The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure
- Autores
- Barquera, Rodrigo; Hernández Zaragoza, Diana Iraíz; Bravo Acevedo, Alicia; Arrieta Bolaños, Esteban; Clayton, Stephen; Acuña Alonzo, Víctor; Martínez Álvarez, Julio César; López Gil, Concepción; Adalid Sáinz, Carmen; Vega Martínez, María del Rosario; Escobedo Ruíz, Araceli; Juárez Cortés, Eva Dolores; Immel, Alexander; Pacheco Ubaldo, Hanna; González Medina, Liliana; Lona Sánchez, Abraham; Lara Riegos, Julio; Sánchez Fernández, María Guadalupe de Jesús; Díaz López, Rosario; Guizar López, Gregorio Ulises; Medina Escobedo, Carolina Elizabeth; Arrazola García, María Araceli; Montiel Hernández, Gustavo Daniel; Hernández Hernández, Ofelia; Ramos de la Cruz, Flor del Rocío; Juárez Nicolás, Francisco; Pantoja Torres, Jorge Arturo; Rodríguez Munguía, Tirzo Jesús; Juárez Barreto, Vicencio; Gonzalez-Jose, Rolando
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ’≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.
Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Hernández Zaragoza, Diana Iraíz. Técnicas Genéticas Aplicadas A la Clínica (tgac); México. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Bravo Acevedo, Alicia. Instituto Mexicano del Seguro Social; México
Fil: Arrieta Bolaños, Esteban. Universitat Essen; Alemania
Fil: Clayton, Stephen. Max Planck Institute For The Science Of Human History; Alemania
Fil: Acuña Alonzo, Víctor. Instituto Nacional de Antropología E Historia, Mexico; México
Fil: Martínez Álvarez, Julio César. Instituto Mexicano del Seguro Social; México
Fil: López Gil, Concepción. Instituto Mexicano del Seguro Social; México
Fil: Adalid Sáinz, Carmen. Instituto Mexicano del Seguro Social; México
Fil: Vega Martínez, María del Rosario. Hospital Central Sur de Alta Especialidad; México
Fil: Escobedo Ruíz, Araceli. Instituto Mexicano del Seguro Social; México
Fil: Juárez Cortés, Eva Dolores. Instituto Mexicano del Seguro Social; México
Fil: Immel, Alexander. Max Planck Institute For The Science Of Human History; Alemania. Christian Albrechts Universitat Zu Kiel; Alemania
Fil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: González Medina, Liliana. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Lona Sánchez, Abraham. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Lara Riegos, Julio. Universidad Autónoma de Yucatán; México
Fil: Sánchez Fernández, María Guadalupe de Jesús. Instituto Mexicano del Seguro Social; México
Fil: Díaz López, Rosario. Hospital Central Militar, Mexico City; México
Fil: Guizar López, Gregorio Ulises. Hospital Central Militar, Mexico City; México
Fil: Medina Escobedo, Carolina Elizabeth. Instituto Mexicano del Seguro Social; México
Fil: Arrazola García, María Araceli. Instituto Mexicano del Seguro Social; México
Fil: Montiel Hernández, Gustavo Daniel. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México
Fil: Hernández Hernández, Ofelia. Técnicas Genéticas Aplicadas a la Clínica ; México
Fil: Ramos de la Cruz, Flor del Rocío. Instituto Mexicano del Seguro Social; México
Fil: Juárez Nicolás, Francisco. Instituto Nacional de Pediatría; México
Fil: Pantoja Torres, Jorge Arturo. Instituto Mexicano del Seguro Social; México
Fil: Rodríguez Munguía, Tirzo Jesús. Hospital General Norberto Treviño Zapata; México
Fil: Juárez Barreto, Vicencio. Hospital Infantil de Mexico Federico Gomez; México
Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina - Materia
-
ADMIXTURE
GENETIC SUBSTRUCTURE
HLA
IMMUNOGENETICS
LATIN AMERICAN POPULATIONS
MEXICO
POPULATION GENETICS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/125846
Ver los metadatos del registro completo
