Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories

Autores
Deiber, Julio Alcides; Ottone, Mariel Lorena; Piaggio, María Virginia; Peirotti, Marta Beatriz
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A new approach is proposed to characterize polyampholytic gelatin hydrogels, cross-linked covalently with glutaraldehyde. An experimental methodology involving simple mechanical extension and compression and equilibrium swelling tests is developed to estimate relevant microstructural parameters and electrokinetic properties of this type of hydrogel, for different cross-linker to gelatin mass ratios. The polyampholytic cross-linked matrices are studied here in the framework of the rubber elasticity and thermodynamic swelling theories. The main purposes of this work are the estimations of average mesh size and toughness of the swollen hydrogels, and the determination of the feasibility of polyion complexation between cross-linked gelatin chains and bioactive macromolecules to be delivered through hydrogel biodegradation.
Fil: Deiber, Julio Alcides. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Ottone, Mariel Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Piaggio, María Virginia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Peirotti, Marta Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
Cross-Linked Gelatin Hydrogels
Mechanical-Electrokinetic Properties
Network Mesh Size
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/26097
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling TheoriesDeiber, Julio AlcidesOttone, Mariel LorenaPiaggio, María VirginiaPeirotti, Marta BeatrizCross-Linked Gelatin HydrogelsMechanical-Electrokinetic PropertiesNetwork Mesh Sizehttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2A new approach is proposed to characterize polyampholytic gelatin hydrogels, cross-linked covalently with glutaraldehyde. An experimental methodology involving simple mechanical extension and compression and equilibrium swelling tests is developed to estimate relevant microstructural parameters and electrokinetic properties of this type of hydrogel, for different cross-linker to gelatin mass ratios. The polyampholytic cross-linked matrices are studied here in the framework of the rubber elasticity and thermodynamic swelling theories. The main purposes of this work are the estimations of average mesh size and toughness of the swollen hydrogels, and the determination of the feasibility of polyion complexation between cross-linked gelatin chains and bioactive macromolecules to be delivered through hydrogel biodegradation.Fil: Deiber, Julio Alcides. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Ottone, Mariel Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Piaggio, María Virginia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Peirotti, Marta Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaElsevier2009-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26097Deiber, Julio Alcides; Ottone, Mariel Lorena; Piaggio, María Virginia; Peirotti, Marta Beatriz; Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories; Elsevier; Polymer; 50; 25; 11-2009; 6065-60750032-3861CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.polymer.2009.10.046info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0032386109009240info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:45Zoai:ri.conicet.gov.ar:11336/26097instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:45.691CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories
title Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories
spellingShingle Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories
Deiber, Julio Alcides
Cross-Linked Gelatin Hydrogels
Mechanical-Electrokinetic Properties
Network Mesh Size
title_short Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories
title_full Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories
title_fullStr Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories
title_full_unstemmed Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories
title_sort Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories
dc.creator.none.fl_str_mv Deiber, Julio Alcides
Ottone, Mariel Lorena
Piaggio, María Virginia
Peirotti, Marta Beatriz
author Deiber, Julio Alcides
author_facet Deiber, Julio Alcides
Ottone, Mariel Lorena
Piaggio, María Virginia
Peirotti, Marta Beatriz
author_role author
author2 Ottone, Mariel Lorena
Piaggio, María Virginia
Peirotti, Marta Beatriz
author2_role author
author
author
dc.subject.none.fl_str_mv Cross-Linked Gelatin Hydrogels
Mechanical-Electrokinetic Properties
Network Mesh Size
topic Cross-Linked Gelatin Hydrogels
Mechanical-Electrokinetic Properties
Network Mesh Size
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv A new approach is proposed to characterize polyampholytic gelatin hydrogels, cross-linked covalently with glutaraldehyde. An experimental methodology involving simple mechanical extension and compression and equilibrium swelling tests is developed to estimate relevant microstructural parameters and electrokinetic properties of this type of hydrogel, for different cross-linker to gelatin mass ratios. The polyampholytic cross-linked matrices are studied here in the framework of the rubber elasticity and thermodynamic swelling theories. The main purposes of this work are the estimations of average mesh size and toughness of the swollen hydrogels, and the determination of the feasibility of polyion complexation between cross-linked gelatin chains and bioactive macromolecules to be delivered through hydrogel biodegradation.
Fil: Deiber, Julio Alcides. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Ottone, Mariel Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Piaggio, María Virginia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Peirotti, Marta Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description A new approach is proposed to characterize polyampholytic gelatin hydrogels, cross-linked covalently with glutaraldehyde. An experimental methodology involving simple mechanical extension and compression and equilibrium swelling tests is developed to estimate relevant microstructural parameters and electrokinetic properties of this type of hydrogel, for different cross-linker to gelatin mass ratios. The polyampholytic cross-linked matrices are studied here in the framework of the rubber elasticity and thermodynamic swelling theories. The main purposes of this work are the estimations of average mesh size and toughness of the swollen hydrogels, and the determination of the feasibility of polyion complexation between cross-linked gelatin chains and bioactive macromolecules to be delivered through hydrogel biodegradation.
publishDate 2009
dc.date.none.fl_str_mv 2009-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/26097
Deiber, Julio Alcides; Ottone, Mariel Lorena; Piaggio, María Virginia; Peirotti, Marta Beatriz; Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories; Elsevier; Polymer; 50; 25; 11-2009; 6065-6075
0032-3861
CONICET Digital
CONICET
url http://hdl.handle.net/11336/26097
identifier_str_mv Deiber, Julio Alcides; Ottone, Mariel Lorena; Piaggio, María Virginia; Peirotti, Marta Beatriz; Characterization of Cross-linked Polyampholytic Gelatin Hydrogels through the Rubber Elasticity and Thermodynamic Swelling Theories; Elsevier; Polymer; 50; 25; 11-2009; 6065-6075
0032-3861
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.polymer.2009.10.046
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0032386109009240
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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