Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging

Autores
Carrascosa, Patricia; Deviggiano, Alejandro; de Zan, Macarena; Capunay, Carlos; Campisi, Roxana; Rodriguez Granillo, Gaston Alfredo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: The aim of this study was to explore the diagnostic performance of dual-energy computed tomography perfusion (DE-CTP) at different energy levels. Methods: Patients with known or suspected coronary artery disease underwent stress and rest DE-CTP and single-photon emission computed tomography. Images were evaluated using monochromatic data, and perfusion defects were initially identified in a qualitative manner and subsequently confirmed using attenuation levels. Results: Thirty-six patients were included. Sensitivity, specificity, positive predictive value, and negative predictive value of DE-CTP for the identification of perfusion defects were 84.1%, 94.2%, 77.3%, and 96.2%, respectively. Perfusion defects showed significantly lower attenuation than normal segments, with the largest differences among low energy levels (sensitivity of 96% and specificity of 98% using a cutoff value ≤ 153 Hounsfield units at 40 keV), progressively declining at the higher levels (P < 0.001). Conclusions: Dual-energy CTP at the lowest energy levels allowed improved discrimination of perfusion defects compared with higher energy levels.
Fil: Carrascosa, Patricia. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: Deviggiano, Alejandro. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: de Zan, Macarena. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: Capunay, Carlos. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: Campisi, Roxana. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
Cardiovascular Diagnostic Technics
Coronary Atherosclerosis
Ischemia
Multidetector Computed Tomography
Stress Test
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/65073
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/65073
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic ImagingCarrascosa, PatriciaDeviggiano, Alejandrode Zan, MacarenaCapunay, CarlosCampisi, RoxanaRodriguez Granillo, Gaston AlfredoCardiovascular Diagnostic TechnicsCoronary AtherosclerosisIschemiaMultidetector Computed TomographyStress Testhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objectives: The aim of this study was to explore the diagnostic performance of dual-energy computed tomography perfusion (DE-CTP) at different energy levels. Methods: Patients with known or suspected coronary artery disease underwent stress and rest DE-CTP and single-photon emission computed tomography. Images were evaluated using monochromatic data, and perfusion defects were initially identified in a qualitative manner and subsequently confirmed using attenuation levels. Results: Thirty-six patients were included. Sensitivity, specificity, positive predictive value, and negative predictive value of DE-CTP for the identification of perfusion defects were 84.1%, 94.2%, 77.3%, and 96.2%, respectively. Perfusion defects showed significantly lower attenuation than normal segments, with the largest differences among low energy levels (sensitivity of 96% and specificity of 98% using a cutoff value ≤ 153 Hounsfield units at 40 keV), progressively declining at the higher levels (P < 0.001). Conclusions: Dual-energy CTP at the lowest energy levels allowed improved discrimination of perfusion defects compared with higher energy levels.Fil: Carrascosa, Patricia. Diagnóstico Maipú, Buenos Aires; ArgentinaFil: Deviggiano, Alejandro. Diagnóstico Maipú, Buenos Aires; ArgentinaFil: de Zan, Macarena. Diagnóstico Maipú, Buenos Aires; ArgentinaFil: Capunay, Carlos. Diagnóstico Maipú, Buenos Aires; ArgentinaFil: Campisi, Roxana. Diagnóstico Maipú, Buenos Aires; ArgentinaFil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaLippincott Williams2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/65073Carrascosa, Patricia; Deviggiano, Alejandro; de Zan, Macarena; Capunay, Carlos; Campisi, Roxana; et al.; Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging; Lippincott Williams; Journal Of Computer Assisted Tomography; 41; 4; 7-2017; 661-6670363-8715CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00004728-201707000-00025info:eu-repo/semantics/altIdentifier/doi/10.1097/RCT.0000000000000584info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:44:39Zoai:ri.conicet.gov.ar:11336/65073instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:44:39.967CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging
title Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging
spellingShingle Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging
Carrascosa, Patricia
Cardiovascular Diagnostic Technics
Coronary Atherosclerosis
Ischemia
Multidetector Computed Tomography
Stress Test
