Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome

Autores
Iglesias Molli, Andrea Elena; Panero, Julieta; Dos Santos, Patricia Carolina; González, Claudio Daniel; Vilariño, Jorge; Sereday, Marta; Cerrone, Gloria Edith; Slavutsky, Irma Rosa; Frechtel, Gustavo Daniel
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Obesity is the principal component in the Metabolic Syndrome (MetS) that determines the progression of metabolic complications. Metabolically healthy obese (MHO) individuals seem to be protected against those complications. Telomere length (TL) as a novel marker of cellular aging had a complex relationship to the MetS. The principal aim of this study was to investigate the TL in MHO, and to study the association between TL and the worsening of the metabolic condition. Material and methods: We have determined the absolute TL (aTL) in 400 women (mean age of 46.76 - 15.47 years; range: 18-86 years), grouped according to the metabolic condition in three groups: metabolically healthy non-obese women (MHNO), MHO and obese women with MetS (MSO); and grouped according to the number of components of MetS. Results: We found that MHO displays significantly higher aTL than MSO (p = 0.033; r = -4.63; 95% CI r = -8.89 / -0.37), but did not differ from MHNO. A decrease in aTL with the progressive increase in the number of MetS components was also observed (p = 0.001; r = -2.06; 95% CI r = -3.13 / -0.99). In this way, our results indicate that aTL is influenced by the presence of MetS, but it is not affected by the presence of obesity. Discussion: We found that shorter aTL is not associated with MHO, but is related to MetS and with the increased number of metabolic abnormalities.
Fil: Iglesias Molli, Andrea Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Panero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Dos Santos, Patricia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: González, Claudio Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Vilariño, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sereday, Marta. Hospital Fiorito; Argentina
Fil: Cerrone, Gloria Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Frechtel, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Materia
METABOLIC SYNDROME (METS)
METABOLICALLY HEALTHY OBESE (MHO)
METABOLICALLY HEALTHY NON-OBESE WOMEN (MHNO)
OBESE WOMEN WITH METS (MSO)
TELOMERE LENGTH (TL)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42271
Acceder
id CONICETDig_ec47c08e8ac022c78f8034868d359380
oai_identifier_str oai:ri.conicet.gov.ar:11336/42271
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Metabolically healthy obese women have longer telomere length than obese women with metabolic syndromeIglesias Molli, Andrea ElenaPanero, JulietaDos Santos, Patricia CarolinaGonzález, Claudio DanielVilariño, JorgeSereday, MartaCerrone, Gloria EdithSlavutsky, Irma RosaFrechtel, Gustavo DanielMETABOLIC SYNDROME (METS)METABOLICALLY HEALTHY OBESE (MHO)METABOLICALLY HEALTHY NON-OBESE WOMEN (MHNO)OBESE WOMEN WITH METS (MSO)TELOMERE LENGTH (TL)https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Obesity is the principal component in the Metabolic Syndrome (MetS) that determines the progression of metabolic complications. Metabolically healthy obese (MHO) individuals seem to be protected against those complications. Telomere length (TL) as a novel marker of cellular aging had a complex relationship to the MetS. The principal aim of this study was to investigate the TL in MHO, and to study the association between TL and the worsening of the metabolic condition. Material and methods: We have determined the absolute TL (aTL) in 400 women (mean age of 46.76 - 15.47 years; range: 18-86 years), grouped according to the metabolic condition in three groups: metabolically healthy non-obese women (MHNO), MHO and obese women with MetS (MSO); and grouped according to the number of components of MetS. Results: We found that MHO displays significantly higher aTL than MSO (p = 0.033; r = -4.63; 95% CI r = -8.89 / -0.37), but did not differ from MHNO. A decrease in aTL with the progressive increase in the number of MetS components was also observed (p = 0.001; r = -2.06; 95% CI r = -3.13 / -0.99). In this way, our results indicate that aTL is influenced by the presence of MetS, but it is not affected by the presence of obesity. Discussion: We found that shorter aTL is not associated with MHO, but is related to MetS and with the increased number of metabolic abnormalities.Fil: Iglesias Molli, Andrea Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Panero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Dos Santos, Patricia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: González, Claudio Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; ArgentinaFil: Vilariño, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Sereday, Marta. Hospital Fiorito; ArgentinaFil: Cerrone, Gloria Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; ArgentinaFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Frechtel, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaPublic Library of Science2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42271Iglesias Molli, Andrea Elena; Panero, Julieta; Dos Santos, Patricia Carolina; González, Claudio Daniel; Vilariño, Jorge; et al.; Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome; Public Library of Science; Plos One; 12; 4; 4-2017; 1-131932-62031932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0174945info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174945info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:06Zoai:ri.conicet.gov.ar:11336/42271instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:06.585CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome
title Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome
spellingShingle Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome
Iglesias Molli, Andrea Elena
METABOLIC SYNDROME (METS)
METABOLICALLY HEALTHY OBESE (MHO)
METABOLICALLY HEALTHY NON-OBESE WOMEN (MHNO)
OBESE WOMEN WITH METS (MSO)
TELOMERE LENGTH (TL)
title_short Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome
title_full Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome
title_fullStr Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome
title_full_unstemmed Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome
title_sort Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome
dc.creator.none.fl_str_mv Iglesias Molli, Andrea Elena
Panero, Julieta
Dos Santos, Patricia Carolina
González, Claudio Daniel
Vilariño, Jorge
Sereday, Marta
Cerrone, Gloria Edith
Slavutsky, Irma Rosa
Frechtel, Gustavo Daniel
author Iglesias Molli, Andrea Elena
author_facet Iglesias Molli, Andrea Elena
Panero, Julieta
Dos Santos, Patricia Carolina
González, Claudio Daniel
Vilariño, Jorge
Sereday, Marta
Cerrone, Gloria Edith
Slavutsky, Irma Rosa
Frechtel, Gustavo Daniel
author_role author
author2 Panero, Julieta
Dos Santos, Patricia Carolina
González, Claudio Daniel
Vilariño, Jorge
Sereday, Marta
Cerrone, Gloria Edith
Slavutsky, Irma Rosa
Frechtel, Gustavo Daniel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv METABOLIC SYNDROME (METS)
METABOLICALLY HEALTHY OBESE (MHO)
METABOLICALLY HEALTHY NON-OBESE WOMEN (MHNO)
OBESE WOMEN WITH METS (MSO)
TELOMERE LENGTH (TL)
topic METABOLIC SYNDROME (METS)
METABOLICALLY HEALTHY OBESE (MHO)
METABOLICALLY HEALTHY NON-OBESE WOMEN (MHNO)
OBESE WOMEN WITH METS (MSO)
TELOMERE LENGTH (TL)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Obesity is the principal component in the Metabolic Syndrome (MetS) that determines the progression of metabolic complications. Metabolically healthy obese (MHO) individuals seem to be protected against those complications. Telomere length (TL) as a novel marker of cellular aging had a complex relationship to the MetS. The principal aim of this study was to investigate the TL in MHO, and to study the association between TL and the worsening of the metabolic condition. Material and methods: We have determined the absolute TL (aTL) in 400 women (mean age of 46.76 - 15.47 years; range: 18-86 years), grouped according to the metabolic condition in three groups: metabolically healthy non-obese women (MHNO), MHO and obese women with MetS (MSO); and grouped according to the number of components of MetS. Results: We found that MHO displays significantly higher aTL than MSO (p = 0.033; r = -4.63; 95% CI r = -8.89 / -0.37), but did not differ from MHNO. A decrease in aTL with the progressive increase in the number of MetS components was also observed (p = 0.001; r = -2.06; 95% CI r = -3.13 / -0.99). In this way, our results indicate that aTL is influenced by the presence of MetS, but it is not affected by the presence of obesity. Discussion: We found that shorter aTL is not associated with MHO, but is related to MetS and with the increased number of metabolic abnormalities.
Fil: Iglesias Molli, Andrea Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Panero, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Dos Santos, Patricia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: González, Claudio Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Vilariño, Jorge. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Sereday, Marta. Hospital Fiorito; Argentina
Fil: Cerrone, Gloria Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Frechtel, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
description Introduction: Obesity is the principal component in the Metabolic Syndrome (MetS) that determines the progression of metabolic complications. Metabolically healthy obese (MHO) individuals seem to be protected against those complications. Telomere length (TL) as a novel marker of cellular aging had a complex relationship to the MetS. The principal aim of this study was to investigate the TL in MHO, and to study the association between TL and the worsening of the metabolic condition. Material and methods: We have determined the absolute TL (aTL) in 400 women (mean age of 46.76 - 15.47 years; range: 18-86 years), grouped according to the metabolic condition in three groups: metabolically healthy non-obese women (MHNO), MHO and obese women with MetS (MSO); and grouped according to the number of components of MetS. Results: We found that MHO displays significantly higher aTL than MSO (p = 0.033; r = -4.63; 95% CI r = -8.89 / -0.37), but did not differ from MHNO. A decrease in aTL with the progressive increase in the number of MetS components was also observed (p = 0.001; r = -2.06; 95% CI r = -3.13 / -0.99). In this way, our results indicate that aTL is influenced by the presence of MetS, but it is not affected by the presence of obesity. Discussion: We found that shorter aTL is not associated with MHO, but is related to MetS and with the increased number of metabolic abnormalities.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42271
Iglesias Molli, Andrea Elena; Panero, Julieta; Dos Santos, Patricia Carolina; González, Claudio Daniel; Vilariño, Jorge; et al.; Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome; Public Library of Science; Plos One; 12; 4; 4-2017; 1-13
1932-6203
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42271
identifier_str_mv Iglesias Molli, Andrea Elena; Panero, Julieta; Dos Santos, Patricia Carolina; González, Claudio Daniel; Vilariño, Jorge; et al.; Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome; Public Library of Science; Plos One; 12; 4; 4-2017; 1-13
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174945
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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