Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study

Autores
Terg, Rubén; Casciato, Paola; Garbe, Cecilia; Cartier, Mariano; Stieben Teodoro; Mendizabal, Manuel; Niveyro, Carla; Benavides Javier; Colombato, Luis; Berbara, Daniel; Salgado, Pablo; Barreyro, Fernando Javier; Fassio, Eduardo; Gadano, Adrián Carlos
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND & AIM Retrospective studies show an association between proton pump inhibitor (PPI) therapy and spontaneous bacterial peritonitis (SBP). We investigate the relationship between PPI and SBP in decompensated cirrhotic patients in a large nationwide prospective study. METHODS: Seven hundred seventy patients with a diagnosis of decompensated cirrhosis were admitted consecutively in 23 hospitals in Argentina from March 2011 to April 2012; the patients were carefully investigated for PPI consumption in the previous 3 months. In total, 251 patients were excluded because of active gastrointestinal hemorrhage, antibiotic use during the preceding weeks, HIV-positive status and immunosuppressive therapy. RESULTS: Two hundred twenty-six out of 519 patients (43.5%) had received PPI therapy within the last 3 months. In 135 patients, PPIs were administered for longer than 2 weeks. A bacterial infection was shown in 255 patients (49.1%). SBP was diagnosed in 95 patients out of 394 patients with ascites (24.7%). There was no significant difference in the rate of PPI consumption between the infected and the non-infected patients (44.3% vs. 42.8%) or between the SBP patients and the patients with ascites without SBP (46% vs. 42%). In the SBP patients, the duration of PPI administration did not influence the rate of SBP occurrence. The type of bacteria and the origin of SBP infection were similar in the patients with and without PPI.CONCLUSION: In the current large, multicenter, prospective study, PPI therapy, specifically evaluated at admission of consecutive cirrhotic patients, was not associated with a higher risk of SBP.
Fil: Terg, Rubén. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
Fil: Casciato, Paola. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garbe, Cecilia. Ministerio de Salud de la Nación. Hospital Nacional Alejandro Posadas; Argentina
Fil: Cartier, Mariano. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
Fil: Stieben Teodoro. Provincia de Entre Rios. Ministerio de Salud. Hospital San Martín; Argentina
Fil: Mendizabal, Manuel. Hospital Universitario Austral; Argentina
Fil: Niveyro, Carla. Provincia de Misiones. Hospital Escuela de Agudos Dr. Ramon Madariaga; Argentina
Fil: Benavides Javier. Hospital Británico de Buenos Aires; Argentina
Fil: Colombato, Luis. Hospital Británico de Buenos Aires; Argentina
Fil: Berbara, Daniel. Provincia de Misiones. Hospital Escuela de Agudos Dr. Ramón Madariaga; Argentina
Fil: Salgado, Pablo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
Fil: Barreyro, Fernando Javier. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fassio, Eduardo. Ministerio de Salud de la Nación. Hospital Nacional Alejandro Posadas; Argentina
Fil: Gadano, Adrián Carlos. Hospital Italiano; Argentina
Materia
Cirrhosis
Proton Pump Inhibitor
Spontaneous Bacterial Peritonitis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37473
Acceder
id CONICETDig_93c3e840650ba16627bb1b5e1413bfac
oai_identifier_str oai:ri.conicet.gov.ar:11336/37473
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective studyTerg, RubénCasciato, PaolaGarbe, CeciliaCartier, MarianoStieben TeodoroMendizabal, ManuelNiveyro, CarlaBenavides JavierColombato, LuisBerbara, DanielSalgado, PabloBarreyro, Fernando JavierFassio, EduardoGadano, Adrián CarlosCirrhosisProton Pump InhibitorSpontaneous Bacterial Peritonitishttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUND & AIM Retrospective studies show an association between proton pump inhibitor (PPI) therapy and spontaneous bacterial peritonitis (SBP). We investigate the relationship between PPI and SBP in decompensated cirrhotic patients in a large nationwide prospective study. METHODS: Seven hundred seventy patients with a diagnosis of decompensated cirrhosis were admitted consecutively in 23 hospitals in Argentina from March 2011 to April 2012; the patients were carefully investigated for PPI consumption in the previous 3 months. In total, 251 patients were excluded because of active gastrointestinal hemorrhage, antibiotic use during the preceding weeks, HIV-positive status and immunosuppressive therapy. RESULTS: Two hundred twenty-six out of 519 patients (43.5%) had received PPI therapy within the last 3 months. In 135 patients, PPIs were administered for longer than 2 weeks. A bacterial infection was shown in 255 patients (49.1%). SBP was diagnosed in 95 patients out of 394 patients with ascites (24.7%). There was no significant difference in the rate of PPI consumption between the infected and the non-infected patients (44.3% vs. 42.8%) or between the SBP patients and the patients with ascites without SBP (46% vs. 42%). In the SBP patients, the duration of PPI administration did not influence the rate of SBP occurrence. The type of bacteria and the origin of SBP infection were similar in the patients with and without PPI.CONCLUSION: In the current large, multicenter, prospective study, PPI therapy, specifically evaluated at admission of consecutive cirrhotic patients, was not associated with a higher risk of SBP.Fil: Terg, Rubén. