Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.

Autores
Ramos Hryb, Ana Belen; Bahor, Z.; McCann, Samuel M.; Senar, Eduardo Santiago; Macleod, M. R.; Lino de Oliveira, Cilene
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective Forced swimming test (FST) in rodents is a widely used behavioural test for screening antidepressants in preclinical research. Translational value of preclinical studies may be improved by appraisal of the quality of experimental design and risk of biases, which remains to be addressed for FST. The present protocol of a systematic review with meta-analysis aims to investigate the quality of preclinical studies employing FST to identify risks of bias in future publications. In addition, this protocol will help to determine the effect sizes (ES) for primary and secondary outcomes according to several aspects of the FST study design. Search strategy, Screening annotation, Data management Publications reporting studies testing different classes of antidepressants in FST will be collected from Medline, SCOPUS and Web of Science databases. A broad list of inclusion criteria will be applied excluding those studies whereby FST is used as a stressor or studies reporting data from co-treatments. For assessing the quality of the included publications, the quality checklist adapted by Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies will be used. If the meta-analysis seems feasible, the ES and the 95% CI will be analysed. The heterogeneity between studies will be assessed by using the χ2 statistic with n−1 degrees of freedom. Subgroup meta-analysis (metaregression, and if necessary, stratified regression) will be performed when possible according to characteristics of study design and study quality to assess their impact on efficacy of the treatments. In addition, funnel plotting, Egger regression, and ‘trim and fill’ will be used to assess the risk of publication bias. Results of this protocol will help to create rational methodological guidelines for application of FST in rodents and improve the quality and translational value of preclinical research on antidepressant discovery. Reporting A preliminary version of the present protocol has been preregistered with Systematic Review Facility (http://syrf.org.uk/). A preprint version of the current protocol has been registered with Open Science Framework (https://osf.io/9kxm4/). Results will be communicated in scientific meetings and peer-reviewed journals. We plan to conduct an anonymous and online survey within the scientific community to ask researchers about their perception of risk of bias and their experience with the publication of negative results.
Fil: Ramos Hryb, Ana Belen. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bahor, Z.. University of Edinburgh; Reino Unido
Fil: McCann, Samuel M.. University of Edinburgh; Reino Unido
Fil: Senar, Eduardo Santiago. University of Edinburgh; Reino Unido
Fil: Macleod, M. R.. University of Edinburgh; Reino Unido
Fil: Lino de Oliveira, Cilene. Universidade Federal de Santa Catarina; Brasil
Materia
ANTIDEPRESSANTS
ANIMAL MODELS
PRECLINICAL
BIAS RISK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/103342

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spelling Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.Ramos Hryb, Ana BelenBahor, Z.McCann, Samuel M.Senar, Eduardo SantiagoMacleod, M. R.Lino de Oliveira, CileneANTIDEPRESSANTSANIMAL MODELSPRECLINICALBIAS RISKhttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objective Forced swimming test (FST) in rodents is a widely used behavioural test for screening antidepressants in preclinical research. Translational value of preclinical studies may be improved by appraisal of the quality of experimental design and risk of biases, which remains to be addressed for FST. The present protocol of a systematic review with meta-analysis aims to investigate the quality of preclinical studies employing FST to identify risks of bias in future publications. In addition, this protocol will help to determine the effect sizes (ES) for primary and secondary outcomes according to several aspects of the FST study design. Search strategy, Screening annotation, Data management Publications reporting studies testing different classes of antidepressants in FST will be collected from Medline, SCOPUS and Web of Science databases. A broad list of inclusion criteria will be applied excluding those studies whereby FST is used as a stressor or studies reporting data from co-treatments. For assessing the quality of the included publications, the quality checklist adapted by Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies will be used. If the meta-analysis seems feasible, the ES and the 95% CI will be analysed. The heterogeneity between studies will be assessed by using the χ2 statistic with n−1 degrees of freedom. Subgroup meta-analysis (metaregression, and if necessary, stratified regression) will be performed when possible according to characteristics of study design and study quality to assess their impact on efficacy of the treatments. In addition, funnel plotting, Egger regression, and ‘trim and fill’ will be used to assess the risk of publication bias. Results of this protocol will help to create rational methodological guidelines for application of FST in rodents and improve the quality and translational value of preclinical research on antidepressant discovery. Reporting A preliminary version of the present protocol has been preregistered with Systematic Review Facility (http://syrf.org.uk/). A preprint version of the current protocol has been registered with Open Science Framework (https://osf.io/9kxm4/). Results will be communicated in scientific meetings and peer-reviewed journals. We plan to conduct an anonymous and online survey within the scientific community to ask researchers about their perception of risk of bias and their experience with the publication of negative results.Fil: Ramos Hryb, Ana Belen. