Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid

Autores
Fariña, Ana Clara; González, Marcela Aída; Scalerandi, María Victoria; Lavandera, Jimena Veronica; Bernal, Claudio Adrian
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study aimed to investigate the differential effects of trans fatty acids (TFA) on the nutritional parameters, serum and tissue triacylglycerol (TAG) levels, as well as the mechanisms involved in their regulation, in male Wistar rats fed linoleic acid-enriched (+LA) or LA-deficient (-LA) diets. The TFA effects on nutritional parameters and TAG metabolism differed depending on the dietary LA status. In the +LA+TFA diet, compared to the +LA diet, TFA did not alter the serum TAG levels despite the increased epididymal adipose tissue (EAT) lipoprotein lipase (LPL) activity and the higher hepatic TAG content associated with a lower CPT-Ia activity. Otherwise, in -LA+TFA rats versus -LA, TFA increased the serum, liver, and adipose tissue TAG levels associated with higher FAS, G6PDH, and ME enzyme activities in both liver and adipose tissue, and a reduced TAG clearance by the adipose tissue LPL enzyme. Although TFA supplementation in both -LA and +LA-rats tended to decrease the CPT-Ib activity, the muscle TAG levels were not modified. We conclude that the nutritional and metabolic TFA effects depended mainly on the changes in the FA profile induced by dietary LA and, in a lesser extent, on the specific type of isomer retained in the tissues.
Fil: Fariña, Ana Clara. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Scalerandi, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Lavandera, Jimena Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Materia
ISOMER RETENTION
LIPOGENIC ENZYMES
LIPOPROTEIN LIPASE
NUTRITION
TRIACYLGLYCEROL SECRETION RAT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85272
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acidFariña, Ana ClaraGonzález, Marcela AídaScalerandi, María VictoriaLavandera, Jimena VeronicaBernal, Claudio AdrianISOMER RETENTIONLIPOGENIC ENZYMESLIPOPROTEIN LIPASENUTRITIONTRIACYLGLYCEROL SECRETION RAThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This study aimed to investigate the differential effects of trans fatty acids (TFA) on the nutritional parameters, serum and tissue triacylglycerol (TAG) levels, as well as the mechanisms involved in their regulation, in male Wistar rats fed linoleic acid-enriched (+LA) or LA-deficient (-LA) diets. The TFA effects on nutritional parameters and TAG metabolism differed depending on the dietary LA status. In the +LA+TFA diet, compared to the +LA diet, TFA did not alter the serum TAG levels despite the increased epididymal adipose tissue (EAT) lipoprotein lipase (LPL) activity and the higher hepatic TAG content associated with a lower CPT-Ia activity. Otherwise, in -LA+TFA rats versus -LA, TFA increased the serum, liver, and adipose tissue TAG levels associated with higher FAS, G6PDH, and ME enzyme activities in both liver and adipose tissue, and a reduced TAG clearance by the adipose tissue LPL enzyme. Although TFA supplementation in both -LA and +LA-rats tended to decrease the CPT-Ib activity, the muscle TAG levels were not modified. We conclude that the nutritional and metabolic TFA effects depended mainly on the changes in the FA profile induced by dietary LA and, in a lesser extent, on the specific type of isomer retained in the tissues.Fil: Fariña, Ana Clara. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Scalerandi, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Lavandera, Jimena Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaWiley VCH Verlag2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85272Fariña, Ana Clara; González, Marcela Aída; Scalerandi, María Victoria; Lavandera, Jimena Veronica; Bernal, Claudio Adrian; Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid; Wiley VCH Verlag; European Journal of Lipid Science and Technology; 117; 7; 7-2015; 933-9441438-7697CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ejlt.201400288info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ejlt.201400288info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:04Zoai:ri.conicet.gov.ar:11336/85272instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:05.11CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
title Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
spellingShingle Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
Fariña, Ana Clara
ISOMER RETENTION
LIPOGENIC ENZYMES
LIPOPROTEIN LIPASE
NUTRITION
TRIACYLGLYCEROL SECRETION RAT
title_short Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
title_full Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
