; Wernicke, Alejandra; Feldman, Leonardo; Matas, Ayelen; Giorello, María Belén; Borzone, Francisco Raúl; Choi, Hosoon; Howard, Scott C.; Chasseing, Norma Alejandra
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues. We evaluated the clinicopathological significance of these ligands and receptors in TEpC and spindle-shaped stromal cells, not associated with the vasculature, to determine their impact on prognosis of patients with early-stage breast cancer.
Fil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Davies, Kevin Mauro. Hospital Italiano; Argentina
Fil: de Luján Calcagno, María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: García Rivello, Hernán. Hospital Italiano; Argentina
Fil: Wernicke, Alejandra. Hospital Italiano; Argentina
Fil: Feldman, Leonardo. Fundación Favaloro; Argentina
Fil: Matas, Ayelen. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Giorello, María Belén. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Borzone, Francisco Raúl. Ministerio de Salud. Instituto Nacional del Cancer; Argentina
Fil: Choi, Hosoon. Central Texas Veterans Research Foundation; Estados Unidos
Fil: Howard, Scott C.. University of Tennessee; Estados Unidos
Fil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
CCR-2
EARLY BREAST CANCER
SPINDLE-SHAPED STROMAL CELLS
TRAIL-R3
TUMOR EPITHELIAL CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24566
Acceder
id CONICETDig_f48bbab1efe9186aa97702cf32d21162
oai_identifier_str oai:ri.conicet.gov.ar:11336/24566
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancerLabovsky, VivianMartinez, Leandro MarceloDavies, Kevin Maurode Luján Calcagno, MaríaGarcía Rivello, HernánWernicke, AlejandraFeldman, LeonardoMatas, AyelenGiorello, María BelénBorzone, Francisco RaúlChoi, HosoonHoward, Scott C.Chasseing, Norma AlejandraCCR-2EARLY BREAST CANCERSPINDLE-SHAPED STROMAL CELLSTRAIL-R3TUMOR EPITHELIAL CELLShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues. We evaluated the clinicopathological significance of these ligands and receptors in TEpC and spindle-shaped stromal cells, not associated with the vasculature, to determine their impact on prognosis of patients with early-stage breast cancer.Fil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Davies, Kevin Mauro. Hospital Italiano; ArgentinaFil: de Luján Calcagno, María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: García Rivello, Hernán. Hospital Italiano; ArgentinaFil: Wernicke, Alejandra. Hospital Italiano; ArgentinaFil: Feldman, Leonardo. Fundación Favaloro; ArgentinaFil: Matas, Ayelen. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Giorello, María Belén. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Borzone, Francisco Raúl. Ministerio de Salud. Instituto Nacional del Cancer; ArgentinaFil: Choi, Hosoon. Central Texas Veterans Research Foundation; Estados UnidosFil: Howard, Scott C.. University of Tennessee; Estados UnidosFil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaBioMed Central2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24566Labovsky, Vivian; Martinez, Leandro Marcelo; Davies, Kevin Mauro; de Luján Calcagno, María; García Rivello, Hernán; et al.; Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer; BioMed Central; Bmc Cancer; 17; 1; 4-2017; 280-2901471-24071471-2407CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3259-8info:eu-repo/semantics/altIdentifier/doi/10.1186/s12885-017-3259-8info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395831/info:eu-repo/semantics/altIdentifier/pmid/28420351info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:34Zoai:ri.conicet.gov.ar:11336/24566instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:34.821CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer
title Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer
spellingShingle Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer
Labovsky, Vivian
CCR-2
EARLY BREAST CANCER
SPINDLE-SHAPED STROMAL CELLS
TRAIL-R3
TUMOR EPITHELIAL CELLS
title_short Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer
title_full Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer
title_fullStr Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer
title_full_unstemmed Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer
title_sort Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer
dc.creator.none.fl_str_mv Labovsky, Vivian
Martinez, Leandro Marcelo
Davies, Kevin Mauro
de Luján Calcagno, María
García Rivello, Hernán
Wernicke, Alejandra
Feldman, Leonardo
Matas, Ayelen
Giorello, María Belén
Borzone, Francisco Raúl
Choi, Hosoon
Howard, Scott C.