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; ArgentinaFil: Casciato, Paola. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garbe, Cecilia. Ministerio de Salud de la Nación. Hospital Nacional Alejandro Posadas; ArgentinaFil: Cartier, Mariano. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; ArgentinaFil: Stieben Teodoro. Provincia de Entre Rios. Ministerio de Salud. Hospital San Martín; ArgentinaFil: Mendizabal, Manuel. Hospital Universitario Austral; ArgentinaFil: Niveyro, Carla. Provincia de Misiones. Hospital Escuela de Agudos Dr. Ramon Madariaga; ArgentinaFil: Benavides Javier. Hospital Británico de Buenos Aires; ArgentinaFil: Colombato, Luis. Hospital Británico de Buenos Aires; ArgentinaFil: Berbara, Daniel. Provincia de Misiones. Hospital Escuela de Agudos Dr. Ramón Madariaga; ArgentinaFil: Salgado, Pablo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; ArgentinaFil: Barreyro, Fernando Javier. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fassio, Eduardo. Ministerio de Salud de la Nación. Hospital Nacional Alejandro Posadas; ArgentinaFil: Gadano, Adrián Carlos. Hospital Italiano; ArgentinaElsevier2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37473Terg, Rubén; Casciato, Paola; Garbe, Cecilia; Cartier, Mariano; Stieben Teodoro; et al.; Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study; Elsevier; Journal Of Hepatology; 62; 5; 3-2015; 1056-10600168-82781600-0641CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jhep.2014.11.036info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016882781400885Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:23:23Zoai:ri.conicet.gov.ar:11336/37473instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:23.258CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study
title Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study
spellingShingle Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study
Terg, Rubén
Cirrhosis
Proton Pump Inhibitor
Spontaneous Bacterial Peritonitis
title_short Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study
title_full Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study
title_fullStr Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study
title_full_unstemmed Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study
title_sort Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study
dc.creator.none.fl_str_mv Terg, Rubén
Casciato, Paola
Garbe, Cecilia
Cartier, Mariano
Stieben Teodoro
Mendizabal, Manuel
Niveyro, Carla
Benavides Javier
Colombato, Luis
Berbara, Daniel
Salgado, Pablo
Barreyro, Fernando Javier
Fassio, Eduardo
Gadano, Adrián Carlos
author Terg, Rubén
author_facet Terg, Rubén
Casciato, Paola
Garbe, Cecilia
Cartier, Mariano
Stieben Teodoro
Mendizabal, Manuel
Niveyro, Carla
Benavides Javier
Colombato, Luis
Berbara, Daniel
Salgado, Pablo
Barreyro, Fernando Javier
Fassio, Eduardo
Gadano, Adrián Carlos
author_role author
author2 Casciato, Paola
Garbe, Cecilia
Cartier, Mariano
Stieben Teodoro
Mendizabal, Manuel
Niveyro, Carla
Benavides Javier
Colombato, Luis
Berbara, Daniel
Salgado, Pablo
Barreyro, Fernando Javier
Fassio, Eduardo
Gadano, Adrián Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cirrhosis
Proton Pump Inhibitor
Spontaneous Bacterial Peritonitis
topic Cirrhosis
Proton Pump Inhibitor
Spontaneous Bacterial Peritonitis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND & AIM Retrospective studies show an association between proton pump inhibitor (PPI) therapy and spontaneous bacterial peritonitis (SBP). We investigate the relationship between PPI and SBP in decompensated cirrhotic patients in a large nationwide prospective study. METHODS: Seven hundred seventy patients with a diagnosis of decompensated cirrhosis were admitted consecutively in 23 hospitals in Argentina from March 2011 to April 2012; the patients were carefully investigated for PPI consumption in the previous 3 months. In total, 251 patients were excluded because of active gastrointestinal hemorrhage, antibiotic use during the preceding weeks, HIV-positive status and immunosuppressive therapy. RESULTS: Two hundred twenty-six out of 519 patients (43.5%) had received PPI therapy within the last 3 months. In 135 patients, PPIs were administered for longer than 2 weeks. A bacterial infection was shown in 255 patients (49.1%). SBP was diagnosed in 95 patients out of 394 patients with ascites (24.7%). There was no significant difference in the rate of PPI consumption between the infected and the non-infected patients (44.3% vs. 42.8%) or between the SBP patients and the patients with ascites without SBP (46% vs. 42%). In the SBP patients, the duration of PPI administration did not influence the rate of SBP occurrence. The type of bacteria and the origin of SBP infection were similar in the patients with and without PPI.CONCLUSION: In the current large, multicenter, prospective study, PPI therapy, specifically evaluated at admission of consecutive cirrhotic patients, was not associated with a higher risk of SBP.
