Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population
- Autores
- Trinks, Julieta; Nishida, Nao; Hulaniuk, María Laura; Caputo, Mariela; Tsuchiura, Takayo; Marciano, Sebastián; Haddad, Leila; Blejer, Jorgelina L.; Bartoli, Sonia; Ameigeiras, Beatriz; Frías, Silvia E.; Vistarini, Cecilia; Heinrich, Fabiana; Remondegui, Carlos; Ceballos, Susana; Echenique, Gustavo; Charre Samman, Miguel; D'Amico, Claudia; Rojas, Amalia; Martínez, Alfredo; Ridruejo, Ezequiel; Fernandez, Roberto Julio; Burgos Pratx, Leandro; Salamone, Horacio J.; Nuñez, Felix A.; Galdame, Omar; Gadano, Adrián Carlos; Corach, Daniel; Sugiyama, Masaya; Flichman, Diego Martin; Tokunaga, Katsushi; Mizokami, Masashi
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background & Aims: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. Methods: a total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. Results: Native American ancestry prevailed in the north-western region when compared with central Argentina (P<.0001). However, no differences were observed among the three groups of each region. The distribution of HBV genotypes revealed significant differences (P<.0001). Three SNPs (rs3077, rs9277542 and rs7453920) showed a significant association with protection against chronic HBV and viral clearance in both regions. The remaining SNP showed a significant association with susceptibility to chronic HBV. The frequency rates of rs3077-T, related to protection against chronic HBV and viral clearance, were lower in north-western Argentina when compared with central Argentina. The same uneven frequency rates were observed for SNP rs9277542. Conclusions: this is the first study addressing the associations between the HLA-DP and HLA-DQ loci and the protection against chronic HBV and viral clearance in a multiethnic South American population. The uneven distribution of HLA-DP and HLA-DQ supports the HBV epidemiological differences observed in these two regions of Argentina with dissimilar ancestry genetic background.
Fil: Trinks, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Nishida, Nao. National Center for Global Health and Medicine; Japón. University of Tokyo; Japón
Fil: Hulaniuk, María Laura. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina
Fil: Caputo, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina
Fil: Tsuchiura, Takayo. National Center for Global Health and Medicine; Japón
Fil: Marciano, Sebastián. Hospital Italiano; Argentina
Fil: Haddad, Leila. Hospital Italiano; Argentina
Fil: Blejer, Jorgelina L.. Fundación Hemocentro Buenos Aires; Argentina
Fil: Bartoli, Sonia. Provincia de Jujuy. Hospital Pablo Soria. Unidad de Hemoterapia; Argentina
Fil: Ameigeiras, Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina
Fil: Frías, Silvia E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina
Fil: Vistarini, Cecilia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina
Fil: Heinrich, Fabiana. Provincia de Entre Ríos. Hospital San Antonio; Argentina
Fil: Remondegui, Carlos. Provincia de Jujuy. Hospital San Roque; Argentina
Fil: Ceballos, Susana. Provincia de Jujuy. Hospital San Roque; Argentina
Fil: Echenique, Gustavo. Clínica Nuestra Señora del Rosario; Argentina
Fil: Charre Samman, Miguel. Laboratorio Central de Salud Pública; Argentina
Fil: D'Amico, Claudia. Centro de Especialidades Médicas Ambulatorias; Argentina
Fil: Rojas, Amalia. Centro de Especialidades Médicas Ambulatorias; Argentina
Fil: Martínez, Alfredo. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina
Fil: Fernandez, Roberto Julio. Fundación Hemocentro Buenos Aires; Argentina
Fil: Burgos Pratx, Leandro. Hospital Italiano; Argentina
Fil: Salamone, Horacio J.. Hospital Italiano; Argentina
Fil: Nuñez, Felix A.. Hospital Italiano; Argentina
Fil: Galdame, Omar. Hospital Italiano; Argentina
Fil: Gadano, Adrián Carlos. Hospital Italiano; Argentina
Fil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina
Fil: Sugiyama, Masaya. National Center for Global Health and Medicine; Japón
Fil: Flichman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina
Fil: Tokunaga, Katsushi. University of Tokyo; Japón
Fil: Mizokami, Masashi. National Center for Global Health and Medicine; Japón - Materia
-
Hbv
Genotypes
Hla Genes
Native American - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/51732
Ver los metadatos del registro completo
