Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case
- Autores
- Favatela, María Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Alvarez, María Victoria; Lassalle, Verónica Leticia
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Gelatin based hydrogels were synthesized by the thawing-freezing method employing gum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) was analyzed aiming to reach a control over the solubility/degradation rate, swelling properties and their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e: 1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogels were well characterized in terms of the main properties regarding the intended application. Hence the swelling behaviour, solubility rate, gel fraction were determined as well as their thermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potential application in the lidocaine administration during dental practices. This drug has been taken as model between other potential therapeutic agents for buccal treatments such as antibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied by means of available mathematical models. The hydrogels loaded LID here presented would be considered as potential raw materials to the fabrication of buccal patches in order to avoid, or at least minimize, the extensive use of injected anaesthesia during dental treatments.
Fil: Favatela, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Bracone, Melina Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Alvarez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina - Materia
-
ANAESTHESIA DRUG DELIVERY
GELATIN
HYDROGELS
LIDOCAINE
NANOCELLULOSE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/147993
Ver los metadatos del registro completo
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Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model caseFavatela, María FlorenciaHorst, María FernandaBracone, Melina EthelGonzalez, Jimena SoledadAlvarez, María VictoriaLassalle, Verónica LeticiaANAESTHESIA DRUG DELIVERYGELATINHYDROGELSLIDOCAINENANOCELLULOSEhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Gelatin based hydrogels were synthesized by the thawing-freezing method employing gum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) was analyzed aiming to reach a control over the solubility/degradation rate, swelling properties and their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e: 1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogels were well characterized in terms of the main properties regarding the intended application. Hence the swelling behaviour, solubility rate, gel fraction were determined as well as their thermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potential application in the lidocaine administration during dental practices. This drug has been taken as model between other potential therapeutic agents for buccal treatments such as antibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied by means of available mathematical models. The hydrogels loaded LID here presented would be considered as potential raw materials to the fabrication of buccal patches in order to avoid, or at least minimize, the extensive use of injected anaesthesia during dental treatments.Fil: Favatela, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; ArgentinaFil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; ArgentinaFil: Bracone, Melina Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Alvarez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; ArgentinaElsevier2021-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147993Favatela, María Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Alvarez, María Victoria; et al.; Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case; Elsevier; Journal of Drug Delivery Science and Technology; 61; 2-2021; 1-381773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1773224720311758info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2020.101886info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:52:25Zoai:ri.conicet.gov.ar:11336/147993instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:52:25.66CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case |
title |
Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case |
spellingShingle |
Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case Favatela, María Florencia ANAESTHESIA DRUG DELIVERY GELATIN HYDROGELS LIDOCAINE NANOCELLULOSE |
title_short |
Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case |
title_full |
Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case |
title_fullStr |
Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case |
title_full_unstemmed |
Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case |
title_sort |
Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case |
dc.creator.none.fl_str_mv |
Favatela, María Florencia Horst, María Fernanda Bracone, Melina Ethel Gonzalez, Jimena Soledad Alvarez, María Victoria Lassalle, Verónica Leticia |
author |
Favatela, María Florencia |
author_facet |
Favatela, María Florencia Horst, María Fernanda Bracone, Melina Ethel Gonzalez, Jimena Soledad Alvarez, María Victoria Lassalle, Verónica Leticia |
author_role |
author |
author2 |
Horst, María Fernanda Bracone, Melina Ethel Gonzalez, Jimena Soledad Alvarez, María Victoria Lassalle, Verónica Leticia |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
ANAESTHESIA DRUG DELIVERY GELATIN HYDROGELS LIDOCAINE NANOCELLULOSE |
topic |
ANAESTHESIA DRUG DELIVERY GELATIN HYDROGELS LIDOCAINE NANOCELLULOSE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Gelatin based hydrogels were synthesized by the thawing-freezing method employing gum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) was analyzed aiming to reach a control over the solubility/degradation rate, swelling properties and their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e: 1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogels were well characterized in terms of the main properties regarding the intended application. Hence the swelling behaviour, solubility rate, gel fraction were determined as well as their thermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potential application in the lidocaine administration during dental practices. This drug has been taken as model between other potential therapeutic agents for buccal treatments such as antibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied by means of available mathematical models. The hydrogels loaded LID here presented would be considered as potential raw materials to the fabrication of buccal patches in order to avoid, or at least minimize, the extensive use of injected anaesthesia during dental treatments. Fil: Favatela, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina Fil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina Fil: Bracone, Melina Ethel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina Fil: Gonzalez, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina Fil: Alvarez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química; Argentina |
description |
Gelatin based hydrogels were synthesized by the thawing-freezing method employing gum Arabic as crosslinking agent. The incorporation of cellulose nanowhiskers (NC) was analyzed aiming to reach a control over the solubility/degradation rate, swelling properties and their ability to load anaesthetic drugs. Three concentrations of NC were explored, i.e: 1, 2 and 5%w/w with respect to the gelatin mass. The raw and NC containing hydrogels were well characterized in terms of the main properties regarding the intended application. Hence the swelling behaviour, solubility rate, gel fraction were determined as well as their thermal, morphological and rheological properties. In this work, the obtained biocompatible hydrogels have tested for their potential application in the lidocaine administration during dental practices. This drug has been taken as model between other potential therapeutic agents for buccal treatments such as antibiotics, analgesics, etc. The kinetic and mechanism of LID release were studied by means of available mathematical models. The hydrogels loaded LID here presented would be considered as potential raw materials to the fabrication of buccal patches in order to avoid, or at least minimize, the extensive use of injected anaesthesia during dental treatments. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/147993 Favatela, María Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Alvarez, María Victoria; et al.; Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case; Elsevier; Journal of Drug Delivery Science and Technology; 61; 2-2021; 1-38 1773-2247 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/147993 |
identifier_str_mv |
Favatela, María Florencia; Horst, María Fernanda; Bracone, Melina Ethel; Gonzalez, Jimena Soledad; Alvarez, María Victoria; et al.; Gelatin/Cellulose nanowhiskers hydrogels intended for the administration of drugs in dental treatments: Study of lidocaine as model case; Elsevier; Journal of Drug Delivery Science and Technology; 61; 2-2021; 1-38 1773-2247 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1773224720311758 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2020.101886 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846083052596363264 |
score |
13.22299 |