Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work

Autores
Larrieu, Edmundo; Mujica, Guillermo; Araya, Daniel; Labanchi, Jose Luis; Arezo, Marcos; Herrero, Eduardo; Santillan, Graciela; Vizcaychipi, Katherina A.; Uchiumi, Leonardo; Salvitti, Juan Carlos; Grizmado, Claudia; Calabro, Arnoldo; Talmon, Gabriel; Sepulveda, Luis; Galvan, Jose Maria; Cabrera, Marta; Seleiman, Marcos; Crowley, Pablo; Céspedes, Graciela; García Cachau, Mariela; Gino, Lilia; Molina, Leonardo; Daffner, Jose; Gauci, Charles G; Donadeu, Meritxell; Lightowlers, Marshall W
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Labanchi, Jose Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Arezo, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Vizcaychipi, Katherina A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Uchiumi, Leonardo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Salvitti, Juan Carlos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Sepulveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Galvan, Jose María. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Cabrera, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina.
Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Molina, Leonardo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Daffner, Jose. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Cystic echinococcosis (CE) is endemic in the Rio Negro province of Argentina. After 30 years of control using praziquantel in dogs the transmission rate to humans and sheep has decreased significantly, however transmission persists. The objective of the study was to assess the inclusion of the EG95 for sheep in the control program and to determine the vaccine's operative feasibility in field conditions. An intervention study was defined in Rio Negro Province in Argentina comprising, in total, an area of 5820 Km2. Lambs received two vaccinations with the EG95 vaccine followed by a single booster injection when the animals were 1-1.5 years of age. Vaccination of lambs born into one trial site was introduced and continued for 8 years. Evidence for Echinococcus granulosus transmission was monitored before and after vaccination by coproantigen ELISA in faecal samples of dog, purgation of dogs to detect E. granulosus worms, necropsy on adult sheep and by ultrasound screening in children of 6-14 years old. 29,323 doses of vaccine were applied between 2009 and 2017, which a vaccination coverage of 80.1%/85.7% (57.3% average for fully vaccinated). Before the introduction of the vaccine 56.3% of the 6-year-old sheep were infected with E. granulosus at necropsy and 84.2% of the farms had infected sheep; 4.3% of the dogs were positive for E. granulosus infection using the arecoline test, and with coproELISA 9.6% of dog fecal samples were positive and 20.3% of the farms had infected dog.After the vaccine was introduced, 21.6% of sheep older than 6 years were found to be infected at necropsy and 20.2% of the farms were found to be infected; in dogs, 4.5% were found positive for E. granulosus using arecoline purgation and with coproELISA 3.7% of samples were positive, with 8.9% of farms having a positive dog. In 2016 only one case of E. granulosus infection was diagnosed by US screening in a 6-14 years old child. Included in the analysis are discussions of difficulties experienced in the field which affected correct vaccine administration as well as social features and practices that may impact on echinococcosis control and the EG95 vaccination program in Rio Negro. Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
Fuente
Acta Trópica 2019;191:1-7
Materia
Control
Equinococosis
Diagnóstico
Ovinos
Vacunación
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/2129

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network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of workLarrieu, EdmundoMujica, GuillermoAraya, DanielLabanchi, Jose LuisArezo, MarcosHerrero, EduardoSantillan, GracielaVizcaychipi, Katherina A.Uchiumi, LeonardoSalvitti, Juan CarlosGrizmado, ClaudiaCalabro, ArnoldoTalmon, GabrielSepulveda, LuisGalvan, Jose MariaCabrera, MartaSeleiman, MarcosCrowley, PabloCéspedes, GracielaGarcía Cachau, MarielaGino, LiliaMolina, LeonardoDaffner, JoseGauci, Charles GDonadeu, MeritxellLightowlers, Marshall WControlEquinococosisDiagnósticoOvinosVacunaciónFil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Labanchi, Jose Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Arezo, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Vizcaychipi, Katherina A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Uchiumi, Leonardo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Salvitti, Juan Carlos. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Sepulveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Galvan, Jose María. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Cabrera, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina.Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Molina, Leonardo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.Fil: Daffner, Jose. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.Cystic echinococcosis (CE) is endemic in the Rio Negro province of Argentina. After 30 years of control using praziquantel in dogs the transmission rate to humans and sheep has decreased significantly, however transmission persists. The objective of the study was to assess the inclusion of the EG95 for sheep in the control program and to determine the vaccine's operative feasibility in field conditions. An intervention study was defined in Rio Negro Province in Argentina comprising, in total, an area of 5820 Km2. Lambs received two vaccinations with the EG95 vaccine followed by a single booster injection when the animals were 1-1.5 years of age. Vaccination of lambs born into one trial site was introduced and continued for 8 years. Evidence for Echinococcus granulosus transmission was monitored before and after vaccination by coproantigen ELISA in faecal samples of dog, purgation of dogs to detect E. granulosus worms, necropsy on adult sheep and by ultrasound screening in children of 6-14 years old. 29,323 doses of vaccine were applied between 2009 and 2017, which a vaccination coverage of 80.1%/85.7% (57.3% average for fully vaccinated). Before the introduction of the vaccine 56.3% of the 6-year-old sheep were infected with E. granulosus at necropsy and 84.2% of the farms had infected sheep; 4.3% of the dogs were positive for E. granulosus infection using the arecoline test, and with coproELISA 9.6% of dog fecal samples were positive and 20.3% of the farms had infected dog.After the vaccine was introduced, 21.6% of sheep older than 6 years were found to be infected at necropsy and 20.2% of the farms were found to be infected; in dogs, 4.5% were found positive for E. granulosus using arecoline purgation and with coproELISA 3.7% of samples were positive, with 8.9% of farms having a positive dog. In 2016 only one case of E. granulosus infection was diagnosed by US screening in a 6-14 years old child. Included in the analysis are discussions of difficulties experienced in the field which affected correct vaccine administration as well as social features and practices that may impact on echinococcosis control and the EG95 vaccination program in Rio Negro. Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.2019-03info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0001-706Xhttp://sgc.anlis.gob.ar/handle/123456789/212910.1016/j.actatropica.2018.12.025Acta Trópica 2019;191:1-7reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISActa tropicanoneinfo:eu-repo/semantics/openAccesseng2025-09-29T14:30:39Zoai:sgc.anlis.gob.ar:Publications/123456789/2129Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:40.02Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
title Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
spellingShingle Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
Larrieu, Edmundo
Control
Equinococosis
Diagnóstico
Ovinos
Vacunación
title_short Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
title_full Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
title_fullStr Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
title_full_unstemmed Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
title_sort Pilot field trial of the EG95 vaccine against ovine cystic echinococcosis in Rio Negro, Argentina: 8 years of work
dc.creator.none.fl_str_mv Larrieu, Edmundo
Mujica, Guillermo
Araya, Daniel
Labanchi, Jose Luis
Arezo, Marcos
Herrero, Eduardo
Santillan, Graciela
Vizcaychipi, Katherina A.
Uchiumi, Leonardo
Salvitti, Juan Carlos
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Sepulveda, Luis
Galvan, Jose Maria
Cabrera, Marta
Seleiman, Marcos
Crowley, Pablo
Céspedes, Graciela
García Cachau, Mariela
Gino, Lilia
Molina, Leonardo
Daffner, Jose
Gauci, Charles G
Donadeu, Meritxell
Lightowlers, Marshall W
author Larrieu, Edmundo
author_facet Larrieu, Edmundo
Mujica, Guillermo
Araya, Daniel
Labanchi, Jose Luis
Arezo, Marcos
Herrero, Eduardo
Santillan, Graciela
Vizcaychipi, Katherina A.
Uchiumi, Leonardo
Salvitti, Juan Carlos
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Sepulveda, Luis
Galvan, Jose Maria
Cabrera, Marta
Seleiman, Marcos
Crowley, Pablo
Céspedes, Graciela
García Cachau, Mariela
Gino, Lilia
Molina, Leonardo
Daffner, Jose
Gauci, Charles G
Donadeu, Meritxell
Lightowlers, Marshall W
author_role author
author2 Mujica, Guillermo
Araya, Daniel
Labanchi, Jose Luis
Arezo, Marcos
Herrero, Eduardo
Santillan, Graciela
Vizcaychipi, Katherina A.
Uchiumi, Leonardo
Salvitti, Juan Carlos
Grizmado, Claudia
Calabro, Arnoldo
Talmon, Gabriel
Sepulveda, Luis
Galvan, Jose Maria
Cabrera, Marta
Seleiman, Marcos
Crowley, Pablo
Céspedes, Graciela
García Cachau, Mariela
Gino, Lilia
Molina, Leonardo
Daffner, Jose
Gauci, Charles G
Donadeu, Meritxell
Lightowlers, Marshall W
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Control
Equinococosis
Diagnóstico
Ovinos
Vacunación
topic Control
Equinococosis
Diagnóstico
Ovinos
Vacunación
dc.description.none.fl_txt_mv Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Mujica, Guillermo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Araya, Daniel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Labanchi, Jose Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Arezo, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Herrero, Eduardo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Santillán, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Vizcaychipi, Katherina A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Uchiumi, Leonardo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Salvitti, Juan Carlos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Grizmado, Claudia. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Calabro, Arnoldo. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Talmon, Gabriel. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Sepulveda, Luis. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Galvan, Jose María. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Cabrera, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Seleiman, Marcos. Ministerio de Salud, Provincia de Río Negro; Argentina.
Fil: Crowley, Pablo. Universidad Nacional de Río Negro. Escuela de Veterinaria; Argentina.
Fil: Cespedes, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: García Cachau, Mariela. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Gino, Lilia. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Molina, Leonardo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
Fil: Daffner, Jose. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Gauci, Charles G. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Donadeu, Meritxell. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Fil: Lightowlers, Marshall W. University of Melbourne. Faculty of Veterinary and Agricultural Sciences; Australia.
Cystic echinococcosis (CE) is endemic in the Rio Negro province of Argentina. After 30 years of control using praziquantel in dogs the transmission rate to humans and sheep has decreased significantly, however transmission persists. The objective of the study was to assess the inclusion of the EG95 for sheep in the control program and to determine the vaccine's operative feasibility in field conditions. An intervention study was defined in Rio Negro Province in Argentina comprising, in total, an area of 5820 Km2. Lambs received two vaccinations with the EG95 vaccine followed by a single booster injection when the animals were 1-1.5 years of age. Vaccination of lambs born into one trial site was introduced and continued for 8 years. Evidence for Echinococcus granulosus transmission was monitored before and after vaccination by coproantigen ELISA in faecal samples of dog, purgation of dogs to detect E. granulosus worms, necropsy on adult sheep and by ultrasound screening in children of 6-14 years old. 29,323 doses of vaccine were applied between 2009 and 2017, which a vaccination coverage of 80.1%/85.7% (57.3% average for fully vaccinated). Before the introduction of the vaccine 56.3% of the 6-year-old sheep were infected with E. granulosus at necropsy and 84.2% of the farms had infected sheep; 4.3% of the dogs were positive for E. granulosus infection using the arecoline test, and with coproELISA 9.6% of dog fecal samples were positive and 20.3% of the farms had infected dog.After the vaccine was introduced, 21.6% of sheep older than 6 years were found to be infected at necropsy and 20.2% of the farms were found to be infected; in dogs, 4.5% were found positive for E. granulosus using arecoline purgation and with coproELISA 3.7% of samples were positive, with 8.9% of farms having a positive dog. In 2016 only one case of E. granulosus infection was diagnosed by US screening in a 6-14 years old child. Included in the analysis are discussions of difficulties experienced in the field which affected correct vaccine administration as well as social features and practices that may impact on echinococcosis control and the EG95 vaccination program in Rio Negro. Vaccination of sheep with the EG95 vaccine provides a valuable new tool which improves the effectiveness of CE control activities. Vaccination was effective even in a difficult, remote environment where only approximately half the lambs born into the communities were fully vaccinated.
description Fil: Larrieu, Edmundo. Universidad Nacional de La Pampa. Facultad de Ciencias Veterinarias; Argentina.
publishDate 2019
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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 0001-706X
http://sgc.anlis.gob.ar/handle/123456789/2129
10.1016/j.actatropica.2018.12.025
identifier_str_mv 0001-706X
10.1016/j.actatropica.2018.12.025
url http://sgc.anlis.gob.ar/handle/123456789/2129
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dc.relation.none.fl_str_mv Acta tropica
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dc.source.none.fl_str_mv Acta Trópica 2019;191:1-7
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
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instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
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institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
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