Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis

Autores
Fantilli, Anabella Clara; Trinks, Julieta; Marciano, Sebastian; Zárate, Raúl Fabián; Balderramo, Domingo; Martínez Wassaf, Maribel G.; Haddad, Leila; Gadano, Adrián; Debes, José D.; Pisano, María Belén; Ré, Viviana Elizabeth
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. Materials and methods: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). Results: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9-11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8-36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81-11.58); p<0.001]. Conclusion: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.
Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Trinks, Julieta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Marciano, Sebastian. Hospital Italiano; Argentina
Fil: Zárate, Raúl Fabián. Hospital Córdoba; Argentina
Fil: Balderramo, Domingo. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Martínez Wassaf, Maribel G.. LACE Laboratorios; Argentina
Fil: Haddad, Leila. Hospital Italiano; Argentina
Fil: Gadano, Adrián. Hospital Italiano; Argentina
Fil: Debes, José D.. University of Minnesota; Estados Unidos
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
HEV
CIRRHOSIS
ALCOHOL USE DISORDER
ARGENTINA
SEROPREVALENCE
ALCOHOL-RELATED CIRRHOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130275
Acceder
id CONICETDig_f28691ccd74d826d345bcfcd8287c11f
oai_identifier_str oai:ri.conicet.gov.ar:11336/130275
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosisFantilli, Anabella ClaraTrinks, JulietaMarciano, SebastianZárate, Raúl FabiánBalderramo, DomingoMartínez Wassaf, Maribel G.Haddad, LeilaGadano, AdriánDebes, José D.Pisano, María BelénRé, Viviana ElizabethHEVCIRRHOSISALCOHOL USE DISORDERARGENTINASEROPREVALENCEALCOHOL-RELATED CIRRHOSIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. Materials and methods: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). Results: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9-11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8-36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81-11.58); p<0.001]. Conclusion: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Trinks, Julieta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Marciano, Sebastian. Hospital Italiano; ArgentinaFil: Zárate, Raúl Fabián. Hospital Córdoba; ArgentinaFil: Balderramo, Domingo. Instituto Universitario del Hospital Italiano de Buenos Aires; ArgentinaFil: Martínez Wassaf, Maribel G.. LACE Laboratorios; ArgentinaFil: Haddad, Leila. Hospital Italiano; ArgentinaFil: Gadano, Adrián. Hospital Italiano; ArgentinaFil: Debes, José D.. University of Minnesota; Estados UnidosFil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaPublic Library of Science2019-10-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130275Fantilli, Anabella Clara; Trinks, Julieta; Marciano, Sebastian; Zárate, Raúl Fabián; Balderramo, Domingo; et al.; Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis; Public Library of Science; Plos One; 14; 10; 24-10-2019; 1-91932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0224404info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224404info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:07Zoai:ri.conicet.gov.ar:11336/130275instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:07.893CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
title Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
spellingShingle Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
Fantilli, Anabella Clara
HEV
CIRRHOSIS
ALCOHOL USE DISORDER
ARGENTINA
SEROPREVALENCE
ALCOHOL-RELATED CIRRHOSIS
title_short Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
title_full Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
title_fullStr Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
title_full_unstemmed Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
title_sort Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis
dc.creator.none.fl_str_mv Fantilli, Anabella Clara
Trinks, Julieta
Marciano, Sebastian
Zárate, Raúl Fabián
Balderramo, Domingo
Martínez Wassaf, Maribel G.
Haddad, Leila
Gadano, Adrián
Debes, José D.
Pisano, María Belén
Ré, Viviana Elizabeth
author Fantilli, Anabella Clara
author_facet Fantilli, Anabella Clara
Trinks, Julieta
Marciano, Sebastian
Zárate, Raúl Fabián
Balderramo, Domingo
Martínez Wassaf, Maribel G.
Haddad, Leila
Gadano, Adrián
Debes, José D.
Pisano, María Belén
Ré, Viviana Elizabeth
author_role author
author2 Trinks, Julieta
Marciano, Sebastian
Zárate, Raúl Fabián
Balderramo, Domingo
Martínez Wassaf, Maribel G.
Haddad, Leila
Gadano, Adrián
Debes, José D.
Pisano, María Belén
Ré, Viviana Elizabeth
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HEV
CIRRHOSIS
ALCOHOL USE DISORDER
ARGENTINA
SEROPREVALENCE
ALCOHOL-RELATED CIRRHOSIS
topic HEV
CIRRHOSIS
ALCOHOL USE DISORDER
ARGENTINA
SEROPREVALENCE
ALCOHOL-RELATED CIRRHOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. Materials and methods: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). Results: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9-11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8-36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81-11.58); p<0.001]. Conclusion: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.
Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Trinks, Julieta. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Marciano, Sebastian. Hospital Italiano; Argentina
Fil: Zárate, Raúl Fabián. Hospital Córdoba; Argentina
Fil: Balderramo, Domingo. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina
Fil: Martínez Wassaf, Maribel G.. LACE Laboratorios; Argentina
Fil: Haddad, Leila. Hospital Italiano; Argentina
Fil: Gadano, Adrián. Hospital Italiano; Argentina
Fil: Debes, José D.. University of Minnesota; Estados Unidos
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Introduction: Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe the frequency of HEV infection and associated risk factors in patients with cirrhosis from Argentina. Materials and methods: We evaluated HEV seroprevalence (IgG anti-HEV) and acute infections (IgM and RNA) in patients with cirrhosis (n = 140) vs. healthy controls (n = 300). Additionally, we compared the same outcomes in individuals with alcohol-related cirrhosis (n = 43) vs. patients with alcohol use disorder (without cirrhosis, n = 72). Results: The overall HEV seroprevalence in the cohort of subjects with cirrhosis was 25% (35/140), compared to 4% in the healthy control group [12/300; OR = 8; (95% CI = 4-15.99); p<0.05]. HEV seropositivity was significantly higher in alcohol-related cirrhosis compared to other causes of cirrhosis [39.5% vs. 12.4%; OR = 4.71; (95% CI = 1.9-11.6); p<0.05] and to healthy controls [OR = 15.7; (95% CI = 6.8-36.4); p = 0.0001]. The HEV seroprevalence in alcoholic-related cirrhosis vs. with alcohol use disorder was 39.5% vs. 12.5% [OR = 4.58; (95% CI = 1.81-11.58); p<0.001]. Conclusion: We found a high seroprevalence of HEV in patients with cirrhosis and in individuals with alcohol use disorder. The simultaneous presence of both factors (cirrhosis + alcohol) showed more association to HEV infection. Larger studies with prospective follow up are needed to further clarify this interaction.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-24
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130275
Fantilli, Anabella Clara; Trinks, Julieta; Marciano, Sebastian; Zárate, Raúl Fabián; Balderramo, Domingo; et al.; Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis; Public Library of Science; Plos One; 14; 10; 24-10-2019; 1-9
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130275
identifier_str_mv Fantilli, Anabella Clara; Trinks, Julieta; Marciano, Sebastian; Zárate, Raúl Fabián; Balderramo, Domingo; et al.; Unexpected high seroprevalence of hepatitis e virus in patients with alcohol-related cirrhosis; Public Library of Science; Plos One; 14; 10; 24-10-2019; 1-9
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0224404
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224404
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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