title_fullStr Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
title_full_unstemmed Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
title_sort Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid
dc.creator.none.fl_str_mv Fariña, Ana Clara
González, Marcela Aída
Scalerandi, María Victoria
Lavandera, Jimena Veronica
Bernal, Claudio Adrian
author Fariña, Ana Clara
author_facet Fariña, Ana Clara
González, Marcela Aída
Scalerandi, María Victoria
Lavandera, Jimena Veronica
Bernal, Claudio Adrian
author_role author
author2 González, Marcela Aída
Scalerandi, María Victoria
Lavandera, Jimena Veronica
Bernal, Claudio Adrian
author2_role author
author
author
author
dc.subject.none.fl_str_mv ISOMER RETENTION
LIPOGENIC ENZYMES
LIPOPROTEIN LIPASE
NUTRITION
TRIACYLGLYCEROL SECRETION RAT
topic ISOMER RETENTION
LIPOGENIC ENZYMES
LIPOPROTEIN LIPASE
NUTRITION
TRIACYLGLYCEROL SECRETION RAT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This study aimed to investigate the differential effects of trans fatty acids (TFA) on the nutritional parameters, serum and tissue triacylglycerol (TAG) levels, as well as the mechanisms involved in their regulation, in male Wistar rats fed linoleic acid-enriched (+LA) or LA-deficient (-LA) diets. The TFA effects on nutritional parameters and TAG metabolism differed depending on the dietary LA status. In the +LA+TFA diet, compared to the +LA diet, TFA did not alter the serum TAG levels despite the increased epididymal adipose tissue (EAT) lipoprotein lipase (LPL) activity and the higher hepatic TAG content associated with a lower CPT-Ia activity. Otherwise, in -LA+TFA rats versus -LA, TFA increased the serum, liver, and adipose tissue TAG levels associated with higher FAS, G6PDH, and ME enzyme activities in both liver and adipose tissue, and a reduced TAG clearance by the adipose tissue LPL enzyme. Although TFA supplementation in both -LA and +LA-rats tended to decrease the CPT-Ib activity, the muscle TAG levels were not modified. We conclude that the nutritional and metabolic TFA effects depended mainly on the changes in the FA profile induced by dietary LA and, in a lesser extent, on the specific type of isomer retained in the tissues.
Fil: Fariña, Ana Clara. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Scalerandi, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Lavandera, Jimena Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
description This study aimed to investigate the differential effects of trans fatty acids (TFA) on the nutritional parameters, serum and tissue triacylglycerol (TAG) levels, as well as the mechanisms involved in their regulation, in male Wistar rats fed linoleic acid-enriched (+LA) or LA-deficient (-LA) diets. The TFA effects on nutritional parameters and TAG metabolism differed depending on the dietary LA status. In the +LA+TFA diet, compared to the +LA diet, TFA did not alter the serum TAG levels despite the increased epididymal adipose tissue (EAT) lipoprotein lipase (LPL) activity and the higher hepatic TAG content associated with a lower CPT-Ia activity. Otherwise, in -LA+TFA rats versus -LA, TFA increased the serum, liver, and adipose tissue TAG levels associated with higher FAS, G6PDH, and ME enzyme activities in both liver and adipose tissue, and a reduced TAG clearance by the adipose tissue LPL enzyme. Although TFA supplementation in both -LA and +LA-rats tended to decrease the CPT-Ib activity, the muscle TAG levels were not modified. We conclude that the nutritional and metabolic TFA effects depended mainly on the changes in the FA profile induced by dietary LA and, in a lesser extent, on the specific type of isomer retained in the tissues.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85272
Fariña, Ana Clara; González, Marcela Aída; Scalerandi, María Victoria; Lavandera, Jimena Veronica; Bernal, Claudio Adrian; Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid; Wiley VCH Verlag; European Journal of Lipid Science and Technology; 117; 7; 7-2015; 933-944
1438-7697
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85272
identifier_str_mv Fariña, Ana Clara; González, Marcela Aída; Scalerandi, María Victoria; Lavandera, Jimena Veronica; Bernal, Claudio Adrian; Nutritional and metabolic effects of dietary trans fats depend on the intake of linoleic acid; Wiley VCH Verlag; European Journal of Lipid Science and Technology; 117; 7; 7-2015; 933-944
1438-7697
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/ejlt.201400288
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ejlt.201400288
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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