Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health

Autores
Newton, Paul N.; Hampton, Christina Y.; Alter-Hall, Krystyn; Teerwarakulpana, Thanongsak; Prakongpan, Sompol; Ruangveerayuth, Ronnatrai; White, Nicholas J.; Day, Nicholas P. J.; Tudino, Mabel Beatriz; Mancuso, Natalia; Fernández, Facundo M.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance.
Fil: Newton, Paul N.. University of Oxford; Reino Unido
Fil: Hampton, Christina Y.. University of Oxford; Reino Unido
Fil: Alter-Hall, Krystyn. Georgia Institute of Technology; Estados Unidos
Fil: Teerwarakulpana, Thanongsak. University of Oxford; Reino Unido
Fil: Prakongpan, Sompol. University of Oxford; Reino Unido
Fil: Ruangveerayuth, Ronnatrai. University of Oxford; Reino Unido
Fil: White, Nicholas J.. University of Oxford; Reino Unido
Fil: Day, Nicholas P. J.. University of Oxford; Reino Unido
Fil: Tudino, Mabel Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Mancuso, Natalia. University of Oxford; Reino Unido
Fil: Fernández, Facundo M.. Georgia Institute of Technology; Estados Unidos
Materia
DRUG RESISTANCE
YAA CHUD
MYANMAR EPIDEMIOLOGY
MALARIA
THAILAND EPIDEMIOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84590
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/84590
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public HealthNewton, Paul N.Hampton, Christina Y.Alter-Hall, KrystynTeerwarakulpana, ThanongsakPrakongpan, SompolRuangveerayuth, RonnatraiWhite, Nicholas J.Day, Nicholas P. J.Tudino, Mabel BeatrizMancuso, NataliaFernández, Facundo M.DRUG RESISTANCEYAA CHUDMYANMAR EPIDEMIOLOGYMALARIATHAILAND EPIDEMIOLOGYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance.Fil: Newton, Paul N.. University of Oxford; Reino UnidoFil: Hampton, Christina Y.. University of Oxford; Reino UnidoFil: Alter-Hall, Krystyn. Georgia Institute of Technology; Estados UnidosFil: Teerwarakulpana, Thanongsak. University of Oxford; Reino UnidoFil: Prakongpan, Sompol. University of Oxford; Reino UnidoFil: Ruangveerayuth, Ronnatrai. University of Oxford; Reino UnidoFil: White, Nicholas J.. University of Oxford; Reino UnidoFil: Day, Nicholas P. J.. University of Oxford; Reino UnidoFil: Tudino, Mabel Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Mancuso, Natalia. University of Oxford; Reino UnidoFil: Fernández, Facundo M.. Georgia Institute of Technology; Estados UnidosAmerican Society of Tropical Medicine and Hygiene2008-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84590Newton, Paul N.; Hampton, Christina Y.; Alter-Hall, Krystyn; Teerwarakulpana, Thanongsak; Prakongpan, Sompol; et al.; Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 79; 5; 11-2008; 662-6690002-9637CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.2008.79.662info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.2008.79.662info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/18981500info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:04Zoai:ri.conicet.gov.ar:11336/84590instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:04.611CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
title Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
spellingShingle Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
Newton, Paul N.
DRUG RESISTANCE
YAA CHUD
MYANMAR EPIDEMIOLOGY
MALARIA
THAILAND EPIDEMIOLOGY
title_short Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
title_full Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
title_fullStr Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
title_full_unstemmed Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
title_sort Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health
dc.creator.none.fl_str_mv Newton, Paul N.
Hampton, Christina Y.
Alter-Hall, Krystyn
Teerwarakulpana, Thanongsak
Prakongpan, Sompol
Ruangveerayuth, Ronnatrai
White, Nicholas J.
Day, Nicholas P. J.
Tudino, Mabel Beatriz
Mancuso, Natalia
Fernández, Facundo M.
author Newton, Paul N.
author_facet Newton, Paul N.
Hampton, Christina Y.
Alter-Hall, Krystyn
Teerwarakulpana, Thanongsak
Prakongpan, Sompol
Ruangveerayuth, Ronnatrai
White, Nicholas J.
Day, Nicholas P. J.
Tudino, Mabel Beatriz
Mancuso, Natalia
Fernández, Facundo M.
author_role author
author2 Hampton, Christina Y.
Alter-Hall, Krystyn
Teerwarakulpana, Thanongsak
Prakongpan, Sompol
Ruangveerayuth, Ronnatrai
White, Nicholas J.
Day, Nicholas P. J.
Tudino, Mabel Beatriz
Mancuso, Natalia
Fernández, Facundo M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DRUG RESISTANCE
YAA CHUD
MYANMAR EPIDEMIOLOGY
MALARIA
THAILAND EPIDEMIOLOGY
topic DRUG RESISTANCE
YAA CHUD
MYANMAR EPIDEMIOLOGY
MALARIA
THAILAND EPIDEMIOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance.
Fil: Newton, Paul N.. University of Oxford; Reino Unido
Fil: Hampton, Christina Y.. University of Oxford; Reino Unido
Fil: Alter-Hall, Krystyn. Georgia Institute of Technology; Estados Unidos
Fil: Teerwarakulpana, Thanongsak. University of Oxford; Reino Unido
Fil: Prakongpan, Sompol. University of Oxford; Reino Unido
Fil: Ruangveerayuth, Ronnatrai. University of Oxford; Reino Unido
Fil: White, Nicholas J.. University of Oxford; Reino Unido
Fil: Day, Nicholas P. J.. University of Oxford; Reino Unido
Fil: Tudino, Mabel Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Mancuso, Natalia. University of Oxford; Reino Unido
Fil: Fernández, Facundo M.. Georgia Institute of Technology; Estados Unidos
description Multidrug-resistant Plasmodium falciparum malaria is a severe public health problem on the Thailand-Myanmar border. Many villagers buy packets of 4-5 mixed medicines ("yaa chud") from shops without medical assessment as their first-line malaria treatment. In 2000-2001 a local researcher purchased 50 yaa chud from 44 shops around Mae Sot, Thailand and Myawaddy, Myanmar (Burma), for his wife who was said to be pregnant with fever and drowsiness. The tablets/capsules were provisionally identified by appearance and active ingredients determined in a subset by using mass and atomic spectrometry. The most frequently detected active ingredients were acetaminophen (22%), chlorpheniramine (13.4%), chloroquine (12.6%), tetracycline/doxycycline (11.4%), and quinine (5.1%). Only seven bags contained potentially curative medicine for malaria. A total of 82% of the bags contained medicines contraindicated in pregnancy. Inappropriate, ineffective antimalarial drugs on the Thailand-Myanmar border are likely to increase malaria morbidity, mortality and health costs and engender the emergence and spread of antimalarial drug resistance.
publishDate 2008
dc.date.none.fl_str_mv 2008-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84590
Newton, Paul N.; Hampton, Christina Y.; Alter-Hall, Krystyn; Teerwarakulpana, Thanongsak; Prakongpan, Sompol; et al.; Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 79; 5; 11-2008; 662-669
0002-9637
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84590
identifier_str_mv Newton, Paul N.; Hampton, Christina Y.; Alter-Hall, Krystyn; Teerwarakulpana, Thanongsak; Prakongpan, Sompol; et al.; Characterization of “Yaa Chud” Medicine on the Thailand–Myanmar Border: selecting for Drug-resistant Malaria and Threatening Public Health; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 79; 5; 11-2008; 662-669
0002-9637
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.2008.79.662
info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.2008.79.662
info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/18981500
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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