Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case

Autores
Favatela, María Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Alvarez, María Victoria; Lassalle, Verónica Leticia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gelatin based hydrogels were synthesized by the thawing-freezing method employing gum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) was analyzed aiming to reach a control over the solubility/degradation rate, swelling properties and their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e: 1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogels were well characterized in terms of the main properties regarding the intended application. Hence the swelling behaviour, solubility rate, gel fraction were determined as well as their thermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potential application in the lidocaine administration during dental practices. This drug has been taken as model between other potential therapeutic agents for buccal treatments such as antibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied by means of available mathematical models. The hydrogels loaded LID here presented would be considered as potential raw materials to the fabrication of buccal patches in order to avoid, or at least minimize, the extensive use of injected anaesthesia during dental treatments.
Fil: Favatela, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Bracone, Melina Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Alvarez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
Materia
ANAESTHESIA DRUG DELIVERY
GELATIN
HYDROGELS
LIDOCAINE
NANOCELLULOSE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147993

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network_name_str CONICET Digital (CONICET)
spelling Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model caseFavatela, María FlorenciaHorst, María FernandaBracone, Melina EthelGonzalez, Jimena SoledadAlvarez, María VictoriaLassalle, Verónica LeticiaANAESTHESIA DRUG DELIVERYGELATINHYDROGELSLIDOCAINENANOCELLULOSEhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Gelatin based hydrogels were synthesized by the thawing-freezing method employing gum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) was analyzed aiming to reach a control over the solubility/degradation rate, swelling properties and their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e: 1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogels were well characterized in terms of the main properties regarding the intended application. Hence the swelling behaviour, solubility rate, gel fraction were determined as well as their thermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potential application in the lidocaine administration during dental practices. This drug has been taken as model between other potential therapeutic agents for buccal treatments such as antibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied by means of available mathematical models. The hydrogels loaded LID here presented would be considered as potential raw materials to the fabrication of buccal patches in order to avoid, or at least minimize, the extensive use of injected anaesthesia during dental treatments.Fil: Favatela, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; ArgentinaFil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; ArgentinaFil: Bracone, Melina Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Alvarez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; ArgentinaElsevier2021-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147993Favatela, María Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Alvarez, María Victoria; et al.; Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case; Elsevier; Journal of Drug Delivery Science and Technology; 61; 2-2021; 1-381773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1773224720311758info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2020.101886info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:25Zoai:ri.conicet.gov.ar:11336/147993instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:25.66CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
title Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
spellingShingle Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
Favatela, María Florencia
ANAESTHESIA DRUG DELIVERY
GELATIN
HYDROGELS
LIDOCAINE
NANOCELLULOSE
title_short Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
title_full Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
title_fullStr Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
title_full_unstemmed Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
title_sort Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
dc.creator.none.fl_str_mv Favatela, María Florencia
Horst, María Fernanda
Bracone, Melina Ethel
Gonzalez, Jimena Soledad
Alvarez, María Victoria
Lassalle, Verónica Leticia
author Favatela, María Florencia
author_facet Favatela, María Florencia
Horst, María Fernanda
Bracone, Melina Ethel
Gonzalez, Jimena Soledad
Alvarez, María Victoria
Lassalle, Verónica Leticia
author_role author
author2 Horst, María Fernanda
Bracone, Melina Ethel
Gonzalez, Jimena Soledad
Alvarez, María Victoria
Lassalle, Verónica Leticia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANAESTHESIA DRUG DELIVERY
GELATIN
HYDROGELS
LIDOCAINE
NANOCELLULOSE
topic ANAESTHESIA DRUG DELIVERY
GELATIN
HYDROGELS
LIDOCAINE
NANOCELLULOSE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Gelatin based hydrogels were synthesized by the thawing-freezing method employing gum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) was analyzed aiming to reach a control over the solubility/degradation rate, swelling properties and their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e: 1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogels were well characterized in terms of the main properties regarding the intended application. Hence the swelling behaviour, solubility rate, gel fraction were determined as well as their thermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potential application in the lidocaine administration during dental practices. This drug has been taken as model between other potential therapeutic agents for buccal treatments such as antibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied by means of available mathematical models. The hydrogels loaded LID here presented would be considered as potential raw materials to the fabrication of buccal patches in order to avoid, or at least minimize, the extensive use of injected anaesthesia during dental treatments.
Fil: Favatela, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Bracone, Melina Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Alvarez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
description Gelatin based hydrogels were synthesized by the thawing-freezing method employing gum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) was analyzed aiming to reach a control over the solubility/degradation rate, swelling properties and their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e: 1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogels were well characterized in terms of the main properties regarding the intended application. Hence the swelling behaviour, solubility rate, gel fraction were determined as well as their thermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potential application in the lidocaine administration during dental practices. This drug has been taken as model between other potential therapeutic agents for buccal treatments such as antibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied by means of available mathematical models. The hydrogels loaded LID here presented would be considered as potential raw materials to the fabrication of buccal patches in order to avoid, or at least minimize, the extensive use of injected anaesthesia during dental treatments.
publishDate 2021
dc.date.none.fl_str_mv 2021-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147993
Favatela, María Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Alvarez, María Victoria; et al.; Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case; Elsevier; Journal of Drug Delivery Science and Technology; 61; 2-2021; 1-38
1773-2247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147993
identifier_str_mv Favatela, María Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Alvarez, María Victoria; et al.; Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case; Elsevier; Journal of Drug Delivery Science and Technology; 61; 2-2021; 1-38
1773-2247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1773224720311758
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2020.101886
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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