Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool

Autores
Fraunhoffer Navarro, Nicolas Alejandro; Abuelafia, Analía Meilerman; Dusetti, Nelson; Iovanna, Juan Lucio
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pancreatic ductal adenocarcinoma (PDAC) is a dismaldisease with a fast evolution and unpredictable treatmentresponse. Nowadays, FOLFIRINOX and gemcitabine are the preferred treatments with a response rateof 33% and 11%, respectively. This poor patient responsehas been associated with an inefficient/non-personalizedtreatment allocation. Consequently, developing a rapidand efficient preclinical tool to test tumor drug sensitivityfor each patient is hugely needed. Biopsy patient-derivedorganoid (PDO) appears to be a promising tool for devel-oping individualized treatments for patients with PDAC.Several PDO-based platforms are in development world-wide as a guide to optimize therapy by directing tailored treatments.
Fil: Fraunhoffer Navarro, Nicolas Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Aix-Marseille University; Francia
Fil: Abuelafia, Analía Meilerman. Aix-Marseille University; Francia
Fil: Dusetti, Nelson. Aix-Marseille University; Francia
Fil: Iovanna, Juan Lucio. Aix-Marseille University; Francia
Materia
PDAC
ORGANOIDS
PRECLINICAL MODELS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/213097
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical toolFraunhoffer Navarro, Nicolas AlejandroAbuelafia, Analía MeilermanDusetti, NelsonIovanna, Juan LucioPDACORGANOIDSPRECLINICAL MODELShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Pancreatic ductal adenocarcinoma (PDAC) is a dismaldisease with a fast evolution and unpredictable treatmentresponse. Nowadays, FOLFIRINOX and gemcitabine are the preferred treatments with a response rateof 33% and 11%, respectively. This poor patient responsehas been associated with an inefficient/non-personalizedtreatment allocation. Consequently, developing a rapidand efficient preclinical tool to test tumor drug sensitivityfor each patient is hugely needed. Biopsy patient-derivedorganoid (PDO) appears to be a promising tool for devel-oping individualized treatments for patients with PDAC.Several PDO-based platforms are in development world-wide as a guide to optimize therapy by directing tailored treatments.Fil: Fraunhoffer Navarro, Nicolas Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Aix-Marseille University; FranciaFil: Abuelafia, Analía Meilerman. Aix-Marseille University; FranciaFil: Dusetti, Nelson. Aix-Marseille University; FranciaFil: Iovanna, Juan Lucio. Aix-Marseille University; FranciaJohn Wiley & Sons2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/213097Fraunhoffer Navarro, Nicolas Alejandro; Abuelafia, Analía Meilerman; Dusetti, Nelson; Iovanna, Juan Lucio; Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool; John Wiley & Sons; Cancer Communications; 42; 10; 10-2022; 1028-10312523-3548CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cac2.12335info:eu-repo/semantics/altIdentifier/doi/10.1002/cac2.12335info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:16:51Zoai:ri.conicet.gov.ar:11336/213097instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:16:52.131CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
title Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
spellingShingle Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
Fraunhoffer Navarro, Nicolas Alejandro
PDAC
ORGANOIDS
PRECLINICAL MODELS
title_short Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
title_full Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
title_fullStr Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
title_full_unstemmed Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
title_sort Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
dc.creator.none.fl_str_mv Fraunhoffer Navarro, Nicolas Alejandro
Abuelafia, Analía Meilerman
Dusetti, Nelson
Iovanna, Juan Lucio
author Fraunhoffer Navarro, Nicolas Alejandro
author_facet Fraunhoffer Navarro, Nicolas Alejandro
Abuelafia, Analía Meilerman
Dusetti, Nelson
Iovanna, Juan Lucio
author_role author
author2 Abuelafia, Analía Meilerman
Dusetti, Nelson
Iovanna, Juan Lucio
author2_role author
author
author
dc.subject.none.fl_str_mv PDAC
ORGANOIDS
PRECLINICAL MODELS
topic PDAC
ORGANOIDS
PRECLINICAL MODELS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pancreatic ductal adenocarcinoma (PDAC) is a dismaldisease with a fast evolution and unpredictable treatmentresponse. Nowadays, FOLFIRINOX and gemcitabine are the preferred treatments with a response rateof 33% and 11%, respectively. This poor patient responsehas been associated with an inefficient/non-personalizedtreatment allocation. Consequently, developing a rapidand efficient preclinical tool to test tumor drug sensitivityfor each patient is hugely needed. Biopsy patient-derivedorganoid (PDO) appears to be a promising tool for devel-oping individualized treatments for patients with PDAC.Several PDO-based platforms are in development world-wide as a guide to optimize therapy by directing tailored treatments.
Fil: Fraunhoffer Navarro, Nicolas Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Aix-Marseille University; Francia
Fil: Abuelafia, Analía Meilerman. Aix-Marseille University; Francia
Fil: Dusetti, Nelson. Aix-Marseille University; Francia
Fil: Iovanna, Juan Lucio. Aix-Marseille University; Francia
description Pancreatic ductal adenocarcinoma (PDAC) is a dismaldisease with a fast evolution and unpredictable treatmentresponse. Nowadays, FOLFIRINOX and gemcitabine are the preferred treatments with a response rateof 33% and 11%, respectively. This poor patient responsehas been associated with an inefficient/non-personalizedtreatment allocation. Consequently, developing a rapidand efficient preclinical tool to test tumor drug sensitivityfor each patient is hugely needed. Biopsy patient-derivedorganoid (PDO) appears to be a promising tool for devel-oping individualized treatments for patients with PDAC.Several PDO-based platforms are in development world-wide as a guide to optimize therapy by directing tailored treatments.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/213097
Fraunhoffer Navarro, Nicolas Alejandro; Abuelafia, Analía Meilerman; Dusetti, Nelson; Iovanna, Juan Lucio; Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool; John Wiley & Sons; Cancer Communications; 42; 10; 10-2022; 1028-1031
2523-3548
CONICET Digital
CONICET
url http://hdl.handle.net/11336/213097
identifier_str_mv Fraunhoffer Navarro, Nicolas Alejandro; Abuelafia, Analía Meilerman; Dusetti, Nelson; Iovanna, Juan Lucio; Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool; John Wiley & Sons; Cancer Communications; 42; 10; 10-2022; 1028-1031
2523-3548
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cac2.12335
info:eu-repo/semantics/altIdentifier/doi/10.1002/cac2.12335
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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