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The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structureBarquera, RodrigoHernández Zaragoza, Diana IraízBravo Acevedo, AliciaArrieta Bolaños, EstebanClayton, StephenAcuña Alonzo, VíctorMartínez Álvarez, Julio CésarLópez Gil, ConcepciónAdalid Sáinz, CarmenVega Martínez, María del RosarioEscobedo Ruíz, AraceliJuárez Cortés, Eva DoloresImmel, AlexanderPacheco Ubaldo, HannaGonzález Medina, LilianaLona Sánchez, AbrahamLara Riegos, JulioSánchez Fernández, María Guadalupe de JesúsDíaz López, RosarioGuizar López, Gregorio UlisesMedina Escobedo, Carolina ElizabethArrazola García, María AraceliMontiel Hernández, Gustavo DanielHernández Hernández, OfeliaRamos de la Cruz, Flor del RocíoJuárez Nicolás, FranciscoPantoja Torres, Jorge ArturoRodríguez Munguía, Tirzo JesúsJuárez Barreto, VicencioGonzalez-Jose, RolandoADMIXTUREGENETIC SUBSTRUCTUREHLAIMMUNOGENETICSLATIN AMERICAN POPULATIONSMEXICOPOPULATION GENETICShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ’≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Hernández Zaragoza, Diana Iraíz. Técnicas Genéticas Aplicadas A la Clínica (tgac); México. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Bravo Acevedo, Alicia. Instituto Mexicano del Seguro Social; MéxicoFil: Arrieta Bolaños, Esteban. Universitat Essen; AlemaniaFil: Clayton, Stephen. Max Planck Institute For The Science Of Human History; AlemaniaFil: Acuña Alonzo, Víctor. Instituto Nacional de Antropología E Historia, Mexico; MéxicoFil: Martínez Álvarez, Julio César. Instituto Mexicano del Seguro Social; MéxicoFil: López Gil, Concepción. Instituto Mexicano del Seguro Social; MéxicoFil: Adalid Sáinz, Carmen. Instituto Mexicano del Seguro Social; MéxicoFil: Vega Martínez, María del Rosario. Hospital Central Sur de Alta Especialidad; MéxicoFil: Escobedo Ruíz, Araceli. Instituto Mexicano del Seguro Social; MéxicoFil: Juárez Cortés, Eva Dolores. Instituto Mexicano del Seguro Social; MéxicoFil: Immel, Alexander. Max Planck Institute For The Science Of Human History; Alemania. Christian Albrechts Universitat Zu Kiel; AlemaniaFil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: González Medina, Liliana. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Lona Sánchez, Abraham. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Lara Riegos, Julio. Universidad Autónoma de Yucatán; MéxicoFil: Sánchez Fernández, María Guadalupe de Jesús. Instituto Mexicano del Seguro Social; MéxicoFil: Díaz López, Rosario. Hospital Central Militar, Mexico City; MéxicoFil: Guizar López, Gregorio Ulises. Hospital Central Militar, Mexico City; MéxicoFil: Medina Escobedo, Carolina Elizabeth. Instituto Mexicano del Seguro Social; MéxicoFil: Arrazola García, María Araceli. Instituto Mexicano del Seguro Social; MéxicoFil: Montiel Hernández, Gustavo Daniel. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; MéxicoFil: Hernández Hernández, Ofelia. Técnicas Genéticas Aplicadas a la Clínica ; MéxicoFil: Ramos de la Cruz, Flor del Rocío. Instituto Mexicano del Seguro Social; MéxicoFil: Juárez Nicolás, Francisco. Instituto Nacional de Pediatría; MéxicoFil: Pantoja Torres, Jorge Arturo. Instituto Mexicano del Seguro Social; MéxicoFil: Rodríguez Munguía, Tirzo Jesús. Hospital General Norberto Treviño Zapata; MéxicoFil: Juárez Barreto, Vicencio. Hospital Infantil de Mexico Federico Gomez; MéxicoFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaElsevier Science Inc2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125846Barquera, Rodrigo; Hernández Zaragoza, Diana Iraíz; Bravo Acevedo, Alicia; Arrieta Bolaños, Esteban; Clayton, Stephen; et al.; The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure; Elsevier Science Inc; Human Immunology; 81; 9; 9-2020; 461-4740198-8859CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.humimm.2020.06.008info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(20)30343-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:58Zoai:ri.conicet.gov.ar:11336/125846instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:58.94CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure |
