Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure

Autores
Fantilli, Anabella Clara; López Villa, Sarah Daniela; Zerega, Alina; Di Cola Bucciarelli, Guadalupe; López, Luis; Wassaf Martínez, Maribel; Pisano, María Belén; Ré, Viviana Elizabeth
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The hepatitis E virus (HEV) infection has been described as a causing factor for acute-on-chronic-liverfailure (ACLF) in patients with underlying chronic liver disease (CLD), such as chronic hepatitis or cirrhosis, which could end in the failure of one or more organs and high short-term mortality. There are scarce data about the association of HEV in patients with chronic liver disorders in South America. Case presentation: A 56-year-old hypertensive male with a history of type 2 diabetes was diagnosed with alcoholrelated-liver cirrhosis in February 2019. A year later, the patient was admitted to hospital due to fatigue, jaundice and acholia. No evidence of hepatitis A virus, hepatitis B virus, hepatitis C virus, Epstein–Barr virus, herpes zoster virus and cytomegalovirus infections were found. Nevertheless, in February and March, 2020 the patient was positive for HEVIgM and HEV-IgG, and HEV genotype 3 RNA was detected in sera. Afterwards, he presented grade I hepatic encephalopathy and, therefore, was diagnosed with acute hepatitis E-on-chronic liver disease. The patient reported a recent travel to the Argentine coast, where he consumed seafood. Besides, he reveled to have consumed pork meat and had no history of blood transfusion. Conclusion: This report describes a unique case of hepatitis E virus infection in a patient with alcohol-related cirrhosis. This is the frst report of a patient with HEV-related ACLF in Argentina and it invokes the importance of HEV surveillance and treatment among patients with CLD, such as alcohol-related cirrhosis.
Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: López Villa, Sarah Daniela. Instituto Modelo de Cardiología; Argentina
Fil: Zerega, Alina. Sanatorio Allende; Argentina
Fil: Di Cola Bucciarelli, Guadalupe. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: López, Luis. Instituto Modelo de Cardiología; Argentina
Fil: Wassaf Martínez, Maribel. LACE Laboratorios; Argentina
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
ACUTE-ON-CHRONIC HEPATITIS
ARGENTINA
CHRONIC LIVER DISEASE
CIRRHOSIS
HEV
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/158066
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/158066
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failureFantilli, Anabella ClaraLópez Villa, Sarah DanielaZerega, AlinaDi Cola Bucciarelli, GuadalupeLópez, LuisWassaf Martínez, MaribelPisano, María BelénRé, Viviana ElizabethACUTE-ON-CHRONIC HEPATITISARGENTINACHRONIC LIVER DISEASECIRRHOSISHEVhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: The hepatitis E virus (HEV) infection has been described as a causing factor for acute-on-chronic-liverfailure (ACLF) in patients with underlying chronic liver disease (CLD), such as chronic hepatitis or cirrhosis, which could end in the failure of one or more organs and high short-term mortality. There are scarce data about the association of HEV in patients with chronic liver disorders in South America. Case presentation: A 56-year-old hypertensive male with a history of type 2 diabetes was diagnosed with alcoholrelated-liver cirrhosis in February 2019. A year later, the patient was admitted to hospital due to fatigue, jaundice and acholia. No evidence of hepatitis A virus, hepatitis B virus, hepatitis C virus, Epstein–Barr virus, herpes zoster virus and cytomegalovirus infections were found. Nevertheless, in February and March, 2020 the patient was positive for HEVIgM and HEV-IgG, and HEV genotype 3 RNA was detected in sera. Afterwards, he presented grade I hepatic encephalopathy and, therefore, was diagnosed with acute hepatitis E-on-chronic liver disease. The patient reported a recent travel to the Argentine coast, where he consumed seafood. Besides, he reveled to have consumed pork meat and had no history of blood transfusion. Conclusion: This report describes a unique case of hepatitis E virus infection in a patient with alcohol-related cirrhosis. This is the frst report of a patient with HEV-related ACLF in Argentina and it invokes the importance of HEV surveillance and treatment among patients with CLD, such as alcohol-related cirrhosis.Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: López Villa, Sarah Daniela. Instituto Modelo de Cardiología; ArgentinaFil: Zerega, Alina. Sanatorio Allende; ArgentinaFil: Di Cola Bucciarelli, Guadalupe. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: López, Luis. Instituto Modelo de Cardiología; ArgentinaFil: Wassaf Martínez, Maribel. LACE Laboratorios; ArgentinaFil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaBioMed Central2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/158066Fantilli, Anabella Clara; López Villa, Sarah Daniela; Zerega, Alina; Di Cola Bucciarelli, Guadalupe; López, Luis; et al.; Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure; BioMed Central; Virology Journal; 18; 1; 12-2021; 1-61743-422X1743-422XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1186/s12985-021-01714-winfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:37Zoai:ri.conicet.gov.ar:11336/158066instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:37.674CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
title Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
spellingShingle Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
Fantilli, Anabella Clara
ACUTE-ON-CHRONIC HEPATITIS
ARGENTINA
CHRONIC LIVER DISEASE
CIRRHOSIS
HEV
