Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador
- Autores
- Bedoya Pilozo, Cesar H.; Medina Magües, Lex G.; Espinosa García, Maylen; Sánchez, Martha; Parrales Valdiviezo, Johanna V.; Molina, Denisse; Ibarra, María A.; Quimis Ponce, María; España, Karool; Párraga Macias, Karla E.; Cajas Flores, Nancy V.; Solon, Orlando A.; Robalino Penaherrera, Jorge A.; Chedraui, Peter; Escobar, Saul; Loja Chango, Rita D.; Ramirez Morán, Cecibel; Espinoza Caicedo, Jasson; Sánchez Giler, Sunny; Limia, Celia M.; Alemán, Yoan; Soto, Yudira; Kouri, Vivian; Culasso, Andrés Carlos Alberto; Badano, Ines
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases. HPV detection and typing was done by PCR-sequencing (MY09/MY11). HPV variants and estimation of the time to most recent common ancestor (tMRCA) was assessed through phylogeny and coalescence analysis. HPV DNA was found in 54.4% of CIN1, 74.7% of CIN2/3 and 78.6% of cancer samples. HPV16 (38.9%) and HPV58 (19.5%) were the most prevalent types. Risk factors for the development of cervical lesions/cancer were the following: three or more pregnancies (OR = 4.3), HPV infection (OR = 3.7 for high-risk types; OR = 3.5 for HPV16), among others. With regard to HPV evolution, HPV16 isolates belonged to lineages A (69%) and D (31%) whereas HPV58 isolates belonged only to lineage A. The period of emergence of HPV16 was in association with human populations (tMRCA = 91. 052 years for HPV16A and 27. 000 years for HPV16D), whereas HPV58A preceded Homo sapiens evolution (322. 257 years). This study provides novel data on HPV epidemiology and evolution in Ecuador, which will be fundamental in the vaccine era.
Fil: Bedoya Pilozo, Cesar H.. Escuela Superior Politécnica del Litoral; Ecuador. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Medina Magües, Lex G.. Escuela Superior Politécnica del Litoral; Ecuador
Fil: Espinosa García, Maylen. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Sánchez, Martha. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Parrales Valdiviezo, Johanna V.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Molina, Denisse. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Ibarra, María A.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Quimis Ponce, María. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: España, Karool. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Párraga Macias, Karla E.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Cajas Flores, Nancy V.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Solon, Orlando A.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador. Universidad Agraria del Ecuador; Ecuador
Fil: Robalino Penaherrera, Jorge A.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador
Fil: Chedraui, Peter. Hospital Gineco-Obstétrico Enrique C. Sotomayor; Ecuador
Fil: Escobar, Saul. Universidad Católica de Guayaquil; Ecuador
Fil: Loja Chango, Rita D.. Universidad Católica de Guayaquil; Ecuador
Fil: Ramirez Morán, Cecibel. Universidad Católica de Guayaquil; Ecuador
Fil: Espinoza Caicedo, Jasson. Universidad Católica de Guayaquil; Ecuador
Fil: Sánchez Giler, Sunny. Universidad Especialidades Espíritu Santo. Facultad de Ciencias Médicas; Ecuador
Fil: Limia, Celia M.. Instituto de Medicina Tropical Pedro Kouri; Cuba
Fil: Alemán, Yoan. Instituto de Medicina Tropical Pedro Kouri; Cuba
Fil: Soto, Yudira. Instituto de Medicina Tropical Pedro Kouri; Cuba
Fil: Kouri, Vivian. Instituto de Medicina Tropical Pedro Kouri; Cuba
Fil: Culasso, Andrés Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina
Fil: Badano, Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Secretaría de Educación Superior, Ciencia, Tecnología e Innovación; Ecuador. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina - Materia
-
CANCER
ECUADOR
HUMAN PAPILLOMA VIRUS
PCR-SEQUENCING
PHYLOGENETIC ANALYSIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/44327
Ver los metadatos del registro completo
| id |
