Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin

Autores
Galeotti, Caroline; Hegde, Pushpa; Das, Mrinmoy; Stephen-Victor, Emmanuel; Canale, Fernando; Muñoz, Marcos David; Sharma, Varun K.; Dimitrov, Jordan D.; Kaveri, Srini V.; Bayry, Jagadeesh
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophages, T and B cells and modulate their functions. Recent studies have reported that heme oxygenase-1 (HO-1) pathway plays an important role in the regulation of inflammatory response in several pathologies. Several therapeutic agents exert anti-inflammatory effects via induction of HO-1. Therefore, we aimed at exploring if anti-inflammatory effects of IVIG are mediated via HO-1 pathway. Confirming the previous reports, we report that IVIG exerts anti-inflammatory effects on innate cells as shown by the inhibitory effects on IL-6 and nitric oxide production and confers protection in experimental autoimmune encephalomyelitis (EAE) model. However, these effects were not associated with an induction of HO-1 either in innate cells such as monocytes, dendritic cells and macrophages or in the kidneys and liver of IVIG-treated EAE mice. Also, inhibition of endogenous HO-1 did not modify anti-inflammatory effects of IVIG. These results thus indicate that IVIG exerts anti-inflammatory effects independent of HO-1 pathway.
Fil: Galeotti, Caroline. Hopital de Bicetre; Francia. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Hegde, Pushpa. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Das, Mrinmoy. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Stephen-Victor, Emmanuel. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Canale, Fernando. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; Francia
Fil: Muñoz, Marcos David. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sharma, Varun K.. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; Francia
Fil: Dimitrov, Jordan D.. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Universite Paris Descartes; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Kaveri, Srini V.. Centre de Recherches Biomedicales Des Cordeliers; Francia. Indian Council Of Medical Research; India. Universite Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Bayry, Jagadeesh. Indian Council Of Medical Research; India. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; Francia. Universite Pierre et Marie Curie; Francia
Materia
Heme-oxygenase
Intravenous Immunology
Inflammation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/57981
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/57981
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulinGaleotti, CarolineHegde, PushpaDas, MrinmoyStephen-Victor, EmmanuelCanale, FernandoMuñoz, Marcos DavidSharma, Varun K.Dimitrov, Jordan D.Kaveri, Srini V.Bayry, JagadeeshHeme-oxygenaseIntravenous ImmunologyInflammationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophages, T and B cells and modulate their functions. Recent studies have reported that heme oxygenase-1 (HO-1) pathway plays an important role in the regulation of inflammatory response in several pathologies. Several therapeutic agents exert anti-inflammatory effects via induction of HO-1. Therefore, we aimed at exploring if anti-inflammatory effects of IVIG are mediated via HO-1 pathway. Confirming the previous reports, we report that IVIG exerts anti-inflammatory effects on innate cells as shown by the inhibitory effects on IL-6 and nitric oxide production and confers protection in experimental autoimmune encephalomyelitis (EAE) model. However, these effects were not associated with an induction of HO-1 either in innate cells such as monocytes, dendritic cells and macrophages or in the kidneys and liver of IVIG-treated EAE mice. Also, inhibition of endogenous HO-1 did not modify anti-inflammatory effects of IVIG. These results thus indicate that IVIG exerts anti-inflammatory effects independent of HO-1 pathway.Fil: Galeotti, Caroline. Hopital de Bicetre; Francia. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; FranciaFil: Hegde, Pushpa. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; FranciaFil: Das, Mrinmoy. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Centre de Recherches Biomedicales Des Cordeliers; FranciaFil: Stephen-Victor, Emmanuel. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Centre de Recherches Biomedicales Des Cordeliers; FranciaFil: Canale, Fernando. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; FranciaFil: Muñoz, Marcos David. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sharma, Varun K.. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; FranciaFil: Dimitrov, Jordan D.. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Universite Paris Descartes; Francia. Centre de Recherches Biomedicales Des Cordeliers; FranciaFil: Kaveri, Srini V.. Centre de Recherches Biomedicales Des Cordeliers; Francia. Indian Council Of Medical Research; India. Universite Pierre et Marie Curie; Francia. Inserm; FranciaFil: Bayry, Jagadeesh. Indian Council Of Medical Research; India. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; Francia. Universite Pierre et Marie Curie; FranciaNature Publishing Group2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57981Galeotti, Caroline; Hegde, Pushpa; Das, Mrinmoy; Stephen-Victor, Emmanuel; Canale, Fernando; et al.; Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin; Nature Publishing Group; Scientific Reports; 6; 1-2016; 1-82045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/srep19592info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep19592info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:33Zoai:ri.conicet.gov.ar:11336/57981instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:33.419CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
spellingShingle Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
Galeotti, Caroline
Heme-oxygenase
Intravenous Immunology
Inflammation
title_short Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_full Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_fullStr Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_full_unstemmed Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
title_sort Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin
dc.creator.none.fl_str_mv Galeotti, Caroline
Hegde, Pushpa
Das, Mrinmoy
Stephen-Victor, Emmanuel
Canale, Fernando
Muñoz, Marcos David
Sharma, Varun K.