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Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic populationTrinks, JulietaNishida, NaoHulaniuk, María LauraCaputo, MarielaTsuchiura, TakayoMarciano, SebastiánHaddad, LeilaBlejer, Jorgelina L.Bartoli, SoniaAmeigeiras, BeatrizFrías, Silvia E.Vistarini, CeciliaHeinrich, FabianaRemondegui, CarlosCeballos, SusanaEchenique, GustavoCharre Samman, MiguelD'Amico, ClaudiaRojas, AmaliaMartínez, AlfredoRidruejo, EzequielFernandez, Roberto JulioBurgos Pratx, LeandroSalamone, Horacio J.Nuñez, Felix A.Galdame, OmarGadano, Adrián CarlosCorach, DanielSugiyama, MasayaFlichman, Diego MartinTokunaga, KatsushiMizokami, MasashiHbvGenotypesHla GenesNative Americanhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background & Aims: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. Methods: a total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. Results: Native American ancestry prevailed in the north-western region when compared with central Argentina (P<.0001). However, no differences were observed among the three groups of each region. The distribution of HBV genotypes revealed significant differences (P<.0001). Three SNPs (rs3077, rs9277542 and rs7453920) showed a significant association with protection against chronic HBV and viral clearance in both regions. The remaining SNP showed a significant association with susceptibility to chronic HBV. The frequency rates of rs3077-T, related to protection against chronic HBV and viral clearance, were lower in north-western Argentina when compared with central Argentina. The same uneven frequency rates were observed for SNP rs9277542. Conclusions: this is the first study addressing the associations between the HLA-DP and HLA-DQ loci and the protection against chronic HBV and viral clearance in a multiethnic South American population. The uneven distribution of HLA-DP and HLA-DQ supports the HBV epidemiological differences observed in these two regions of Argentina with dissimilar ancestry genetic background.Fil: Trinks, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Nishida, Nao. National Center for Global Health and Medicine; Japón. University of Tokyo; JapónFil: Hulaniuk, María Laura. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Caputo, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; ArgentinaFil: Tsuchiura, Takayo. National Center for Global Health and Medicine; JapónFil: Marciano, Sebastián. Hospital Italiano; ArgentinaFil: Haddad, Leila. Hospital Italiano; ArgentinaFil: Blejer, Jorgelina L.. Fundación Hemocentro Buenos Aires; ArgentinaFil: Bartoli, Sonia. Provincia de Jujuy. Hospital Pablo Soria. Unidad de Hemoterapia; ArgentinaFil: Ameigeiras, Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; ArgentinaFil: Frías, Silvia E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; ArgentinaFil: Vistarini, Cecilia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; ArgentinaFil: Heinrich, Fabiana. Provincia de Entre Ríos. Hospital San Antonio; ArgentinaFil: Remondegui, Carlos. Provincia de Jujuy. Hospital San Roque; ArgentinaFil: Ceballos, Susana. Provincia de Jujuy. Hospital San Roque; ArgentinaFil: Echenique, Gustavo. Clínica Nuestra Señora del Rosario; ArgentinaFil: Charre Samman, Miguel. Laboratorio Central de Salud Pública; ArgentinaFil: D'Amico, Claudia. Centro de Especialidades Médicas Ambulatorias; ArgentinaFil: Rojas, Amalia. Centro de Especialidades Médicas Ambulatorias; ArgentinaFil: Martínez, Alfredo. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; ArgentinaFil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; ArgentinaFil: Fernandez, Roberto Julio. Fundación Hemocentro Buenos Aires; ArgentinaFil: Burgos Pratx, Leandro. Hospital Italiano; ArgentinaFil: Salamone, Horacio J.. Hospital Italiano; ArgentinaFil: Nuñez, Felix A.. Hospital Italiano; ArgentinaFil: Galdame, Omar. Hospital Italiano; ArgentinaFil: Gadano, Adrián Carlos. Hospital Italiano; ArgentinaFil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; ArgentinaFil: Sugiyama, Masaya. National Center for Global Health and Medicine; JapónFil: Flichman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; ArgentinaFil: Tokunaga, Katsushi. University of Tokyo; JapónFil: Mizokami, Masashi. National Center for Global Health and Medicine; JapónWiley Blackwell Publishing, Inc2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/51732Trinks, Julieta; Nishida, Nao; Hulaniuk, María Laura; Caputo, Mariela; Tsuchiura, Takayo; et al.; Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population; Wiley Blackwell Publishing, Inc; Liver International; 37; 10; 10-2017; 1476-14871478-32231478-3231CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/liv.13405info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.13405info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:14Zoai:ri.conicet.gov.ar:11336/51732instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:14.598CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population |