Chasseing, Norma Alejandra
author Labovsky, Vivian
author_facet Labovsky, Vivian
Martinez, Leandro Marcelo
Davies, Kevin Mauro
de Luján Calcagno, María
García Rivello, Hernán
Wernicke, Alejandra
Feldman, Leonardo
Matas, Ayelen
Giorello, María Belén
Borzone, Francisco Raúl
Choi, Hosoon
Howard, Scott C.
Chasseing, Norma Alejandra
author_role author
author2 Martinez, Leandro Marcelo
Davies, Kevin Mauro
de Luján Calcagno, María
García Rivello, Hernán
Wernicke, Alejandra
Feldman, Leonardo
Matas, Ayelen
Giorello, María Belén
Borzone, Francisco Raúl
Choi, Hosoon
Howard, Scott C.
Chasseing, Norma Alejandra
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CCR-2
EARLY BREAST CANCER
SPINDLE-SHAPED STROMAL CELLS
TRAIL-R3
TUMOR EPITHELIAL CELLS
topic CCR-2
EARLY BREAST CANCER
SPINDLE-SHAPED STROMAL CELLS
TRAIL-R3
TUMOR EPITHELIAL CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues. We evaluated the clinicopathological significance of these ligands and receptors in TEpC and spindle-shaped stromal cells, not associated with the vasculature, to determine their impact on prognosis of patients with early-stage breast cancer.
Fil: Labovsky, Vivian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Martinez, Leandro Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Davies, Kevin Mauro. Hospital Italiano; Argentina
Fil: de Luján Calcagno, María. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: García Rivello, Hernán. Hospital Italiano; Argentina
Fil: Wernicke, Alejandra. Hospital Italiano; Argentina
Fil: Feldman, Leonardo. Fundación Favaloro; Argentina
Fil: Matas, Ayelen. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Giorello, María Belén. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Borzone, Francisco Raúl. Ministerio de Salud. Instituto Nacional del Cancer; Argentina
Fil: Choi, Hosoon. Central Texas Veterans Research Foundation; Estados Unidos
Fil: Howard, Scott C.. University of Tennessee; Estados Unidos
Fil: Chasseing, Norma Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description Tumor epithelial cells (TEpCs) and spindle-shaped stromal cells, not associated with the vasculature, of patients with early breast cancer express osteoprotegerin (OPG), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), receptor activator of nuclear factor kappa B ligand, stromal cell derived factor-1, interleukin-6, macrophage colony stimulating factor, chemokine (C-C motif) ligand-2 (CCL-2) and their receptors at significantly higher levels compared with non-neoplastic breast tissues. We evaluated the clinicopathological significance of these ligands and receptors in TEpC and spindle-shaped stromal cells, not associated with the vasculature, to determine their impact on prognosis of patients with early-stage breast cancer.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24566
Labovsky, Vivian; Martinez, Leandro Marcelo; Davies, Kevin Mauro; de Luján Calcagno, María; García Rivello, Hernán; et al.; Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer; BioMed Central; Bmc Cancer; 17; 1; 4-2017; 280-290
1471-2407
1471-2407
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24566
identifier_str_mv Labovsky, Vivian; Martinez, Leandro Marcelo; Davies, Kevin Mauro; de Luján Calcagno, María; García Rivello, Hernán; et al.; Prognostic significance of TRAIL-R3 and CCR-2 expression in tumor epithelial cells of patients with early breast cancer; BioMed Central; Bmc Cancer; 17; 1; 4-2017; 280-290
1471-2407
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3259-8
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12885-017-3259-8
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395831/
info:eu-repo/semantics/altIdentifier/pmid/28420351
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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