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bahor, Z.. University of Edinburgh; Reino UnidoFil: McCann, Samuel M.. University of Edinburgh; Reino UnidoFil: Senar, Eduardo Santiago. University of Edinburgh; Reino UnidoFil: Macleod, M. R.. University of Edinburgh; Reino UnidoFil: Lino de Oliveira, Cilene. Universidade Federal de Santa Catarina; BrasilBMJ Publishing Group2019-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/103342Ramos Hryb, Ana Belen; Bahor, Z.; McCann, Samuel M.; Senar, Eduardo Santiago; Macleod, M. R.; et al.; Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.; BMJ Publishing Group; BMJ Open Science; 2019; 3; 2-2019; 1-62398-8703CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://openscience.bmj.com/content/3/1/e000043info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjos-2017-000043info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:12Zoai:ri.conicet.gov.ar:11336/103342instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:12.935CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
title Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
spellingShingle Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
Ramos Hryb, Ana Belen
ANTIDEPRESSANTS
ANIMAL MODELS
PRECLINICAL
BIAS RISK
title_short Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
title_full Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
title_fullStr Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
title_full_unstemmed Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
title_sort Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.
dc.creator.none.fl_str_mv Ramos Hryb, Ana Belen
Bahor, Z.
McCann, Samuel M.
Senar, Eduardo Santiago
Macleod, M. R.
Lino de Oliveira, Cilene
author Ramos Hryb, Ana Belen
author_facet Ramos Hryb, Ana Belen
Bahor, Z.
McCann, Samuel M.
Senar, Eduardo Santiago
Macleod, M. R.
Lino de Oliveira, Cilene
author_role author
author2 Bahor, Z.
McCann, Samuel M.
Senar, Eduardo Santiago
Macleod, M. R.
Lino de Oliveira, Cilene
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTIDEPRESSANTS
ANIMAL MODELS
PRECLINICAL
BIAS RISK
topic ANTIDEPRESSANTS
ANIMAL MODELS
PRECLINICAL
BIAS RISK
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective Forced swimming test (FST) in rodents is a widely used behavioural test for screening antidepressants in preclinical research. Translational value of preclinical studies may be improved by appraisal of the quality of experimental design and risk of biases, which remains to be addressed for FST. The present protocol of a systematic review with meta-analysis aims to investigate the quality of preclinical studies employing FST to identify risks of bias in future publications. In addition, this protocol will help to determine the effect sizes (ES) for primary and secondary outcomes according to several aspects of the FST study design. Search strategy, Screening annotation, Data management Publications reporting studies testing different classes of antidepressants in FST will be collected from Medline, SCOPUS and Web of Science databases. A broad list of inclusion criteria will be applied excluding those studies whereby FST is used as a stressor or studies reporting data from co-treatments. For assessing the quality of the included publications, the quality checklist adapted by Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies will be used. If the meta-analysis seems feasible, the ES and the 95% CI will be analysed. The heterogeneity between studies will be assessed by using the χ2 statistic with n−1 degrees of freedom. Subgroup meta-analysis (metaregression, and if necessary, stratified regression) will be performed when possible according to characteristics of study design and study quality to assess their impact on efficacy of the treatments. In addition, funnel plotting, Egger regression, and ‘trim and fill’ will be used to assess the risk of publication bias. Results of this protocol will help to create rational methodological guidelines for application of FST in rodents and improve the quality and translational value of preclinical research on antidepressant discovery. Reporting A preliminary version of the present protocol has been preregistered with Systematic Review Facility (http://syrf.org.uk/). A preprint version of the current protocol has been registered with Open Science Framework (https://osf.io/9kxm4/). Results will be communicated in scientific meetings and peer-reviewed journals. We plan to conduct an anonymous and online survey within the scientific community to ask researchers about their perception of risk of bias and their experience with the publication of negative results.