Dimitrov, Jordan D.
Kaveri, Srini V.
Bayry, Jagadeesh
author Galeotti, Caroline
author_facet Galeotti, Caroline
Hegde, Pushpa
Das, Mrinmoy
Stephen-Victor, Emmanuel
Canale, Fernando
Muñoz, Marcos David
Sharma, Varun K.
Dimitrov, Jordan D.
Kaveri, Srini V.
Bayry, Jagadeesh
author_role author
author2 Hegde, Pushpa
Das, Mrinmoy
Stephen-Victor, Emmanuel
Canale, Fernando
Muñoz, Marcos David
Sharma, Varun K.
Dimitrov, Jordan D.
Kaveri, Srini V.
Bayry, Jagadeesh
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Heme-oxygenase
Intravenous Immunology
Inflammation
topic Heme-oxygenase
Intravenous Immunology
Inflammation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophages, T and B cells and modulate their functions. Recent studies have reported that heme oxygenase-1 (HO-1) pathway plays an important role in the regulation of inflammatory response in several pathologies. Several therapeutic agents exert anti-inflammatory effects via induction of HO-1. Therefore, we aimed at exploring if anti-inflammatory effects of IVIG are mediated via HO-1 pathway. Confirming the previous reports, we report that IVIG exerts anti-inflammatory effects on innate cells as shown by the inhibitory effects on IL-6 and nitric oxide production and confers protection in experimental autoimmune encephalomyelitis (EAE) model. However, these effects were not associated with an induction of HO-1 either in innate cells such as monocytes, dendritic cells and macrophages or in the kidneys and liver of IVIG-treated EAE mice. Also, inhibition of endogenous HO-1 did not modify anti-inflammatory effects of IVIG. These results thus indicate that IVIG exerts anti-inflammatory effects independent of HO-1 pathway.
Fil: Galeotti, Caroline. Hopital de Bicetre; Francia. Universite Pierre et Marie Curie; Francia. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Hegde, Pushpa. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Das, Mrinmoy. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Stephen-Victor, Emmanuel. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Canale, Fernando. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; Francia
Fil: Muñoz, Marcos David. Inserm; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sharma, Varun K.. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; Francia
Fil: Dimitrov, Jordan D.. Inserm; Francia. Universite Pierre et Marie Curie; Francia. Universite Paris Descartes; Francia. Centre de Recherches Biomedicales Des Cordeliers; Francia
Fil: Kaveri, Srini V.. Centre de Recherches Biomedicales Des Cordeliers; Francia. Indian Council Of Medical Research; India. Universite Pierre et Marie Curie; Francia. Inserm; Francia
Fil: Bayry, Jagadeesh. Indian Council Of Medical Research; India. Centre de Recherches Biomedicales Des Cordeliers; Francia. Inserm; Francia. Universite Pierre et Marie Curie; Francia
description Intravenous immunoglobulin G (IVIG) is used in the therapy of various autoimmune and inflammatory conditions. The mechanisms by which IVIG exerts anti-inflammatory effects are not completely understood. IVIG interacts with numerous components of the immune system including dendritic cells, macrophages, T and B cells and modulate their functions. Recent studies have reported that heme oxygenase-1 (HO-1) pathway plays an important role in the regulation of inflammatory response in several pathologies. Several therapeutic agents exert anti-inflammatory effects via induction of HO-1. Therefore, we aimed at exploring if anti-inflammatory effects of IVIG are mediated via HO-1 pathway. Confirming the previous reports, we report that IVIG exerts anti-inflammatory effects on innate cells as shown by the inhibitory effects on IL-6 and nitric oxide production and confers protection in experimental autoimmune encephalomyelitis (EAE) model. However, these effects were not associated with an induction of HO-1 either in innate cells such as monocytes, dendritic cells and macrophages or in the kidneys and liver of IVIG-treated EAE mice. Also, inhibition of endogenous HO-1 did not modify anti-inflammatory effects of IVIG. These results thus indicate that IVIG exerts anti-inflammatory effects independent of HO-1 pathway.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/57981
Galeotti, Caroline; Hegde, Pushpa; Das, Mrinmoy; Stephen-Victor, Emmanuel; Canale, Fernando; et al.; Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin; Nature Publishing Group; Scientific Reports; 6; 1-2016; 1-8
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/57981
identifier_str_mv Galeotti, Caroline; Hegde, Pushpa; Das, Mrinmoy; Stephen-Victor, Emmanuel; Canale, Fernando; et al.; Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin; Nature Publishing Group; Scientific Reports; 6; 1-2016; 1-8
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/srep19592
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep19592
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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