| title |
The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure |
| spellingShingle |
The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure Barquera, Rodrigo ADMIXTURE GENETIC SUBSTRUCTURE HLA IMMUNOGENETICS LATIN AMERICAN POPULATIONS MEXICO POPULATION GENETICS |
| title_short |
The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure |
| title_full |
The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure |
| title_fullStr |
The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure |
| title_full_unstemmed |
The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure |
| title_sort |
The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure |
| dc.creator.none.fl_str_mv |
Barquera, Rodrigo Hernández Zaragoza, Diana Iraíz Bravo Acevedo, Alicia Arrieta Bolaños, Esteban Clayton, Stephen Acuña Alonzo, Víctor Martínez Álvarez, Julio César López Gil, Concepción Adalid Sáinz, Carmen Vega Martínez, María del Rosario Escobedo Ruíz, Araceli Juárez Cortés, Eva Dolores Immel, Alexander Pacheco Ubaldo, Hanna González Medina, Liliana Lona Sánchez, Abraham Lara Riegos, Julio Sánchez Fernández, María Guadalupe de Jesús Díaz López, Rosario Guizar López, Gregorio Ulises Medina Escobedo, Carolina Elizabeth Arrazola García, María Araceli Montiel Hernández, Gustavo Daniel Hernández Hernández, Ofelia Ramos de la Cruz, Flor del Rocío Juárez Nicolás, Francisco Pantoja Torres, Jorge Arturo Rodríguez Munguía, Tirzo Jesús Juárez Barreto, Vicencio Gonzalez-Jose, Rolando |
| author |
Barquera, Rodrigo |
| author_facet |
Barquera, Rodrigo Hernández Zaragoza, Diana Iraíz Bravo Acevedo, Alicia Arrieta Bolaños, Esteban Clayton, Stephen Acuña Alonzo, Víctor Martínez Álvarez, Julio César López Gil, Concepción Adalid Sáinz, Carmen Vega Martínez, María del Rosario Escobedo Ruíz, Araceli Juárez Cortés, Eva Dolores Immel, Alexander Pacheco Ubaldo, Hanna González Medina, Liliana Lona Sánchez, Abraham Lara Riegos, Julio Sánchez Fernández, María Guadalupe de Jesús Díaz López, Rosario Guizar López, Gregorio Ulises Medina Escobedo, Carolina Elizabeth Arrazola García, María Araceli Montiel Hernández, Gustavo Daniel Hernández Hernández, Ofelia Ramos de la Cruz, Flor del Rocío Juárez Nicolás, Francisco Pantoja Torres, Jorge Arturo Rodríguez Munguía, Tirzo Jesús Juárez Barreto, Vicencio Gonzalez-Jose, Rolando |
| author_role |
author |
| author2 |
Hernández Zaragoza, Diana Iraíz Bravo Acevedo, Alicia Arrieta Bolaños, Esteban Clayton, Stephen Acuña Alonzo, Víctor Martínez Álvarez, Julio César López Gil, Concepción Adalid Sáinz, Carmen Vega Martínez, María del Rosario Escobedo Ruíz, Araceli Juárez Cortés, Eva Dolores Immel, Alexander Pacheco Ubaldo, Hanna González Medina, Liliana Lona Sánchez, Abraham Lara Riegos, Julio Sánchez Fernández, María Guadalupe de Jesús Díaz López, Rosario Guizar López, Gregorio Ulises Medina Escobedo, Carolina Elizabeth Arrazola García, María Araceli Montiel Hernández, Gustavo Daniel Hernández Hernández, Ofelia Ramos de la Cruz, Flor del Rocío Juárez Nicolás, Francisco Pantoja Torres, Jorge Arturo Rodríguez Munguía, Tirzo Jesús Juárez Barreto, Vicencio Gonzalez-Jose, Rolando |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ADMIXTURE GENETIC SUBSTRUCTURE HLA IMMUNOGENETICS LATIN AMERICAN POPULATIONS MEXICO POPULATION GENETICS |
| topic |
