Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
- Autores
- Larrieu, Edmundo; Mujica, Guillermo; Araya, Daniel; Labanchi, Jose Luis; Arezo, Marcos; Herrero, Eduardo; Santillan, Graciela; Vizcaychipi, Katherina A.; Uchiumi, Leonardo; Salvitti, Juan Carlos; Grizmado, Claudia; Calabro, Arnoldo; Talmon, Gabriel; Sepulveda, Luis; Galvan, Jose Maria; Cabrera, Marta; Seleiman, Marcos; Crowley, Pablo; Céspedes, Graciela; García Cachau, Mariela; Gino, Lilia; Molina, Leonardo; Daffner, Jose; Gauci, Charles G; Donadeu, Meritxell; Lightowlers, Marshall W
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Labanchi, Jose Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Arezo, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Vizcaychipi, Katherina A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Uchiumi, Leonardo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Salvitti, Juan Carlos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Sepulveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Galvan, Jose María. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Cabrera, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina.
Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Molina, Leonardo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Daffner, Jose. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Cystic echinococcosis (CE) is endemic in the Rio Negro province of Argentina. After 30 years of control using praziquantel in dogs the transmission rate to humans and sheep has decreased significantly, however transmission persists. The objective of the study was to assess the inclusion of the EG95 for sheep in the control program and to determine the vaccine's operative feasibility in field conditions. An intervention study was defined in Rio Negro Province in Argentina comprising, in total, an area of 5820 Km2. Lambs received two vaccinations with the EG95 vaccine followed by a single booster injection when the animals were 1-1.5 years of age. Vaccination of lambs born into one trial site was introduced and continued for 8 years. Evidence for Echinococcus granulosus transmission was monitored before and after vaccination by coproantigen ELISA in faecal samples of dog, purgation of dogs to detect E. granulosus worms, necropsy on adult sheep and by ultrasound screening in children of 6-14 years old. 29,323 doses of vaccine were applied between 2009 and 2017, which a vaccination coverage of 80.1%/85.7% (57.3% average for fully vaccinated). Before the introduction of the vaccine 56.3% of the 6-year-old sheep were infected with E. granulosus at necropsy and 84.2% of the farms had infected sheep; 4.3% of the dogs were positive for E. granulosus infection using the arecoline test, and with coproELISA 9.6% of dog fecal samples were positive and 20.3% of the farms had infected dog.After the vaccine was introduced, 21.6% of sheep older than 6 years were found to be infected at necropsy and 20.2% of the farms were found to be infected; in dogs, 4.5% were found positive for E. granulosus using arecoline purgation and with coproELISA 3.7% of samples were positive, with 8.9% of farms having a positive dog. In 2016 only one case of E. granulosus infection was diagnosed by US screening in a 6-14 years old child. Included in the analysis are discussions of difficulties experienced in the field which affected correct vaccine administration as well as social features and practices that may impact on echinococcosis control and the EG95 vaccination program in Rio Negro. Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated. - Fuente
- Acta Trópica 2019;191:1-7
- Materia
-
Control
Equinococosis
Diagnóstico
Ovinos
Vacunación - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- none
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:Publications/123456789/2129
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Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of workLarrieu, EdmundoMujica, GuillermoAraya, DanielLabanchi, Jose LuisArezo, MarcosHerrero, EduardoSantillan, GracielaVizcaychipi, Katherina A.Uchiumi, LeonardoSalvitti, Juan CarlosGrizmado, ClaudiaCalabro, ArnoldoTalmon, GabrielSepulveda, LuisGalvan, Jose MariaCabrera, MartaSeleiman, MarcosCrowley, PabloCéspedes, GracielaGarcía Cachau, MarielaGino, LiliaMolina, LeonardoDaffner, JoseGauci, Charles GDonadeu, MeritxellLightowlers, Marshall WControlEquinococosisDiagnósticoOvinosVacunaciónFil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Labanchi, Jose Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Arezo, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Vizcaychipi, Katherina A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Uchiumi, Leonardo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Salvitti, Juan Carlos. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Sepulveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Galvan, Jose María. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Cabrera, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina.Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Molina, Leonardo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Daffner, Jose. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Cystic echinococcosis (CE) is endemic in the Rio Negro province of Argentina. After 30 years of control using praziquantel in dogs the transmission rate to humans and sheep has decreased significantly, however transmission persists. The objective of the study was to assess the inclusion of the EG95 for sheep in the control program and to determine the vaccine's operative feasibility in field conditions. An intervention study was defined in Rio Negro Province in Argentina comprising, in total, an area of 5820 Km2. Lambs received two vaccinations with the EG95 vaccine followed by a single booster injection when the animals were 1-1.5 years of age. Vaccination of lambs born into one trial site was introduced and continued for 8 years. Evidence for Echinococcus granulosus transmission was monitored before and after vaccination by coproantigen ELISA in faecal samples of dog, purgation of dogs to detect E. granulosus worms, necropsy on adult sheep and by ultrasound screening in children of 6-14 years old. 29,323 doses of vaccine were applied between 2009 and 2017, which a vaccination coverage of 80.1%/85.7% (57.3% average for fully vaccinated). Before the introduction of the vaccine 56.3% of the 6-year-old sheep were infected with E. granulosus at necropsy and 84.2% of the farms had infected sheep; 4.3% of the dogs were positive for E. granulosus infection using the arecoline test, and with coproELISA 9.6% of dog fecal samples were positive and 20.3% of the farms had infected dog.After the vaccine was introduced, 21.6% of sheep older than 6 years were found to be infected at necropsy and 20.2% of the farms were found to be infected; in dogs, 4.5% were found positive for E. granulosus using arecoline purgation and with coproELISA 3.7% of samples were positive, with 8.9% of farms having a positive dog. In 2016 only one case of E. granulosus infection was diagnosed by US screening in a 6-14 years old child. Included in the analysis are discussions of difficulties experienced in the field which affected correct vaccine administration as well as social features and practices that may impact on echinococcosis control and the EG95 vaccination program in Rio Negro. Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.2019-03info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0001-706Xhttp://sgc.anlis.gob.ar/handle/123456789/212910.1016/j.actatropica.2018.12.025Acta Trópica 2019;191:1-7reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. 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dc.title.none.fl_str_mv |
Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work |
title |
Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work |
spellingShingle |
Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work Larrieu, Edmundo Control Equinococosis Diagnóstico Ovinos Vacunación |
title_short |
Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work |
title_full |
Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work |
title_fullStr |
Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work |
title_full_unstemmed |
Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work |
title_sort |
Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work |
dc.creator.none.fl_str_mv |
Larrieu, Edmundo Mujica, Guillermo Araya, Daniel Labanchi, Jose Luis Arezo, Marcos Herrero, Eduardo Santillan, Graciela Vizcaychipi, Katherina A. Uchiumi, Leonardo Salvitti, Juan Carlos Grizmado, Claudia Calabro, Arnoldo Talmon, Gabriel Sepulveda, Luis Galvan, Jose Maria Cabrera, Marta Seleiman, Marcos Crowley, Pablo Céspedes, Graciela García Cachau, Mariela Gino, Lilia Molina, Leonardo Daffner, Jose Gauci, Charles G Donadeu, Meritxell Lightowlers, Marshall W |
author |
Larrieu, Edmundo |
author_facet |
Larrieu, Edmundo Mujica, Guillermo Araya, Daniel Labanchi, Jose Luis Arezo, Marcos Herrero, Eduardo Santillan, Graciela Vizcaychipi, Katherina A. Uchiumi, Leonardo Salvitti, Juan Carlos Grizmado, Claudia Calabro, Arnoldo Talmon, Gabriel Sepulveda, Luis Galvan, Jose Maria Cabrera, Marta Seleiman, Marcos Crowley, Pablo Céspedes, Graciela García Cachau, Mariela Gino, Lilia Molina, Leonardo Daffner, Jose Gauci, Charles G Donadeu, Meritxell Lightowlers, Marshall W |
author_role |
author |
author2 |
Mujica, Guillermo Araya, Daniel Labanchi, Jose Luis Arezo, Marcos Herrero, Eduardo Santillan, Graciela Vizcaychipi, Katherina A. Uchiumi, Leonardo Salvitti, Juan Carlos Grizmado, Claudia Calabro, Arnoldo Talmon, Gabriel Sepulveda, Luis Galvan, Jose Maria Cabrera, Marta Seleiman, Marcos Crowley, Pablo Céspedes, Graciela García Cachau, Mariela Gino, Lilia Molina, Leonardo Daffner, Jose Gauci, Charles G Donadeu, Meritxell Lightowlers, Marshall W |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Control Equinococosis Diagnóstico Ovinos Vacunación |
topic |
Control Equinococosis Diagnóstico Ovinos Vacunación |
dc.description.none.fl_txt_mv |
Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina. Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Labanchi, Jose Luis. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Arezo, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina. Fil: Vizcaychipi, Katherina A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina. Fil: Uchiumi, Leonardo. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Salvitti, Juan Carlos. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Sepulveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Galvan, Jose María. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Cabrera, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina. Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina. Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina. Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina. Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina. Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina. Fil: Molina, Leonardo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina. Fil: Daffner, Jose. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina. Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia. Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia. Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia. Cystic echinococcosis (CE) is endemic in the Rio Negro province of Argentina. After 30 years of control using praziquantel in dogs the transmission rate to humans and sheep has decreased significantly, however transmission persists. The objective of the study was to assess the inclusion of the EG95 for sheep in the control program and to determine the vaccine's operative feasibility in field conditions. An intervention study was defined in Rio Negro Province in Argentina comprising, in total, an area of 5820 Km2. Lambs received two vaccinations with the EG95 vaccine followed by a single booster injection when the animals were 1-1.5 years of age. Vaccination of lambs born into one trial site was introduced and continued for 8 years. Evidence for Echinococcus granulosus transmission was monitored before and after vaccination by coproantigen ELISA in faecal samples of dog, purgation of dogs to detect E. granulosus worms, necropsy on adult sheep and by ultrasound screening in children of 6-14 years old. 29,323 doses of vaccine were applied between 2009 and 2017, which a vaccination coverage of 80.1%/85.7% (57.3% average for fully vaccinated). Before the introduction of the vaccine 56.3% of the 6-year-old sheep were infected with E. granulosus at necropsy and 84.2% of the farms had infected sheep; 4.3% of the dogs were positive for E. granulosus infection using the arecoline test, and with coproELISA 9.6% of dog fecal samples were positive and 20.3% of the farms had infected dog.After the vaccine was introduced, 21.6% of sheep older than 6 years were found to be infected at necropsy and 20.2% of the farms were found to be infected; in dogs, 4.5% were found positive for E. granulosus using arecoline purgation and with coproELISA 3.7% of samples were positive, with 8.9% of farms having a positive dog. In 2016 only one case of E. granulosus infection was diagnosed by US screening in a 6-14 years old child. Included in the analysis are discussions of difficulties experienced in the field which affected correct vaccine administration as well as social features and practices that may impact on echinococcosis control and the EG95 vaccination program in Rio Negro. Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated. |
description |
Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-03 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
0001-706X http://sgc.anlis.gob.ar/handle/123456789/2129 10.1016/j.actatropica.2018.12.025 |
identifier_str_mv |
0001-706X 10.1016/j.actatropica.2018.12.025 |
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http://sgc.anlis.gob.ar/handle/123456789/2129 |
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eng |
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eng |
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Acta tropica |
dc.rights.none.fl_str_mv |
none info:eu-repo/semantics/openAccess |
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none |
eu_rights_str_mv |
openAccess |
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application/pdf |
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Acta Trópica 2019;191:1-7 reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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