Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats

Autores
Escobar, Franco Matias; Sabini, Maria Carola; Cariddi, Laura Noelia; Sabini, Maria Carola; Mañas, Fernando Javier; Cristofolini, Andrea Lorena; Bagnis, Guillermo; Gallucci, Mauro Nicolas; Cavaglieri, Lilia Reneé
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Minthostachys verticillata (Lamiaceae), popularly known as peperina is largely used in popular medicine for its digestive, carminative, antispasmodic and antirheumatic properties. There are no reports of repeated exposure toxicity to guarantee their safety. The present study investigated the chemical composition, analyzed by GC-FID, and the 90-day toxicity and genotoxicity effect of M. verticillata essential oil (Mv-EO), using Wistar rats as test animals. The rats were divided into four groups (5. rats/sex/group) and Mv-EO was administered on diet at doses of 0, 1, 4 and 7. g/kg feed. The main components of Mv-EO were pulegone (64.65%) and menthone (23.92%). There was no mortality, adverse effects on general conditions or changes in body weight, food consumption and feed conversion efficiency throughout the study in male and female rats. Subchronic administration of Mv-EO did not alter the weights, morphological and histopathological analyses of liver, kidney and intestine. Genotoxicity was tested by micronucleus and comet assays. Mv-EO up to a concentration of 7 g/kg feed for 90. days did not exert a cyto-genotoxic effect on the bone marrow and cells blood of Wistar rats. These results suggest that Mv-EO appears to be safe and could be devoid of any toxic risk.
Fil: Escobar, Franco Matias. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sabini, Maria Carola. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cariddi, Laura Noelia. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sabini, Maria Carola. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mañas, Fernando Javier. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cristofolini, Andrea Lorena. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bagnis, Guillermo. Universidad Nacional de Río Cuarto; Argentina
Fil: Gallucci, Mauro Nicolas. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Santiago del Estero. Universidad Nacional de Santiago del Estero. Centro de Investigaciones y Transferencia de Santiago del Estero; Argentina
Fil: Cavaglieri, Lilia Reneé. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
90-Day Subchronic Toxicity
Essential Oil
Genotoxicity
Minthostachys Verticillata
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38425
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/38425
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in ratsEscobar, Franco MatiasSabini, Maria CarolaCariddi, Laura NoeliaSabini, Maria CarolaMañas, Fernando JavierCristofolini, Andrea LorenaBagnis, GuillermoGallucci, Mauro NicolasCavaglieri, Lilia Reneé90-Day Subchronic ToxicityEssential OilGenotoxicityMinthostachys Verticillatahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Minthostachys verticillata (Lamiaceae), popularly known as peperina is largely used in popular medicine for its digestive, carminative, antispasmodic and antirheumatic properties. There are no reports of repeated exposure toxicity to guarantee their safety. The present study investigated the chemical composition, analyzed by GC-FID, and the 90-day toxicity and genotoxicity effect of M. verticillata essential oil (Mv-EO), using Wistar rats as test animals. The rats were divided into four groups (5. rats/sex/group) and Mv-EO was administered on diet at doses of 0, 1, 4 and 7. g/kg feed. The main components of Mv-EO were pulegone (64.65%) and menthone (23.92%). There was no mortality, adverse effects on general conditions or changes in body weight, food consumption and feed conversion efficiency throughout the study in male and female rats. Subchronic administration of Mv-EO did not alter the weights, morphological and histopathological analyses of liver, kidney and intestine. Genotoxicity was tested by micronucleus and comet assays. Mv-EO up to a concentration of 7 g/kg feed for 90. days did not exert a cyto-genotoxic effect on the bone marrow and cells blood of Wistar rats. These results suggest that Mv-EO appears to be safe and could be devoid of any toxic risk.Fil: Escobar, Franco Matias. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sabini, Maria Carola. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cariddi, Laura Noelia. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sabini, Maria Carola. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mañas, Fernando Javier. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cristofolini, Andrea Lorena. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bagnis, Guillermo. Universidad Nacional de Río Cuarto; ArgentinaFil: Gallucci, Mauro Nicolas. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Santiago del Estero. Universidad Nacional de Santiago del Estero. Centro de Investigaciones y Transferencia de Santiago del Estero; ArgentinaFil: Cavaglieri, Lilia Reneé. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAcademic Press Inc Elsevier Science2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38425Escobar, Franco Matias; Sabini, Maria Carola; Cariddi, Laura Noelia; Sabini, Maria Carola; Mañas, Fernando Javier; et al.; Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats; Academic Press Inc Elsevier Science; Regulatory Toxicology And Pharmacology : Rtp.; 71; 1; 2-2015; 1-70273-2300CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.yrtph.2014.11.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0273230014002591info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:52:57Zoai:ri.conicet.gov.ar:11336/38425instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:52:57.39CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats
title Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats
spellingShingle Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats
Escobar, Franco Matias
90-Day Subchronic Toxicity
Essential Oil
Genotoxicity
Minthostachys Verticillata
title_short Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats
title_full Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats
title_fullStr Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats
title_full_unstemmed Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats
title_sort Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats
dc.creator.none.fl_str_mv Escobar, Franco Matias
Sabini, Maria Carola
Cariddi, Laura Noelia
Sabini, Maria Carola
Mañas, Fernando Javier
Cristofolini, Andrea Lorena
Bagnis, Guillermo
Gallucci, Mauro Nicolas
Cavaglieri, Lilia Reneé
author Escobar, Franco Matias
author_facet Escobar, Franco Matias
Sabini, Maria Carola
Cariddi, Laura Noelia
Mañas, Fernando Javier
Cristofolini, Andrea Lorena
Bagnis, Guillermo
Gallucci, Mauro Nicolas
Cavaglieri, Lilia Reneé
author_role author
author2 Sabini, Maria Carola
Cariddi, Laura Noelia
Mañas, Fernando Javier
Cristofolini, Andrea Lorena
Bagnis, Guillermo
Gallucci, Mauro Nicolas
Cavaglieri, Lilia Reneé
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 90-Day Subchronic Toxicity
Essential Oil
Genotoxicity
Minthostachys Verticillata
topic 90-Day Subchronic Toxicity
Essential Oil
Genotoxicity
Minthostachys Verticillata
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Minthostachys verticillata (Lamiaceae), popularly known as peperina is largely used in popular medicine for its digestive, carminative, antispasmodic and antirheumatic properties. There are no reports of repeated exposure toxicity to guarantee their safety. The present study investigated the chemical composition, analyzed by GC-FID, and the 90-day toxicity and genotoxicity effect of M. verticillata essential oil (Mv-EO), using Wistar rats as test animals. The rats were divided into four groups (5. rats/sex/group) and Mv-EO was administered on diet at doses of 0, 1, 4 and 7. g/kg feed. The main components of Mv-EO were pulegone (64.65%) and menthone (23.92%). There was no mortality, adverse effects on general conditions or changes in body weight, food consumption and feed conversion efficiency throughout the study in male and female rats. Subchronic administration of Mv-EO did not alter the weights, morphological and histopathological analyses of liver, kidney and intestine. Genotoxicity was tested by micronucleus and comet assays. Mv-EO up to a concentration of 7 g/kg feed for 90. days did not exert a cyto-genotoxic effect on the bone marrow and cells blood of Wistar rats. These results suggest that Mv-EO appears to be safe and could be devoid of any toxic risk.
Fil: Escobar, Franco Matias. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sabini, Maria Carola. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cariddi, Laura Noelia. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sabini, Maria Carola. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mañas, Fernando Javier. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cristofolini, Andrea Lorena. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bagnis, Guillermo. Universidad Nacional de Río Cuarto; Argentina
Fil: Gallucci, Mauro Nicolas. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Santiago del Estero. Universidad Nacional de Santiago del Estero. Centro de Investigaciones y Transferencia de Santiago del Estero; Argentina
Fil: Cavaglieri, Lilia Reneé. Universidad Nacional de Río Cuarto; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Minthostachys verticillata (Lamiaceae), popularly known as peperina is largely used in popular medicine for its digestive, carminative, antispasmodic and antirheumatic properties. There are no reports of repeated exposure toxicity to guarantee their safety. The present study investigated the chemical composition, analyzed by GC-FID, and the 90-day toxicity and genotoxicity effect of M. verticillata essential oil (Mv-EO), using Wistar rats as test animals. The rats were divided into four groups (5. rats/sex/group) and Mv-EO was administered on diet at doses of 0, 1, 4 and 7. g/kg feed. The main components of Mv-EO were pulegone (64.65%) and menthone (23.92%). There was no mortality, adverse effects on general conditions or changes in body weight, food consumption and feed conversion efficiency throughout the study in male and female rats. Subchronic administration of Mv-EO did not alter the weights, morphological and histopathological analyses of liver, kidney and intestine. Genotoxicity was tested by micronucleus and comet assays. Mv-EO up to a concentration of 7 g/kg feed for 90. days did not exert a cyto-genotoxic effect on the bone marrow and cells blood of Wistar rats. These results suggest that Mv-EO appears to be safe and could be devoid of any toxic risk.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38425
Escobar, Franco Matias; Sabini, Maria Carola; Cariddi, Laura Noelia; Sabini, Maria Carola; Mañas, Fernando Javier; et al.; Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats; Academic Press Inc Elsevier Science; Regulatory Toxicology And Pharmacology : Rtp.; 71; 1; 2-2015; 1-7
0273-2300
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38425
identifier_str_mv Escobar, Franco Matias; Sabini, Maria Carola; Cariddi, Laura Noelia; Sabini, Maria Carola; Mañas, Fernando Javier; et al.; Safety assessment of essential oil from Minthostachys verticillata (Griseb.) Epling (peperina): 90-Days oral subchronic toxicity study in rats; Academic Press Inc Elsevier Science; Regulatory Toxicology And Pharmacology : Rtp.; 71; 1; 2-2015; 1-7
0273-2300
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0273230014002591
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
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dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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