Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk

Autores
Cruces, Pablo Daniel; Alvarado Rodríguez, Francisco Javier; Romo Vázquez, Rebeca; Arini, Pedro David
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The detection of proarrhythmic side effects in many marketed drugs has prompted the search for complementary non-invasive markers of cardiotoxicity risk. Novel indices based on the study of cardiac vector dynamics have now emerged. Herein, we use quaternion methods to study alterations in the angular velocity during ventricular repolarization. The assessment was conducted in patients with Torsade de Pointes episodes when undergoing a Sotalol treatment. The algorithm includes a Principal Component Analysis to homogenize the information from three databases and, at the same time, reduce the space to three dimensions. Significant differences were found (p < 5E-4) in the angular velocity of the second half of repolarization loop (T-wave). The ratio between the maximums of the angular velocity in both T-wave halves showed a trend to 1 in the proximity of an arrhythmic event and reached sensitivity/specificity pair of 97/100 (AUC 0.99) in the comparison of healthy population with at-risk patients. The high performance of the method exceeded the expectations of the standard measurement and it becomes a promising outcome for the development of safe drug therapies.
Fil: Cruces, Pablo Daniel. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina
Fil: Alvarado Rodríguez, Francisco Javier. Universidad Autónoma de Guadalajara; México
Fil: Romo Vázquez, Rebeca. Universidad de Guadalajara; México
Fil: Arini, Pedro David. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina
XIX Reunión de trabajo en procesamiento de la información y control
San Juan
Argentina
Universidad Nacional de San Juan. Instituto de Automática
Materia
TORSADE DE POINTES
QUATERNION
ANGULAR VELOCITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/156263
Acceder
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spelling Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic riskCruces, Pablo DanielAlvarado Rodríguez, Francisco JavierRomo Vázquez, RebecaArini, Pedro DavidTORSADE DE POINTESQUATERNIONANGULAR VELOCITYhttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2The detection of proarrhythmic side effects in many marketed drugs has prompted the search for complementary non-invasive markers of cardiotoxicity risk. Novel indices based on the study of cardiac vector dynamics have now emerged. Herein, we use quaternion methods to study alterations in the angular velocity during ventricular repolarization. The assessment was conducted in patients with Torsade de Pointes episodes when undergoing a Sotalol treatment. The algorithm includes a Principal Component Analysis to homogenize the information from three databases and, at the same time, reduce the space to three dimensions. Significant differences were found (p < 5E-4) in the angular velocity of the second half of repolarization loop (T-wave). The ratio between the maximums of the angular velocity in both T-wave halves showed a trend to 1 in the proximity of an arrhythmic event and reached sensitivity/specificity pair of 97/100 (AUC 0.99) in the comparison of healthy population with at-risk patients. The high performance of the method exceeded the expectations of the standard measurement and it becomes a promising outcome for the development of safe drug therapies.Fil: Cruces, Pablo Daniel. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; ArgentinaFil: Alvarado Rodríguez, Francisco Javier. Universidad Autónoma de Guadalajara; MéxicoFil: Romo Vázquez, Rebeca. Universidad de Guadalajara; MéxicoFil: Arini, Pedro David. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; ArgentinaXIX Reunión de trabajo en procesamiento de la información y controlSan JuanArgentinaUniversidad Nacional de San Juan. Instituto de AutomáticaRPICRoberti, FlavioToibero, Juan MarcosAmicarelli, Adriana NatachaSlawiñski, Emanuel2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/156263Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk; XIX Reunión de trabajo en procesamiento de la información y control; San Juan; Argentina; 2021; 212-217978-987-88-2891-6CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.rpic.com.ar/memorias.phpNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:00Zoai:ri.conicet.gov.ar:11336/156263instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:00.323CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
title Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
spellingShingle Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
Cruces, Pablo Daniel
TORSADE DE POINTES
