Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder

Autores
Ortega Toro, Rodrigo; López, Vladimir; Carrasco, Ximena; Escobar, María Josefina; García, Adolfo Martín; Parra, Mario; Aboitiz, Francisco
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retain information rather than on the attention-dependent stages of encoding and retrieval. The current study uses a visual short-term memory binding task, measuring both behavioral and electrophysiological responses to characterize WM encoding, binding and retrieval comparing ADHD and non-ADHD matched adolescents. ADHD exhibited poorer accuracy and larger reaction times than non-ADHD on all conditions but especially when a change across encoding and test displays occurred. Binding manipulation affected equally both groups. Encoding P3 was larger in the non-ADHD group. Retrieval P3 discriminated change only in the non-ADHD group. Binding-dependent ERP modulations did not reveal group differences. Encoding and retrieval P3 were significantly correlated only in non-ADHD. These results suggest that while binding processes seem to be intact in ADHD, attention-related encoding and retrieval processes are compromised, resulting in a failure in the prioritization of relevant information. This new evidence can also inform recent theories of binding in visual WM.
Fil: Ortega Toro, Rodrigo. Universidad de Chile; Chile
Fil: López, Vladimir. Pontificia Universidad Católica de Chile; Chile
Fil: Carrasco, Ximena. Universidad de Chile; Chile
Fil: Escobar, María Josefina. Universidad Adolfo Ibañez; Chile
Fil: García, Adolfo Martín. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad de Santiago de Chile; Chile
Fil: Parra, Mario. Universidad Autónoma del Caribe; Colombia
Fil: Aboitiz, Francisco. Universidad de Chile; Chile
Materia
WORKING MEMORY
BINDING
RETRIEVAL
ENCODING
ATTENTION DEFICIT/HYPERACTIVITY DISORDER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140897
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity DisorderOrtega Toro, RodrigoLópez, VladimirCarrasco, XimenaEscobar, María JosefinaGarcía, Adolfo MartínParra, MarioAboitiz, FranciscoWORKING MEMORYBINDINGRETRIEVALENCODINGATTENTION DEFICIT/HYPERACTIVITY DISORDERhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retain information rather than on the attention-dependent stages of encoding and retrieval. The current study uses a visual short-term memory binding task, measuring both behavioral and electrophysiological responses to characterize WM encoding, binding and retrieval comparing ADHD and non-ADHD matched adolescents. ADHD exhibited poorer accuracy and larger reaction times than non-ADHD on all conditions but especially when a change across encoding and test displays occurred. Binding manipulation affected equally both groups. Encoding P3 was larger in the non-ADHD group. Retrieval P3 discriminated change only in the non-ADHD group. Binding-dependent ERP modulations did not reveal group differences. Encoding and retrieval P3 were significantly correlated only in non-ADHD. These results suggest that while binding processes seem to be intact in ADHD, attention-related encoding and retrieval processes are compromised, resulting in a failure in the prioritization of relevant information. This new evidence can also inform recent theories of binding in visual WM.Fil: Ortega Toro, Rodrigo. Universidad de Chile; ChileFil: López, Vladimir. Pontificia Universidad Católica de Chile; ChileFil: Carrasco, Ximena. Universidad de Chile; ChileFil: Escobar, María Josefina. Universidad Adolfo Ibañez; ChileFil: García, Adolfo Martín. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad de Santiago de Chile; ChileFil: Parra, Mario. Universidad Autónoma del Caribe; ColombiaFil: Aboitiz, Francisco. Universidad de Chile; ChileNature Publishing Group2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140897Ortega Toro, Rodrigo; López, Vladimir; Carrasco, Ximena; Escobar, María Josefina; García, Adolfo Martín; et al.; Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder; Nature Publishing Group; Scientific Reports; 10; 1; 5-2020; 1-132045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-64678-xinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-64678-xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:17Zoai:ri.conicet.gov.ar:11336/140897instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:17.738CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
title Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
spellingShingle Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
Ortega Toro, Rodrigo
WORKING MEMORY
BINDING
RETRIEVAL
ENCODING
ATTENTION DEFICIT/HYPERACTIVITY DISORDER