CONICETDig_f0e14d204d4ad5d467b3566deae442f8 |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/44327 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of EcuadorEpidemiología molecular y análisis filogenético de la infección por el virus del papiloma humano en mujeres con lesiones cervicales y cáncer en la región litoral del EcuadorBedoya Pilozo, Cesar H.Medina Magües, Lex G.Espinosa García, MaylenSánchez, MarthaParrales Valdiviezo, Johanna V.Molina, DenisseIbarra, María A.Quimis Ponce, MaríaEspaña, KaroolPárraga Macias, Karla E.Cajas Flores, Nancy V.Solon, Orlando A.Robalino Penaherrera, Jorge A.Chedraui, PeterEscobar, SaulLoja Chango, Rita D.Ramirez Morán, CecibelEspinoza Caicedo, JassonSánchez Giler, SunnyLimia, Celia M.Alemán, YoanSoto, YudiraKouri, VivianCulasso, Andrés Carlos AlbertoBadano, InesCANCERECUADORHUMAN PAPILLOMA VIRUSPCR-SEQUENCINGPHYLOGENETIC ANALYSIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases. HPV detection and typing was done by PCR-sequencing (MY09/MY11). HPV variants and estimation of the time to most recent common ancestor (tMRCA) was assessed through phylogeny and coalescence analysis. HPV DNA was found in 54.4% of CIN1, 74.7% of CIN2/3 and 78.6% of cancer samples. HPV16 (38.9%) and HPV58 (19.5%) were the most prevalent types. Risk factors for the development of cervical lesions/cancer were the following: three or more pregnancies (OR = 4.3), HPV infection (OR = 3.7 for high-risk types; OR = 3.5 for HPV16), among others. With regard to HPV evolution, HPV16 isolates belonged to lineages A (69%) and D (31%) whereas HPV58 isolates belonged only to lineage A. The period of emergence of HPV16 was in association with human populations (tMRCA = 91. 052 years for HPV16A and 27. 000 years for HPV16D), whereas HPV58A preceded Homo sapiens evolution (322. 257 years). This study provides novel data on HPV epidemiology and evolution in Ecuador, which will be fundamental in the vaccine era.Fil: Bedoya Pilozo, Cesar H.. Escuela Superior Politécnica del Litoral; Ecuador. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Medina Magües, Lex G.. Escuela Superior Politécnica del Litoral; EcuadorFil: Espinosa García, Maylen. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Sánchez, Martha. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Parrales Valdiviezo, Johanna V.. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Molina, Denisse. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Ibarra, María A.. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Quimis Ponce, María. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: España, Karool. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Párraga Macias, Karla E.. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Cajas Flores, Nancy V.. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Solon, Orlando A.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador. Universidad Agraria del Ecuador; EcuadorFil: Robalino Penaherrera, Jorge A.. Instituto Nacional de Investigaciones en Salud Pública; EcuadorFil: Chedraui, Peter. Hospital Gineco-Obstétrico Enrique C. Sotomayor; EcuadorFil: Escobar, Saul. Universidad Católica de Guayaquil; EcuadorFil: Loja Chango, Rita D.. Universidad Católica de Guayaquil; EcuadorFil: Ramirez Morán, Cecibel. Universidad Católica de Guayaquil; EcuadorFil: Espinoza Caicedo, Jasson. Universidad Católica de Guayaquil; EcuadorFil: Sánchez Giler, Sunny. Universidad Especialidades Espíritu Santo. Facultad de Ciencias Médicas; EcuadorFil: Limia, Celia M.. Instituto de Medicina Tropical Pedro Kouri; CubaFil: Alemán, Yoan. Instituto de Medicina Tropical Pedro Kouri; CubaFil: Soto, Yudira. Instituto de Medicina Tropical Pedro Kouri; CubaFil: Kouri, Vivian. Instituto de Medicina Tropical Pedro Kouri; CubaFil: Culasso, Andrés Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; ArgentinaFil: Badano, Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Secretaría de Educación Superior, Ciencia, Tecnología e Innovación; Ecuador. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; ArgentinaAsociación Argentina de Microbiología2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44327Bedoya Pilozo, Cesar H.; Medina Magües, Lex G.; Espinosa García, Maylen; Sánchez, Martha; Parrales Valdiviezo, Johanna V.; et al.; Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 12-2017; 1-110325-75411851-7617CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ram.2017.06.004info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0325754117301372info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:47:01Zoai:ri.conicet.gov.ar:11336/44327instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:47:02.242CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador Epidemiología molecular y análisis filogenético de la infección por el virus del papiloma humano en mujeres con lesiones cervicales y cáncer en la región litoral del Ecuador |
