Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives
- Autores
- Llères, David; Cardozo Gizzi, Andres Mauricio; Nollmann, Marcelo
- Año de publicación
- 2025
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This review explores recent emerging insights into enhanceraction, focusing on underexplored aspects such as the phys-ical size of regulatory elements, the stochasticity of transcrip-tion factor binding and chromatin structure, and the role ofnonlinear processes in reconciling longstanding discrepanciesbetween theoretical models and experimental observations.Together, these insights provide a nuanced view of enhancerbiology, highlighting the complexity of gene regulation and theneed for innovative methodologies to further decode enhancermechanisms.
Fil: Llères, David. Université Montpellier II; Francia
Fil: Cardozo Gizzi, Andres Mauricio. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Nollmann, Marcelo. Université Montpellier II; Francia - Materia
-
ENHANCER-PROMOTER INTERACTION
CHROMATIN STRUCTURE
TRANSCRIPTIONAL REGULATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/271013
Ver los metadatos del registro completo
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Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectivesLlères, DavidCardozo Gizzi, Andres MauricioNollmann, MarceloENHANCER-PROMOTER INTERACTIONCHROMATIN STRUCTURETRANSCRIPTIONAL REGULATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This review explores recent emerging insights into enhanceraction, focusing on underexplored aspects such as the phys-ical size of regulatory elements, the stochasticity of transcrip-tion factor binding and chromatin structure, and the role ofnonlinear processes in reconciling longstanding discrepanciesbetween theoretical models and experimental observations.Together, these insights provide a nuanced view of enhancerbiology, highlighting the complexity of gene regulation and theneed for innovative methodologies to further decode enhancermechanisms.Fil: Llères, David. Université Montpellier II; FranciaFil: Cardozo Gizzi, Andres Mauricio. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Nollmann, Marcelo. Université Montpellier II; FranciaCurrent Biology2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271013Llères, David; Cardozo Gizzi, Andres Mauricio; Nollmann, Marcelo; Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives; Current Biology; Current Opinion In Cell Biology; 95; 8-2025; 1-110955-0674CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0955067425000651info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceb.2025.102527info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:00Zoai:ri.conicet.gov.ar:11336/271013instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:00.863CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives |
title |
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives |
spellingShingle |
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives Llères, David ENHANCER-PROMOTER INTERACTION CHROMATIN STRUCTURE TRANSCRIPTIONAL REGULATION |
title_short |
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives |
title_full |
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives |
title_fullStr |
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives |
title_full_unstemmed |
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives |
title_sort |
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives |
dc.creator.none.fl_str_mv |
Llères, David Cardozo Gizzi, Andres Mauricio Nollmann, Marcelo |
author |
Llères, David |
author_facet |
Llères, David Cardozo Gizzi, Andres Mauricio Nollmann, Marcelo |
author_role |
author |
author2 |
Cardozo Gizzi, Andres Mauricio Nollmann, Marcelo |
author2_role |
author author |
dc.subject.none.fl_str_mv |
ENHANCER-PROMOTER INTERACTION CHROMATIN STRUCTURE TRANSCRIPTIONAL REGULATION |
topic |
ENHANCER-PROMOTER INTERACTION CHROMATIN STRUCTURE TRANSCRIPTIONAL REGULATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
This review explores recent emerging insights into enhanceraction, focusing on underexplored aspects such as the phys-ical size of regulatory elements, the stochasticity of transcrip-tion factor binding and chromatin structure, and the role ofnonlinear processes in reconciling longstanding discrepanciesbetween theoretical models and experimental observations.Together, these insights provide a nuanced view of enhancerbiology, highlighting the complexity of gene regulation and theneed for innovative methodologies to further decode enhancermechanisms. Fil: Llères, David. Université Montpellier II; Francia Fil: Cardozo Gizzi, Andres Mauricio. Instituto Universitario de Ciencias Biomédicas de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Nollmann, Marcelo. Université Montpellier II; Francia |
description |
This review explores recent emerging insights into enhanceraction, focusing on underexplored aspects such as the phys-ical size of regulatory elements, the stochasticity of transcrip-tion factor binding and chromatin structure, and the role ofnonlinear processes in reconciling longstanding discrepanciesbetween theoretical models and experimental observations.Together, these insights provide a nuanced view of enhancerbiology, highlighting the complexity of gene regulation and theneed for innovative methodologies to further decode enhancermechanisms. |
publishDate |
2025 |
dc.date.none.fl_str_mv |
2025-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/271013 Llères, David; Cardozo Gizzi, Andres Mauricio; Nollmann, Marcelo; Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives; Current Biology; Current Opinion In Cell Biology; 95; 8-2025; 1-11 0955-0674 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/271013 |
identifier_str_mv |
Llères, David; Cardozo Gizzi, Andres Mauricio; Nollmann, Marcelo; Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives; Current Biology; Current Opinion In Cell Biology; 95; 8-2025; 1-11 0955-0674 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0955067425000651 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ceb.2025.102527 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Current Biology |
publisher.none.fl_str_mv |
Current Biology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |