Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact
- Autores
- Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; Herrero, Eduardo; Labanchi, José Luis; Araya, Daniel; Sepúlveda, Luis; Grizmado, Claudia; Calabro, Arnoldo; Talmon, Gabriel; Poggio, Thelma Veronica; Crowley, Pablo; Cespedes, Graciela; Santillán, Graciela; García Cachau, Mariela; Lamberti, Roberto; Gino, Lilia; Donadeu, Meritxell; Lightowlers, Marshall W.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
Fil: Larrieu, Edmundo Juan. Universidad Nacional de La Pampa; Argentina. Universidad Nacional de Río Negro; Argentina
Fil: Mujica, Guillermo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Gauci, Charles G.. University of Melbourne; Australia
Fil: Vizcaychipi, Katherina. Instituto Nacional de Enfermedades Infecciosas; Argentina. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Seleiman, Marcos. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Herrero, Eduardo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Labanchi, José Luis. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Araya, Daniel. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Sepúlveda, Luis. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Grizmado, Claudia. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Calabro, Arnoldo. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Talmon, Gabriel. Provincia de Río Negro, Ministerio de Salud; Argentina
Fil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina
Fil: Crowley, Pablo. Universidad Nacional de Río Negro; Argentina
Fil: Cespedes, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Santillán, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: García Cachau, Mariela. Universidad Nacional de La Pampa; Argentina
Fil: Lamberti, Roberto. Universidad Nacional de La Pampa; Argentina
Fil: Gino, Lilia. Universidad Nacional de La Pampa; Argentina
Fil: Donadeu, Meritxell. University of Melbourne; Australia
Fil: Lightowlers, Marshall W.. University of Melbourne; Australia - Materia
-
Echinococcosis quistica
Vacuna EG95
Ovinos
Ensayo a campo - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/65675
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/65675 |
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Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of ImpactLarrieu, Edmundo JuanMujica, GuillermoGauci, Charles G.Vizcaychipi, KatherinaSeleiman, MarcosHerrero, EduardoLabanchi, José LuisAraya, DanielSepúlveda, LuisGrizmado, ClaudiaCalabro, ArnoldoTalmon, GabrielPoggio, Thelma VeronicaCrowley, PabloCespedes, GracielaSantillán, GracielaGarcía Cachau, MarielaLamberti, RobertoGino, LiliaDonadeu, MeritxellLightowlers, Marshall W.Echinococcosis quisticaVacuna EG95OvinosEnsayo a campohttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.Fil: Larrieu, Edmundo Juan. Universidad Nacional de La Pampa; Argentina. Universidad Nacional de Río Negro; ArgentinaFil: Mujica, Guillermo. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Gauci, Charles G.. University of Melbourne; AustraliaFil: Vizcaychipi, Katherina. Instituto Nacional de Enfermedades Infecciosas; Argentina. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Seleiman, Marcos. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Herrero, Eduardo. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Labanchi, José Luis. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Araya, Daniel. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Sepúlveda, Luis. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Grizmado, Claudia. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Calabro, Arnoldo. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Talmon, Gabriel. Provincia de Río Negro, Ministerio de Salud; ArgentinaFil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; ArgentinaFil: Crowley, Pablo. Universidad Nacional de Río Negro; ArgentinaFil: Cespedes, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Santillán, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: García Cachau, Mariela. Universidad Nacional de La Pampa; ArgentinaFil: Lamberti, Roberto. Universidad Nacional de La Pampa; ArgentinaFil: Gino, Lilia. Universidad Nacional de La Pampa; ArgentinaFil: Donadeu, Meritxell. University of Melbourne; AustraliaFil: Lightowlers, Marshall W.. University of Melbourne; AustraliaPublic Library of Science2015-10-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/65675Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; et al.; Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact; Public Library of Science; PLoS Neglected Tropical Diseases; 9; 10; 30-10-2015; 1-101935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0004134info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004134info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:05:36Zoai:ri.conicet.gov.ar:11336/65675instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:05:37.053CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact |
title |
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact |
spellingShingle |
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact Larrieu, Edmundo Juan Echinococcosis quistica Vacuna EG95 Ovinos Ensayo a campo |
title_short |
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact |
title_full |
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact |
title_fullStr |
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact |
title_full_unstemmed |
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact |
title_sort |
Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact |
dc.creator.none.fl_str_mv |
Larrieu, Edmundo Juan Mujica, Guillermo Gauci, Charles G. Vizcaychipi, Katherina Seleiman, Marcos Herrero, Eduardo Labanchi, José Luis Araya, Daniel Sepúlveda, Luis Grizmado, Claudia Calabro, Arnoldo Talmon, Gabriel Poggio, Thelma Veronica Crowley, Pablo Cespedes, Graciela Santillán, Graciela García Cachau, Mariela Lamberti, Roberto Gino, Lilia Donadeu, Meritxell Lightowlers, Marshall W. |
author |
Larrieu, Edmundo Juan |
author_facet |
Larrieu, Edmundo Juan Mujica, Guillermo Gauci, Charles G. Vizcaychipi, Katherina Seleiman, Marcos Herrero, Eduardo Labanchi, José Luis Araya, Daniel Sepúlveda, Luis Grizmado, Claudia Calabro, Arnoldo Talmon, Gabriel Poggio, Thelma Veronica Crowley, Pablo Cespedes, Graciela Santillán, Graciela García Cachau, Mariela Lamberti, Roberto Gino, Lilia Donadeu, Meritxell Lightowlers, Marshall W. |
author_role |
author |
author2 |
Mujica, Guillermo Gauci, Charles G. Vizcaychipi, Katherina Seleiman, Marcos Herrero, Eduardo Labanchi, José Luis Araya, Daniel Sepúlveda, Luis Grizmado, Claudia Calabro, Arnoldo Talmon, Gabriel Poggio, Thelma Veronica Crowley, Pablo Cespedes, Graciela Santillán, Graciela García Cachau, Mariela Lamberti, Roberto Gino, Lilia Donadeu, Meritxell Lightowlers, Marshall W. |
author2_role |
author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Echinococcosis quistica Vacuna EG95 Ovinos Ensayo a campo |
topic |
Echinococcosis quistica Vacuna EG95 Ovinos Ensayo a campo |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated. Fil: Larrieu, Edmundo Juan. Universidad Nacional de La Pampa; Argentina. Universidad Nacional de Río Negro; Argentina Fil: Mujica, Guillermo. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Gauci, Charles G.. University of Melbourne; Australia Fil: Vizcaychipi, Katherina. Instituto Nacional de Enfermedades Infecciosas; Argentina. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Seleiman, Marcos. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Herrero, Eduardo. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Labanchi, José Luis. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Araya, Daniel. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Sepúlveda, Luis. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Grizmado, Claudia. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Calabro, Arnoldo. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Talmon, Gabriel. Provincia de Río Negro, Ministerio de Salud; Argentina Fil: Poggio, Thelma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología "Dr. César Milstein". Fundación Pablo Cassará. Instituto de Ciencia y Tecnología ; Argentina Fil: Crowley, Pablo. Universidad Nacional de Río Negro; Argentina Fil: Cespedes, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: Santillán, Graciela. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: García Cachau, Mariela. Universidad Nacional de La Pampa; Argentina Fil: Lamberti, Roberto. Universidad Nacional de La Pampa; Argentina Fil: Gino, Lilia. Universidad Nacional de La Pampa; Argentina Fil: Donadeu, Meritxell. University of Melbourne; Australia Fil: Lightowlers, Marshall W.. University of Melbourne; Australia |
description |
Cystic echinococcosis (CE) is an important zoonotic disease caused by the cestode parasite Echinococcus granulosus. It occurs in many parts of the world where pastoral activities predominate, including the Rio Negro province of Argentina. Although CE control activities have been undertaken in the western regions of Rio Negro for more than two decades, the disease continues to remain prevalent in both the human and livestock animal populations. Vaccination of animal intermediate hosts of CE with the EG95 vaccine may provide a new opportunity to improve the effectiveness of CE control measures, although data are lacking about field application of the vaccine. Aims: Evaluate the impact of EG95 vaccination in sheep on the transmission of Echinococcus granulosus in a field environment. Methodology: Two trial sites were established in western Rio Negro province within indigenous communities. Vaccination of lambs born into one trial site was introduced and continued for 6 years. Prior to initiation of the trial, and at the end of the trial, the prevalence of CE in sheep was determined by necropsy. Weaned lambs received two injections of EG95 vaccine, approximately one month apart, and a single booster injection one year later. Vaccination was not implemented at the second trial site. A total of 2725 animals were vaccinated in the first year. Animals from this cohort as well as age-matched sheep from the control area were evaluated by necropsy. Key results: Introduction of the vaccine led to a statistically significant in the number and size of hydatid cysts in comparison to the situation prior to the introduction of the vaccine, or compared to CE prevalence in the control area where the vaccine was not applied. The prevalence of infection in the vaccinated area was also significantly reduced by 62% compared to the re-intervention level, being lower than the prevalence seen in the control area, although the difference from the control area after the intervention was not significant possibly due to limitations in the numbers of animals available for necropsy. Conclusions: Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-30 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/65675 Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; et al.; Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact; Public Library of Science; PLoS Neglected Tropical Diseases; 9; 10; 30-10-2015; 1-10 1935-2735 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/65675 |
identifier_str_mv |
Larrieu, Edmundo Juan; Mujica, Guillermo; Gauci, Charles G.; Vizcaychipi, Katherina; Seleiman, Marcos; et al.; Pilot Field Trial of the EG95 Vaccine Against Ovine Cystic Echinococcosis in Rio Negro, Argentina: Second Study of Impact; Public Library of Science; PLoS Neglected Tropical Diseases; 9; 10; 30-10-2015; 1-10 1935-2735 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0004134 info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004134 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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