| title |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador |
| spellingShingle |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador Bedoya Pilozo, Cesar H. CANCER ECUADOR HUMAN PAPILLOMA VIRUS PCR-SEQUENCING PHYLOGENETIC ANALYSIS |
| title_short |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador |
| title_full |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador |
| title_fullStr |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador |
| title_full_unstemmed |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador |
| title_sort |
Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador |
| dc.creator.none.fl_str_mv |
Bedoya Pilozo, Cesar H. Medina Magües, Lex G. Espinosa García, Maylen Sánchez, Martha Parrales Valdiviezo, Johanna V. Molina, Denisse Ibarra, María A. Quimis Ponce, María España, Karool Párraga Macias, Karla E. Cajas Flores, Nancy V. Solon, Orlando A. Robalino Penaherrera, Jorge A. Chedraui, Peter Escobar, Saul Loja Chango, Rita D. Ramirez Morán, Cecibel Espinoza Caicedo, Jasson Sánchez Giler, Sunny Limia, Celia M. Alemán, Yoan Soto, Yudira Kouri, Vivian Culasso, Andrés Carlos Alberto Badano, Ines |
| author |
Bedoya Pilozo, Cesar H. |
| author_facet |
Bedoya Pilozo, Cesar H. Medina Magües, Lex G. Espinosa García, Maylen Sánchez, Martha Parrales Valdiviezo, Johanna V. Molina, Denisse Ibarra, María A. Quimis Ponce, María España, Karool Párraga Macias, Karla E. Cajas Flores, Nancy V. Solon, Orlando A. Robalino Penaherrera, Jorge A. Chedraui, Peter Escobar, Saul Loja Chango, Rita D. Ramirez Morán, Cecibel Espinoza Caicedo, Jasson Sánchez Giler, Sunny Limia, Celia M. Alemán, Yoan Soto, Yudira Kouri, Vivian Culasso, Andrés Carlos Alberto Badano, Ines |
| author_role |
author |
| author2 |
Medina Magües, Lex G. Espinosa García, Maylen Sánchez, Martha Parrales Valdiviezo, Johanna V. Molina, Denisse Ibarra, María A. Quimis Ponce, María España, Karool Párraga Macias, Karla E. Cajas Flores, Nancy V. Solon, Orlando A. Robalino Penaherrera, Jorge A. Chedraui, Peter Escobar, Saul Loja Chango, Rita D. Ramirez Morán, Cecibel Espinoza Caicedo, Jasson Sánchez Giler, Sunny Limia, Celia M. Alemán, Yoan Soto, Yudira Kouri, Vivian Culasso, Andrés Carlos Alberto Badano, Ines |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
CANCER ECUADOR HUMAN PAPILLOMA VIRUS PCR-SEQUENCING PHYLOGENETIC ANALYSIS |
| topic |
CANCER ECUADOR HUMAN PAPILLOMA VIRUS PCR-SEQUENCING PHYLOGENETIC ANALYSIS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases. HPV detection and typing was done by PCR-sequencing (MY09/MY11). HPV variants and estimation of the time to most recent common ancestor (tMRCA) was assessed through phylogeny and coalescence analysis. HPV DNA was found in 54.4% of CIN1, 74.7% of CIN2/3 and 78.6% of cancer samples. HPV16 (38.9%) and HPV58 (19.5%) were the most prevalent types. Risk factors for the development of cervical lesions/cancer were the following: three or more pregnancies (OR = 4.3), HPV infection (OR = 3.7 for high-risk types; OR = 3.5 for HPV16), among others. With regard to HPV evolution, HPV16 isolates belonged to lineages A (69%) and D (31%) whereas HPV58 isolates belonged only to lineage A. The period of emergence of HPV16 was in association with human populations (tMRCA = 91. 052 years for HPV16A and 27. 000 years for HPV16D), whereas HPV58A preceded Homo sapiens evolution (322. 257 years). This study provides novel data on HPV epidemiology and evolution in Ecuador, which will be fundamental in the vaccine era. Fil: Bedoya Pilozo, Cesar H.. Escuela Superior Politécnica del Litoral; Ecuador. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Medina Magües, Lex G.. Escuela Superior Politécnica del Litoral; Ecuador Fil: Espinosa García, Maylen. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Sánchez, Martha. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Parrales Valdiviezo, Johanna V.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Molina, Denisse. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Ibarra, María A.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Quimis Ponce, María. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: España, Karool. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Párraga Macias, Karla E.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Cajas Flores, Nancy V.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Solon, Orlando A.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador. Universidad Agraria del Ecuador; Ecuador Fil: Robalino Penaherrera, Jorge A.. Instituto Nacional de Investigaciones en Salud Pública; Ecuador Fil: Chedraui, Peter. Hospital Gineco-Obstétrico Enrique C. Sotomayor; Ecuador Fil: Escobar, Saul. Universidad Católica de Guayaquil; Ecuador Fil: Loja Chango, Rita D.. Universidad Católica de Guayaquil; Ecuador Fil: Ramirez Morán, Cecibel. Universidad Católica de Guayaquil; Ecuador Fil: Espinoza Caicedo, Jasson. Universidad Católica de Guayaquil; Ecuador Fil: Sánchez Giler, Sunny. Universidad Especialidades Espíritu Santo. Facultad de Ciencias Médicas; Ecuador Fil: Limia, Celia M.. Instituto de Medicina Tropical Pedro Kouri; Cuba Fil: Alemán, Yoan. Instituto de Medicina Tropical Pedro Kouri; Cuba Fil: Soto, Yudira. Instituto de Medicina Tropical Pedro Kouri; Cuba Fil: Kouri, Vivian. Instituto de Medicina Tropical Pedro Kouri; Cuba Fil: Culasso, Andrés Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina Fil: Badano, Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Secretaría de Educación Superior, Ciencia, Tecnología e Innovación; Ecuador. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Laboratorio de Biología Molecular Aplicada; Argentina |
| description |
The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases. HPV detection and typing was done by PCR-sequencing (MY09/MY11). HPV variants and estimation of the time to most recent common ancestor (tMRCA) was assessed through phylogeny and coalescence analysis. HPV DNA was found in 54.4% of CIN1, 74.7% of CIN2/3 and 78.6% of cancer samples. HPV16 (38.9%) and HPV58 (19.5%) were the most prevalent types. Risk factors for the development of cervical lesions/cancer were the following: three or more pregnancies (OR = 4.3), HPV infection (OR = 3.7 for high-risk types; OR = 3.5 for HPV16), among others. With regard to HPV evolution, HPV16 isolates belonged to lineages A (69%) and D (31%) whereas HPV58 isolates belonged only to lineage A. The period of emergence of HPV16 was in association with human populations (tMRCA = 91. 052 years for HPV16A and 27. 000 years for HPV16D), whereas HPV58A preceded Homo sapiens evolution (322. 257 years). This study provides novel data on HPV epidemiology and evolution in Ecuador, which will be fundamental in the vaccine era. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-12 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/44327 Bedoya Pilozo, Cesar H.; Medina Magües, Lex G.; Espinosa García, Maylen; Sánchez, Martha; Parrales Valdiviezo, Johanna V.; et al.; Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 12-2017; 1-11 0325-7541 1851-7617 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/44327 |
| identifier_str_mv |
Bedoya Pilozo, Cesar H.; Medina Magües, Lex G.; Espinosa García, Maylen; Sánchez, Martha; Parrales Valdiviezo, Johanna V.; et al.; Molecular epidemiology and phylogenetic analysis of human papillomavirus infection in women with cervical lesions and cancer from the coastal region of Ecuador; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 12-2017; 1-11 0325-7541 1851-7617 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ram.2017.06.004 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0325754117301372 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Asociación Argentina de Microbiología |
| publisher.none.fl_str_mv |
Asociación Argentina de Microbiología |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1848597924161781760 |
| score |
13.25334 |