Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic

Autores
Ferder, Leon Fernando; Martín Giménez, Virna Margarita; Inserra, Felipe; Tajer, Carlos Daniel; Antonietti, Laura; Mariani, Javier; Manucha, Walter Ariel Fernando
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
COVID-19 pandemic reached most of the countries of the world causing death as a result of the inflammatory storm, oxidative imbalance from the severe acute respiratory syndrome. Many laboratories fight against the clock in search of a specific and definitive treatment. Additionally, it is interesting the evaluation -preventive and therapeutic- of the existing pharmacological agents that could be used to avoid or attenuate the severity at the pulmonary level as well as in other organs of the body is of interest. In this regard, there is evidence of vitamin D that -in high doses- could be a promising preventive and therapeutic option, especially if it is considered that this hormone modulates the same inflammatory and oxidative signaling pathways triggered during COVID-19 infection. Similarly, it is useful to highlight that vitamin D is opposed to the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response by COVID-19. Finally, the purpose of this review is to call for reflection and to discuss the suggestion to implement vitamin D for preventive/therapeutic purposes in groups at risk or infected with COVID-19. This proposal could be extended to the entire community as a preventive measure. Also, our objective points to the debate and critical reflection of health professionals and health policymakers in a way that contributes to the development of consistent clinical designs to evaluate the possible benefits of using high doses of vitamin D for the benefit of public health in pandemic time.
Fil: Ferder, Leon Fernando. Universidad Maimónides; Argentina
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Inserra, Felipe. Universidad Maimónides; Argentina
Fil: Tajer, Carlos Daniel. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Antonietti, Laura. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina. Universidad Nacional Arturo Jauretche; Argentina
Fil: Mariani, Javier. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Materia
COVID-19
VITAMIN D
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
PREVENTION/TREATMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115804
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/115804
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemicFerder, Leon FernandoMartín Giménez, Virna MargaritaInserra, FelipeTajer, Carlos DanielAntonietti, LauraMariani, JavierManucha, Walter Ariel FernandoCOVID-19VITAMIN DRENIN-ANGIOTENSIN-ALDOSTERONE SYSTEMPREVENTION/TREATMENThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3COVID-19 pandemic reached most of the countries of the world causing death as a result of the inflammatory storm, oxidative imbalance from the severe acute respiratory syndrome. Many laboratories fight against the clock in search of a specific and definitive treatment. Additionally, it is interesting the evaluation -preventive and therapeutic- of the existing pharmacological agents that could be used to avoid or attenuate the severity at the pulmonary level as well as in other organs of the body is of interest. In this regard, there is evidence of vitamin D that -in high doses- could be a promising preventive and therapeutic option, especially if it is considered that this hormone modulates the same inflammatory and oxidative signaling pathways triggered during COVID-19 infection. Similarly, it is useful to highlight that vitamin D is opposed to the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response by COVID-19. Finally, the purpose of this review is to call for reflection and to discuss the suggestion to implement vitamin D for preventive/therapeutic purposes in groups at risk or infected with COVID-19. This proposal could be extended to the entire community as a preventive measure. Also, our objective points to the debate and critical reflection of health professionals and health policymakers in a way that contributes to the development of consistent clinical designs to evaluate the possible benefits of using high doses of vitamin D for the benefit of public health in pandemic time.Fil: Ferder, Leon Fernando. Universidad Maimónides; ArgentinaFil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Inserra, Felipe. Universidad Maimónides; ArgentinaFil: Tajer, Carlos Daniel. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Antonietti, Laura. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina. Universidad Nacional Arturo Jauretche; ArgentinaFil: Mariani, Javier. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; ArgentinaAmerican Physiological Society2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/115804Ferder, Leon Fernando; Martín Giménez, Virna Margarita; Inserra, Felipe; Tajer, Carlos Daniel; Antonietti, Laura; et al.; Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic; American Physiological Society; American Journal Of Physiology-lung Cellular And Molecular Physiology; 319; 6; 7-2020; L941-L9481040-0605CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/abs/10.1152/ajplung.00186.2020info:eu-repo/semantics/altIdentifier/doi/10.1152/ajplung.00186.2020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:25Zoai:ri.conicet.gov.ar:11336/115804instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:26.202CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
title Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
spellingShingle Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
Ferder, Leon Fernando
COVID-19
VITAMIN D
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
PREVENTION/TREATMENT