title_short Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
title_full Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
title_fullStr Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
title_full_unstemmed Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
title_sort Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure
dc.creator.none.fl_str_mv Fantilli, Anabella Clara
López Villa, Sarah Daniela
Zerega, Alina
Di Cola Bucciarelli, Guadalupe
López, Luis
Wassaf Martínez, Maribel
Pisano, María Belén
Ré, Viviana Elizabeth
author Fantilli, Anabella Clara
author_facet Fantilli, Anabella Clara
López Villa, Sarah Daniela
Zerega, Alina
Di Cola Bucciarelli, Guadalupe
López, Luis
Wassaf Martínez, Maribel
Pisano, María Belén
Ré, Viviana Elizabeth
author_role author
author2 López Villa, Sarah Daniela
Zerega, Alina
Di Cola Bucciarelli, Guadalupe
López, Luis
Wassaf Martínez, Maribel
Pisano, María Belén
Ré, Viviana Elizabeth
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ACUTE-ON-CHRONIC HEPATITIS
ARGENTINA
CHRONIC LIVER DISEASE
CIRRHOSIS
HEV
topic ACUTE-ON-CHRONIC HEPATITIS
ARGENTINA
CHRONIC LIVER DISEASE
CIRRHOSIS
HEV
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The hepatitis E virus (HEV) infection has been described as a causing factor for acute-on-chronic-liverfailure (ACLF) in patients with underlying chronic liver disease (CLD), such as chronic hepatitis or cirrhosis, which could end in the failure of one or more organs and high short-term mortality. There are scarce data about the association of HEV in patients with chronic liver disorders in South America. Case presentation: A 56-year-old hypertensive male with a history of type 2 diabetes was diagnosed with alcoholrelated-liver cirrhosis in February 2019. A year later, the patient was admitted to hospital due to fatigue, jaundice and acholia. No evidence of hepatitis A virus, hepatitis B virus, hepatitis C virus, Epstein–Barr virus, herpes zoster virus and cytomegalovirus infections were found. Nevertheless, in February and March, 2020 the patient was positive for HEVIgM and HEV-IgG, and HEV genotype 3 RNA was detected in sera. Afterwards, he presented grade I hepatic encephalopathy and, therefore, was diagnosed with acute hepatitis E-on-chronic liver disease. The patient reported a recent travel to the Argentine coast, where he consumed seafood. Besides, he reveled to have consumed pork meat and had no history of blood transfusion. Conclusion: This report describes a unique case of hepatitis E virus infection in a patient with alcohol-related cirrhosis. This is the frst report of a patient with HEV-related ACLF in Argentina and it invokes the importance of HEV surveillance and treatment among patients with CLD, such as alcohol-related cirrhosis.
Fil: Fantilli, Anabella Clara. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: López Villa, Sarah Daniela. Instituto Modelo de Cardiología; Argentina
Fil: Zerega, Alina. Sanatorio Allende; Argentina
Fil: Di Cola Bucciarelli, Guadalupe. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: López, Luis. Instituto Modelo de Cardiología; Argentina
Fil: Wassaf Martínez, Maribel. LACE Laboratorios; Argentina
Fil: Pisano, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Background: The hepatitis E virus (HEV) infection has been described as a causing factor for acute-on-chronic-liverfailure (ACLF) in patients with underlying chronic liver disease (CLD), such as chronic hepatitis or cirrhosis, which could end in the failure of one or more organs and high short-term mortality. There are scarce data about the association of HEV in patients with chronic liver disorders in South America. Case presentation: A 56-year-old hypertensive male with a history of type 2 diabetes was diagnosed with alcoholrelated-liver cirrhosis in February 2019. A year later, the patient was admitted to hospital due to fatigue, jaundice and acholia. No evidence of hepatitis A virus, hepatitis B virus, hepatitis C virus, Epstein–Barr virus, herpes zoster virus and cytomegalovirus infections were found. Nevertheless, in February and March, 2020 the patient was positive for HEVIgM and HEV-IgG, and HEV genotype 3 RNA was detected in sera. Afterwards, he presented grade I hepatic encephalopathy and, therefore, was diagnosed with acute hepatitis E-on-chronic liver disease. The patient reported a recent travel to the Argentine coast, where he consumed seafood. Besides, he reveled to have consumed pork meat and had no history of blood transfusion. Conclusion: This report describes a unique case of hepatitis E virus infection in a patient with alcohol-related cirrhosis. This is the frst report of a patient with HEV-related ACLF in Argentina and it invokes the importance of HEV surveillance and treatment among patients with CLD, such as alcohol-related cirrhosis.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/158066
Fantilli, Anabella Clara; López Villa, Sarah Daniela; Zerega, Alina; Di Cola Bucciarelli, Guadalupe; López, Luis; et al.; Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure; BioMed Central; Virology Journal; 18; 1; 12-2021; 1-6
1743-422X
1743-422X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/158066
identifier_str_mv Fantilli, Anabella Clara; López Villa, Sarah Daniela; Zerega, Alina; Di Cola Bucciarelli, Guadalupe; López, Luis; et al.; Hepatitis E virus infection in a patient with alcohol related chronic liver disease: a case report of acute-on-chronic liver failure; BioMed Central; Virology Journal; 18; 1; 12-2021; 1-6
1743-422X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12985-021-01714-w
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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