Mechanisms involved in the relationship between low calcium intake and high blood pressure

Autores
Villa Etchegoyen, Cecilia; Lombarte, Mercedes; Matamoros, Natalia; Belizan, Jose; Cormick, Gabriela
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is increasing epidemiologic and animal evidence that a low calcium diet increases blood pressure. The aim of this review is to compile the information on the link between low calcium intake and blood pressure. Calcium intake may regulate blood pressure by modifying intracellular calcium in vascular smooth muscle cells and by varying vascular volume through the renin–angiotensin–aldosterone system. Low calcium intake produces a rise of parathyroid gland activity. The parathyroid hormone increases intracellular calcium in vascular smooth muscles resulting in vasoconstriction. Parathyroidectomized animals did not show an increase in blood pressure when fed a low calcium diet as did sham-operated animals. Low calcium intake also increases the synthesis of calcitriol in a direct manner or mediated by parathyroid hormone (PTH). Calcitriol increases intracellular calcium in vascular smooth muscle cells. Both low calcium intake and PTH may stimulate renin release and consequently angiotensin II and aldosterone synthesis. We are willing with this review to promote discussions and contributions to achieve a better understanding of these mechanisms, and if required, the design of future studies.
Fil: Villa Etchegoyen, Cecilia. Universidad de Buenos Aires; Argentina
Fil: Lombarte, Mercedes. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Matamoros, Natalia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Universidad Nacional de La Matanza; Argentina
Materia
BLOOD PRESSURE
CALCIUM INTAKE
PARATHYROID FUNCTION
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
VITAMIN D
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147509
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Mechanisms involved in the relationship between low calcium intake and high blood pressureVilla Etchegoyen, CeciliaLombarte, MercedesMatamoros, NataliaBelizan, JoseCormick, GabrielaBLOOD PRESSURECALCIUM INTAKEPARATHYROID FUNCTIONRENIN-ANGIOTENSIN-ALDOSTERONE SYSTEMVITAMIN Dhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3There is increasing epidemiologic and animal evidence that a low calcium diet increases blood pressure. The aim of this review is to compile the information on the link between low calcium intake and blood pressure. Calcium intake may regulate blood pressure by modifying intracellular calcium in vascular smooth muscle cells and by varying vascular volume through the renin–angiotensin–aldosterone system. Low calcium intake produces a rise of parathyroid gland activity. The parathyroid hormone increases intracellular calcium in vascular smooth muscles resulting in vasoconstriction. Parathyroidectomized animals did not show an increase in blood pressure when fed a low calcium diet as did sham-operated animals. Low calcium intake also increases the synthesis of calcitriol in a direct manner or mediated by parathyroid hormone (PTH). Calcitriol increases intracellular calcium in vascular smooth muscle cells. Both low calcium intake and PTH may stimulate renin release and consequently angiotensin II and aldosterone synthesis. We are willing with this review to promote discussions and contributions to achieve a better understanding of these mechanisms, and if required, the design of future studies.Fil: Villa Etchegoyen, Cecilia. Universidad de Buenos Aires; ArgentinaFil: Lombarte, Mercedes. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Matamoros, Natalia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; ArgentinaFil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Universidad Nacional de La Matanza; ArgentinaMolecular Diversity Preservation International2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147509Villa Etchegoyen, Cecilia; Lombarte, Mercedes; Matamoros, Natalia; Belizan, Jose; Cormick, Gabriela; Mechanisms involved in the relationship between low calcium intake and high blood pressure; Molecular Diversity Preservation International; Nutrients; 11; 5; 5-2019; 1-162072-6643CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6643/11/5/1112info:eu-repo/semantics/altIdentifier/doi/10.3390/nu11051112info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:28:50Zoai:ri.conicet.gov.ar:11336/147509instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:28:51.144CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanisms involved in the relationship between low calcium intake and high blood pressure
title Mechanisms involved in the relationship between low calcium intake and high blood pressure
spellingShingle Mechanisms involved in the relationship between low calcium intake and high blood pressure
Villa Etchegoyen, Cecilia
BLOOD PRESSURE
CALCIUM INTAKE
PARATHYROID FUNCTION
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
VITAMIN D