title_short Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
title_full Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
title_fullStr Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
title_full_unstemmed Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
title_sort Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
dc.creator.none.fl_str_mv Ortega Toro, Rodrigo
López, Vladimir
Carrasco, Ximena
Escobar, María Josefina
García, Adolfo Martín
Parra, Mario
Aboitiz, Francisco
author Ortega Toro, Rodrigo
author_facet Ortega Toro, Rodrigo
López, Vladimir
Carrasco, Ximena
Escobar, María Josefina
García, Adolfo Martín
Parra, Mario
Aboitiz, Francisco
author_role author
author2 López, Vladimir
Carrasco, Ximena
Escobar, María Josefina
García, Adolfo Martín
Parra, Mario
Aboitiz, Francisco
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv WORKING MEMORY
BINDING
RETRIEVAL
ENCODING
ATTENTION DEFICIT/HYPERACTIVITY DISORDER
topic WORKING MEMORY
BINDING
RETRIEVAL
ENCODING
ATTENTION DEFICIT/HYPERACTIVITY DISORDER
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retain information rather than on the attention-dependent stages of encoding and retrieval. The current study uses a visual short-term memory binding task, measuring both behavioral and electrophysiological responses to characterize WM encoding, binding and retrieval comparing ADHD and non-ADHD matched adolescents. ADHD exhibited poorer accuracy and larger reaction times than non-ADHD on all conditions but especially when a change across encoding and test displays occurred. Binding manipulation affected equally both groups. Encoding P3 was larger in the non-ADHD group. Retrieval P3 discriminated change only in the non-ADHD group. Binding-dependent ERP modulations did not reveal group differences. Encoding and retrieval P3 were significantly correlated only in non-ADHD. These results suggest that while binding processes seem to be intact in ADHD, attention-related encoding and retrieval processes are compromised, resulting in a failure in the prioritization of relevant information. This new evidence can also inform recent theories of binding in visual WM.
Fil: Ortega Toro, Rodrigo. Universidad de Chile; Chile
Fil: López, Vladimir. Pontificia Universidad Católica de Chile; Chile
Fil: Carrasco, Ximena. Universidad de Chile; Chile
Fil: Escobar, María Josefina. Universidad Adolfo Ibañez; Chile
Fil: García, Adolfo Martín. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad de Santiago de Chile; Chile
Fil: Parra, Mario. Universidad Autónoma del Caribe; Colombia
Fil: Aboitiz, Francisco. Universidad de Chile; Chile
description Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retain information rather than on the attention-dependent stages of encoding and retrieval. The current study uses a visual short-term memory binding task, measuring both behavioral and electrophysiological responses to characterize WM encoding, binding and retrieval comparing ADHD and non-ADHD matched adolescents. ADHD exhibited poorer accuracy and larger reaction times than non-ADHD on all conditions but especially when a change across encoding and test displays occurred. Binding manipulation affected equally both groups. Encoding P3 was larger in the non-ADHD group. Retrieval P3 discriminated change only in the non-ADHD group. Binding-dependent ERP modulations did not reveal group differences. Encoding and retrieval P3 were significantly correlated only in non-ADHD. These results suggest that while binding processes seem to be intact in ADHD, attention-related encoding and retrieval processes are compromised, resulting in a failure in the prioritization of relevant information. This new evidence can also inform recent theories of binding in visual WM.
publishDate 2020
dc.date.none.fl_str_mv 2020-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140897
Ortega Toro, Rodrigo; López, Vladimir; Carrasco, Ximena; Escobar, María Josefina; García, Adolfo Martín; et al.; Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder; Nature Publishing Group; Scientific Reports; 10; 1; 5-2020; 1-13
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140897
identifier_str_mv Ortega Toro, Rodrigo; López, Vladimir; Carrasco, Ximena; Escobar, María Josefina; García, Adolfo Martín; et al.; Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder; Nature Publishing Group; Scientific Reports; 10; 1; 5-2020; 1-13
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-020-64678-x
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-64678-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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