Fil: Ramos Hryb, Ana Belen. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bahor, Z.. University of Edinburgh; Reino Unido
Fil: McCann, Samuel M.. University of Edinburgh; Reino Unido
Fil: Senar, Eduardo Santiago. University of Edinburgh; Reino Unido
Fil: Macleod, M. R.. University of Edinburgh; Reino Unido
Fil: Lino de Oliveira, Cilene. Universidade Federal de Santa Catarina; Brasil
description Objective Forced swimming test (FST) in rodents is a widely used behavioural test for screening antidepressants in preclinical research. Translational value of preclinical studies may be improved by appraisal of the quality of experimental design and risk of biases, which remains to be addressed for FST. The present protocol of a systematic review with meta-analysis aims to investigate the quality of preclinical studies employing FST to identify risks of bias in future publications. In addition, this protocol will help to determine the effect sizes (ES) for primary and secondary outcomes according to several aspects of the FST study design. Search strategy, Screening annotation, Data management Publications reporting studies testing different classes of antidepressants in FST will be collected from Medline, SCOPUS and Web of Science databases. A broad list of inclusion criteria will be applied excluding those studies whereby FST is used as a stressor or studies reporting data from co-treatments. For assessing the quality of the included publications, the quality checklist adapted by Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies will be used. If the meta-analysis seems feasible, the ES and the 95% CI will be analysed. The heterogeneity between studies will be assessed by using the χ2 statistic with n−1 degrees of freedom. Subgroup meta-analysis (metaregression, and if necessary, stratified regression) will be performed when possible according to characteristics of study design and study quality to assess their impact on efficacy of the treatments. In addition, funnel plotting, Egger regression, and ‘trim and fill’ will be used to assess the risk of publication bias. Results of this protocol will help to create rational methodological guidelines for application of FST in rodents and improve the quality and translational value of preclinical research on antidepressant discovery. Reporting A preliminary version of the present protocol has been preregistered with Systematic Review Facility (http://syrf.org.uk/). A preprint version of the current protocol has been registered with Open Science Framework (https://osf.io/9kxm4/). Results will be communicated in scientific meetings and peer-reviewed journals. We plan to conduct an anonymous and online survey within the scientific community to ask researchers about their perception of risk of bias and their experience with the publication of negative results.
publishDate 2019
dc.date.none.fl_str_mv 2019-02
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/103342
Ramos Hryb, Ana Belen; Bahor, Z.; McCann, Samuel M.; Senar, Eduardo Santiago; Macleod, M. R.; et al.; Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.; BMJ Publishing Group; BMJ Open Science; 2019; 3; 2-2019; 1-6
2398-8703
CONICET Digital
CONICET
url http://hdl.handle.net/11336/103342
identifier_str_mv Ramos Hryb, Ana Belen; Bahor, Z.; McCann, Samuel M.; Senar, Eduardo Santiago; Macleod, M. R.; et al.; Protocol for a systematic review and meta-analysis of data from preclinical studies employing the forced swimming test: an update.; BMJ Publishing Group; BMJ Open Science; 2019; 3; 2-2019; 1-6
2398-8703
CONICET Digital
CONICET
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info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjos-2017-000043
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