Coronary intimal thickening in newborn babies and ≤i-Year-old infants

Autores
Milei, Jose; Grana, Daniel Rodolfo; Navari, Carlos; Azzato, Francisco; Guerri Guttenberg, Roberto Andrés; Ambrosio, Giuseppe
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We performed a morphological characterization of intimal thickenings in coronary arteries in the very early stages of life to obtain insights into initial coronary atherogenesis. We examined specimens from 67 infants who had died of noncardiac causes within their first year of life. Serially cut sections were stained with hematoxylin-eosin, Azan, Alcian blue, acetic orceine, and immunotypified for CD68, CD34, and α-smooth muscle (SM) actin. Substantial changes were detected in about 1 of 3 participants. Alterations ranged from focal areas with mild myointimal thickening to diffuse moderate thickening. In those lesions, smooth muscle cells (SMCs) showed loss of polarity, infiltrating the subendothelium, mostly with rupture of the internal elastic lamina and without neoangiogenesis. Morphometrically, in musculoelastic intimal thickenings, neointimal thickness averaged 58.3 ± 17.8 Âμm, affecting 46% of the internal elastic membrane perimeter; lumen stenosis averaged 13.7% ± 5.0%. These lesions can be present very early in life and SMCs seem to play an essential role.
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Navari, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Azzato, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Guerri Guttenberg, Roberto Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Ambrosio, Giuseppe. Università di Perugia; Italia
Materia
Coronary Artery
Early Atherosclerosis
Smooth Muscle Cells
Subintimal Thickening
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67620
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Coronary intimal thickening in newborn babies and ≤i-Year-old infantsMilei, JoseGrana, Daniel RodolfoNavari, CarlosAzzato, FranciscoGuerri Guttenberg, Roberto AndrésAmbrosio, GiuseppeCoronary ArteryEarly AtherosclerosisSmooth Muscle CellsSubintimal Thickeninghttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We performed a morphological characterization of intimal thickenings in coronary arteries in the very early stages of life to obtain insights into initial coronary atherogenesis. We examined specimens from 67 infants who had died of noncardiac causes within their first year of life. Serially cut sections were stained with hematoxylin-eosin, Azan, Alcian blue, acetic orceine, and immunotypified for CD68, CD34, and α-smooth muscle (SM) actin. Substantial changes were detected in about 1 of 3 participants. Alterations ranged from focal areas with mild myointimal thickening to diffuse moderate thickening. In those lesions, smooth muscle cells (SMCs) showed loss of polarity, infiltrating the subendothelium, mostly with rupture of the internal elastic lamina and without neoangiogenesis. Morphometrically, in musculoelastic intimal thickenings, neointimal thickness averaged 58.3 ± 17.8 Âμm, affecting 46% of the internal elastic membrane perimeter; lumen stenosis averaged 13.7% ± 5.0%. These lesions can be present very early in life and SMCs seem to play an essential role.Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Navari, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Azzato, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Guerri Guttenberg, Roberto Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Ambrosio, Giuseppe. Università di Perugia; ItaliaSAGE Publications2010-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67620Milei, Jose; Grana, Daniel Rodolfo; Navari, Carlos; Azzato, Francisco; Guerri Guttenberg, Roberto Andrés; et al.; Coronary intimal thickening in newborn babies and ≤i-Year-old infants; SAGE Publications; Angiology; 61; 4; 4-2010; 350-3560003-3197CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/0003319709352487info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/0003319709352487info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:34Zoai:ri.conicet.gov.ar:11336/67620instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:35.139CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Coronary intimal thickening in newborn babies and ≤i-Year-old infants
title Coronary intimal thickening in newborn babies and ≤i-Year-old infants
spellingShingle Coronary intimal thickening in newborn babies and ≤i-Year-old infants
Milei, Jose
Coronary Artery
Early Atherosclerosis
Smooth Muscle Cells
Subintimal Thickening
