Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases
- Autores
- Funes, Samanta Celeste; Rios, Mariana; Fernández Fierro, Ayleen; Covián, Camila; Bueno, Susan M.; Riedel, Claudia A.; Mackern Oberti, Juan Pablo; Kalergis, Alexis M.
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity.
Fil: Funes, Samanta Celeste. Pontificia Universidad Católica de Chile; Chile
Fil: Rios, Mariana. Pontificia Universidad Católica de Chile; Chile
Fil: Fernández Fierro, Ayleen. Pontificia Universidad Católica de Chile; Chile
Fil: Covián, Camila. Pontificia Universidad Católica de Chile; Chile
Fil: Bueno, Susan M.. Pontificia Universidad Católica de Chile; Chile
Fil: Riedel, Claudia A.. Universidad Andrés Bello; Chile
Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile - Materia
-
AUTOIMMUNITY
HEME OXYGENASE 1
HO-1
INFLAMMATION
NATURALLY DERIVED COMPOUNDS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/138870
Ver los metadatos del registro completo
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Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated DiseasesFunes, Samanta CelesteRios, MarianaFernández Fierro, AyleenCovián, CamilaBueno, Susan M.Riedel, Claudia A.Mackern Oberti, Juan PabloKalergis, Alexis M.AUTOIMMUNITYHEME OXYGENASE 1HO-1INFLAMMATIONNATURALLY DERIVED COMPOUNDShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity.Fil: Funes, Samanta Celeste. Pontificia Universidad Católica de Chile; ChileFil: Rios, Mariana. Pontificia Universidad Católica de Chile; ChileFil: Fernández Fierro, Ayleen. Pontificia Universidad Católica de Chile; ChileFil: Covián, Camila. Pontificia Universidad Católica de Chile; ChileFil: Bueno, Susan M.. Pontificia Universidad Católica de Chile; ChileFil: Riedel, Claudia A.. Universidad Andrés Bello; ChileFil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; ChileFrontiers Media S.A.2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138870Funes, Samanta Celeste; Rios, Mariana; Fernández Fierro, Ayleen; Covián, Camila; Bueno, Susan M.; et al.; Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases; Frontiers Media S.A.; Frontiers in Immunology; 11; 7-2020; 1-211664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/article/10.3389/fimmu.2020.01467/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.01467info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:12:46Zoai:ri.conicet.gov.ar:11336/138870instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:12:47.266CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases |
| title |
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases |
| spellingShingle |
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases Funes, Samanta Celeste AUTOIMMUNITY HEME OXYGENASE 1 HO-1 INFLAMMATION NATURALLY DERIVED COMPOUNDS |
| title_short |
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases |
| title_full |
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases |
| title_fullStr |
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases |
| title_full_unstemmed |
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases |
| title_sort |
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases |
| dc.creator.none.fl_str_mv |
Funes, Samanta Celeste Rios, Mariana Fernández Fierro, Ayleen Covián, Camila Bueno, Susan M. Riedel, Claudia A. Mackern Oberti, Juan Pablo Kalergis, Alexis M. |
| author |
Funes, Samanta Celeste |
| author_facet |
Funes, Samanta Celeste Rios, Mariana Fernández Fierro, Ayleen Covián, Camila Bueno, Susan M. Riedel, Claudia A. Mackern Oberti, Juan Pablo Kalergis, Alexis M. |
| author_role |
author |
| author2 |
Rios, Mariana Fernández Fierro, Ayleen Covián, Camila Bueno, Susan M. Riedel, Claudia A. Mackern Oberti, Juan Pablo Kalergis, Alexis M. |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
AUTOIMMUNITY HEME OXYGENASE 1 HO-1 INFLAMMATION NATURALLY DERIVED COMPOUNDS |
| topic |
AUTOIMMUNITY HEME OXYGENASE 1 HO-1 INFLAMMATION NATURALLY DERIVED COMPOUNDS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity. Fil: Funes, Samanta Celeste. Pontificia Universidad Católica de Chile; Chile Fil: Rios, Mariana. Pontificia Universidad Católica de Chile; Chile Fil: Fernández Fierro, Ayleen. Pontificia Universidad Católica de Chile; Chile Fil: Covián, Camila. Pontificia Universidad Católica de Chile; Chile Fil: Bueno, Susan M.. Pontificia Universidad Católica de Chile; Chile Fil: Riedel, Claudia A.. Universidad Andrés Bello; Chile Fil: Mackern Oberti, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile |
| description |
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity. |
| publishDate |
2020 |
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2020-07 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/138870 Funes, Samanta Celeste; Rios, Mariana; Fernández Fierro, Ayleen; Covián, Camila; Bueno, Susan M.; et al.; Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases; Frontiers Media S.A.; Frontiers in Immunology; 11; 7-2020; 1-21 1664-3224 CONICET Digital CONICET |
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http://hdl.handle.net/11336/138870 |
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Funes, Samanta Celeste; Rios, Mariana; Fernández Fierro, Ayleen; Covián, Camila; Bueno, Susan M.; et al.; Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases; Frontiers Media S.A.; Frontiers in Immunology; 11; 7-2020; 1-21 1664-3224 CONICET Digital CONICET |
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eng |
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eng |
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Frontiers Media S.A. |
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Frontiers Media S.A. |
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