title_short Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging
title_full Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging
title_fullStr Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging
title_full_unstemmed Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging
title_sort Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging
dc.creator.none.fl_str_mv Carrascosa, Patricia
Deviggiano, Alejandro
de Zan, Macarena
Capunay, Carlos
Campisi, Roxana
Rodriguez Granillo, Gaston Alfredo
author Carrascosa, Patricia
author_facet Carrascosa, Patricia
Deviggiano, Alejandro
de Zan, Macarena
Capunay, Carlos
Campisi, Roxana
Rodriguez Granillo, Gaston Alfredo
author_role author
author2 Deviggiano, Alejandro
de Zan, Macarena
Capunay, Carlos
Campisi, Roxana
Rodriguez Granillo, Gaston Alfredo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Cardiovascular Diagnostic Technics
Coronary Atherosclerosis
Ischemia
Multidetector Computed Tomography
Stress Test
topic Cardiovascular Diagnostic Technics
Coronary Atherosclerosis
Ischemia
Multidetector Computed Tomography
Stress Test
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: The aim of this study was to explore the diagnostic performance of dual-energy computed tomography perfusion (DE-CTP) at different energy levels. Methods: Patients with known or suspected coronary artery disease underwent stress and rest DE-CTP and single-photon emission computed tomography. Images were evaluated using monochromatic data, and perfusion defects were initially identified in a qualitative manner and subsequently confirmed using attenuation levels. Results: Thirty-six patients were included. Sensitivity, specificity, positive predictive value, and negative predictive value of DE-CTP for the identification of perfusion defects were 84.1%, 94.2%, 77.3%, and 96.2%, respectively. Perfusion defects showed significantly lower attenuation than normal segments, with the largest differences among low energy levels (sensitivity of 96% and specificity of 98% using a cutoff value ≤ 153 Hounsfield units at 40 keV), progressively declining at the higher levels (P < 0.001). Conclusions: Dual-energy CTP at the lowest energy levels allowed improved discrimination of perfusion defects compared with higher energy levels.
Fil: Carrascosa, Patricia. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: Deviggiano, Alejandro. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: de Zan, Macarena. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: Capunay, Carlos. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: Campisi, Roxana. Diagnóstico Maipú, Buenos Aires; Argentina
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description Objectives: The aim of this study was to explore the diagnostic performance of dual-energy computed tomography perfusion (DE-CTP) at different energy levels. Methods: Patients with known or suspected coronary artery disease underwent stress and rest DE-CTP and single-photon emission computed tomography. Images were evaluated using monochromatic data, and perfusion defects were initially identified in a qualitative manner and subsequently confirmed using attenuation levels. Results: Thirty-six patients were included. Sensitivity, specificity, positive predictive value, and negative predictive value of DE-CTP for the identification of perfusion defects were 84.1%, 94.2%, 77.3%, and 96.2%, respectively. Perfusion defects showed significantly lower attenuation than normal segments, with the largest differences among low energy levels (sensitivity of 96% and specificity of 98% using a cutoff value ≤ 153 Hounsfield units at 40 keV), progressively declining at the higher levels (P < 0.001). Conclusions: Dual-energy CTP at the lowest energy levels allowed improved discrimination of perfusion defects compared with higher energy levels.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/65073
Carrascosa, Patricia; Deviggiano, Alejandro; de Zan, Macarena; Capunay, Carlos; Campisi, Roxana; et al.; Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging; Lippincott Williams; Journal Of Computer Assisted Tomography; 41; 4; 7-2017; 661-667
0363-8715
CONICET Digital
CONICET
url http://hdl.handle.net/11336/65073
identifier_str_mv Carrascosa, Patricia; Deviggiano, Alejandro; de Zan, Macarena; Capunay, Carlos; Campisi, Roxana; et al.; Improved Discrimination of Myocardial Perfusion Defects at Low Energy Levels Using Virtual Monochromatic Imaging; Lippincott Williams; Journal Of Computer Assisted Tomography; 41; 4; 7-2017; 661-667
0363-8715
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00004728-201707000-00025
info:eu-repo/semantics/altIdentifier/doi/10.1097/RCT.0000000000000584
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082957499957248
score 13.22299

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