Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool
- Autores
- Fraunhoffer Navarro, Nicolas Alejandro; Abuelafia, Analía Meilerman; Dusetti, Nelson; Iovanna, Juan Lucio
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Pancreatic ductal adenocarcinoma (PDAC) is a dismaldisease with a fast evolution and unpredictable treatmentresponse. Nowadays, FOLFIRINOX and gemcitabine are the preferred treatments with a response rateof 33% and 11%, respectively. This poor patient responsehas been associated with an inefficient/non-personalizedtreatment allocation. Consequently, developing a rapidand efficient preclinical tool to test tumor drug sensitivityfor each patient is hugely needed. Biopsy patient-derivedorganoid (PDO) appears to be a promising tool for devel-oping individualized treatments for patients with PDAC.Several PDO-based platforms are in development world-wide as a guide to optimize therapy by directing tailored treatments.
Fil: Fraunhoffer Navarro, Nicolas Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Aix-Marseille University; Francia
Fil: Abuelafia, Analía Meilerman. Aix-Marseille University; Francia
Fil: Dusetti, Nelson. Aix-Marseille University; Francia
Fil: Iovanna, Juan Lucio. Aix-Marseille University; Francia - Materia
-
PDAC
ORGANOIDS
PRECLINICAL MODELS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/213097
Ver los metadatos del registro completo
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Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical toolFraunhoffer Navarro, Nicolas AlejandroAbuelafia, Analía MeilermanDusetti, NelsonIovanna, Juan LucioPDACORGANOIDSPRECLINICAL MODELShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Pancreatic ductal adenocarcinoma (PDAC) is a dismaldisease with a fast evolution and unpredictable treatmentresponse. Nowadays, FOLFIRINOX and gemcitabine are the preferred treatments with a response rateof 33% and 11%, respectively. This poor patient responsehas been associated with an inefficient/non-personalizedtreatment allocation. Consequently, developing a rapidand efficient preclinical tool to test tumor drug sensitivityfor each patient is hugely needed. Biopsy patient-derivedorganoid (PDO) appears to be a promising tool for devel-oping individualized treatments for patients with PDAC.Several PDO-based platforms are in development world-wide as a guide to optimize therapy by directing tailored treatments.Fil: Fraunhoffer Navarro, Nicolas Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Aix-Marseille University; FranciaFil: Abuelafia, Analía Meilerman. Aix-Marseille University; FranciaFil: Dusetti, Nelson. Aix-Marseille University; FranciaFil: Iovanna, Juan Lucio. Aix-Marseille University; FranciaJohn Wiley & Sons2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/213097Fraunhoffer Navarro, Nicolas Alejandro; Abuelafia, Analía Meilerman; Dusetti, Nelson; Iovanna, Juan Lucio; Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool; John Wiley & Sons; Cancer Communications; 42; 10; 10-2022; 1028-10312523-3548CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cac2.12335info:eu-repo/semantics/altIdentifier/doi/10.1002/cac2.12335info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:00Zoai:ri.conicet.gov.ar:11336/213097instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:01.234CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool |
title |
Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool |
spellingShingle |
Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool Fraunhoffer Navarro, Nicolas Alejandro PDAC ORGANOIDS PRECLINICAL MODELS |
title_short |
Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool |
title_full |
Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool |
title_fullStr |
Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool |
title_full_unstemmed |
Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool |
title_sort |
Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool |
dc.creator.none.fl_str_mv |
Fraunhoffer Navarro, Nicolas Alejandro Abuelafia, Analía Meilerman Dusetti, Nelson Iovanna, Juan Lucio |
author |
Fraunhoffer Navarro, Nicolas Alejandro |
author_facet |
Fraunhoffer Navarro, Nicolas Alejandro Abuelafia, Analía Meilerman Dusetti, Nelson Iovanna, Juan Lucio |
author_role |
author |
author2 |
Abuelafia, Analía Meilerman Dusetti, Nelson Iovanna, Juan Lucio |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
PDAC ORGANOIDS PRECLINICAL MODELS |
topic |
PDAC ORGANOIDS PRECLINICAL MODELS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Pancreatic ductal adenocarcinoma (PDAC) is a dismaldisease with a fast evolution and unpredictable treatmentresponse. Nowadays, FOLFIRINOX and gemcitabine are the preferred treatments with a response rateof 33% and 11%, respectively. This poor patient responsehas been associated with an inefficient/non-personalizedtreatment allocation. Consequently, developing a rapidand efficient preclinical tool to test tumor drug sensitivityfor each patient is hugely needed. Biopsy patient-derivedorganoid (PDO) appears to be a promising tool for devel-oping individualized treatments for patients with PDAC.Several PDO-based platforms are in development world-wide as a guide to optimize therapy by directing tailored treatments. Fil: Fraunhoffer Navarro, Nicolas Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. Aix-Marseille University; Francia Fil: Abuelafia, Analía Meilerman. Aix-Marseille University; Francia Fil: Dusetti, Nelson. Aix-Marseille University; Francia Fil: Iovanna, Juan Lucio. Aix-Marseille University; Francia |
description |
Pancreatic ductal adenocarcinoma (PDAC) is a dismaldisease with a fast evolution and unpredictable treatmentresponse. Nowadays, FOLFIRINOX and gemcitabine are the preferred treatments with a response rateof 33% and 11%, respectively. This poor patient responsehas been associated with an inefficient/non-personalizedtreatment allocation. Consequently, developing a rapidand efficient preclinical tool to test tumor drug sensitivityfor each patient is hugely needed. Biopsy patient-derivedorganoid (PDO) appears to be a promising tool for devel-oping individualized treatments for patients with PDAC.Several PDO-based platforms are in development world-wide as a guide to optimize therapy by directing tailored treatments. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/213097 Fraunhoffer Navarro, Nicolas Alejandro; Abuelafia, Analía Meilerman; Dusetti, Nelson; Iovanna, Juan Lucio; Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool; John Wiley & Sons; Cancer Communications; 42; 10; 10-2022; 1028-1031 2523-3548 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/213097 |
identifier_str_mv |
Fraunhoffer Navarro, Nicolas Alejandro; Abuelafia, Analía Meilerman; Dusetti, Nelson; Iovanna, Juan Lucio; Limitation and challenges in using pancreatic cancer-derived organoids as a preclinical tool; John Wiley & Sons; Cancer Communications; 42; 10; 10-2022; 1028-1031 2523-3548 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/cac2.12335 info:eu-repo/semantics/altIdentifier/doi/10.1002/cac2.12335 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons |
publisher.none.fl_str_mv |
John Wiley & Sons |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613494279766016 |
score |
13.070432 |