title_short Mechanisms involved in the relationship between low calcium intake and high blood pressure
title_full Mechanisms involved in the relationship between low calcium intake and high blood pressure
title_fullStr Mechanisms involved in the relationship between low calcium intake and high blood pressure
title_full_unstemmed Mechanisms involved in the relationship between low calcium intake and high blood pressure
title_sort Mechanisms involved in the relationship between low calcium intake and high blood pressure
dc.creator.none.fl_str_mv Villa Etchegoyen, Cecilia
Lombarte, Mercedes
Matamoros, Natalia
Belizan, Jose
Cormick, Gabriela
author Villa Etchegoyen, Cecilia
author_facet Villa Etchegoyen, Cecilia
Lombarte, Mercedes
Matamoros, Natalia
Belizan, Jose
Cormick, Gabriela
author_role author
author2 Lombarte, Mercedes
Matamoros, Natalia
Belizan, Jose
Cormick, Gabriela
author2_role author
author
author
author
dc.subject.none.fl_str_mv BLOOD PRESSURE
CALCIUM INTAKE
PARATHYROID FUNCTION
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
VITAMIN D
topic BLOOD PRESSURE
CALCIUM INTAKE
PARATHYROID FUNCTION
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
VITAMIN D
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There is increasing epidemiologic and animal evidence that a low calcium diet increases blood pressure. The aim of this review is to compile the information on the link between low calcium intake and blood pressure. Calcium intake may regulate blood pressure by modifying intracellular calcium in vascular smooth muscle cells and by varying vascular volume through the renin–angiotensin–aldosterone system. Low calcium intake produces a rise of parathyroid gland activity. The parathyroid hormone increases intracellular calcium in vascular smooth muscles resulting in vasoconstriction. Parathyroidectomized animals did not show an increase in blood pressure when fed a low calcium diet as did sham-operated animals. Low calcium intake also increases the synthesis of calcitriol in a direct manner or mediated by parathyroid hormone (PTH). Calcitriol increases intracellular calcium in vascular smooth muscle cells. Both low calcium intake and PTH may stimulate renin release and consequently angiotensin II and aldosterone synthesis. We are willing with this review to promote discussions and contributions to achieve a better understanding of these mechanisms, and if required, the design of future studies.
Fil: Villa Etchegoyen, Cecilia. Universidad de Buenos Aires; Argentina
Fil: Lombarte, Mercedes. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Matamoros, Natalia. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de La Plata; Argentina
Fil: Belizan, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Cormick, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Universidad Nacional de La Matanza; Argentina
description There is increasing epidemiologic and animal evidence that a low calcium diet increases blood pressure. The aim of this review is to compile the information on the link between low calcium intake and blood pressure. Calcium intake may regulate blood pressure by modifying intracellular calcium in vascular smooth muscle cells and by varying vascular volume through the renin–angiotensin–aldosterone system. Low calcium intake produces a rise of parathyroid gland activity. The parathyroid hormone increases intracellular calcium in vascular smooth muscles resulting in vasoconstriction. Parathyroidectomized animals did not show an increase in blood pressure when fed a low calcium diet as did sham-operated animals. Low calcium intake also increases the synthesis of calcitriol in a direct manner or mediated by parathyroid hormone (PTH). Calcitriol increases intracellular calcium in vascular smooth muscle cells. Both low calcium intake and PTH may stimulate renin release and consequently angiotensin II and aldosterone synthesis. We are willing with this review to promote discussions and contributions to achieve a better understanding of these mechanisms, and if required, the design of future studies.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147509
Villa Etchegoyen, Cecilia; Lombarte, Mercedes; Matamoros, Natalia; Belizan, Jose; Cormick, Gabriela; Mechanisms involved in the relationship between low calcium intake and high blood pressure; Molecular Diversity Preservation International; Nutrients; 11; 5; 5-2019; 1-16
2072-6643
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147509
identifier_str_mv Villa Etchegoyen, Cecilia; Lombarte, Mercedes; Matamoros, Natalia; Belizan, Jose; Cormick, Gabriela; Mechanisms involved in the relationship between low calcium intake and high blood pressure; Molecular Diversity Preservation International; Nutrients; 11; 5; 5-2019; 1-16
2072-6643
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6643/11/5/1112
info:eu-repo/semantics/altIdentifier/doi/10.3390/nu11051112
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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