Fil: Terg, Rubén. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
Fil: Casciato, Paola. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garbe, Cecilia. Ministerio de Salud de la Nación. Hospital Nacional Alejandro Posadas; Argentina
Fil: Cartier, Mariano. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
Fil: Stieben Teodoro. Provincia de Entre Rios. Ministerio de Salud. Hospital San Martín; Argentina
Fil: Mendizabal, Manuel. Hospital Universitario Austral; Argentina
Fil: Niveyro, Carla. Provincia de Misiones. Hospital Escuela de Agudos Dr. Ramon Madariaga; Argentina
Fil: Benavides Javier. Hospital Británico de Buenos Aires; Argentina
Fil: Colombato, Luis. Hospital Británico de Buenos Aires; Argentina
Fil: Berbara, Daniel. Provincia de Misiones. Hospital Escuela de Agudos Dr. Ramón Madariaga; Argentina
Fil: Salgado, Pablo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología ; Argentina
Fil: Barreyro, Fernando Javier. Hospital Británico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fassio, Eduardo. Ministerio de Salud de la Nación. Hospital Nacional Alejandro Posadas; Argentina
Fil: Gadano, Adrián Carlos. Hospital Italiano; Argentina
description BACKGROUND & AIM Retrospective studies show an association between proton pump inhibitor (PPI) therapy and spontaneous bacterial peritonitis (SBP). We investigate the relationship between PPI and SBP in decompensated cirrhotic patients in a large nationwide prospective study. METHODS: Seven hundred seventy patients with a diagnosis of decompensated cirrhosis were admitted consecutively in 23 hospitals in Argentina from March 2011 to April 2012; the patients were carefully investigated for PPI consumption in the previous 3 months. In total, 251 patients were excluded because of active gastrointestinal hemorrhage, antibiotic use during the preceding weeks, HIV-positive status and immunosuppressive therapy. RESULTS: Two hundred twenty-six out of 519 patients (43.5%) had received PPI therapy within the last 3 months. In 135 patients, PPIs were administered for longer than 2 weeks. A bacterial infection was shown in 255 patients (49.1%). SBP was diagnosed in 95 patients out of 394 patients with ascites (24.7%). There was no significant difference in the rate of PPI consumption between the infected and the non-infected patients (44.3% vs. 42.8%) or between the SBP patients and the patients with ascites without SBP (46% vs. 42%). In the SBP patients, the duration of PPI administration did not influence the rate of SBP occurrence. The type of bacteria and the origin of SBP infection were similar in the patients with and without PPI.CONCLUSION: In the current large, multicenter, prospective study, PPI therapy, specifically evaluated at admission of consecutive cirrhotic patients, was not associated with a higher risk of SBP.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37473
Terg, Rubén; Casciato, Paola; Garbe, Cecilia; Cartier, Mariano; Stieben Teodoro; et al.; Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study; Elsevier; Journal Of Hepatology; 62; 5; 3-2015; 1056-1060
0168-8278
1600-0641
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37473
identifier_str_mv Terg, Rubén; Casciato, Paola; Garbe, Cecilia; Cartier, Mariano; Stieben Teodoro; et al.; Proton pump inhibitor therapy does not increase the incidence of spontaneous bacterial peritonitis in cirrhosis: a multicenter prospective study; Elsevier; Journal Of Hepatology; 62; 5; 3-2015; 1056-1060
0168-8278
1600-0641
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jhep.2014.11.036
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016882781400885X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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