title_short Coronary intimal thickening in newborn babies and ≤i-Year-old infants
title_full Coronary intimal thickening in newborn babies and ≤i-Year-old infants
title_fullStr Coronary intimal thickening in newborn babies and ≤i-Year-old infants
title_full_unstemmed Coronary intimal thickening in newborn babies and ≤i-Year-old infants
title_sort Coronary intimal thickening in newborn babies and ≤i-Year-old infants
dc.creator.none.fl_str_mv Milei, Jose
Grana, Daniel Rodolfo
Navari, Carlos
Azzato, Francisco
Guerri Guttenberg, Roberto Andrés
Ambrosio, Giuseppe
author Milei, Jose
author_facet Milei, Jose
Grana, Daniel Rodolfo
Navari, Carlos
Azzato, Francisco
Guerri Guttenberg, Roberto Andrés
Ambrosio, Giuseppe
author_role author
author2 Grana, Daniel Rodolfo
Navari, Carlos
Azzato, Francisco
Guerri Guttenberg, Roberto Andrés
Ambrosio, Giuseppe
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Coronary Artery
Early Atherosclerosis
Smooth Muscle Cells
Subintimal Thickening
topic Coronary Artery
Early Atherosclerosis
Smooth Muscle Cells
Subintimal Thickening
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We performed a morphological characterization of intimal thickenings in coronary arteries in the very early stages of life to obtain insights into initial coronary atherogenesis. We examined specimens from 67 infants who had died of noncardiac causes within their first year of life. Serially cut sections were stained with hematoxylin-eosin, Azan, Alcian blue, acetic orceine, and immunotypified for CD68, CD34, and α-smooth muscle (SM) actin. Substantial changes were detected in about 1 of 3 participants. Alterations ranged from focal areas with mild myointimal thickening to diffuse moderate thickening. In those lesions, smooth muscle cells (SMCs) showed loss of polarity, infiltrating the subendothelium, mostly with rupture of the internal elastic lamina and without neoangiogenesis. Morphometrically, in musculoelastic intimal thickenings, neointimal thickness averaged 58.3 ± 17.8 Âμm, affecting 46% of the internal elastic membrane perimeter; lumen stenosis averaged 13.7% ± 5.0%. These lesions can be present very early in life and SMCs seem to play an essential role.
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Navari, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Azzato, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Guerri Guttenberg, Roberto Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Ambrosio, Giuseppe. Università di Perugia; Italia
description We performed a morphological characterization of intimal thickenings in coronary arteries in the very early stages of life to obtain insights into initial coronary atherogenesis. We examined specimens from 67 infants who had died of noncardiac causes within their first year of life. Serially cut sections were stained with hematoxylin-eosin, Azan, Alcian blue, acetic orceine, and immunotypified for CD68, CD34, and α-smooth muscle (SM) actin. Substantial changes were detected in about 1 of 3 participants. Alterations ranged from focal areas with mild myointimal thickening to diffuse moderate thickening. In those lesions, smooth muscle cells (SMCs) showed loss of polarity, infiltrating the subendothelium, mostly with rupture of the internal elastic lamina and without neoangiogenesis. Morphometrically, in musculoelastic intimal thickenings, neointimal thickness averaged 58.3 ± 17.8 Âμm, affecting 46% of the internal elastic membrane perimeter; lumen stenosis averaged 13.7% ± 5.0%. These lesions can be present very early in life and SMCs seem to play an essential role.
publishDate 2010
dc.date.none.fl_str_mv 2010-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67620
Milei, Jose; Grana, Daniel Rodolfo; Navari, Carlos; Azzato, Francisco; Guerri Guttenberg, Roberto Andrés; et al.; Coronary intimal thickening in newborn babies and ≤i-Year-old infants; SAGE Publications; Angiology; 61; 4; 4-2010; 350-356
0003-3197
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67620
identifier_str_mv Milei, Jose; Grana, Daniel Rodolfo; Navari, Carlos; Azzato, Francisco; Guerri Guttenberg, Roberto Andrés; et al.; Coronary intimal thickening in newborn babies and ≤i-Year-old infants; SAGE Publications; Angiology; 61; 4; 4-2010; 350-356
0003-3197
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/0003319709352487
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/0003319709352487
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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