title_short Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
title_full Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
title_fullStr Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
title_full_unstemmed Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
title_sort Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic
dc.creator.none.fl_str_mv Ferder, Leon Fernando
Martín Giménez, Virna Margarita
Inserra, Felipe
Tajer, Carlos Daniel
Antonietti, Laura
Mariani, Javier
Manucha, Walter Ariel Fernando
author Ferder, Leon Fernando
author_facet Ferder, Leon Fernando
Martín Giménez, Virna Margarita
Inserra, Felipe
Tajer, Carlos Daniel
Antonietti, Laura
Mariani, Javier
Manucha, Walter Ariel Fernando
author_role author
author2 Martín Giménez, Virna Margarita
Inserra, Felipe
Tajer, Carlos Daniel
Antonietti, Laura
Mariani, Javier
Manucha, Walter Ariel Fernando
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
VITAMIN D
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
PREVENTION/TREATMENT
topic COVID-19
VITAMIN D
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
PREVENTION/TREATMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv COVID-19 pandemic reached most of the countries of the world causing death as a result of the inflammatory storm, oxidative imbalance from the severe acute respiratory syndrome. Many laboratories fight against the clock in search of a specific and definitive treatment. Additionally, it is interesting the evaluation -preventive and therapeutic- of the existing pharmacological agents that could be used to avoid or attenuate the severity at the pulmonary level as well as in other organs of the body is of interest. In this regard, there is evidence of vitamin D that -in high doses- could be a promising preventive and therapeutic option, especially if it is considered that this hormone modulates the same inflammatory and oxidative signaling pathways triggered during COVID-19 infection. Similarly, it is useful to highlight that vitamin D is opposed to the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response by COVID-19. Finally, the purpose of this review is to call for reflection and to discuss the suggestion to implement vitamin D for preventive/therapeutic purposes in groups at risk or infected with COVID-19. This proposal could be extended to the entire community as a preventive measure. Also, our objective points to the debate and critical reflection of health professionals and health policymakers in a way that contributes to the development of consistent clinical designs to evaluate the possible benefits of using high doses of vitamin D for the benefit of public health in pandemic time.
Fil: Ferder, Leon Fernando. Universidad Maimónides; Argentina
Fil: Martín Giménez, Virna Margarita. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Inserra, Felipe. Universidad Maimónides; Argentina
Fil: Tajer, Carlos Daniel. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Antonietti, Laura. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina. Universidad Nacional Arturo Jauretche; Argentina
Fil: Mariani, Javier. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
description COVID-19 pandemic reached most of the countries of the world causing death as a result of the inflammatory storm, oxidative imbalance from the severe acute respiratory syndrome. Many laboratories fight against the clock in search of a specific and definitive treatment. Additionally, it is interesting the evaluation -preventive and therapeutic- of the existing pharmacological agents that could be used to avoid or attenuate the severity at the pulmonary level as well as in other organs of the body is of interest. In this regard, there is evidence of vitamin D that -in high doses- could be a promising preventive and therapeutic option, especially if it is considered that this hormone modulates the same inflammatory and oxidative signaling pathways triggered during COVID-19 infection. Similarly, it is useful to highlight that vitamin D is opposed to the actions of the renin-angiotensin system, which has a determining role in the pathophysiology of the inflammatory response by COVID-19. Finally, the purpose of this review is to call for reflection and to discuss the suggestion to implement vitamin D for preventive/therapeutic purposes in groups at risk or infected with COVID-19. This proposal could be extended to the entire community as a preventive measure. Also, our objective points to the debate and critical reflection of health professionals and health policymakers in a way that contributes to the development of consistent clinical designs to evaluate the possible benefits of using high doses of vitamin D for the benefit of public health in pandemic time.
publishDate 2020
dc.date.none.fl_str_mv 2020-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115804
Ferder, Leon Fernando; Martín Giménez, Virna Margarita; Inserra, Felipe; Tajer, Carlos Daniel; Antonietti, Laura; et al.; Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic; American Physiological Society; American Journal Of Physiology-lung Cellular And Molecular Physiology; 319; 6; 7-2020; L941-L948
1040-0605
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115804
identifier_str_mv Ferder, Leon Fernando; Martín Giménez, Virna Margarita; Inserra, Felipe; Tajer, Carlos Daniel; Antonietti, Laura; et al.; Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic; American Physiological Society; American Journal Of Physiology-lung Cellular And Molecular Physiology; 319; 6; 7-2020; L941-L948
1040-0605
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/abs/10.1152/ajplung.00186.2020
info:eu-repo/semantics/altIdentifier/doi/10.1152/ajplung.00186.2020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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