Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels

Autores
Ciocci Pardo, Alejandro; Rinaldi, Gustavo Juan; Mosca, Susana Maria
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim was to study the mitochondrial Ca2+ handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2+ addition, Ca2+-retention capacity (CRC) by calcium green method, and membrane potential (ΔΨm) were assessed. SBP was 124 ± 1 (WKY) and 235 ± 6 mm Hg (SHR). CRC, Ca2+ response and ΔΨm were lower in SHR than WKY mitochondria. The conclusion is: the more depolarized state of SHR than WKY mitochondria results in an abnormal Ca2+ handling and this event is closely associated with the SBP.
Fil: Ciocci Pardo, Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Rinaldi, Gustavo Juan. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Mosca, Susana Maria. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Materia
Wky And Shr
Mitochondria
Calcium
Blood Pressure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/11936
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/11936
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levelsCiocci Pardo, AlejandroRinaldi, Gustavo JuanMosca, Susana MariaWky And ShrMitochondriaCalciumBlood Pressurehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim was to study the mitochondrial Ca2+ handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2+ addition, Ca2+-retention capacity (CRC) by calcium green method, and membrane potential (ΔΨm) were assessed. SBP was 124 ± 1 (WKY) and 235 ± 6 mm Hg (SHR). CRC, Ca2+ response and ΔΨm were lower in SHR than WKY mitochondria. The conclusion is: the more depolarized state of SHR than WKY mitochondria results in an abnormal Ca2+ handling and this event is closely associated with the SBP.Fil: Ciocci Pardo, Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Rinaldi, Gustavo Juan. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaFil: Mosca, Susana Maria. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; ArgentinaElsevier Science2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/11936Ciocci Pardo, Alejandro; Rinaldi, Gustavo Juan; Mosca, Susana Maria; Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels; Elsevier Science; Mitochondrion; 20; 1-2015; 75-811567-7249enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.mito.2014.12.003info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S156772491400186X?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:32Zoai:ri.conicet.gov.ar:11336/11936instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:32.869CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
title Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
spellingShingle Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
Ciocci Pardo, Alejandro
Wky And Shr
Mitochondria
Calcium
Blood Pressure
title_short Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
title_full Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
title_fullStr Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
title_full_unstemmed Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
title_sort Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels
dc.creator.none.fl_str_mv Ciocci Pardo, Alejandro
Rinaldi, Gustavo Juan
Mosca, Susana Maria
author Ciocci Pardo, Alejandro
author_facet Ciocci Pardo, Alejandro
Rinaldi, Gustavo Juan
Mosca, Susana Maria
author_role author
author2 Rinaldi, Gustavo Juan
Mosca, Susana Maria
author2_role author
author
dc.subject.none.fl_str_mv Wky And Shr
Mitochondria
Calcium
Blood Pressure
topic Wky And Shr
Mitochondria
Calcium
Blood Pressure
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim was to study the mitochondrial Ca2+ handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2+ addition, Ca2+-retention capacity (CRC) by calcium green method, and membrane potential (ΔΨm) were assessed. SBP was 124 ± 1 (WKY) and 235 ± 6 mm Hg (SHR). CRC, Ca2+ response and ΔΨm were lower in SHR than WKY mitochondria. The conclusion is: the more depolarized state of SHR than WKY mitochondria results in an abnormal Ca2+ handling and this event is closely associated with the SBP.
Fil: Ciocci Pardo, Alejandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Rinaldi, Gustavo Juan. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
Fil: Mosca, Susana Maria. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico la Plata. Centro de Investigaciones Cardiovasculares "dr. Horacio Eugenio Cingolani"; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
description The aim was to study the mitochondrial Ca2+ handling of mitochondria isolated from normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) hearts and to establish a possible correlation with systolic blood pressure (SBP). Mitochondrial swelling after Ca2+ addition, Ca2+-retention capacity (CRC) by calcium green method, and membrane potential (ΔΨm) were assessed. SBP was 124 ± 1 (WKY) and 235 ± 6 mm Hg (SHR). CRC, Ca2+ response and ΔΨm were lower in SHR than WKY mitochondria. The conclusion is: the more depolarized state of SHR than WKY mitochondria results in an abnormal Ca2+ handling and this event is closely associated with the SBP.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/11936
Ciocci Pardo, Alejandro; Rinaldi, Gustavo Juan; Mosca, Susana Maria; Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels; Elsevier Science; Mitochondrion; 20; 1-2015; 75-81
1567-7249
url http://hdl.handle.net/11336/11936
identifier_str_mv Ciocci Pardo, Alejandro; Rinaldi, Gustavo Juan; Mosca, Susana Maria; Mitochondrial calcium handling in normotensive and spontaneously hypertensive rats: Correlation with systolic blood pressure levels; Elsevier Science; Mitochondrion; 20; 1-2015; 75-81
1567-7249
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mito.2014.12.003
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S156772491400186X?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268738141814784
score 13.13397

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