Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatme...

Autores
Hereñú, Claudia Beatriz; Crespo, Rosana
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The proposed model for mechanisms of action involved in C. reticulata and P. ternata -induced NSCLC growth inhibition would be the modulation of the nuclear receptor (ESR1)—Co-repressor (NCOA3) complex in control of cell cycle via c-Fos transcription factor. Diverse phytochemicals showed their modulatory effects in all these molecular events as the downregulation of c-Fos signaling by flavonoids from the peels of Citrus unshiu (Vu 2021), the modulatory effects of the phytochemicals of Punica granatum against estrogen receptors (Usha 2021), or even their impact on the production of inflammatory mediators AP-1 and MAPKs among others (Prasad 2022), suggesting that phytochemicals are natural reserves of novel drugs for cancer therapy. As concluding remarks, the antiproliferative effect of phytocompounds from medicinal plants through the modulation of estrogen receptors, specifically in lung cells, is a promising mechanism of action that could provide scientific information to find new therapeutic targets.
Fil: Hereñú, Claudia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Crespo, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Materia
Citrus reticulata (C. reticulata)
Pinellia ternata (P. ternata)
Estrogen receptor pathway (ER pathway)
Non-small cell lung cancer (NSCLC)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/230372
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatmentHereñú, Claudia BeatrizCrespo, RosanaCitrus reticulata (C. reticulata)Pinellia ternata (P. ternata)Estrogen receptor pathway (ER pathway)Non-small cell lung cancer (NSCLC)https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The proposed model for mechanisms of action involved in C. reticulata and P. ternata -induced NSCLC growth inhibition would be the modulation of the nuclear receptor (ESR1)—Co-repressor (NCOA3) complex in control of cell cycle via c-Fos transcription factor. Diverse phytochemicals showed their modulatory effects in all these molecular events as the downregulation of c-Fos signaling by flavonoids from the peels of Citrus unshiu (Vu 2021), the modulatory effects of the phytochemicals of Punica granatum against estrogen receptors (Usha 2021), or even their impact on the production of inflammatory mediators AP-1 and MAPKs among others (Prasad 2022), suggesting that phytochemicals are natural reserves of novel drugs for cancer therapy. As concluding remarks, the antiproliferative effect of phytocompounds from medicinal plants through the modulation of estrogen receptors, specifically in lung cells, is a promising mechanism of action that could provide scientific information to find new therapeutic targets.Fil: Hereñú, Claudia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Crespo, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaAME Publishing Company2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/230372Hereñú, Claudia Beatriz; Crespo, Rosana; Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment; AME Publishing Company; Translational Cancer Research; 12; 12; 12-2023; 3249-32542219-68032218-676XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://tcr.amegroups.org/article/view/80794/htmlinfo:eu-repo/semantics/altIdentifier/doi/10.21037/tcr-23-1440info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:42Zoai:ri.conicet.gov.ar:11336/230372instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:43.271CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
title Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
spellingShingle Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
Hereñú, Claudia Beatriz
Citrus reticulata (C. reticulata)
Pinellia ternata (P. ternata)
Estrogen receptor pathway (ER pathway)
Non-small cell lung cancer (NSCLC)
title_short Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
title_full Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
title_fullStr Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
title_full_unstemmed Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
title_sort Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment
dc.creator.none.fl_str_mv Hereñú, Claudia Beatriz
Crespo, Rosana
author Hereñú, Claudia Beatriz
author_facet Hereñú, Claudia Beatriz
Crespo, Rosana
author_role author
author2 Crespo, Rosana
author2_role author
dc.subject.none.fl_str_mv Citrus reticulata (C. reticulata)
Pinellia ternata (P. ternata)
Estrogen receptor pathway (ER pathway)
Non-small cell lung cancer (NSCLC)
topic Citrus reticulata (C. reticulata)
Pinellia ternata (P. ternata)
Estrogen receptor pathway (ER pathway)
Non-small cell lung cancer (NSCLC)
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The proposed model for mechanisms of action involved in C. reticulata and P. ternata -induced NSCLC growth inhibition would be the modulation of the nuclear receptor (ESR1)—Co-repressor (NCOA3) complex in control of cell cycle via c-Fos transcription factor. Diverse phytochemicals showed their modulatory effects in all these molecular events as the downregulation of c-Fos signaling by flavonoids from the peels of Citrus unshiu (Vu 2021), the modulatory effects of the phytochemicals of Punica granatum against estrogen receptors (Usha 2021), or even their impact on the production of inflammatory mediators AP-1 and MAPKs among others (Prasad 2022), suggesting that phytochemicals are natural reserves of novel drugs for cancer therapy. As concluding remarks, the antiproliferative effect of phytocompounds from medicinal plants through the modulation of estrogen receptors, specifically in lung cells, is a promising mechanism of action that could provide scientific information to find new therapeutic targets.
Fil: Hereñú, Claudia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Crespo, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
description The proposed model for mechanisms of action involved in C. reticulata and P. ternata -induced NSCLC growth inhibition would be the modulation of the nuclear receptor (ESR1)—Co-repressor (NCOA3) complex in control of cell cycle via c-Fos transcription factor. Diverse phytochemicals showed their modulatory effects in all these molecular events as the downregulation of c-Fos signaling by flavonoids from the peels of Citrus unshiu (Vu 2021), the modulatory effects of the phytochemicals of Punica granatum against estrogen receptors (Usha 2021), or even their impact on the production of inflammatory mediators AP-1 and MAPKs among others (Prasad 2022), suggesting that phytochemicals are natural reserves of novel drugs for cancer therapy. As concluding remarks, the antiproliferative effect of phytocompounds from medicinal plants through the modulation of estrogen receptors, specifically in lung cells, is a promising mechanism of action that could provide scientific information to find new therapeutic targets.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/230372
Hereñú, Claudia Beatriz; Crespo, Rosana; Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment; AME Publishing Company; Translational Cancer Research; 12; 12; 12-2023; 3249-3254
2219-6803
2218-676X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/230372
identifier_str_mv Hereñú, Claudia Beatriz; Crespo, Rosana; Phytochemicals as estrogen receptor modulators?-a commentary of a network pharmacology study of two commonly employed Chinese herbal medicines in non-small cell lung cancer treatment; AME Publishing Company; Translational Cancer Research; 12; 12; 12-2023; 3249-3254
2219-6803
2218-676X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://tcr.amegroups.org/article/view/80794/html
info:eu-repo/semantics/altIdentifier/doi/10.21037/tcr-23-1440
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AME Publishing Company
publisher.none.fl_str_mv AME Publishing Company
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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