QUATERNION
ANGULAR VELOCITY
title_short Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
title_full Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
title_fullStr Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
title_full_unstemmed Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
title_sort Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk
dc.creator.none.fl_str_mv Cruces, Pablo Daniel
Alvarado Rodríguez, Francisco Javier
Romo Vázquez, Rebeca
Arini, Pedro David
author Cruces, Pablo Daniel
author_facet Cruces, Pablo Daniel
Alvarado Rodríguez, Francisco Javier
Romo Vázquez, Rebeca
Arini, Pedro David
author_role author
author2 Alvarado Rodríguez, Francisco Javier
Romo Vázquez, Rebeca
Arini, Pedro David
author2_role author
author
author
dc.contributor.none.fl_str_mv Roberti, Flavio
Toibero, Juan Marcos
Amicarelli, Adriana Natacha
Slawiñski, Emanuel
dc.subject.none.fl_str_mv TORSADE DE POINTES
QUATERNION
ANGULAR VELOCITY
topic TORSADE DE POINTES
QUATERNION
ANGULAR VELOCITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The detection of proarrhythmic side effects in many marketed drugs has prompted the search for complementary non-invasive markers of cardiotoxicity risk. Novel indices based on the study of cardiac vector dynamics have now emerged. Herein, we use quaternion methods to study alterations in the angular velocity during ventricular repolarization. The assessment was conducted in patients with Torsade de Pointes episodes when undergoing a Sotalol treatment. The algorithm includes a Principal Component Analysis to homogenize the information from three databases and, at the same time, reduce the space to three dimensions. Significant differences were found (p < 5E-4) in the angular velocity of the second half of repolarization loop (T-wave). The ratio between the maximums of the angular velocity in both T-wave halves showed a trend to 1 in the proximity of an arrhythmic event and reached sensitivity/specificity pair of 97/100 (AUC 0.99) in the comparison of healthy population with at-risk patients. The high performance of the method exceeded the expectations of the standard measurement and it becomes a promising outcome for the development of safe drug therapies.
Fil: Cruces, Pablo Daniel. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina
Fil: Alvarado Rodríguez, Francisco Javier. Universidad Autónoma de Guadalajara; México
Fil: Romo Vázquez, Rebeca. Universidad de Guadalajara; México
Fil: Arini, Pedro David. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderón; Argentina
XIX Reunión de trabajo en procesamiento de la información y control
San Juan
Argentina
Universidad Nacional de San Juan. Instituto de Automática
description The detection of proarrhythmic side effects in many marketed drugs has prompted the search for complementary non-invasive markers of cardiotoxicity risk. Novel indices based on the study of cardiac vector dynamics have now emerged. Herein, we use quaternion methods to study alterations in the angular velocity during ventricular repolarization. The assessment was conducted in patients with Torsade de Pointes episodes when undergoing a Sotalol treatment. The algorithm includes a Principal Component Analysis to homogenize the information from three databases and, at the same time, reduce the space to three dimensions. Significant differences were found (p < 5E-4) in the angular velocity of the second half of repolarization loop (T-wave). The ratio between the maximums of the angular velocity in both T-wave halves showed a trend to 1 in the proximity of an arrhythmic event and reached sensitivity/specificity pair of 97/100 (AUC 0.99) in the comparison of healthy population with at-risk patients. The high performance of the method exceeded the expectations of the standard measurement and it becomes a promising outcome for the development of safe drug therapies.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/156263
Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk; XIX Reunión de trabajo en procesamiento de la información y control; San Juan; Argentina; 2021; 212-217
978-987-88-2891-6
CONICET Digital
CONICET
url http://hdl.handle.net/11336/156263
identifier_str_mv Towards a new generation of dynamic indices for the assessment of drug-induced proarrhythmic risk; XIX Reunión de trabajo en procesamiento de la información y control; San Juan; Argentina; 2021; 212-217
978-987-88-2891-6
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.rpic.com.ar/memorias.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv RPIC
publisher.none.fl_str_mv RPIC
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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