| title |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population |
| spellingShingle |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population Trinks, Julieta Hbv Genotypes Hla Genes Native American |
| title_short |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population |
| title_full |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population |
| title_fullStr |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population |
| title_full_unstemmed |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population |
| title_sort |
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population |
| dc.creator.none.fl_str_mv |
Trinks, Julieta Nishida, Nao Hulaniuk, María Laura Caputo, Mariela Tsuchiura, Takayo Marciano, Sebastián Haddad, Leila Blejer, Jorgelina L. Bartoli, Sonia Ameigeiras, Beatriz Frías, Silvia E. Vistarini, Cecilia Heinrich, Fabiana Remondegui, Carlos Ceballos, Susana Echenique, Gustavo Charre Samman, Miguel D'Amico, Claudia Rojas, Amalia Martínez, Alfredo Ridruejo, Ezequiel Fernandez, Roberto Julio Burgos Pratx, Leandro Salamone, Horacio J. Nuñez, Felix A. Galdame, Omar Gadano, Adrián Carlos Corach, Daniel Sugiyama, Masaya Flichman, Diego Martin Tokunaga, Katsushi Mizokami, Masashi |
| author |
Trinks, Julieta |
| author_facet |
Trinks, Julieta Nishida, Nao Hulaniuk, María Laura Caputo, Mariela Tsuchiura, Takayo Marciano, Sebastián Haddad, Leila Blejer, Jorgelina L. Bartoli, Sonia Ameigeiras, Beatriz Frías, Silvia E. Vistarini, Cecilia Heinrich, Fabiana Remondegui, Carlos Ceballos, Susana Echenique, Gustavo Charre Samman, Miguel D'Amico, Claudia Rojas, Amalia Martínez, Alfredo Ridruejo, Ezequiel Fernandez, Roberto Julio Burgos Pratx, Leandro Salamone, Horacio J. Nuñez, Felix A. Galdame, Omar Gadano, Adrián Carlos Corach, Daniel Sugiyama, Masaya Flichman, Diego Martin Tokunaga, Katsushi Mizokami, Masashi |
| author_role |
author |
| author2 |
Nishida, Nao Hulaniuk, María Laura Caputo, Mariela Tsuchiura, Takayo Marciano, Sebastián Haddad, Leila Blejer, Jorgelina L. Bartoli, Sonia Ameigeiras, Beatriz Frías, Silvia E. Vistarini, Cecilia Heinrich, Fabiana Remondegui, Carlos Ceballos, Susana Echenique, Gustavo Charre Samman, Miguel D'Amico, Claudia Rojas, Amalia Martínez, Alfredo Ridruejo, Ezequiel Fernandez, Roberto Julio Burgos Pratx, Leandro Salamone, Horacio J. Nuñez, Felix A. Galdame, Omar Gadano, Adrián Carlos Corach, Daniel Sugiyama, Masaya Flichman, Diego Martin Tokunaga, Katsushi Mizokami, Masashi |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Hbv Genotypes Hla Genes Native American |
| topic |
Hbv Genotypes Hla Genes Native American |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Background & Aims: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. Methods: a total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. Results: Native American ancestry prevailed in the north-western region when compared with central Argentina (P<.0001). However, no differences were observed among the three groups of each region. The distribution of HBV genotypes revealed significant differences (P<.0001). Three SNPs (rs3077, rs9277542 and rs7453920) showed a significant association with protection against chronic HBV and viral clearance in both regions. The remaining SNP showed a significant association with susceptibility to chronic HBV. The frequency rates of rs3077-T, related to protection against chronic HBV and viral clearance, were lower in north-western Argentina when compared with central Argentina. The same uneven frequency rates were observed for SNP rs9277542. Conclusions: this is the first study addressing the associations between the HLA-DP and HLA-DQ loci and the protection against chronic HBV and viral clearance in a multiethnic South American population. The uneven distribution of HLA-DP and HLA-DQ supports the HBV epidemiological differences observed in these two regions of Argentina with dissimilar ancestry genetic background. Fil: Trinks, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina Fil: Nishida, Nao. National Center for Global Health and Medicine; Japón. University of Tokyo; Japón Fil: Hulaniuk, María Laura. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina Fil: Caputo, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina Fil: Tsuchiura, Takayo. National Center for Global Health and Medicine; Japón Fil: Marciano, Sebastián. Hospital Italiano; Argentina Fil: Haddad, Leila. Hospital Italiano; Argentina Fil: Blejer, Jorgelina L.. Fundación Hemocentro Buenos Aires; Argentina Fil: Bartoli, Sonia. Provincia de Jujuy. Hospital Pablo Soria. Unidad de Hemoterapia; Argentina Fil: Ameigeiras, Beatriz. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina Fil: Frías, Silvia E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina Fil: Vistarini, Cecilia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; Argentina Fil: Heinrich, Fabiana. Provincia de Entre Ríos. Hospital San Antonio; Argentina Fil: Remondegui, Carlos. Provincia de Jujuy. Hospital San Roque; Argentina Fil: Ceballos, Susana. Provincia de Jujuy. Hospital San Roque; Argentina Fil: Echenique, Gustavo. Clínica Nuestra Señora del Rosario; Argentina Fil: Charre Samman, Miguel. Laboratorio Central de Salud Pública; Argentina Fil: D'Amico, Claudia. Centro de Especialidades Médicas Ambulatorias; Argentina Fil: Rojas, Amalia. Centro de Especialidades Médicas Ambulatorias; Argentina Fil: Martínez, Alfredo. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina Fil: Fernandez, Roberto Julio. Fundación Hemocentro Buenos Aires; Argentina Fil: Burgos Pratx, Leandro. Hospital Italiano; Argentina Fil: Salamone, Horacio J.. Hospital Italiano; Argentina Fil: Nuñez, Felix A.. Hospital Italiano; Argentina Fil: Galdame, Omar. Hospital Italiano; Argentina Fil: Gadano, Adrián Carlos. Hospital Italiano; Argentina Fil: Corach, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina Fil: Sugiyama, Masaya. National Center for Global Health and Medicine; Japón Fil: Flichman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina Fil: Tokunaga, Katsushi. University of Tokyo; Japón Fil: Mizokami, Masashi. National Center for Global Health and Medicine; Japón |
| description |
Background & Aims: HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown. Methods: a total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients. Results: Native American ancestry prevailed in the north-western region when compared with central Argentina (P<.0001). However, no differences were observed among the three groups of each region. The distribution of HBV genotypes revealed significant differences (P<.0001). Three SNPs (rs3077, rs9277542 and rs7453920) showed a significant association with protection against chronic HBV and viral clearance in both regions. The remaining SNP showed a significant association with susceptibility to chronic HBV. The frequency rates of rs3077-T, related to protection against chronic HBV and viral clearance, were lower in north-western Argentina when compared with central Argentina. The same uneven frequency rates were observed for SNP rs9277542. Conclusions: this is the first study addressing the associations between the HLA-DP and HLA-DQ loci and the protection against chronic HBV and viral clearance in a multiethnic South American population. The uneven distribution of HLA-DP and HLA-DQ supports the HBV epidemiological differences observed in these two regions of Argentina with dissimilar ancestry genetic background. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-10 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/51732 Trinks, Julieta; Nishida, Nao; Hulaniuk, María Laura; Caputo, Mariela; Tsuchiura, Takayo; et al.; Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population; Wiley Blackwell Publishing, Inc; Liver International; 37; 10; 10-2017; 1476-1487 1478-3223 1478-3231 CONICET Digital CONICET |
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http://hdl.handle.net/11336/51732 |
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Trinks, Julieta; Nishida, Nao; Hulaniuk, María Laura; Caputo, Mariela; Tsuchiura, Takayo; et al.; Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population; Wiley Blackwell Publishing, Inc; Liver International; 37; 10; 10-2017; 1476-1487 1478-3223 1478-3231 CONICET Digital CONICET |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1111/liv.13405 info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.13405 |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
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Wiley Blackwell Publishing, Inc |
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Wiley Blackwell Publishing, Inc |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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