ADMIXTURE GENETIC SUBSTRUCTURE HLA IMMUNOGENETICS LATIN AMERICAN POPULATIONS MEXICO POPULATION GENETICS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ’≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources. Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Hernández Zaragoza, Diana Iraíz. Técnicas Genéticas Aplicadas A la Clínica (tgac); México. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Bravo Acevedo, Alicia. Instituto Mexicano del Seguro Social; México Fil: Arrieta Bolaños, Esteban. Universitat Essen; Alemania Fil: Clayton, Stephen. Max Planck Institute For The Science Of Human History; Alemania Fil: Acuña Alonzo, Víctor. Instituto Nacional de Antropología E Historia, Mexico; México Fil: Martínez Álvarez, Julio César. Instituto Mexicano del Seguro Social; México Fil: López Gil, Concepción. Instituto Mexicano del Seguro Social; México Fil: Adalid Sáinz, Carmen. Instituto Mexicano del Seguro Social; México Fil: Vega Martínez, María del Rosario. Hospital Central Sur de Alta Especialidad; México Fil: Escobedo Ruíz, Araceli. Instituto Mexicano del Seguro Social; México Fil: Juárez Cortés, Eva Dolores. Instituto Mexicano del Seguro Social; México Fil: Immel, Alexander. Max Planck Institute For The Science Of Human History; Alemania. Christian Albrechts Universitat Zu Kiel; Alemania Fil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: González Medina, Liliana. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Lona Sánchez, Abraham. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Lara Riegos, Julio. Universidad Autónoma de Yucatán; México Fil: Sánchez Fernández, María Guadalupe de Jesús. Instituto Mexicano del Seguro Social; México Fil: Díaz López, Rosario. Hospital Central Militar, Mexico City; México Fil: Guizar López, Gregorio Ulises. Hospital Central Militar, Mexico City; México Fil: Medina Escobedo, Carolina Elizabeth. Instituto Mexicano del Seguro Social; México Fil: Arrazola García, María Araceli. Instituto Mexicano del Seguro Social; México Fil: Montiel Hernández, Gustavo Daniel. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Hernández Hernández, Ofelia. Técnicas Genéticas Aplicadas a la Clínica ; México Fil: Ramos de la Cruz, Flor del Rocío. Instituto Mexicano del Seguro Social; México Fil: Juárez Nicolás, Francisco. Instituto Nacional de Pediatría; México Fil: Pantoja Torres, Jorge Arturo. Instituto Mexicano del Seguro Social; México Fil: Rodríguez Munguía, Tirzo Jesús. Hospital General Norberto Treviño Zapata; México Fil: Juárez Barreto, Vicencio. Hospital Infantil de Mexico Federico Gomez; México Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina |
| description |
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ’≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-09 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/125846 Barquera, Rodrigo; Hernández Zaragoza, Diana Iraíz; Bravo Acevedo, Alicia; Arrieta Bolaños, Esteban; Clayton, Stephen; et al.; The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure; Elsevier Science Inc; Human Immunology; 81; 9; 9-2020; 461-474 0198-8859 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/125846 |
| identifier_str_mv |
Barquera, Rodrigo; Hernández Zaragoza, Diana Iraíz; Bravo Acevedo, Alicia; Arrieta Bolaños, Esteban; Clayton, Stephen; et al.; The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure; Elsevier Science Inc; Human Immunology; 81; 9; 9-2020; 461-474 0198-8859 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.humimm.2020.06.008 info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(20)30343-8 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier Science Inc |
| publisher.none.fl_str_mv |
Elsevier Science Inc |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1842269777758781440 |
| score |
13.13397 |