Biology of Small cell lung cancer: State of art and novel perspectives

Autores
Denninghoff, Valeria Cecilia; Russo, Alessandro; de Miguel Perez, Diego; Malapelle, Umberto; Benyounes, Amin; Gittens, Allison; Cardona, Andrés Felipe; Rolfo, Christian
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Small cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. Understanding the molecular and genetic landscape of this heterogeneous and lethal disease will pave the way for novel drug development.
Fil: Denninghoff, Valeria Cecilia. Comisión Nacional de Investigación Científica y Tecnológica; Chile. Universidad de Buenos Aires; Argentina
Fil: Russo, Alessandro. University of Maryland; Estados Unidos. Università degli Studi di Messina; Italia
Fil: de Miguel Perez, Diego. University of Maryland; Estados Unidos
Fil: Malapelle, Umberto. Università degli Studi di Napoli Federico II; Italia
Fil: Benyounes, Amin. Inova Fairfax Hospital; Estados Unidos
Fil: Gittens, Allison. University of Maryland; Estados Unidos
Fil: Cardona, Andrés Felipe. Clínica del Country. Clinical and Translational Oncology Group; Colombia. Fundación para la Investigación Clínica y Molecular Aplicada al Cáncer; Colombia. Universidad el Bosque; Colombia
Fil: Rolfo, Christian. University of Maryland; Estados Unidos
Materia
SMALL CELL LUNG CANCER
GENE PATHWAY
PATHOBIOLOGY
TARGET THERAPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/155269
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Biology of Small cell lung cancer: State of art and novel perspectivesDenninghoff, Valeria CeciliaRusso, Alessandrode Miguel Perez, DiegoMalapelle, UmbertoBenyounes, AminGittens, AllisonCardona, Andrés FelipeRolfo, ChristianSMALL CELL LUNG CANCERGENE PATHWAYPATHOBIOLOGYTARGET THERAPYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Small cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. Understanding the molecular and genetic landscape of this heterogeneous and lethal disease will pave the way for novel drug development.Fil: Denninghoff, Valeria Cecilia. Comisión Nacional de Investigación Científica y Tecnológica; Chile. Universidad de Buenos Aires; ArgentinaFil: Russo, Alessandro. University of Maryland; Estados Unidos. Università degli Studi di Messina; ItaliaFil: de Miguel Perez, Diego. University of Maryland; Estados UnidosFil: Malapelle, Umberto. Università degli Studi di Napoli Federico II; ItaliaFil: Benyounes, Amin. Inova Fairfax Hospital; Estados UnidosFil: Gittens, Allison. University of Maryland; Estados UnidosFil: Cardona, Andrés Felipe. Clínica del Country. Clinical and Translational Oncology Group; Colombia. Fundación para la Investigación Clínica y Molecular Aplicada al Cáncer; Colombia. Universidad el Bosque; ColombiaFil: Rolfo, Christian. University of Maryland; Estados UnidosMultidisciplinary Digital Publishing Institute2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/155269Denninghoff, Valeria Cecilia; Russo, Alessandro; de Miguel Perez, Diego; Malapelle, Umberto; Benyounes, Amin; et al.; Biology of Small cell lung cancer: State of art and novel perspectives; Multidisciplinary Digital Publishing Institute; Cancers; 13; 7; 3-2021; 1-122072-6694CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/cancers13071723info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/7/1723info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:43Zoai:ri.conicet.gov.ar:11336/155269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:43.707CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biology of Small cell lung cancer: State of art and novel perspectives
title Biology of Small cell lung cancer: State of art and novel perspectives
spellingShingle Biology of Small cell lung cancer: State of art and novel perspectives
Denninghoff, Valeria Cecilia
SMALL CELL LUNG CANCER
GENE PATHWAY
PATHOBIOLOGY
TARGET THERAPY
title_short Biology of Small cell lung cancer: State of art and novel perspectives
title_full Biology of Small cell lung cancer: State of art and novel perspectives
title_fullStr Biology of Small cell lung cancer: State of art and novel perspectives
title_full_unstemmed Biology of Small cell lung cancer: State of art and novel perspectives
title_sort Biology of Small cell lung cancer: State of art and novel perspectives
dc.creator.none.fl_str_mv Denninghoff, Valeria Cecilia
Russo, Alessandro
de Miguel Perez, Diego
Malapelle, Umberto
Benyounes, Amin
Gittens, Allison
Cardona, Andrés Felipe
Rolfo, Christian
author Denninghoff, Valeria Cecilia
author_facet Denninghoff, Valeria Cecilia
Russo, Alessandro
de Miguel Perez, Diego
Malapelle, Umberto
Benyounes, Amin
Gittens, Allison
Cardona, Andrés Felipe
Rolfo, Christian
author_role author
author2 Russo, Alessandro
de Miguel Perez, Diego
Malapelle, Umberto
Benyounes, Amin
Gittens, Allison
Cardona, Andrés Felipe
Rolfo, Christian
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SMALL CELL LUNG CANCER
GENE PATHWAY
PATHOBIOLOGY
TARGET THERAPY
topic SMALL CELL LUNG CANCER
GENE PATHWAY
PATHOBIOLOGY
TARGET THERAPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Small cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. Understanding the molecular and genetic landscape of this heterogeneous and lethal disease will pave the way for novel drug development.
Fil: Denninghoff, Valeria Cecilia. Comisión Nacional de Investigación Científica y Tecnológica; Chile. Universidad de Buenos Aires; Argentina
Fil: Russo, Alessandro. University of Maryland; Estados Unidos. Università degli Studi di Messina; Italia
Fil: de Miguel Perez, Diego. University of Maryland; Estados Unidos
Fil: Malapelle, Umberto. Università degli Studi di Napoli Federico II; Italia
Fil: Benyounes, Amin. Inova Fairfax Hospital; Estados Unidos
Fil: Gittens, Allison. University of Maryland; Estados Unidos
Fil: Cardona, Andrés Felipe. Clínica del Country. Clinical and Translational Oncology Group; Colombia. Fundación para la Investigación Clínica y Molecular Aplicada al Cáncer; Colombia. Universidad el Bosque; Colombia
Fil: Rolfo, Christian. University of Maryland; Estados Unidos
description Small cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. Understanding the molecular and genetic landscape of this heterogeneous and lethal disease will pave the way for novel drug development.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/155269
Denninghoff, Valeria Cecilia; Russo, Alessandro; de Miguel Perez, Diego; Malapelle, Umberto; Benyounes, Amin; et al.; Biology of Small cell lung cancer: State of art and novel perspectives; Multidisciplinary Digital Publishing Institute; Cancers; 13; 7; 3-2021; 1-12
2072-6694
CONICET Digital
CONICET
url http://hdl.handle.net/11336/155269
identifier_str_mv Denninghoff, Valeria Cecilia; Russo, Alessandro; de Miguel Perez, Diego; Malapelle, Umberto; Benyounes, Amin; et al.; Biology of Small cell lung cancer: State of art and novel perspectives; Multidisciplinary Digital Publishing Institute; Cancers; 13; 7; 3-2021; 1-12
2072-6694
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/cancers13071723
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/7/1723
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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