Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives

Autores
Llères, David; Cardozo Gizzi, Andres Mauricio; Nollmann, Marcelo
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review explores recent emerging insights into enhanceraction, focusing on underexplored aspects such as the phys-ical size of regulatory elements, the stochasticity of transcrip-tion factor binding and chromatin structure, and the role ofnonlinear processes in reconciling longstanding discrepanciesbetween theoretical models and experimental observations.Together, these insights provide a nuanced view of enhancerbiology, highlighting the complexity of gene regulation and theneed for innovative methodologies to further decode enhancermechanisms.
Fil: Llères, David. Université Montpellier II; Francia
Fil: Cardozo Gizzi, Andres Mauricio. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Nollmann, Marcelo. Université Montpellier II; Francia
Materia
ENHANCER-PROMOTER INTERACTION
CHROMATIN STRUCTURE
TRANSCRIPTIONAL REGULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271013
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectivesLlères, DavidCardozo Gizzi, Andres MauricioNollmann, MarceloENHANCER-PROMOTER INTERACTIONCHROMATIN STRUCTURETRANSCRIPTIONAL REGULATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This review explores recent emerging insights into enhanceraction, focusing on underexplored aspects such as the phys-ical size of regulatory elements, the stochasticity of transcrip-tion factor binding and chromatin structure, and the role ofnonlinear processes in reconciling longstanding discrepanciesbetween theoretical models and experimental observations.Together, these insights provide a nuanced view of enhancerbiology, highlighting the complexity of gene regulation and theneed for innovative methodologies to further decode enhancermechanisms.Fil: Llères, David. Université Montpellier II; FranciaFil: Cardozo Gizzi, Andres Mauricio. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Nollmann, Marcelo. Université Montpellier II; FranciaCurrent Biology2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271013Llères, David; Cardozo Gizzi, Andres Mauricio; Nollmann, Marcelo; Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives; Current Biology; Current Opinion In Cell Biology; 95; 8-2025; 1-110955-0674CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0955067425000651info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceb.2025.102527info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:03:25Zoai:ri.conicet.gov.ar:11336/271013instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:03:25.462CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
title Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
spellingShingle Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
Llères, David
ENHANCER-PROMOTER INTERACTION
CHROMATIN STRUCTURE
TRANSCRIPTIONAL REGULATION
title_short Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
title_full Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
title_fullStr Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
title_full_unstemmed Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
title_sort Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
dc.creator.none.fl_str_mv Llères, David
Cardozo Gizzi, Andres Mauricio
Nollmann, Marcelo
author Llères, David
author_facet Llères, David
Cardozo Gizzi, Andres Mauricio
Nollmann, Marcelo
author_role author
author2 Cardozo Gizzi, Andres Mauricio
Nollmann, Marcelo
author2_role author
author
dc.subject.none.fl_str_mv ENHANCER-PROMOTER INTERACTION
CHROMATIN STRUCTURE
TRANSCRIPTIONAL REGULATION
topic ENHANCER-PROMOTER INTERACTION
CHROMATIN STRUCTURE
TRANSCRIPTIONAL REGULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This review explores recent emerging insights into enhanceraction, focusing on underexplored aspects such as the phys-ical size of regulatory elements, the stochasticity of transcrip-tion factor binding and chromatin structure, and the role ofnonlinear processes in reconciling longstanding discrepanciesbetween theoretical models and experimental observations.Together, these insights provide a nuanced view of enhancerbiology, highlighting the complexity of gene regulation and theneed for innovative methodologies to further decode enhancermechanisms.
Fil: Llères, David. Université Montpellier II; Francia
Fil: Cardozo Gizzi, Andres Mauricio. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Nollmann, Marcelo. Université Montpellier II; Francia
description This review explores recent emerging insights into enhanceraction, focusing on underexplored aspects such as the phys-ical size of regulatory elements, the stochasticity of transcrip-tion factor binding and chromatin structure, and the role ofnonlinear processes in reconciling longstanding discrepanciesbetween theoretical models and experimental observations.Together, these insights provide a nuanced view of enhancerbiology, highlighting the complexity of gene regulation and theneed for innovative methodologies to further decode enhancermechanisms.
publishDate 2025
dc.date.none.fl_str_mv 2025-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271013
Llères, David; Cardozo Gizzi, Andres Mauricio; Nollmann, Marcelo; Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives; Current Biology; Current Opinion In Cell Biology; 95; 8-2025; 1-11
0955-0674
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271013
identifier_str_mv Llères, David; Cardozo Gizzi, Andres Mauricio; Nollmann, Marcelo; Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives; Current Biology; Current Opinion In Cell Biology; 95; 8-2025; 1-11
0955-0674
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0955067425000651
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceb.2025.102527
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Current Biology
publisher.none.fl_str_mv Current Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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