Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact

Autores
Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; Herrero, Eduardo; Labanchi, José Luis; Araya, Daniel; Sepúlveda, Luis; Grizmado, Claudia; Calabro, Arnoldo; Talmon, Gabriel; Poggio, Thelma Veronica; Crowley, Pablo; Cespedes, Graciela; Santillán, Graciela; García Cachau, Mariela; Lamberti, Roberto; Gino, Lilia; Donadeu, Meritxell; Lightowlers, Marshall W.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
Fil: Larrieu, Edmundo Juan. Universidad Nacional de La Pampa; Argentina. Universidad Nacional de Río Negro; Argentina
Fil: Mujica, Guillermo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Gauci, Charles G.. University of Melbourne; Australia
Fil: Vizcaychipi, Katherina. Instituto Nacional de Enfermedades Infecciosas; Argentina. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Seleiman, Marcos. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Herrero, Eduardo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Labanchi, José Luis. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Araya, Daniel. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Sepúlveda, Luis. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Grizmado, Claudia. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Calabro, Arnoldo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Talmon, Gabriel. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
Fil: Crowley, Pablo. Universidad Nacional de Río Negro; Argentina
Fil: Cespedes, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Santillán, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: García Cachau, Mariela. Universidad Nacional de La Pampa; Argentina
Fil: Lamberti, Roberto. Universidad Nacional de La Pampa; Argentina
Fil: Gino, Lilia. Universidad Nacional de La Pampa; Argentina
Fil: Donadeu, Meritxell. University of Melbourne; Australia
Fil: Lightowlers, Marshall W.. University of Melbourne; Australia
Materia
Echinococcosis quistica
Vacuna EG95
Ovinos
Ensayo a campo
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/65675

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network_name_str CONICET Digital (CONICET)
spelling Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of ImpactLarrieu, Edmundo JuanMujica, GuillermoGauci, Charles G.Vizcaychipi, KatherinaSeleiman, MarcosHerrero, EduardoLabanchi, José LuisAraya, DanielSepúlveda, LuisGrizmado, ClaudiaCalabro, ArnoldoTalmon, GabrielPoggio, Thelma VeronicaCrowley, PabloCespedes, GracielaSantillán, GracielaGarcía Cachau, MarielaLamberti, RobertoGino, LiliaDonadeu, MeritxellLightowlers, Marshall W.Echinococcosis quisticaVacuna EG95OvinosEnsayo a campohttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.Fil: Larrieu, Edmundo Juan. Universidad Nacional de La Pampa; Argentina. Universidad Nacional de Río Negro; ArgentinaFil: Mujica, Guillermo. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Gauci, Charles G.. University of Melbourne; AustraliaFil: Vizcaychipi, Katherina. Instituto Nacional de Enfermedades Infecciosas; Argentina. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Seleiman, Marcos. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Herrero, Eduardo. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Labanchi, José Luis. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Araya, Daniel. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Sepúlveda, Luis. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Grizmado, Claudia. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Calabro, Arnoldo. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Talmon, Gabriel. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; ArgentinaFil: Crowley, Pablo. Universidad Nacional de Río Negro; ArgentinaFil: Cespedes, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Santillán, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: García Cachau, Mariela. Universidad Nacional de La Pampa; ArgentinaFil: Lamberti, Roberto. Universidad Nacional de La Pampa; ArgentinaFil: Gino, Lilia. Universidad Nacional de La Pampa; ArgentinaFil: Donadeu, Meritxell. University of Melbourne; AustraliaFil: Lightowlers, Marshall W.. University of Melbourne; AustraliaPublic Library of Science2015-10-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/65675Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; et al.; Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact; Public Library of Science; PLoS Neglected Tropical Diseases; 9; 10; 30-10-2015; 1-101935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0004134info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004134info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:36Zoai:ri.conicet.gov.ar:11336/65675instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:37.053CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
spellingShingle Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
Larrieu, Edmundo Juan
Echinococcosis quistica
Vacuna EG95
Ovinos
Ensayo a campo
title_short Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title_full Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title_fullStr Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title_full_unstemmed Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
title_sort Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
dc.creator.none.fl_str_mv Larrieu, Edmundo Juan
Mujica, Guillermo
Gauci, Charles G.
Vizcaychipi, Katherina
Seleiman, Marcos
Herrero, Eduardo
Labanchi, José Luis
Araya, Daniel
Sepúlveda, Luis
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Poggio, Thelma Veronica
Crowley, Pablo
Cespedes, Graciela
Santillán, Graciela
García Cachau, Mariela
Lamberti, Roberto
Gino, Lilia
Donadeu, Meritxell
Lightowlers, Marshall W.
author Larrieu, Edmundo Juan
author_facet Larrieu, Edmundo Juan
Mujica, Guillermo
Gauci, Charles G.
Vizcaychipi, Katherina
Seleiman, Marcos
Herrero, Eduardo
Labanchi, José Luis
Araya, Daniel
Sepúlveda, Luis
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Poggio, Thelma Veronica
Crowley, Pablo
Cespedes, Graciela
Santillán, Graciela
García Cachau, Mariela
Lamberti, Roberto
Gino, Lilia
Donadeu, Meritxell
Lightowlers, Marshall W.
author_role author
author2 Mujica, Guillermo
Gauci, Charles G.
Vizcaychipi, Katherina
Seleiman, Marcos
Herrero, Eduardo
Labanchi, José Luis
Araya, Daniel
Sepúlveda, Luis
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Poggio, Thelma Veronica
Crowley, Pablo
Cespedes, Graciela
Santillán, Graciela
García Cachau, Mariela
Lamberti, Roberto
Gino, Lilia
Donadeu, Meritxell
Lightowlers, Marshall W.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Echinococcosis quistica
Vacuna EG95
Ovinos
Ensayo a campo
topic Echinococcosis quistica
Vacuna EG95
Ovinos
Ensayo a campo
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
Fil: Larrieu, Edmundo Juan. Universidad Nacional de La Pampa; Argentina. Universidad Nacional de Río Negro; Argentina
Fil: Mujica, Guillermo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Gauci, Charles G.. University of Melbourne; Australia
Fil: Vizcaychipi, Katherina. Instituto Nacional de Enfermedades Infecciosas; Argentina. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Seleiman, Marcos. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Herrero, Eduardo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Labanchi, José Luis. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Araya, Daniel. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Sepúlveda, Luis. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Grizmado, Claudia. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Calabro, Arnoldo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Talmon, Gabriel. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
Fil: Crowley, Pablo. Universidad Nacional de Río Negro; Argentina
Fil: Cespedes, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Santillán, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: García Cachau, Mariela. Universidad Nacional de La Pampa; Argentina
Fil: Lamberti, Roberto. Universidad Nacional de La Pampa; Argentina
Fil: Gino, Lilia. Universidad Nacional de La Pampa; Argentina
Fil: Donadeu, Meritxell. University of Melbourne; Australia
Fil: Lightowlers, Marshall W.. University of Melbourne; Australia
description Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/65675
Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; et al.; Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact; Public Library of Science; PLoS Neglected Tropical Diseases; 9; 10; 30-10-2015; 1-10
1935-2735
CONICET Digital
CONICET
url http://hdl.handle.net/11336/65675
identifier_str_mv Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; et al.; Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact; Public Library of Science; PLoS Neglected Tropical Diseases; 9; 10; 30-10-2015; 1-10
1935-2735
CONICET Digital
CONICET
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